SU1303936A1 - Method of determining degree of myocardium lesion in infant acute pneumonia - Google Patents

Abstract

To improve the accuracy of the method, patient serum is electrophoresized on a cellulose acetate film, followed by fluorodensitometry and computerized densitograms to determine the level of creatine phosphokinase at admission or for 1-2 days and in the dynamics: on day 7, etc. time, taking into account the patient's condition. If this indicator is 2-4%, a mild degree is diagnosed, 4.5-14.4 - a moderate degree, 14.5% and more - a severe degree of myocardial lesion. co o co stock ot

Description

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The invention relates to medicine, in particular, to methods of diagnosing and predicting the course and outcome of cardiovascular disorders in the case of acute osteoarthritis in young children.

The purpose of the invention is to improve the accuracy of the method by determining the content of the isoenzyme creatine phosphokinase.

The method is carried out as follows.

Patient's serum is taken in an amount of 0.2 ml and electrophoresis is carried out on cellulose acetate film followed by fluorodensitometry and computerized densitogram to determine the level of the cardiac isoenzyme creatine phosphokinase upon admission or for 1-2 day and in the dynamics: on day 7 and other periods, taking into account the condition of the patient. In healthy children, this enzyme is undetectable or gives a very low content (g 1Z). In children with acute pneumonia complicated by cardiovascular insufficiency, it was first established that its activity varies from 2 to 21%.

Example 1. In a child G., 8 months who was hospitalized for acute pneumonia, confirmed radiographically, the activity of the isoenzyme MV-KFK 2% on the 2nd day of illness, on the 7th day of illness, activity increased to 4% the favorable lung course of the disease was noted, changes in the cardiovascular system were not detected clinically.

no instrumental and laboratory research methods. The child was discharged in a satisfactory condition on the 12th day of illness.

Example 2. Child V., 1 g 3 months. with acute pneumonia, a serum myocardial lesion was diagnosed by the level of IV-CP isoenzyme in the serum of the myocardium degree on the 2nd day of illness 4.5%, on the 5th day the isoenzyme activity increased to 14%, and clinical, instrumental and laboratory studies cardiovascular system revealed a moderate myocardial damage only on the 7th day

Medical measures of heart disorders for a sick child from the 2nd day allowed to reduce the length of

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, the hospital stay is up to 18 days.

Example 3. Patient S., 1 year, 2 months .. was treated in the hospital with a diagnosis of bronchopneumonia, polysegmental, acute, respiratory failure II degree, uncomplicated, confirmed, radiographically.

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45 - 50 admission was average. The effects of intoxication were moderate. There are no obvious clinical symptoms from the side of the cardiovascular system. There were no changes on the ECG. Already on the 2nd day of the disease, the level of MB-CPK in the serum was higher than 4% -6.5%, on the 5th day of the disease it remained elevated - 11%. The II degree of myocardial damage was diagnosed and the course of moderate severity was predicted, which could have lasted for a longer time with inadequate treatment. But she was prescribed timely therapy for cardiac disorders. The child was discharged in a satisfactory condition on the 18th day of hospitalization.

Example 4. A child D., 1 g. 1 month. From the 2nd stay in the hospital, the level of MB-CPK in serum was 14.5%, symptoms of cardiac disorders were clinically noted. Taking into account such a high level of activity (above 14.5%), severe damage was diagnosed; in myocardium. In this child, on the 6th day, the activity increased to 18%, the course of the disease was up to 2 months.

The proposed method for diagnosing and predicting the degree of myocardial damage in acute pneumonia in young children by determining the cardiac specific isoenzyme in the blood serum is more accurate than the prototype based on the determination of the enzyme lactate dehydrogenosis - 4. The prototype does not have a strict cardiospecificity, an insensitive method, since it depends on many factors: the time taken to draw blood and the procedure for determining LDH-4 (in serum, this fever is destroyed in prolonged standing - 55 ment), the ambient temperature, the duration and the complexity of carrying out the method, there is no criterion of digital indicators, making it impossible

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313039364

Claims (1)

application of the method for the prediction and core-shifts of the heart muscle, which gives the reaction therapy. Distinguished by the possibility of prediction. From the prototype, the method of determining the MB-CPK enzyme is significantly technical — the formula is inventively simple, independent of the duration serum is more a method for diagnosing the degree of damage, since the occurrence of MV-CK myocardium in acute pneumonia in blood flow indicates that, in infants of young children, by defining the myocardium, the level of biochemical content of the enzyme in serum processes, from the extent of damage to the blood area, differs processes, which is clinically established by the fact that, in order to increase accuracy No new doctor is possible. Thus, in the serum, the determination, as compared with the prototype, determines the initial content of the isoenzyme The proposed method is technically simpler, creatine phosphokinase in both the dynamics and The accuracy of diagnostics is 10 times greater, 15th this indicator is 2-4% of the diagrams of interpretation of indicators of lightness, 4.5-14.4 is much broader, the average degree and 14.5%, and the degree and frequency of the pathological degree of myocardial damage is higher .