SK83197A3 - Bleaching composition consisting of peroxy salt, lipophilic substance with aromatic, cooling or antimicrobial effects and of dimethicone - Google Patents

Abstract

A bleach composition comprising an inorganic persalt bleaching agent, a lipophile selected from flavorants, perfumes, physiological coolants, antimicrobial agents and mixtures thereof, and a dimethicone copolyol selected from alkyl- and alkoxy-dimethicone copolyols having formula (I) wherein: X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms, Y is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms, n is from about 0 to about 200, m is from about 1 to about 40, q is from about 1 to about 100, the molecular weight of the residue (C2H4O-)x(C3H6O-)yX is from about 50 to about 2000, and x and y are such that the weight ratio of oxyethylene: oxypropylene is from about 100:0 to about 0:100. The composition provides improved lipophile and bleach stability.

Description

Technical field

The present invention relates to compositions containing silicones and their use in various consumer articles, hygiene articles, household cleaners, laundry powders, bleaching agents and the like. In particular, the present invention relates to lipophilic formulations containing silicones, the lipophilic components of which are flavor delivery agents, perfumes, coolants or antimicrobial agents, and which are characterized by improved surface retention and surface durability and improved surface performance to which they have been applied, such as are surfaces of teeth, dentures, skin, linen, dishes, work surfaces and the like. The present invention also relates to bleaching compositions containing silicones, the other ingredients of which are ingredients sensitive to the presence of bleaching compositions such as perfumes, flavor delivery agents and the like and which are characterized by increased durability.

BACKGROUND OF THE INVENTION

The use of lipophilic preparations which serve as flavor delivery agents and as cooling and disinfecting agents is widespread. These preparations are used directly or in a variety of household products, including cosmetics, mouthwashes and dental care products, bleaching agents, dishwashing agents, solid surface cleaners, laundry powders and the like. A major problem with the use of lipophilic compositions is the need to improve their ability to retain on the surfaces to which they have been applied. In the case of the predominant use of these compositions in the home, it would be desirable to improve these properties in order, for example, to increase the intensity of the fragrance, increase the effectiveness of the perfume or improve the antimicrobial effect.

For example, modern oral hygiene and dental care compositions commonly include anti-plaque and anti-tartar agents, as well as antimicrobial agents and flavor delivery agents. Antimicrobial agents can affect the coating by reducing the number of bacteria in the oral cavity or on the dental prosthesis, or by destroying the bacteria trapped in the coating and thereby preventing their further growth. Aromatic additives can be used as breath deodorants. Certain animicrobial agents, such as menthol, may also be used to breathe the breath. However, the effectiveness of antimicrobial agents depends largely on their ability to remain within the oral cavity or on the surface of the denture where the coating is formed.

A common disadvantage of dental preparations is that the antimicrobial compositions containing them can act only for a relatively short period of time during which the teeth are cleaned or the oral cavity is rinsed. Dental hygiene products are not used frequently, in most cases once or twice a day. Thus, in a relatively long time between tooth brushing, a majority of the population can develop a dental plaque.

In addition to many other uses, it is desirable to achieve better grip on surfaces. For example, better perfume retention on fabrics would make the scent of fabrics after washing more intense. Improved entrapment of antimicrobial additives would also be desirable to reduce odor caused by decomposition of sweat or other impurities. Improved entrapment would also be beneficial for perfumes and perfumed cosmetic compositions. It would also be advantageous for cough and cold compositions to prolong and increase the effect of cooling agents.

There is also a need for the development of lipophilic compositions having improved surface retention and retention capability, enhanced activity, and / or increased antimicrobial activity.

The use of lipophilic formulations such as perfumes, flavor enhancers and the like in bleaching compositions can cause other problems, which may be loss of the nature of the substance or its intensity as a result of interaction with the bleaching composition. The efficacy of the bleaching agent may also be adversely affected. For this reason, it is desirable to increase the stability and efficacy of compositions comprising ingredients sensitive to the presence of bleaching compositions.

It is known that dentistry compositions contain silicones to coat the teeth and prevent tooth decay and coloring. For example, GB-A-689,679 discloses a mouthwash containing an organopolysiloxane which prevents the capture of dirt and food particles on the teeth and the formation of tartar. This mouthwash may contain antiseptic ingredients such as thymol and fragrances and perfumes.

US-A-2 806 814 discloses dental compositions which comprise, inter alia, the active substances of higher aliphatic amides derived from amino acids and a silicone compound. According to this patent, the use of a silicone compound is designed to prevent the adhesion of impurities, the formation and coloring of tartar, or to facilitate their removal. Silicone compounds are said to have a synergistic effect in the antibacterial action of the active compound and in the neutralization of acids by the active compound. Dimethyl polysiloxanes have been reported to be particularly effective. Fragrant oils and / or menthol may also be present.

US-A-3624120 discloses the use of quaternary ammonium salts of cyclic siloxane polymers as cationic surfactants, bactericides, and anticarogenic agents.

SUMMARY OF THE INVENTION

It is an object of the present invention to provide lipophilic formulations comprising flavor delivery agents, perfumes, coolants, and anitimicrobial agents which are characterized by enhanced surface retention and / or improved efficacy.

