SMT201600416B - Uso di sali di 3-carbossi-n-etil-n,n-dimetilpropan-1-amminio nel trattamento di malattie cardiovascolari - Google Patents
Uso di sali di 3-carbossi-n-etil-n,n-dimetilpropan-1-amminio nel trattamento di malattie cardiovascolariInfo
- Publication number
- SMT201600416B SMT201600416B SM201600416T SM201600416T SMT201600416B SM T201600416 B SMT201600416 B SM T201600416B SM 201600416 T SM201600416 T SM 201600416T SM 201600416 T SM201600416 T SM 201600416T SM T201600416 B SMT201600416 B SM T201600416B
- Authority
- SM
- San Marino
- Prior art keywords
- carbossi
- aminio
- etyl
- dimethylpropan
- salts
- Prior art date
Links
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
- C07C225/06—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and acyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/10—Succinic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/14—Acetic acid esters of monohydroxylic compounds
- C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
- C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11163840 | 2011-04-27 | ||
| EP11163839 | 2011-04-27 | ||
| EP11163841 | 2011-04-27 | ||
| EP11163872 | 2011-04-27 | ||
| EP11163871 | 2011-04-27 | ||
| EP12720465.9A EP2702033B1 (en) | 2011-04-27 | 2012-04-27 | Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium salts in the treatment of cardiovascular disease |
| PCT/EP2012/057806 WO2012146736A1 (en) | 2011-04-27 | 2012-04-27 | Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium salts in the treatment of cardiovascular disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600416B true SMT201600416B (it) | 2017-01-10 |
Family
ID=46062261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600416T SMT201600416B (it) | 2011-04-27 | 2016-11-16 | Uso di sali di 3-carbossi-n-etil-n,n-dimetilpropan-1-amminio nel trattamento di malattie cardiovascolari |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20140088125A1 (it) |
| EP (1) | EP2702033B1 (it) |
| JP (1) | JP5997762B2 (it) |
| KR (1) | KR20130138827A (it) |
| CN (1) | CN103608326B (it) |
| AU (1) | AU2012247467B2 (it) |
| BR (1) | BR112013027065B1 (it) |
| CA (1) | CA2832693C (it) |
| CY (1) | CY1117890T1 (it) |
| DK (1) | DK2702033T3 (it) |
| EA (1) | EA023547B1 (it) |
| ES (1) | ES2585558T3 (it) |
| GE (1) | GEP20156373B (it) |
| HR (1) | HRP20160998T1 (it) |
| HU (1) | HUE030415T2 (it) |
| IL (1) | IL228891A (it) |
| LT (1) | LT2702033T (it) |
| MX (1) | MX351765B (it) |
| PE (1) | PE20140777A1 (it) |
| PL (1) | PL2702033T3 (it) |
| PT (1) | PT2702033T (it) |
| RS (1) | RS55092B1 (it) |
| SI (1) | SI2702033T1 (it) |
| SM (1) | SMT201600416B (it) |
| WO (1) | WO2012146736A1 (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3117B1 (ar) * | 2012-12-20 | 2017-09-20 | Grindeks Jsc | استعمال 3- كربوكسي- ن-إيثيل- ن، ن- ثاني ميثيل بروبان-1– أمينيوم أو ملح منه مقبول صيدلانياً في معالجة تصلب الشرايين |
