SU1690368A1 - Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their production - Google Patents
Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their productionInfo
- Publication number
- SU1690368A1 SU1690368A1 SU4757924/05A SU4757924A SU1690368A1 SU 1690368 A1 SU1690368 A1 SU 1690368A1 SU 4757924/05 A SU4757924/05 A SU 4757924/05A SU 4757924 A SU4757924 A SU 4757924A SU 1690368 A1 SU1690368 A1 SU 1690368A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- production
- toxic compounds
- low toxic
- hypotensive action
- copolymers
- Prior art date
Links
Abstract
FIELD: high molecular weight compounds. SUBSTANCE: desired copolymers having formulawhere m:n=1:1-1:3 are prepared by reaction of N-carboxyanhydride-Σ-Z-L--lysine with carbonate of dihydroxyphenyl alanine at molar ratio 1:1-3:1. The process is carried out in the presence of triethylamine, its quantity being equimolar to quantity of carbonate of dihydroxyphenyl alanine. Then products of reaction are treated by 4.0-6.0 N solution of HBr, the process takes place in glacial acetic acid within day at room temperature. ЛД, of desired copolymers is 37-140 mg/kg at dose 2-5 mg/kg. EFFECT: decreases toxicity of product. 3 cl, 3 tbl
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4757924/05A SU1690368A1 (en) | 1989-07-20 | 1989-07-20 | Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their production |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4757924/05A SU1690368A1 (en) | 1989-07-20 | 1989-07-20 | Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their production |
Publications (1)
Publication Number | Publication Date |
---|---|
SU1690368A1 true SU1690368A1 (en) | 1995-08-20 |
Family
ID=60530610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU4757924/05A SU1690368A1 (en) | 1989-07-20 | 1989-07-20 | Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their production |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU1690368A1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6939539B2 (en) | 1994-05-24 | 2005-09-06 | Yeda Research & Development | Copolymer-1 improvements in compositions of copolymers |
US7163802B2 (en) | 1998-09-25 | 2007-01-16 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
US7279172B2 (en) | 1998-07-23 | 2007-10-09 | Yeda Research And Development Co., Ltd. | Treatment of autoimmune conditions with copolymer 1 and related copolymers |
US7425332B2 (en) | 1998-07-23 | 2008-09-16 | Yeda Research And Development Co., Ltd. | Treatment of autoimmune conditions with Copolymer 1 and related Copolymers |
US7429374B2 (en) | 2001-12-04 | 2008-09-30 | Teva Pharmaceutical Industries, Ltd. | Process for the measurement of the potency of glatiramer acetate |
US7495072B2 (en) | 2004-09-09 | 2009-02-24 | Teva Pharmaceutical Industries, Ltd. | Process for preparation of mixtures of polypeptides using purified hydrobromic acid |
US7560100B2 (en) | 2004-09-09 | 2009-07-14 | Yeda Research And Development Co., Ltd. | Mixtures of polypeptides, compositions containing and processes for preparing same, for treating neurodegenerative diseases |
-
1989
- 1989-07-20 SU SU4757924/05A patent/SU1690368A1/en active
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7625861B2 (en) | 1994-05-24 | 2009-12-01 | Yeda Research And Development Co., Ltd. | Copolymer-1 improvements in compositions of copolymers |
US8367605B2 (en) | 1994-05-24 | 2013-02-05 | Yeda Research And Development Co. Ltd. | Copolymer-1 improvements in compositions of copolymers |
US7199098B2 (en) | 1994-05-24 | 2007-04-03 | Yeda Research And Development Co., Ltd. | Copolymer-1 improvements in compositions of copolymers |
US6939539B2 (en) | 1994-05-24 | 2005-09-06 | Yeda Research & Development | Copolymer-1 improvements in compositions of copolymers |
US7279172B2 (en) | 1998-07-23 | 2007-10-09 | Yeda Research And Development Co., Ltd. | Treatment of autoimmune conditions with copolymer 1 and related copolymers |
US7425332B2 (en) | 1998-07-23 | 2008-09-16 | Yeda Research And Development Co., Ltd. | Treatment of autoimmune conditions with Copolymer 1 and related Copolymers |
US7615359B2 (en) | 1998-09-25 | 2009-11-10 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
US7163802B2 (en) | 1998-09-25 | 2007-01-16 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
US8399211B2 (en) | 1998-09-25 | 2013-03-19 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
US7429374B2 (en) | 2001-12-04 | 2008-09-30 | Teva Pharmaceutical Industries, Ltd. | Process for the measurement of the potency of glatiramer acetate |
US7923215B2 (en) | 2001-12-04 | 2011-04-12 | Teva Pharmaceutical Industries, Ltd. | Process for the measurement of the potency of glatiramer acetate |
US8389228B2 (en) | 2001-12-04 | 2013-03-05 | Teva Pharmaceutical Industries, Ltd. | Process for the measurement of the potency of glatiramer acetate |
US7495072B2 (en) | 2004-09-09 | 2009-02-24 | Teva Pharmaceutical Industries, Ltd. | Process for preparation of mixtures of polypeptides using purified hydrobromic acid |
US7560100B2 (en) | 2004-09-09 | 2009-07-14 | Yeda Research And Development Co., Ltd. | Mixtures of polypeptides, compositions containing and processes for preparing same, for treating neurodegenerative diseases |
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