The present invention further provides bleaching compositions comprising, as a bleaching agent, an inorganic peroxysol and a lipophilic compound, such as an aroma and / or perfume delivery agent, which is characterized by enhanced stability.

According to a first aspect of the present invention there is provided a flavor delivery composition acting as a perfume, as a cooling or antimicrobial agent or other lipophilic composition, which contains alkyl and alkoxy derivatives of dimethicone with polyether chains of formula (I) =

CH ο

I

Cho-SiO

I ch ₃

CH o 1 CH o 1 C, · X OlU | U 1U 1 ch ₃ | (CH ₂ ) ₃ n 1 0 | (C ₂ H ₄₀ ) _x - ( ^c ₃ H ₆₀ ) _y X

CH _q

I

S i 0-I

Y q

CH o

I ³

Si — CH o

I ch ₃ (D wherein X is hydrogen, alkyl, alkoxy or acyl of 1 to 16 carbon atoms, Y is alkyl or alkoxy of 8 to 22 carbon atoms, n is 0 to 200, m is 1 to 40, q is 1 to 40 100, the molecular weight of the - (C ₂ H ₄ O) _x - (C ₃ H ₆ O) _y X is 50 to 2000, preferably 250 to 1000, and the x and y values are such that the oxyethylene: oxypropylene ratio is 100: 0 to 0: 100, preferably 100: 0 to 20: 80.

The invention also relates to polyether chain dimethicones comprising a lipophilic component, which is an aroma delivery agent, perfume, physiological coolant, antimicrobial agent and mixtures thereof, which are characterized by enhanced surface retention capability which are alkyl and alkoxy derivatives of dimethicone with polyether chains of formula (I).

According to a further aspect of the present invention there is provided a bleaching composition comprising an inorganic peroxygen bleaching agent, a lipophilic agent selected from the group consisting of flavor delivery agents, perfumes, physiological refrigerants, antimicrobial agents and mixtures thereof, and alkyl- and alkoxy derivatives of dimethicones with polyether chains of formula (I):

CH ο

I

CH-SiO

I ch ₃

CH o

I

SiO-I ch ₃ n

CH o

I

-SiO -------------- I (CH ₂ ) ₃ o

I (C ₂ H ₄ O) _x - (C ₃ H ₆ O) _y X

CH o

I

-S-I

Y q

CH-2

Si-CHa

I ch ₃ (I) wherein X is hydrogen, alkyl, alkoxy or acyl of 1 to 16 carbon atoms, Y is alkyl or alkoxy of 8 to 22 carbon atoms, n is 0 to 200, m is 1 to 40, q is 1 to 100, the molecular weight of the - (C ₂ H ₄ O) _x - (C ₃ H ₆ O) _y X is 50 to 2000, and the x and y values are such that the oxyethylene: oxypropylene ratio is 100: 0 to 0: 100 , preferably 100: 0 to 20: 80.

The invention also relates to the use of polyether chain dimethicones comprising an inorganic peroxy salt bleaching agent and a lipophilic agent selected from the group consisting of flavor delivery agents, perfumes, physiological refrigerants, antimicrobial agents and mixtures thereof, wherein said polyether chain dimethicone is an alkyl and alkoxy derivative of dimethicones having polyether chains of formula (I).

All concentration data are given in percent by weight and the substance ratios are by weight.

Thus, the composition comprises a dimethicone with polyether chains which acts as an antiplaque agent and a lipophilic agent which is a flavor delivery agent, perfume, physiological cooling agent, antimicrobial agent and mixtures thereof. Other compositions of the present invention are bleaching compositions or detergents which contain a dimethicone with polyether chains, acting as an antifoaming agent, and a lipophilic agent.

In general, the polyether chain dimethicones mentioned are alkyl- and alkoxy derivatives of polyether chain dimethicones of formula (I):

CH o

I

Cho-SiO

I ch ₃

CH n

I

SiO-I ch ₃ n

CH o

I

-SiO-I (ch ₂ ) ₃ o

I ( ^c 2 ^H 4 °) x - ( ^C 3 ^H 6 °) y ^X m

CH o

I

You are about

I

Y

CH o

I ^J

Si-cho

I ch ₃ (I) wherein X is hydrogen, alkyl, alkoxy or acyl of 1 to 16 carbon atoms, Y is alkyl or alkoxy of 8 to 22 carbon atoms, n is 0 to 200, m is 1 to 40, q is 1 to 100, the molecular weight of the chain - (C ₂ H ₄ O) _x - (C ₃ H ₆ O) _y X is 50 to 2000, preferably 250 to 1000, and the x and y values are such that the oxyethylene: oxypropylene ratio is 10: 0 to 0: 100, preferably 100: 0 to 20: 80.

In a preferred embodiment said dimethicones with _{C12- C20} polyether chains are alkyl derivatives of dimethicones with polyether chains of formula (I) and mixtures thereof. Particularly preferred is polyether chain cetyl dimethicone sold under the trade name Abil EM 90. Polyether chain dimethicones are generally used from 0.01 to 25% by weight, preferably 0.1 to 5% by weight, more preferably 0.5 to 1.5% by weight weight.

