SU13086A1 - The method of preparation of chloride compounds of iodopyridines, as well as iodine and iodine derivatives of them - Google Patents

Description

It is well known that when chlorine acts on substituted pyridine derivatives, 8B is very easy, even in the cold, chlorination of the core (cf. German patent 400191); so under the action of pure chlorine on pyridine derivatives, such as 2-chloro, 5 aiinopyridine, 2-6-diaminopyridine, 2-amine-5-nitropyridine 2-amino, bc-bromopyridine, the products are chlorinated. The same happens with the chlorination of pyridine compounds containing iodine on the 2nd, 4th or 6th place.

The proposed method for the preparation of xjarous compounds of iodopyridines is based on the observed that. the reaction proceeds completely differently if such compounds are used as starting material, which contain iodine. 3rd or 5th yueste. In this case, the draw is not halogenated at all, but it gives CJf a good yield of the corresponding iodine-chlorine. So, for example, get Yz 5-iodopyridine iodo-chloride

Xjipp-5-iodine-pyridine nodo-hrrid

S1

.X

 f h Semi amide chlorides

The DOH has a strong antibacterial effect. Their chri, applications act on the part of dispersed chlorine chlorine, on the other hand, the samxy decomposition product, for example, 2-chloro-r-b-iodopyridine. Obtained according to the invented pyr-din. Oxygen-chlorine is, for its part, similar materials for the manufacture of enan iodo-and iodo-di organic compounds. MyEio, for example, irdin-nodochlorides, of the general formula of ner dnn-TSC, is averaged by treatment with alkalis in accordance with the dosage pyridium of the general formula, d

J --- 0. Thus obtained iodo-pyri; phnya darkly then, sometimes in the presence of water or an aqueous gift, as a decomposing transfer, were heated by heating in appropriate form of the general formula, tirydil-Ji-402-B1, it was clear that iodization of the general formula was carried out before transferring to the iodine interface before transferring it to the iodine interface; , ye need.

. When I er I.-In the ohlaader ice solution - pyridine iodine in chloroform in diggsl chlorine, to saturation. The iodoloride is precipitated by thin yellow needles, which dissolve in common organic solvents. in the cold; It is very difficult, and it is easier when heated. Exit-theoretic. The compound melts at 128 ° - 130 ° and decays. The resulting iodo-chloride has an intense, chlorine-like odor. .- x-, Pr and measures 2. ГГ-В solution; - chloro-iodopyridine in chlorofme — chlorine is added to saturation: It is formed by proper iodon-chloro, which is given in the form of a yellow crystalline powder, etc. 104 ° -105 ° (s, release of chlorine, ra). Yield-theory etcheshesky. Gender iodine-3: loride in ordinary organic solvent V and is almost insoluble in water. He had an intense zanach, remind; nayP1, and chlor.,

 ; Example 3.-Chlorine a-iodo-chloride pyridine is weighed; it is in dilute alkaline alkali, sucked off after a long hour, and washed with water. The yellow needles of irdo-x. 10 are turned

in, surrounded by a weak yellow color dose setting, intion (a-t-chloro-iodo-pyridine).

The latter decays at 2QO ° -205 ° with a division and £ /. , Irdozo compound is amorphous, soluble in glacial acetic acid. It is poorly soluble in water and common organic solvents, and is a strong oxidizing agent.

Example 4. Through α-chloro p-iodosopyridine, coked in water, water is blown through. A-chloro-p-iodiridine is entrained in Naramsh water, while white needles and chlorine-iodoniridine crystallize out when the residue is distilled off with water vapor. At temperatures between 210 and 215 ° C, chloro-α-iodoniridine springs up with iodine release. In conventional organic solvents it dissolves with great difficulty; soluble in glacial acetic acid. The compound is a sully oxidizing agent; hydrochloric acid, iodine free xiop.

P; .. odm patent.

1. The method of preparation of chloride compounds of iodiridines, inconsistent with the fact that chlorine is acted upon on the iodine derivatives of pyridine substituted in position 3 and 5.

2. Acceptance of the procedure indicated in paragraph 1 of the method for obtaining iodoso- and; iodine compounds, characterized in that the chlorides obtained by the method indicated in paragraph 1; compounds are treated with alkalis and the compounds obtained by this route are treated with water and water vapor to transform their i.o.-iodo compounds. . .