SU1417446A1 - 5-morpholino- 2,2,10-trimethyl- 8-phenyl- 1,2-dihydro-4h-pyrano- - [4',3':4,5]- pyrido-[2,3-b]- thieno-[3,2-b]- pyridine-9-carboxylic acid - Google Patents

5-morpholino- 2,2,10-trimethyl- 8-phenyl- 1,2-dihydro-4h-pyrano- - [4',3':4,5]- pyrido-[2,3-b]- thieno-[3,2-b]- pyridine-9-carboxylic acid

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Publication number
SU1417446A1
SU1417446A1 SU4172622/04A SU4172622A SU1417446A1 SU 1417446 A1 SU1417446 A1 SU 1417446A1 SU 4172622/04 A SU4172622/04 A SU 4172622/04A SU 4172622 A SU4172622 A SU 4172622A SU 1417446 A1 SU1417446 A1 SU 1417446A1
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SU
USSR - Soviet Union
Prior art keywords
pyrido
morpholino
dihydro
pyrano
thieno
Prior art date
Application number
SU4172622/04A
Other languages
Russian (ru)
Inventor
Е.Г. Пароникян
А.С. Норавян
Г.В. Мирзоян
С.А. Вартанян
Р.Г. Пароникян
Н.Е. Акопян
Original Assignee
Институт Тонкой Органической Химии Им.А.Л.Мнджояна
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Priority to SU4172622/04A priority Critical patent/SU1417446A1/en
Application granted granted Critical
Publication of SU1417446A1 publication Critical patent/SU1417446A1/en

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

FIELD: heterocyclic compounds. SUBSTANCE: product: 5-morpholino- 2,2,10- trimethyl-8- phenyl-1,2- dihydro-4H- pyran- o-[4',3':4,5-] -pyrido-[2,3-b] thieno-[3,2-b] pyridine-9-carboxylic acid. Synthesis of new heterocyclic system is carried out from 3-amino-2- benzoyl-5,5- dimethyl-4,5- dihydro-8- morpholino-7H- pyrano- [4',3':4,5] pyrido-[2,3-b] thiophene and acetoacetic acid ethyl ester in the presence of ZnClin the medium of m-xylene at boiling and distilling off aqueous azeotrope. The yield is 82.2% empirical formula is CHNOS. Activity is reached at the dose 200 mg/kg, maximally tolerated dose is 3000 mg/kg. Synthesized compound shows anticonvulsant activity and low toxicity. EFFECT: increased yield of product, low toxicity.
SU4172622/04A 1986-12-30 1986-12-30 5-morpholino- 2,2,10-trimethyl- 8-phenyl- 1,2-dihydro-4h-pyrano- - [4',3':4,5]- pyrido-[2,3-b]- thieno-[3,2-b]- pyridine-9-carboxylic acid SU1417446A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU4172622/04A SU1417446A1 (en) 1986-12-30 1986-12-30 5-morpholino- 2,2,10-trimethyl- 8-phenyl- 1,2-dihydro-4h-pyrano- - [4',3':4,5]- pyrido-[2,3-b]- thieno-[3,2-b]- pyridine-9-carboxylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU4172622/04A SU1417446A1 (en) 1986-12-30 1986-12-30 5-morpholino- 2,2,10-trimethyl- 8-phenyl- 1,2-dihydro-4h-pyrano- - [4',3':4,5]- pyrido-[2,3-b]- thieno-[3,2-b]- pyridine-9-carboxylic acid

Publications (1)

Publication Number Publication Date
SU1417446A1 true SU1417446A1 (en) 1995-09-10

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Application Number Title Priority Date Filing Date
SU4172622/04A SU1417446A1 (en) 1986-12-30 1986-12-30 5-morpholino- 2,2,10-trimethyl- 8-phenyl- 1,2-dihydro-4h-pyrano- - [4',3':4,5]- pyrido-[2,3-b]- thieno-[3,2-b]- pyridine-9-carboxylic acid

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SU (1) SU1417446A1 (en)

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