The composition of the invention preferably also comprises a lipophilic substance. In general, lipophilic substances suitable for use in the present invention are oily substances which are soluble or solubilizable in dimethicones with polyether chains at a concentration of 1% by weight, more preferably at least 5% by weight at 25 ° C. Preferred lipophilic substances are flavorings which impart aroma , perfumes, physiological coolants and antimicrobial agents. Dimethicone with polyether chains causes an increased ability to retain the lipophilic compound on the surface to which the composition is applied, thereby giving it an increased activity and / or a more stable odor or better cooling or antibacterial effect. Lipophilic flavor delivery agents suitable for use in the present invention include one or more active agents selected from the group consisting of wintergreen oil, oregano oil, laurel fat, peppermint oil, peppermint oil, clove oil, sage oil, sasafras oil, lemon. , orange essential oil, anise essential oil, benzaldehyde, bitter almond oil, camphor, cedar leaf oil, marjoram oil, lemon essential oil, lavender essential oil, mustard essential oil, pine essential oil, essential oil essential oils, essential oil, mixture.

Lipophilic perfumes suitable for use in the present invention include one or more perfumes, including natural products such as essential oils, resins and the like, and synthetic perfume ingredients such as hydrocarbons, alcohols, aldehydes, ketones, ethers, acids, esters, acetals, ketals, nitriles, etc. including saturated and unsaturated compounds, aliphatic, carboxyl and heterocyclic compounds. Examples of perfumes suitable for use in the present invention are geraniol acetate, linalool acetate, citricellol acetate, dihydromyrcenol acetate, terpineol acetate, tricyclodecenylpropionate, 2-phenethyl acetate, benzyl acetate, benzylsalicytate, benzylbenzoate, methisyl acetate, methylsulfate, trichloromethylphenylcarbinol acetate, p-tert.-butylcyclohexyl acetate, isononylacetate, cedrylacetate, vetiveryl acetate, benzyl alcohol, 2-phenylethanol, linalool, tetrahydrolinalool, citranelol, dimethylbenzylcarbinol, dihydromyrcenol, vethydromyrenol e, terhydromyrenol e, terhydromyrenol, terhydromyrenol, terpromine, ger,

3-Isocampyl-cyclohexanol, 2-methyl-3- (p-tert-butylphenyl) -

-propanol, 2-methyl-3- (p-isopropylphenyl) -propanol, 3- (p-tert-butylphenyl) -propanol, nerol, cinnamic acid α-amylaldehyde, 4- (4-hydroxy-4-methylpentyl) aldehyde -3-cyclohexenecarboxylic acid, 4- (4-hydroxy-3-pentenyl) -3-cyclohexenecarboxylic acid aldehyde, 4-acetoxy-3-pentyltetrahydropyran, 2-heptyl-cyclopentanone, 3-methyl-2-pentyl-cyclopentanone, 3- methyl-2-pentylcyclopentanone, n-decanal, n-dodecanal, hydroxycitronelal, phenylacetaldehyde dimethylacetal, phenylacetaldehyde diethyl acetal, geraniic nitrile, citric acid nitrile, methylcedrylether, isolongifolane, aubepinil nitrile, difluorinone, aubepinilium, aubepinilium, aubepinilium, heparin, isomethylionones, cis-3-hexenol and its esters, indane musk, tetralin musk, isochroman musk, macrocyclic ketones, ethylene brazlate, aromatic musk containing nitro groups and mixtures thereof.

Lipophilic antimicrobials suitable for use in the present invention are thymol, menthol, tricosan,

4-hexylresorcinol, phenol, eucalyptol, benzoic acid, benzoyl peroxide, butylparaben, methylparaben, propylparaben, salicylic amides and mixtures thereof.

Physiological refrigerants suitable for use in the present invention are carboxamides, esters and ethers of menthane and mixtures thereof.

Menthane ethers suitable for use in the present invention are those of the general formula:

wherein R ₅ is an aliphatic hydrocarbon radical having a maximum of 25 carbons, preferably 5 carbon atoms, which may optionally be hydroxy-substituted and X is hydrogen or hydroxy. These substances are manufactured by Takasago International Corporation and can be purchased under the trade name Takasago. A particularly suitable refrigerant for use in the present invention is Takasago 10 [3-1-methoxypropane-1,2-diol (MPD) J]. MPD is a monoglycerol derivative of menthol and has an excellent cooling capacity.

Carboxamides which are most suitable for this purpose are described in U.S. Pat. No. 4,136,163 to Watson et al., Issued Jan. 23, 1979, and U.S. Pat. No. 4,230,688 to Rawell et al. October 1980.

The concentration of lipophilic substances in the composition according to the invention is generally in the range of 0.01 to 10% by weight, preferably 0.05 to 5% by weight, more preferably 0.1 to 3% by weight.

The compositions of the invention may further comprise one or more surfactants, the presence of which is particularly advantageous in the lipophilic compositions of the invention where they solubilize the lipophilic substance and increase its effectiveness. Suitable surfactants are anionic, nonionic, cationic, zwitterionic and amphoteric soap detergents. A number of such suitable substances are described in US-A-4

No. 051,234, Gieske et al., Issued Sep. 27, 1977.

