SU1143745A1 - Method of obtaining derivatives of 3-(3-benzoxazolonyl) propionic acid - Google Patents
Method of obtaining derivatives of 3-(3-benzoxazolonyl) propionic acid Download PDFInfo
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- SU1143745A1 SU1143745A1 SU833665476A SU3665476A SU1143745A1 SU 1143745 A1 SU1143745 A1 SU 1143745A1 SU 833665476 A SU833665476 A SU 833665476A SU 3665476 A SU3665476 A SU 3665476A SU 1143745 A1 SU1143745 A1 SU 1143745A1
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- USSR - Soviet Union
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- acid
- reaction mixture
- general formula
- benzoxazolonyl
- propionic acid
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Abstract
СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 3-METHOD FOR OBTAINING DERIVATIVES 3-
Description
Целью изобретени вл етс упроще-, Пример 3. Получение 3-(3ние технологии процесса, а также расширение ассортимента целевых продуктов .5$(0,5 моль) о-аминофенола, 43 гThe aim of the invention is a simpler, Example 3. Obtaining 3- (3 process technologies, as well as expanding the range of target products. $ 5 (0.5 mol) o-aminophenol, 43 g
Поставленна цель достигаетс тем,(0,5 моль) кротоновой кислоты и 60 гThe goal is achieved by (0.5 mol) crotonic acid and 60 g
что согласно способу получени сое-мочевины аналогично примеру 1 с выдинений общей формулы (I),за1шючак де-ходвм 79,3 г (72,1%). Характеристи .новую кислоту.according to the method of producing co-urea, analogously to example 1, with elimination of the general formula (I), zachyuchak de hodvm 79.3 g (72.1%). Characterize .New acid.
бе« 0ксазолонн )-3-метилпропановойbe "0xazolonn) -3-methylpropanoic
киел9ты осуществл ют из 54,5 г ки и данные анализа приведены в таблице. Пример 4. Получение 3-(5хлор-3-бензоксазолонил )пропановой кислоты. Кип т т 1А,7 г (0,1 моль 4-хлор-2-аминоф нола,7,9 г (0,11 мол акриловой кислоты и 20 мл воды 2 ч, добавл ют 9,0 г (0,15 мол мочевины, 30 мл лед ной уксусной 454 кислоты и продолжают кип tить еще 3 ч. Затем в реакционную смесь добавл ют 30 мл концентрированной сол ной кислоты, перемешивают 3 мин и содержимое выливают в 300 мл воды. При охлаждении выделившуюс 3-(5хлор-3-бензоксазолонил )пропановую кислоту отфильтровывают. Выход 17,5 г (73%). Характеристики полученных соединений приведены в таблице.Kiel9ty is carried out from 54.5 g ki and the analysis data is shown in the table. Example 4. Obtaining 3- (5 chloro-3-benzoxazolonyl) propanoic acid. 1A, 7 g (0.1 mol of 4-chloro-2-aminofol, 7.9 g (0.11 mol of acrylic acid and 20 ml of water for 2 hours) are boiled, 9.0 g (0.15 mol urea, 30 ml of glacial acetic acid 454 and continue to boil for another 3 hours. Then 30 ml of concentrated hydrochloric acid is added to the reaction mixture, stirred for 3 minutes and the contents poured into 300 ml of water. When cooled, the separated 3- (5 chloro-3 -benzoxazolonyl) propanoic acid is filtered off. The yield is 17.5 g (73%). The characteristics of the compounds obtained are shown in the table.
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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SU833665476A SU1143745A1 (en) | 1983-11-23 | 1983-11-23 | Method of obtaining derivatives of 3-(3-benzoxazolonyl) propionic acid |
Applications Claiming Priority (1)
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SU833665476A SU1143745A1 (en) | 1983-11-23 | 1983-11-23 | Method of obtaining derivatives of 3-(3-benzoxazolonyl) propionic acid |
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SU1143745A1 true SU1143745A1 (en) | 1985-03-07 |
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SU833665476A SU1143745A1 (en) | 1983-11-23 | 1983-11-23 | Method of obtaining derivatives of 3-(3-benzoxazolonyl) propionic acid |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015091647A1 (en) | 2013-12-19 | 2015-06-25 | Glaxosmithkline Intellectual Property Development Limited | 3-(5-chloro-2-oxobenzo[d]oxazol-3(2h)-yl)propanoic acid derivatives as kmo inhibitors |
-
1983
- 1983-11-23 SU SU833665476A patent/SU1143745A1/en active
Non-Patent Citations (1)
Title |
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1. Алиев Н.А и др. Получение 3-бензоксазолрнил-/3- пропионитрилов. Узбекский химический журнал, 1979, Н 6, с. 51. 2. Lespagnol А. et al., 3-Benzoxazolinone alkanoic acids, Chlm. Ther, 1967, 2 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015091647A1 (en) | 2013-12-19 | 2015-06-25 | Glaxosmithkline Intellectual Property Development Limited | 3-(5-chloro-2-oxobenzo[d]oxazol-3(2h)-yl)propanoic acid derivatives as kmo inhibitors |
CN105829290A (en) * | 2013-12-19 | 2016-08-03 | 葛兰素史密斯克莱知识产权发展有限公司 | 3-(5-chloro-2-oxobenzo[d]oxazol-3(2h)-yl)propanoic acid derivatives as kmo inhibitors |
KR20160098433A (en) * | 2013-12-19 | 2016-08-18 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 3-(5-chloro-2-oxobenzo[d]oxazol-3(2h)-yl)propanoic acid derivatives as kmo inhibitors |
AU2014368765B2 (en) * | 2013-12-19 | 2017-12-07 | The University Court Of The University Of Edinburgh | 3-(5-chloro-2-oxobenzo(d)oxazol-3(2H)-yl)propanoic acid derivatives as KMO inhibitors |
RU2693016C1 (en) * | 2013-12-19 | 2019-07-01 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Derivatives of 3-(5-chloro-2-oxobenzo[d]oxazol-3(2h)-yl)propanoic acid as kmo inhibitors |
KR102340548B1 (en) * | 2013-12-19 | 2021-12-20 | 더 유니버시티 코트 오브 더 유니버시티 오브 에딘버그 | 3-(5-chloro-2-oxobenzo[d]oxazol-3(2h)-yl)propanoic acid derivatives as kmo inhibitors |
US11352334B2 (en) | 2013-12-19 | 2022-06-07 | The University Court Of The University Of Edinburgh | 3-(5-chloro-2-oxobenzo[d]oxazol-3(2H)-yl) propanoic acid derivatives as KMO inhibitors |
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