SU1690368A1 - Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their production - Google Patents

Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their production

Info

Publication number
SU1690368A1
SU1690368A1 SU4757924/05A SU4757924A SU1690368A1 SU 1690368 A1 SU1690368 A1 SU 1690368A1 SU 4757924/05 A SU4757924/05 A SU 4757924/05A SU 4757924 A SU4757924 A SU 4757924A SU 1690368 A1 SU1690368 A1 SU 1690368A1
Authority
SU
USSR - Soviet Union
Prior art keywords
production
toxic compounds
low toxic
hypotensive action
copolymers
Prior art date
Application number
SU4757924/05A
Other languages
Russian (ru)
Inventor
Г.П. Власов
Л.Б. Надеждина
М.А. Харина
Е.Н. Андреева
А.В. Сыренский
Н.С. Рубанова
Н.В. Манкаускене
Н.В. Балашов
А.А. Добрынин
Original Assignee
Институт Высокомолекулярных Соединений Ан Ссср
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт Высокомолекулярных Соединений Ан Ссср filed Critical Институт Высокомолекулярных Соединений Ан Ссср
Priority to SU4757924/05A priority Critical patent/SU1690368A1/en
Application granted granted Critical
Publication of SU1690368A1 publication Critical patent/SU1690368A1/en

Links

Abstract

FIELD: high molecular weight compounds. SUBSTANCE: desired copolymers having formulawhere m:n=1:1-1:3 are prepared by reaction of N-carboxyanhydride-Σ-Z-L--lysine with carbonate of dihydroxyphenyl alanine at molar ratio 1:1-3:1. The process is carried out in the presence of triethylamine, its quantity being equimolar to quantity of carbonate of dihydroxyphenyl alanine. Then products of reaction are treated by 4.0-6.0 N solution of HBr, the process takes place in glacial acetic acid within day at room temperature. ЛД, of desired copolymers is 37-140 mg/kg at dose 2-5 mg/kg. EFFECT: decreases toxicity of product. 3 cl, 3 tbl
SU4757924/05A 1989-07-20 1989-07-20 Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their production SU1690368A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU4757924/05A SU1690368A1 (en) 1989-07-20 1989-07-20 Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU4757924/05A SU1690368A1 (en) 1989-07-20 1989-07-20 Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their production

Publications (1)

Publication Number Publication Date
SU1690368A1 true SU1690368A1 (en) 1995-08-20

Family

ID=60530610

Family Applications (1)

Application Number Title Priority Date Filing Date
SU4757924/05A SU1690368A1 (en) 1989-07-20 1989-07-20 Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their production

Country Status (1)

Country Link
SU (1) SU1690368A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939539B2 (en) 1994-05-24 2005-09-06 Yeda Research & Development Copolymer-1 improvements in compositions of copolymers
US7163802B2 (en) 1998-09-25 2007-01-16 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US7279172B2 (en) 1998-07-23 2007-10-09 Yeda Research And Development Co., Ltd. Treatment of autoimmune conditions with copolymer 1 and related copolymers
US7425332B2 (en) 1998-07-23 2008-09-16 Yeda Research And Development Co., Ltd. Treatment of autoimmune conditions with Copolymer 1 and related Copolymers
US7429374B2 (en) 2001-12-04 2008-09-30 Teva Pharmaceutical Industries, Ltd. Process for the measurement of the potency of glatiramer acetate
US7495072B2 (en) 2004-09-09 2009-02-24 Teva Pharmaceutical Industries, Ltd. Process for preparation of mixtures of polypeptides using purified hydrobromic acid
US7560100B2 (en) 2004-09-09 2009-07-14 Yeda Research And Development Co., Ltd. Mixtures of polypeptides, compositions containing and processes for preparing same, for treating neurodegenerative diseases