Examples of surface uses of this C ₆ -C ₁₈ alkyl ether sulfates, active agents useful in the invention are alkyl sulfates and ethoxylated with 0.5 to 20 moles of ethylene oxide per mole of starting material, anionic sulfonates including C ₅ -C ₂₀ linear alkylbenzenesulfonates, primary or secondary alkane sulphonates C ₆ -C ₂₂ olefin C ₆ -C _24, alkyl glycerol acylsulfonáty glycerol with higher fatty acyl groups, and mixtures thereof, anionic carboxylates inclusive of primary and secondary _{CR-C g} alkyl carboxylates, surfactants based on ethoxy carboxylates, and the average polyetoxykarboxylátov a degree of ethoxylation of 0 to

10, C ₅ -C ₁₇ sarcosinates such as sodium acyl sarcosinate with coconut oil fatty acids, sodium laurolsarcosinate (Hamposyl-95, manufactured by WR Grace), condensation products of ethylene oxide or propylene oxide with fatty acids, higher alcohols, higher amides, polyols, (e.g., sorbitan monostearate, sorbitan oleate), alkylphenols (e.g. Terginol) and polypropylene oxide or polyoxybutylene (e.g., Pluronic), alkylpolysaccharides described in U.S. Pat. dimethyl lauryl amine oxide, polysorbates such as Tween 40 and Tween 80, sorbitan stearates, sorbitan monooleate, cationic surfactants such as cetylpyridinium chloride, cetyltrimethylammonium bromide and alkyl trimethylammonium nitrate with alkyls derived from coconut oil fatty acids.

In view of the solubilization of the lipophilic substance, nonionic surfactants are highly preferred for use in the processes of this invention. One type of nonionic surfactant suitable for this purpose is a surfactant having the following general formula:

^ - (OCHCHX - _{(OCH2 CH2) n} - OH

I CH ₃ wherein R ₁ is an alk (en) yl or alk (en) yl phenyl group having 8 to 22, preferably 10 to 20 carbon atoms in the alk (en) yl portion of Aman, the weight average of the values of 0 to 80 and 2 to 80. Shorter alkyl groups are generally less suitable because their presence results in a decrease in efficacy and because the presence of unreacted higher alcohols in such surfactants results in their odor and possibly may also cause skin irritation. Surfactants of this type are normally a mixture of substances with varying degrees of ethoxylation and / or propoxylation, and therefore the values of m and n are merely the weight average of the numbers of propoxy or ethoxy groups. Nonionic surfactants of the aforementioned general type are also mixed alkoxylates in which the values of m and n are in the range of 2 to 80, wherein the value of m is preferably 2 to 20, more preferably 3 to 10 and the value of n is preferably 2 to 60, more preferably One such agent is PPG-5-ceteth-20 (manufactured by Croda Inc. as Procetyl AWS) having m = 5 and n = 20. Other suitable nonionic surfactants are polyethoxylated surfactants, e.g. ethoxylated alkylphenole ethers, especially octylphenol ether and nonylfenolétery containing ethoxy groups 8 to 16, aliphatic alcohols ethoxylated _{Cg-C 20,} which may be linear or branched and which may contain from 8 to 16, preferably 9 to 15 ethoxy groups and ethoxylated hydrogenated castor oils.

Generally, the ratio of surfactant to perfume or other oily material is 50: 1 to 1: 10, preferably 20: 1 to 1: 2, more preferably 10: 1 to 1: 1.

The bleaching compositions of the present invention additionally comprise one or more bleaching agents, which may optionally be used simultaneously with organic acids which are their precursors, effervescent additives, chelating agents and the like.

Bleaching agents are inorganic peroxy salts, which may be included in any of the household bleaching agents, detergents, toothpastes and the like. Such substances are, for example, alkali metal persulphates and ammonium persulfate, perborate salts including their monohydrates and tetrahydrates, percarbonates (optionally in the form of granules coated with the patent GB-A-1 466 799), perphosphoric acid salts and alkali metal and alkali metal peroxides earth. Examples of suitable bleaching agents are potassium, ammonium, sodium and lithium persulfates, and perborate mono- and tetrahydrates, sodium peroxydiphosphate hydrate, and magnesium, calcium, strontium and zinc peroxides. Of these, alkali metal persulfates, perborates, percarborates and mixtures thereof are preferred, and alkali metal perborates and percarbonates are highly preferred.

The amount of bleaching agent in the bleaching compositions of the present invention is 5 to 70% by weight, preferably 10 to 50% by weight.

The bleaching compositions may also contain an effervescent additive, which in a preferred embodiment is present in the form of a solid, releasing carbon dioxide or oxygen in the presence of water. An effervescent additive which is active in an acid, neutral or alkaline medium may be used, but is preferably composed of a combination of an effervescent agent that is effective or maximally effective in an acidic environment and a effervescent agent that is effective or maximally effective in an alkaline environment. Effervescent additives which are active in an acidic and neutral environment are composed of a combination of at least one alkali metal carbonate or alkali metal bicarbonate, such as sodium bicarbonate, sodium carbonate, potassium carbonate, potassium bicarbonate or mixtures thereof, and an admixture of at least one nontoxic, physiologically acceptable acids such as oxalic acid, fumaric acid, malic acid, maleic acid, gluconic acid, succinic acid, salicylic acid, adipic or sulfamic acid, sodium fumarate, sodium or potassium hydrogen phosphates, betaine hydrochloride and mixtures thereof. The preferred acid is malic acid. Effervescent substances which are active in an alkaline medium are the peroxy salts such as alkali metal and alkaline earth metal peroxyborate salts, as well as the above-mentioned perborate, persulfate, percarbonate, and mixtures thereof, for example a mixture of alkali metal peroxyborate (anhydrous, monohydrate) or tetrahydrates) with a persulfate such as Caroat ^R , manufactured by EI du Pont de Nemours Co., which has a mixture of persulfate, potassium sulfate and potassium hydrogen sulfate having an active oxygen content of about 4.5%.

