SU1731811A1 - Strain b/60/32/p of influenza virus b, used for preparation of living intranasal vaccine for adult and children - Google Patents
Strain b/60/32/p of influenza virus b, used for preparation of living intranasal vaccine for adult and children Download PDFInfo
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- SU1731811A1 SU1731811A1 SU904841460A SU4841460A SU1731811A1 SU 1731811 A1 SU1731811 A1 SU 1731811A1 SU 904841460 A SU904841460 A SU 904841460A SU 4841460 A SU4841460 A SU 4841460A SU 1731811 A1 SU1731811 A1 SU 1731811A1
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Abstract
Использование: иммунологи , медицина . Сущность изобретени : вакцинный штамм В/60/32/Р - рекомбинант, полученный путем скрещивани эпидемического вируса В/СССР/3/87 с холодо- адаптированным штаммом В/СССР/60/69, донором аттенуации, безвредным дл взрослых и детей 3-14 лет, свойства которого дают возможность получать рекомбинан- тные вакцинные штаммы из вновь по вл ющихс эпидемических вирусов. Штамм В/60/32/Р активно репродуцируетс (6,5-7,5 Ig ЭИДбо)/0,2 мл в развивающихс куриных эмбрионах при оптимальной Uses: immunologists, medicine. The essence of the invention: vaccine strain B / 60/32 / P - a recombinant obtained by crossing an epidemic virus B / USSR / 3/87 with a cold adapted strain B / USSR / 60/69, an attenuation donor harmless to adults and children 3- 14 years of age, whose properties make it possible to obtain recombinant vaccine strains from newly emerging epidemic viruses. Strain B / 60/32 / P is actively reproduced (6.5-7.5 Ig EIDbo) /0.2 ml in developing chicken embryos at optimal
Description
Изобретение относитс к медицинской вирусологии и может быть использовано дл профилактики эпидемического гриппа.This invention relates to medical virology and can be used for the prevention of epidemic influenza.
Целью изобретени вл етс получение вакцинного штамма актуальной антигенной разновидности на основе эпидемического вируса В/СССР/3/87.The aim of the invention is to obtain a vaccine strain of the current antigenic variety based on the epidemic virus B / USSR / 3/87.
Вакцинный штамм В/60/32/Р получен методом генетической рекомбинацииэпидемического вирусаVaccine strain B / 60/32 / P obtained by genetic recombination of the epidemic virus
В/СССР/3/87 с холодоадаптированным штаммом В/СССР/60/69-донором аттенуации с последующей селекцией в присутствии антисыворотки В/СССР/60/69. Штамм депонирован в Государственной коллекции вирусов под № 2229.B / USSR / 3/87 with a cold-adapted strain B / USSR / 60/69-donor attenuation followed by selection in the presence of antiserum B / USSR / 60/69. The strain is deposited in the State collection of viruses under No. 2229.
Штамм В/60/32/Р унаследовал от донора аттенуации 6 генов, кодирующих внутренние белки РВ I, РВ2, PA, NP, М, и NS и от эпидемического вируса 2 гена, кодирующих поверхностные белки: гемагглюти- нин и нейраминидазу.Strain B / 60/32 / P inherited from the donor attenuation 6 genes encoding the internal proteins PB I, PB2, PA, NP, M, and NS and the epidemic virus 2 genes encoding surface proteins: hemagglutinin and neuraminidase.
Морфологи штамма В/60/32/Р - полиморфна , типична дл вируса гриппа.The morphology of strain B / 60/32 / P is polymorphic, typical of the influenza virus.
Характеристики штамма В/60/32/Р.Characteristics of the strain B / 60/32 / P.
Состав генома: гены 5 и 6 от эпидемического вируса, гены 1,2,3,4,7 и 8 - от донора аттенуации.Composition of the genome: genes 5 and 6 from the epidemic virus, genes 1,2,3,4,7 and 8 from the donor attenuation.
Инфекционна активность при репродукции в развивающихс куриных эмбрионах при 32°С в течение 72 ч - 6,5 Ig ЭИД50/0,2мл.Infectious activity during reproduction in developing chicken embryos at 32 ° C for 72 hours - 6.5 Ig EID50 / 0.2 ml.
Гемагглютинирующа активность - 1:32. Штамм про вл ет генетическую стабильность биологических признаков послеHemagglutination activity - 1:32. The strain exhibits genetic stability of biological traits after
00
5 пассажей на куриных эмбрионах (при использовании больших заражающих доз вируса ). Обладает ареактогенностью и выраженной иммуногенной активностью при интраназальном введении взрослым и дет м и соответствует требовани м, предъ вл емым к вакцинным штаммам фармакопейной статьей ФС 42-298 ВС-89 на живую гриппозную вакцину при интраназальном применении.5 passages on chicken embryos (when using large infecting doses of the virus). It has areactogenic and pronounced immunogenic activity when intranasally administered to adults and children, and meets the requirements imposed on vaccine strains by the pharmacopoeial article FS 42-298 BC-89 for live influenza vaccine when administered intranasally.
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU904841460A SU1731811A1 (en) | 1990-07-10 | 1990-07-10 | Strain b/60/32/p of influenza virus b, used for preparation of living intranasal vaccine for adult and children |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU904841460A SU1731811A1 (en) | 1990-07-10 | 1990-07-10 | Strain b/60/32/p of influenza virus b, used for preparation of living intranasal vaccine for adult and children |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1731811A1 true SU1731811A1 (en) | 1992-05-07 |
Family
ID=21522133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU904841460A SU1731811A1 (en) | 1990-07-10 | 1990-07-10 | Strain b/60/32/p of influenza virus b, used for preparation of living intranasal vaccine for adult and children |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1731811A1 (en) |
-
1990
- 1990-07-10 SU SU904841460A patent/SU1731811A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Патент US № 3992522, кл. А 61 К 39/18, 1976. Патент US № 4552758, кл. А 61 К 39/145, 1985. * |
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