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7625861B2 (en) 1994-05-24 2009-12-01 Yeda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
US8367605B2 (en) 1994-05-24 2013-02-05 Yeda Research And Development Co. Ltd. Copolymer-1 improvements in compositions of copolymers
US7199098B2 (en) 1994-05-24 2007-04-03 Yeda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
US6939539B2 (en) 1994-05-24 2005-09-06 Yeda Research & Development Copolymer-1 improvements in compositions of copolymers
US7279172B2 (en) 1998-07-23 2007-10-09 Yeda Research And Development Co., Ltd. Treatment of autoimmune conditions with copolymer 1 and related copolymers
US7425332B2 (en) 1998-07-23 2008-09-16 Yeda Research And Development Co., Ltd. Treatment of autoimmune conditions with Copolymer 1 and related Copolymers
US7615359B2 (en) 1998-09-25 2009-11-10 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US7163802B2 (en) 1998-09-25 2007-01-16 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US8399211B2 (en) 1998-09-25 2013-03-19 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US7429374B2 (en) 2001-12-04 2008-09-30 Teva Pharmaceutical Industries, Ltd. Process for the measurement of the potency of glatiramer acetate
US7923215B2 (en) 2001-12-04 2011-04-12 Teva Pharmaceutical Industries, Ltd. Process for the measurement of the potency of glatiramer acetate
US8389228B2 (en) 2001-12-04 2013-03-05 Teva Pharmaceutical Industries, Ltd. Process for the measurement of the potency of glatiramer acetate
US7495072B2 (en) 2004-09-09 2009-02-24 Teva Pharmaceutical Industries, Ltd. Process for preparation of mixtures of polypeptides using purified hydrobromic acid
US7560100B2 (en) 2004-09-09 2009-07-14 Yeda Research And Development Co., Ltd. Mixtures of polypeptides, compositions containing and processes for preparing same, for treating neurodegenerative diseases

Similar Documents

Publication Publication Date Title
GEP20002205B (en) Copolymer-1; Composition for Treating Disseminated Sclerosis, Method for Production of Copolymer-1
ATE191728T1 (en) CROSS-LINKED POLYASPRICIC ACID AND SALTS
IL112020A0 (en) Arylacetic acid derivatives, their preparation and their use as fungicides
SU1690368A1 (en) Statistic copolymers as low toxic compounds having prolonged hypotensive action and method for their production
JPS5690031A (en) Preparation of aromatic aldehyde
JPS57179147A (en) Amidine derivative
JPS55139375A (en) Production of hydroxyflavan
GR3006438T3 (en)
JPS57108072A (en) Preparation of n-acylcarnosine
FI860210A (en) Process for the preparation of 4- / 2- (imidazol-1-yl) ethylthio / benzoic acid derivatives useful as a drug
JPS5533416A (en) Production of hexamethyene bis-dicyandiamide
JPS56110664A (en) Guanidinobenzoate and anticomplementary agent
JPS5653694A (en) Novel antibiotic, botryticidin a and its preparation and antibacterial for agriculture and horticulture
DE3369842D1 (en) Bis-(norbornyl or substituted norbornyl) derivatives of a phenol or a phenylamine, process for their preparation and compositions containing same
JPS5524156A (en) Novel cyclohexylacetic acid derivative
JPS5590504A (en) Preparation of unsoluble chitin derivative
JPS6460391A (en) Production of gamma-halo-beta(r)-hydroxybutyric acid ester
SU1541218A1 (en) Method for production of dextran derivatives
JPS5718638A (en) Preparation of perfluoroalkyl-substituted benzene derivative
JPS55120597A (en) Galactosamine derivative and its preparation
JPS56104843A (en) Preparation of unsaturated carboxylic acid
SU1658619A1 (en) Di-(3-dimethoxyphosphorylpropyl) ester of n-acetyl-dl-aspartic acid possessing nootropic activity
JPS5459202A (en) Antibiotic su-2 and its preparation
JPS577494A (en) Antibiotic derivative mf-300
JPS56108759A (en) Novel bisphenol compound and its preparation