In preferred whitening compositions suitable for use in dentifrice cleaning, the solids present in the solid state is a carbonate / effervescent couple, or an additive, commonly in combination with a persulfate effervescent additive, an acidic carbonate / effervescent with perborate or oxygen based. This combination of effervescent additives is important to achieve appropriate solubility and pH at which the cleaning and antimicrobial properties are optimal. The content of carbonate or bicarbonate is 5 to 65% by weight, preferably 25 to 55% by weight, based on the total weight of the composition, the acid component content is 5 to 50% by weight, preferably 10 to 30% by weight, based on the total weight of the composition.

The bleaching compositions of the present invention may be supplemented with other suitable ingredients. A particularly preferred component is an organic peroxyacid precursor, which may generally be defined as a compound having a titer of at least 1.5 mL of 0.1 sodium thiosulfate in the following peroxyacid formation assay.

The test solution is prepared by dissolving the following substances in 1000 ml of distilled water:

sodium pyrophosphate (Na ₄ P ₂ O ₇ · 1OH ₂ O) 2.5 g sodium perborate (NaBO ₂ H ₂ O ₂ · ₃ H ₂ O) containing 10.4% active oxygen 0.615 g sodium dodecylbenzenesulfonate 0.5 g

To this solution is added such an amount of activator at 60 ° C that an equivalent amount of activator is present for each active oxygen atom.

The mixture obtained by the addition of the activator is vigorously stirred and kept at 60 ° C. After 5 minutes of addition, 100 ml of this solution are taken and immediately pipetted onto a mixture of 250 g of crushed ice and 15 ml of glacial acetic acid. Potassium iodide is then added and the liberated iodine is immediately titrated with 0.1 n sodium thiosulfate using starch as an indicator until the first sign of the blue color disappears. The number of milliliters of thiosulfate solution consumed is the bleach activator titer.

Organic peroxyacid precursors are commonly substances which contain one or more acyl groups that are subject to perhydrolysis. Preferred activators are N-acyl or O-acyl type activators containing R-CO groups, wherein R is an unsubstituted or substituted hydrocarbon group having 1 to 20 carbon atoms. Examples of suitable organic peroxyacid precursors are:

1 / The derivatives of acid amides of the formula RCONR ₁ R _2, where RCO is an acyl group, _t R is also an acyl group and R ₂ is other organic radical, as disclosed in US-A-3117148th

Examples of such substances are:

a) Ν, Ν-diacetylanilide and N-acetylphthalimide, b) N-acylhydantoins such as N, N'-diacetyl-5,5-dimethylhydantoin, c) polyacylated alkylenediamines such as N, N, N ', N'-tetraacetylethylenediamine (TAED) and the corresponding hexamethylene derivatives (TAHD) disclosed in GB-A-907 357 and GB-A-907 358, d / acyl glucurils such as tetraacetylglucouril, described in GB-A-1 246 338, GB -A-1,246,339 and GB-A-1,247,429.

2) Acylated sulfonamides such as N-methyl-N-benzoylmentanesulfonamide and N-phenyl-N-acetyl-menthanesulfonamide, described in GB-A-3 183 266. j.

3 / Carboxylic acid esters described in patents GB-A-836 988, GB-A-963 135 and GB-A-1 147 871. Examples of such compounds are phenylacetate, sodium acetoxybenzenesulfonate, trichloroacetate, sorbitolhexa acetate, fructose pentaacetate, p -nitrobenzaldehyde diacetate, isopropenyl acetate, acetylacetohydroxamic acid and acetylsalicylic acid. Other examples are esters of phenols or substituted phenols with α-chlorinated lower carboxylic acids, such as chloroacetylphenol and chloroacetylsalicylic acid, which are described in U.S. Pat. No. 3,130,165.

4) Carboxylic acids of the general formula Ac L, wherein Ac is an acyl which contains a linear or branched C ₆ -C ₂₀ alkyl or alkenyl group or an aryl group substituted with a C ₆ -C ₂₀ alkyl and L is a leaving group whose conjugated acid has a pK a in the region of 4 to 13, for example oxybenzenesulfonate or oxybenzoate. Preferred compounds of this type are those wherein a / Ac is R ₃ -CO and R ₃ is a linear or branched alkyl group containing 6 to 20, preferably 6 to 12, more preferably 7 to 9 carbon atoms, the longest linear alkyl chain bonded to a carbonyl carbon containing from 5 to 18, preferably 5 to 10, carbon atoms, including the carbonyl carbon atom R ₃ is optionally substituted (preferably in the - position to the carbonyl group) Cl, Br, OCH, or OC, H.