| JO3333B1 (ar) | 2013-09-26 | 2019-03-13 | Grindeks Jsc | استعمال 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium أو ملح مقبول دوائيا منه للوقاية من السكري وعلاجه |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1103259A (en) * | 1913-04-23 | 1914-07-14 | John J Buckley | Fly-paper holder. |
| GB1238868A (it) | 1967-08-08 | 1971-07-14 | ||
| SU997646A1 (ru) | 1978-11-27 | 1983-02-23 | Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср | Кормова добавка |
| IT1210935B (it) | 1981-09-17 | 1989-09-29 | Inst Orch Sinteza Akademi Nauk | Composizione farmaceutica per il trattamento di malattie cardiovascolari. |
| SU1680693A1 (ru) * | 1987-03-25 | 1991-09-30 | Институт Органического Синтеза Ан Латвсср | Этил-3-(2,2-диметил-2-этилгидразиний)пропионат иодистый, про вл ющий антиаритмическую активность |
| JP3119430B2 (ja) * | 1995-07-25 | 2000-12-18 | 大鵬薬品工業株式会社 | 水酸基ラジカル消去剤 |
| LV11728B (en) * | 1995-08-21 | 1997-08-20 | Kalvins Ivars | Pharmaceutical composition |
| LV11727B (en) * | 1995-08-21 | 1997-08-20 | Kalvins Ivars | Pharmaceutical composition |
| US5973026A (en) | 1998-02-02 | 1999-10-26 | Xerox Corporation | Ink jet inks |
| DE19956772A1 (de) * | 1999-11-25 | 2001-06-07 | Basf Ag | Verwendung von y-Butyrobetain Salzen zur Herstellung von Zubereitungen für die menschliche und tierische Ernährung |
| HRP20080192T3 (hr) * | 2003-08-04 | 2008-05-31 | "Joint Stock Company Grindeks" | Meldonijeve soli, postupci za njihovu pripravu i farmaceutski sastav na njihovoj osnovi |
| CA2508094A1 (en) | 2005-05-20 | 2006-11-20 | Vivier Canada Inc. | Composition for accelerating collagen synthesis |
| US7863274B2 (en) | 2005-07-29 | 2011-01-04 | Concert Pharmaceuticals Inc. | Deuterium enriched analogues of tadalafil as PDE5 inhibitors |
| LV13705B (en) | 2006-11-06 | 2008-07-20 | Ivars Kalvins | Process for producing high purity intermolecular salt of 3-carboxy-n,n,n-trimethyl-propane-1-amine hydroxide |
| JP4761265B2 (ja) | 2007-10-17 | 2011-08-31 | 学校法人甲南学園 | 核酸合成を促進する化合物を含む組成物およびその利用、並びに当該化合物の製造方法 |
| TWI391131B (zh) * | 2007-12-05 | 2013-04-01 | Grindeks Jsc | ３－（２，２，２－三甲基肼）丙酸鹽的新用途 |
| WO2009074498A1 (en) * | 2007-12-12 | 2009-06-18 | Grindeks | Medical use of 3- (2, 2, 2-trimethylhydrazinixm) propionate orotate |
| US8889902B2 (en) * | 2009-06-25 | 2014-11-18 | Tetra, Sia | Acetylsalicylic acid salts |
| WO2010149654A1 (en) * | 2009-06-25 | 2010-12-29 | Grindeks, A Joint Stock Company | Pharmaceutical composition of gamma-butyrobetaine or a pharmaceutically acceptable salt and meldonium or a pharmaceutically acceptable salt |
| LV14345B (lv) * | 2009-10-22 | 2011-07-20 | Grindeks, A/S | 4-[Etil(dimetil)amonija]butanoāts un tā izmantošana kardiovaskulāro slimību ārstēšanai |
-
2012
- 2012-04-27 US US14/113,709 patent/US20140088125A1/en not_active Abandoned
- 2012-04-27 CN CN201280020494.9A patent/CN103608326B/zh active Active
- 2012-04-27 PT PT127204659T patent/PT2702033T/pt unknown
- 2012-04-27 GE GEAP201213252A patent/GEP20156373B/en unknown
- 2012-04-27 AU AU2012247467A patent/AU2012247467B2/en active Active
- 2012-04-27 LT LTEP12720465.9T patent/LT2702033T/lt unknown
