SU1595507A1 - Method of extraocular infusion of medicine - Google Patents

Abstract

The invention relates to medicine, namely to ophthalmology, and concerns methods for administering drugs. The purpose of the invention is to eliminate irritation of the conjunctiva with a catheter. The essence of the method is to supply the medicinal solution to the conjunctival cavity through a catheter, the fixing part of which is inserted into the upper lacrimal canal so that the solution delivery opening is located at the level of the lacrimal point, while the proximal section of the catheter is connected to the medication dispenser with a given infusion regimen . The method of extraocular infusion expands the arsenal of existing methods of drug administration and can be used in the treatment of various eye diseases.

Description

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The invention relates to medicine, namely to ophthalmology, and concerns methods of administering drugs.

The purpose of the invention is to eliminate irritation of the conjunctiva with a catheter.

The method is carried out as follows.

After local anesthesia with a 0.5% solution of dikain, the fixation part of the catheter is inserted through the upper lacrimal point into the tubule in such a way that the opening for supplying the medicinal solution is located at the level of the lacrimal point. The other end of the catheter is connected via a transition nipple to a portable wearable medication dispenser, providing a round-the-clock supply of the solution in the desired infusion mode. There are a variety of options for mounting the dispenser on the patient, not violating its normal physiological movement. gala activity (body, head, arm, shirt pocket, pajamas, etc.). To provide the necessary regimen of infusion, portable portable dispensers of drugs like "NDL-ZAA," DTLN-1, "DTLN-2, etc. can be used.

An example. Patient C, 32 years old, diagnosis: herpetic stromal keratitis with ulceration of the right eye.

Upon receipt, the sharpness of the vision of the right eye with diffra. 0.3-0.4 noncorr., Left-eye - 1.0. When examining the right eye against the background of a pericorneal injection, there is a limited opacification in the central zone of the cornea of 2x3 mm of irregular shape with fuzzy edges due to infiltration and swelling of all layers of the cornea. In this zone, epitheliopathies with a slight superficial ulceration. On the posterior surface of the cornea single precipitates. The cornea is thickened in the central regions 1.5 times. Medical mydriasis up to 7 mm.

 Against the background of traditional drug therapy for four days there was no significant change in the state of /

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riHHti,) the status and acuity of the right eye.

Instead of interferon instillation, its extraocular infusion was prescribed; After local anesthesia of the upper tear point with a 0.5% solution of dicain, the fixation part of the catheter is inserted into the tubule in such a way that the opening for the supply of the solution is located at the lacrimal opening, while the proximal part of the catheter

upon examination (04/16/88) the right eye is calm.

Epithelization of the ulcers, epithelnonati disappeared, slight residual infiltration, corneal thickening disappeared in the central section, isolated precipitates became smaller with uneven edges, which indicated their reverse development. The acuity of the vision in the right eye increased to 0.7 with the diaphra. After removal of the infusion, the patient was discharged on the third day (04/18/88)

 SPECIAL POINTS, with the iriksimaliiti U1-uujionLJn pi ipv, .r, .i «--1

The i catheter case is connected to a portable Yu with a 0.9 sec. diaphra of the right eye.

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iiocHMOMy dispenser of drugs GNDL-ZAA. The pa dosing unit was set up with a {yop.pk.ch injection rate of 1.6 ml / day, which ensured the supply of 1 µl of the solution with an interval of 54 seconds around the clock. The catheter is additionally fixed. It is fixed in small pieces of adhesive tape to the skin at the transfer {temple and temple spharya). The dispenser is laid out in the pocket of the patient's shirt.

The extraocular infusion was carried out continuously for 3 days with a daily change of infusate. For the entire period from deciding Kii to removing the infusion, the patient did not note any unpleasant sensations due to (; a. The fixing part of the catheter in the upper lacrimal canaliculis. There were no overflows of tears in the lake and there was no expansion of the lacrimal streams. There was no overflow of infusion. and removing the catheter of the upper and :: r tears, the point II of the tubule without any particularities. At the same time, a positive attitude was noted from the local status and visual acuity of the right eye.

15

The proposed method is characterized by atraumatic, safe and well tolerated.

In the proposed method, the contact of the catheter with the conjunctival tissue is completely eliminated and the reliability of its fixation is increased. A variety of constructive versions of the fixation part of the catheter are possible for carrying out 20 extraocular infusions by the proposed method.

Claims (1)

Invention Formula The method of extraocular infusion of drugs by supplying their solutions. Into the conjunctival cavity through a catheter, characterized in that, in order to eliminate irritation of the conjunctiva with a catheter, the fixation part is inserted into the lacrimal canal of NFs, the opening for supplying the solution is located at the level of the lacrimal opening. upon examination (04/16/88) the right eye is calm. Epithelization of the ulcers, epithelnonati disappeared, slight residual infiltration, thickening of the cornea} in the central section disappeared, isolated precipitates became smaller with uneven edges, which indicated their reverse development. The acuity of the vision in the right eye increased to 0.7 with the diaphra. After removal of the infusion, the patient was discharged on the third day (04/18/88) uujionLJn pi ipv, .r, .i "--1  visual acuity of the right eye 0.9 with diaphra.  visual acuity of the right eye 0.9 with diaphra.   The branch of TTL UPLNI IT RP and .4 five The proposed method is characterized by atraumatic, safe and well tolerated. In the proposed method, the contact of the catheter with the conjunctival tissue is completely eliminated and the reliability of its fixation is increased. A variety of constructive versions of the fixation part of the catheter are possible for carrying out 20 extraocular infusions by the proposed method. Invention Formula The method of extraocular infusion of drugs, venous funds by supplying their solutions. Into the conjunctival cavity through a catheter, characterized in that, in order to eliminate the irritation of the conjunctiva with a catheter, the fixing part is inserted into the lacrimal canal, the opening for supplying the solution is located at the level of the lacrimal opening.