Examples of these materials are 3,5,5-trimethylhexanoyloxybenzanesulfonate sodium, 3,5,5-trimethylhexanoyloxybenzoate sodium, 2-ethylhexanoyloxybenzenesulfonate sodium, nonanoyloxybenzenesulfonate sodium, and octanoyloxybenzenesulfonate sodium in the preferred case, wherein the acetylatedbenzenesulfonate is all, .

b / Ac has the formula _R3 (AO) _m XA wherein _R3 is a branched or unbranched alkyl or aralkyl, wherein the alkyl group is 6 to 20, preferably from 6 to 15 carbon atoms, R _g is optionally substituted by Cl, Br, OCH ₃ or OC ₂ H ₅ , AO is oxyethylene or oxypropylene, m is 0 to 100, X is O, NR ₄ or CO-NR ₄ and A is CO, CO-CO, R ₆ -CO, CO-NR ₄ - R ₆ -CO wherein R ₄ is C ₄ -C ₄ alkyl and R ₆ is alkylene, alkenylene, arylene or aralkylene of 1 to 8 carbon atoms in the alkylene or alkenylene. Substances of this type used as bleach activators include carboxylic acid derivatives of formula R ₃ (AO) _m OCOL, succinic acid derivatives of formula R ₃ OCO (CH ₂ ) ₂ COL, glycolic acid derivatives of formula

R ₃ OCO (CH ₂ ) ₂ COL, hydroxypropionic acid derivatives of the formula R ₃ OCH ₂ CH ₂ COL, oxalic acid derivatives of the formula R ₃ OCOCOL, maleic and filmic derivatives of the formula R ₃ OCOCH = CHCOL, aminocaproic acid acyl derivatives of the formula R ₃ CONR ₁ CH ₂ COL and 6-oxocaproic acid derivatives of general formula R ₃ N (R ₁ ) CO (CH ₂ ) ₄ COL. In the above formulas, m is 0 to 10, preferably R ₃ is C ₆ -C ₁₂ alkyl, more preferably C ₆ -C ₁₀ when m = 0 and C ₉ -C ₁₅ if m is not zero. The leaving group L has been defined previously.

5) Acyl cyanurates such as the triacetyl or tribenzoyl cyanurates described in U.S. Pat. 3,332,882.

6) Substituted and unsubstituted benzoic or phthalic anhydrides, for example benzoic anhydride, m-chlorobenzoic anhydride and phthalic anhydride.

7 / N-acetylated starting materials for the synthesis of lactams, generally disclosed in GB-A-855 735, especially caprolactas and valerolacts such as benzoylvalerolactam, benzoylcaprolactam and their substituted benzoylanalogs such as chloro-, amino-, alkyl-, aryl and alkoxy derivatives.

Particularly preferred are organic peroxyacid precursors of type 1 (c), 4 (a) and 7.

If a peroxyacid bleach precursor is present, its concentration is preferably 0.1 to 10% by weight, more preferably 0.5 to 5% by weight, and is conveniently added in the form of an agglomerate.

The bleach precursor agglomerate, preferably used in the processes of the present invention, typically contains a binder or agglomerating agent in concentrations of 5 to 40% by weight, typically in concentrations of 10 to 30% by weight of the agglomerate. Suitable agglomerating agents are poly vinylpyrrolidone, poly (oxyethylene) 20,000 to 500,000, Carbowax 4,000-20,000, nonionic surfactants, fatty acids, sodium carboxymethylcellulose, gelatin, higher alcohols, phosphates, and polyphosphates , clays, aluminosilicates and polymeric polycarboxylates. Most preferred of the above are polyethylene glycols, especially polyethylene glycols having molecular weights of 1,000 to 30,000, preferably 2,000 to 10,000.

In terms of solubility and pH, optimum bleach precursor agglomerates containing 10 to 75% by weight, preferably 20 to 60% by weight bleach precursor, 5 to 60% by weight, preferably 5 to 50% by weight, more preferably 10 to 40% by weight an effervescent additive combination of carbonate / acid or bicarbonate / acid, 0 to 20% by weight of peroxyborate and 5 to 40% by weight, preferably 10 to 30% by weight, of an agglomerating agent. It is desirable that the agglomerated bleach precursor granules have an average size of 500 to 1500 µm, preferably 500 to 1000 µm, which is most preferred in terms of both optimum solubility and aesthetics. The bleaching agent agglomerates are preferably present in the composition at concentrations of 1 to 20% by weight, more preferably 5 to 15% by weight.

The bleaching compositions of the invention may be in the form of a paste, tablets, granules or powder. Tablet formulations may be monolayer or multilayer tablets.

The bleaching compositions of the present invention may further contain other conventional ingredients such as the above-described surfactants, chelating agents, enzymes, colorants, sweeteners, binders and tablet fillers, suds suppressors such as dimethylpolysiloxanes, foam stabilizers such as sugar esters and higher fatty esters. acids, preservatives, lubricating agents such as talc, magnesium stearate, fine powdered fumed silica and the like.

