SU1659413A1 - 3-amino-2-benzyl-4-(1-methylbenzumudazole-2-yl)-7-nitro-1(2n) isochinolone as reagent for photometric determination of copper and method for its preparation - Google Patents

3-amino-2-benzyl-4-(1-methylbenzumudazole-2-yl)-7-nitro-1(2n) isochinolone as reagent for photometric determination of copper and method for its preparation Download PDF

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Publication number
SU1659413A1
SU1659413A1 SU894669042A SU4669042A SU1659413A1 SU 1659413 A1 SU1659413 A1 SU 1659413A1 SU 894669042 A SU894669042 A SU 894669042A SU 4669042 A SU4669042 A SU 4669042A SU 1659413 A1 SU1659413 A1 SU 1659413A1
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SU
USSR - Soviet Union
Prior art keywords
copper
nitro
reagent
amino
benzyl
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Application number
SU894669042A
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Russian (ru)
Inventor
Федор Семенович Бабичев
Юлиан Михайлович Воловенко
Эльза Федоровна Гаврилова
Любовь Леонтьевна Коломиец
Алексей Георгиевич Немазаный
Людмила Анатольевна Пилипенко
Татьяна Анатольевна Силаева
Original Assignee
Киевский Государственный Университет Им.Т.Г.Шевченко
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Priority to SU894669042A priority Critical patent/SU1659413A1/en
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Publication of SU1659413A1 publication Critical patent/SU1659413A1/en

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Abstract

Изобретение относитс  к гетероциклическим соединени м, в частности к 3-амино2-бензил-4- (1-метилбензимидазол-2-ил)-7- нитро-1(2Н)изохинолону как реагенту дл  фотометрического определени  меди, что может быть использовано в аналитической химии. Цель - создание способа получени  нового более эффективного соединени  указанного класса. Синтез ведут реакцией 12 метил-8-нитро-11-цианобензимидазоло 1,2-Ь изохинолона-6 с бензиламином в ди- метилформамиде в присутствии К2СОз при кипении с последующей обработкой реакционной смеси водой и уксусной кислотой. Выход 27%, т. пл. 311°С. брутто-ф-ла .С24Нч9№Оз. Новое соединение при фотометрическом определении меди имеет чувствительность на пор док более высокую, чем примен емый по тому же назначению купроин. 1 табл.The invention relates to heterocyclic compounds, in particular to 3-amino2-benzyl-4- (1-methylbenzimidazol-2-yl) -7-nitro-1 (2H) isoquinolone as a reagent for photometric determination of copper, which can be used in analytical chemistry The goal is to create a way to get a new, more efficient connection of the specified class. The synthesis is carried out by the reaction of 12 methyl-8-nitro-11-cyanobenzimidazolo 1,2-b isoquinolone-6 with benzylamine in dimethylformamide in the presence of K 2 CO 3 at boiling followed by treatment of the reaction mixture with water and acetic acid. Yield 27%, so pl. 311 ° C. Gross-lla. С24Нч9№Оз. In the case of photometric determination of copper, the compound has a sensitivity that is of an order of magnitude higher than the cuproin used for the same purpose. 1 tab.

Description

Купроин 6,4-10Kuproin 6.4-10

1,5-101.5-10

-5-five

10ten

500,787±0,01500,787 ± 0,01

4,0-104.0-10

2,5-102.5-10

-ьto

0,20.2

100,,006100, 006

Claims (2)

Формула изобретенияClaim 1.3-Амино-2-бензил-4-(1-метилбензимидазол-2-ил)-7-нитро-1(2Н)-изохинолон формулы б1.3-amino-2-benzyl-4- (1-methylbenzimidazol-2-yl) -7-nitro-1 (2H) -isoquinolone of the formula b как реагент для фотометрического определения меди.as a reagent for photometric determination of copper. 2, Способ получения З-амино-2-бензил4-(1-метил бензимидазол-2-ил)-7-нитро-1(2 Н)изохинолона формулы:2, a method of obtaining a 3-amino-2-benzyl4- (1-methyl benzimidazol-2-yl) -7-nitro-1 (2 N) isoquinolone of the formula: о енгСбН5 ο,νo en g SBN 5 ο, ν UAAnhj бUAAnhj b отличающийся тем. что 12-метил-8нитро-11-цианобензимидазоло-(1,2-в)изох инолон-6 подвергают взаимодействию с бензиламином в диметилформамиде в . нии с последующей обработкой реакци •присутствии карбоната калия при кипе- онной смеси водой и уксусной кислотой.characterized in that. that 12-methyl-8nitro-11-cyanobenzimidazolo- (1,2-c) isocholone-6 is reacted with benzylamine in dimethylformamide c. followed by reaction treatment with the presence of potassium carbonate in a boiling mixture with water and acetic acid. Реагент Reagent е ........ e ........ Предел обнаруж. меди, М Limit Detected. copper, M Объем аликв. части, мл The volume of aliquots. parts, ml Время экстрагиров., мин The time of extraction., Min Объем израсх. р-рителя, мл Volume expended. r-repeater, ml Найдено меди, % (Р = = 0,95, п=5) Found copper,% (P = 0.95, n = 5) Купроин Cuproin 6,4-Ю3 6,4-U 3 1,5-10 5 1,5-10 5 10 10 6 6 50 fifty 0,78710,01 0.78710.01 Предлагав- Offering мое соеди- my com- нение nation 4,0-10* 4.0-10 * 2,5 -10 2.5-10 0,2 0.2 3 3 10 10 0,78810,006 0.78810.006
SU894669042A 1989-03-30 1989-03-30 3-amino-2-benzyl-4-(1-methylbenzumudazole-2-yl)-7-nitro-1(2n) isochinolone as reagent for photometric determination of copper and method for its preparation SU1659413A1 (en)

Priority Applications (1)

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SU894669042A SU1659413A1 (en) 1989-03-30 1989-03-30 3-amino-2-benzyl-4-(1-methylbenzumudazole-2-yl)-7-nitro-1(2n) isochinolone as reagent for photometric determination of copper and method for its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU894669042A SU1659413A1 (en) 1989-03-30 1989-03-30 3-amino-2-benzyl-4-(1-methylbenzumudazole-2-yl)-7-nitro-1(2n) isochinolone as reagent for photometric determination of copper and method for its preparation

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004054979A1 (en) * 2002-12-18 2004-07-01 Takeda Pharmaceutical Company Limited Jnk inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Марченко 3. Фотометрическое определение элементов. М.: Мир, 1971, с. 244. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004054979A1 (en) * 2002-12-18 2004-07-01 Takeda Pharmaceutical Company Limited Jnk inhibitors

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