Институт Тонкой Органической Химии Им.А.Л.Мнджояна
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Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur
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Abstract
FIELD: heterocyclic compounds. SUBSTANCE: product: 5-morpholino- 2,2,10- trimethyl-8- phenyl-1,2- dihydro-4H- pyran- o-[4',3':4,5-] -pyrido-[2,3-b] thieno-[3,2-b] pyridine-9-carboxylic acid. Synthesis of new heterocyclic system is carried out from 3-amino-2- benzoyl-5,5- dimethyl-4,5- dihydro-8- morpholino-7H- pyrano- [4',3':4,5] pyrido-[2,3-b] thiophene and acetoacetic acid ethyl ester in the presence of ZnClin the medium of m-xylene at boiling and distilling off aqueous azeotrope. The yield is 82.2% empirical formula is CHNOS. Activity is reached at the dose 200 mg/kg, maximally tolerated dose is 3000 mg/kg. Synthesized compound shows anticonvulsant activity and low toxicity. EFFECT: increased yield of product, low toxicity.