Binders and tablet fillers suitable for use in the present invention are polyvinylpyrrolidone, poly (oxyethylene) 20,000-500,000, polyethylene glycols 1,000-50,000, Carbowax 4,000-20,000, nonionic surfactants, fatty acids, sodium carboxymethylcellulose, gelatin, higher alcohols, clays, polymeric polycarboxylates, sodium carbonate, calcium carbonate, calcium hydroxide, magnesium oxide, basic magnesium carbonate, sodium sulfate, proteins, cellulose ethers, cellulose esters, polyvinyl alcohol , alginic acid esters and plant hydrophobic materials of a pseudo-colloidal nature. Of the above, polyethylene glycols, especially polyethylene glycols having a molecular weight in the range of 1000 to 30,000 or even more preferably having a molecular weight in the range of 12,000 to 30,000 are particularly preferred.

Chelating agents advantageously promote the stability of the cleansing and whitening properties by keeping metal ions such as calcium, magnesium and heavy metals in solution. Examples of suitable chelating agents are sodium triphosphate, sodium trihydrogen diphosphate, sodium pyrophosphate, aminopolycarboxylates such as nitrilotriacetic acid and ethylenediaminotetraacetic acid and their salts and polyphosphonates and aminopolyphosphonates such as hydroxyethanephosphonamide, ethylenediamine ethanediamine. It is not essential which chelating agent is selected, but it is necessary to be compatible with the dentifrice composition both in dry state and in aqueous solution. Preferably, the chelating agent content is from 0.1 to 60% by weight, preferably from 0.5 to 30% by weight. However, phosphonic acid chelating agents preferably contain from 0.1 to 1% by weight, more preferably from 0.1 to 0.5% by weight of the agent, based on the total weight of the composition.

Enzymes suitable for use in the methods of the invention are, for example, proteases, alkalases, amylases, lipases of bacterial or fungal origin, dextranase, mutanase, glucanase, esterase, cellulase, pectinase, lactase, peroxidase and others. Suitable enzymes are disclosed in US-A-3,519,570 and US-A-3,533,139.

The following examples illustrate a preferred embodiment of the processes within the scope of the present invention.

DETAILED DESCRIPTION OF THE INVENTION

Examples 1 to 5

The following are typical examples of dentifrice tablets of the present invention. The compositions are given in percent by weight and refer to the total weight of the tablets. Tablets are prepared by compressing the mixture of granular ingredients in a hand tablet press at a pressure of about 10 ² MPa.

Tablet composition (% by weight)

component 1 Example 2 number 3 4 5 malic acid 12 10 15 - 14 sodium carbonate - 10 - 15 - sulfamic acid 5 - - 3 3 PEG 20,000 - 3 7 8 5 PVP 40,000 6 3 - - - sodium bicarbonate 23 24 25 23 24 sodium perborate monohydrate 15 12 16 30 15 potassium persulfate 15 18 13 - 14 pyrogenic silica - 3 1 1 - talc 2 - - - - EDTA - - 1 - 3 EDTMP ¹ 1 - - 1 - , 2 aroma 2 1 2 1 2 Abil EM90 ³ 1 1.5 0.5 2 1 bleach precursor in the form of an agglomerate 9 8 10 12 10

¹ ethylenediaminotetramethylenephosphonic acid ² aroma based on peppermint essential oil ³ cetyldimethicone with polyether chains

Composition of precursor bleaching ingredients within a agglomerate component 1 Example 2 3 number 4 5 TAED ^{1 2} 2 - 4 5 2.5 TMHOS2 2 3 - - - and sulfamic acid 2 2 2 2 3.5 sodium carbonate 0.5 2 2.4 2.5 1.5 PEG 6000 2.5 2 2.4 2.5 1.5 color - 0.8 1.4 2 0.5

¹ tetraacetylenediamine ² sodium 3,5,5-trimethylhexanoyloxybenzenesulfonate

In Examples 1 to 5, the total weight of the tablet was 3 g and the diameter was 25 mm.

The dentifrice tablets of Examples 1 to 5 are characterized by improved anti-plaque effect, improved cleansing performance and increased antibacterial activity, while excellent cohesion and other physical characteristics and performance characteristics.

Examples 6 to 11

The following are typical examples of the compositions of the present invention with the aromatic, flavor, cooling and antimicrobial effects of the present invention. The compositions are given in percent by weight and are based on the total weight of the preparation.

Example number Preparation component 6 7 8 9 PPG-5-ceteth-20 3.0 3.0 4.5 3.0 WITH PEG-40 hydrogenated castor oil - 1.8 4.5 3.0 Trideceth-12 2.0 - - - » Trideceth-9 - 2.0 - 3.0 aroma ^{1 2} 2.0 - - 3.0 2 perfume - 3.0 - - trimethylbutanamide 0.3 0.5 - - Triclosan - - 1.0 0.5 Abil EM-90 ³ 1.0 1.5 5,0 ' 1.0 Water < ----- up to 100% - ---->

aroma based on peppermint essential oil ² mixture of additives used as flavorings ³ cetyldimethicone with polyether chains

The aromatic, flavor, cooling and antimicrobial formulations of Examples 6 to 10 are characterized by improved spreading capability, effect and / or efficacy.