- 2012-04-27 JP JP2014506893A patent/JP5997762B2/ja active Active
- 2012-04-27 EP EP12720465.9A patent/EP2702033B1/en active Active
- 2012-04-27 EA EA201301080A patent/EA023547B1/ru unknown
- 2012-04-27 HR HRP20160998TT patent/HRP20160998T1/hr unknown
- 2012-04-27 CA CA2832693A patent/CA2832693C/en active Active
- 2012-04-27 PE PE2013002405A patent/PE20140777A1/es not_active Application Discontinuation
- 2012-04-27 RS RS20160684A patent/RS55092B1/sr unknown
- 2012-04-27 ES ES12720465.9T patent/ES2585558T3/es active Active
- 2012-04-27 PL PL12720465T patent/PL2702033T3/pl unknown
- 2012-04-27 DK DK12720465.9T patent/DK2702033T3/en active
- 2012-04-27 HU HUE12720465A patent/HUE030415T2/en unknown
- 2012-04-27 BR BR112013027065A patent/BR112013027065B1/pt active IP Right Grant
- 2012-04-27 KR KR1020137027933A patent/KR20130138827A/ko not_active Ceased
- 2012-04-27 MX MX2013012551A patent/MX351765B/es active IP Right Grant
- 2012-04-27 WO PCT/EP2012/057806 patent/WO2012146736A1/en not_active Ceased
- 2012-04-27 SI SI201230664A patent/SI2702033T1/sl unknown
-
2013
- 2013-10-15 IL IL228891A patent/IL228891A/en active IP Right Grant
-
2016
- 2016-08-09 CY CY20161100780T patent/CY1117890T1/el unknown
- 2016-11-16 SM SM201600416T patent/SMT201600416B/it unknown
-
2017
- 2017-12-01 US US15/828,660 patent/US10351534B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2663304A4 (en) | COMBINATION THERAPY | |
| CO6801645A2 (es) | Nuevos inmunoconjugados | |
| PL2683384T3 (pl) | Sposoby leczenia nowotworu z użyciem 3-(5-amino-2-metylo-4-okso-4h-chinazolin-3-ylo)piperydyno-2,6-dionu | |
| LT3026064T (lt) | Antikūnai, skirti vėžio gydymui, ekspresuojantys klaudiną 6 | |
| CO6890099A2 (es) | Nuevos derivados dihidroquinolina-2-ona | |
| LT2707030T (lt) | Vėžio gydymas | |
| LT3406251T (lt) | Piruvatkinazės aktyvatoriai, skirti panaudoti terapijai | |
| DK2760886T3 (da) | Immunocytokin-kombinationsterapi | |
| DK3421470T3 (da) | Substituerede 5-fluor-1h-pyrazolopyridiner i krytallinsk form | |
| EP2726095A4 (en) | COMBINATION THERAPY | |
| FI20115876A0 (fi) | Yhdistelmähoito | |
| HRP20160989T1 (hr) | Otopina za oralnu primjenu | |
| BR112014002830A2 (pt) | fotossensibilizador para uso terapêutico | |
| SMT201600082B (it) | Vaccino pcsk9 | |
| EP2783256A4 (en) | Therapeutic eyewear | |
| IL227732A0 (en) | Cosmetic use | |
| PL2742356T3 (pl) | Środki prognostyczne w leczeniu nowotworów | |
| IL229081A0 (en) | Isoxazolines as therapeutic agents | |
| CO6880064A2 (es) | Métodos terapéuticos | |
| FI20115640A0 (fi) | Yhdistelmähoito | |
| BR112014010432A2 (pt) | uso médico | |
| ME02908B (me) | Supstituisani 2-alkil-1-okso-n-fenil-3-heteroaril-1,2,3,4-tetrahidroizohinolin-4-karboksamidi za antimalarijske terapije | |
| HRP20180011T1 (hr) | Spojevi za uporabu u liječenju filariaza | |
| SMT201600416B (it) | Uso di sali di 3-carbossi-n-etil-n,n-dimetilpropan-1-amminio nel trattamento di malattie cardiovascolari | |
| FI20116047L (fi) | Menetelmä terveyskortin hallinnoimiseksi |