Claims (11)

Patent claims (1) A bleaching composition consisting of a bleaching agent which is an inorganic peroxysol, lipophilic substances selected from flavorings, perfumes, physiological coolants, antimicrobial agents and mixtures thereof, and alkyl or alkoxy derivatives of dimethicones with polyether chains of formula (I): CH o I Cho-SiO I ch ₃ CH o I s i o— I ch ₃ n CH o I -S i 0 ---------------- I (CH ₂ ) ₃ o I (C ₂ H ₄ O) _x - (C ₃ H ₆ O) _y X CH o I -S i 0-I Y q CHI ³ Si-CHN I ³ _CH3 (I) wherein X is hydrogen, alkyl, alkoxy and acyl groups having 1 to 16 carbon atoms, Y is an alkyl or alkoxy group having 8 to 22 »carbon atoms, n is 0 to 200, m is from 1 to 40, q is 1 to 100, the molecular weight of the - (C ₂ H ₄ O) _x - (C ₃ H ₆ O) _y x is from 50 to <· 2 000 and the value of x and y are such that the weight ratio of oxyethylene: oxypropylene is 100: 0 to 0: 100. 2 / The composition according to claim 1, characterized in characterized in that said silicone oil is a chain poyléterovými _{C12 20} alkyl dimethicone copolyol, or a mixture of such alkyl dimethicone. The composition according to claims 1 or 2, characterized in that said polyethene chain dimethicone is polyether chain cetyl dimethicone. Composition according to any one of claims 1 to 3, characterized in that it contains 0.01 to 25% by weight, preferably 0.1 to 5% by weight, of dimethicone with polyether chains. Composition according to any one of claims 1 to 4, characterized in that said bleaching agent consists of one or more inorganic bleaching agents selected from the group consisting of alkali metal persulfates, alkali metal perborates and mixtures thereof. Composition according to any one of claims 1 to 5, characterized in that it contains one or more flavor delivery agents selected from the group consisting of wintergreen oil, oregano oil, laurel fat, peppermint oil, menthol, clove oil, sage oil, sasafrasic oil. essential oil, lemon essential oil, orange essential oil, aniseed essential oil, benzaldehyde, bitter oil, camphor, cedar leaf oil, marjoram oil, lemon essential oil, lavender essential oil, mustard essential oil, pine essential oil, essential oil, cinnamon oil and mixtures thereof. A composition according to any one of claims 1 to 6, characterized in that it contains one or more perfume components selected from the group of perfumes consisting of geraniol acetate, linalool acetate, citricellol acetate, dihydromyrcenol acetate, terpineol acetate, tricyclodecenylacetate, tricyclodecompropecenylpropionate, tricyclodecenylpropionate, tricyclodecenylpropionate. fenetylacetátom, benzyl acetate, benzyl salicylate, benzyl benzoate, styrallyl acetate, amyl salicylate, metyldihydrojasmónátom, fenoxyetylisobutyrátom, neryl acetate, ethyl trichlórmetylfenylkarbinolu, p-tert-butyl-cyclohexyl acetate, izononylacetátom, cedryl acetate, vetiveryl acetate, benzyl alcohol, 2-phenylethanol, linalool, tetrahydrolinalool, citronellol, dimetylbenzylkarbinolom, dihydromyrcenol, tetrahydromyrcenol, terpineol, eugenol, geraniol, vetiverol, 3-isocampyl-cyclohexanol, 2-methyl-3- (p-tert-butyl phenol) -propanol, 2-methyl-3- (p-isopropylphenyl) -propanol, 3- (p-tert-butylphenyl) -propanol, nerol, aa cinnamic acid mylaldehyde, cinnamic alpha-hexylaldehyde, 4- (4-hydroxy-4-methylpentyl) -3-cyclohexenecarboxylic acid aldehydes, 4- (4-hydroxy-3-pentenyl) -3-cyclohexenecarboxylic acid aldehyde, 4-acetoxy- 3-pentyltetrahydropyranom, 2-heptylcyclopentanone, 3-methyl-2-pentylcyclopentanone, 3-methyl-2-pentylcyclopentanone, n-decanal, n-dodecanal, hydroxycitronelalom, phenylacetaldehyde dimethylacetal, nitrile acetal, nitrile acetal, citric acid, methylcedrylether, isolongifolane, aubepinic nitrile, aubepine, heliotropin, coumarin, vanillin, diphenyloxide, ions, methyliones, isomethylionones, cis-3-hexenol and its esters, indian muskman, trombone, trombone, macrolactones, ethylene brazlate, musk based on aromatic nitro compounds and mixtures thereof. Composition according to any one of claims 1 to 7, characterized in that it further comprises a substance with effervescent effects. The composition according to any one of claims 1 to 8, further comprising an organic substance which is a precursor of a peroxyacid bleaching agent. A composition according to claim 9, characterized in that said organic substance which is a precursor of a peroxyacid bleaching agent is selected from the group consisting of acylated polyalkyldiamines, in particular tetraacetylethylenediamine and carboxylic acid esters of the general formula AcL, where Ac is acyl or carboxylic acid that includes a substituted or unsubstituted straight or _a branched alkyl or alkenyl ζ C ₆ -C ₂₀ aryl or substituted C ₆ -C ₂₀ alkyl, and L ► a leaving group, the conjugate acid has a pK _and in the range of 4 to 13. 11 / Use of a combination of an alkyldimethicone or alkoxydimethicone with polyether chains of formula (I), inorganic peroxy salts and lipophilic substances selected from the group consisting of flavor delivery agents, perfumes, physiological refrigerants, antimicrobial agents and mixtures thereof to enhance the stability of the lipophilic substance .