HUT77711A - Silicone compositions - Google Patents

Description

BACKGROUND OF THE INVENTION The present invention relates to silicone-containing compositions and their use in various household products, such as personal care products, detergents, or bleaching compositions. In particular, the present invention relates to a silicone-containing lipophilic composition containing a lipophilic component as a flavoring agent, perfume, refrigerant or antimicrobial agent, which improves the surface and effect on treated surfaces such as teeth, dentures, skin, hair, washed textiles, utensils or work surfaces. or show efficacy. The invention also relates to silicone-containing bleaching agents which contain bleach-sensitive additives, such as perfume or flavoring agent, and exhibit improved stability.

Lipophilic compositions such as flavorings, perfumes, refrigerants and disinfectants are widely used. They can be used in combination with direct or various household products, including cosmetics, oral or dental care products, bleaching agents, hard surface cleaners and detergents. A common problem with such lipophilic formulations is to improve the adhesion of the lipophilic component to the surface, i.e. to increase the residual material.

For many, if not all, household applications, it would be desirable to improve the retention of lipophilic material on the surface to enhance the taste or odor or antimicrobial activity.

For example, modern dental hygiene and denture cleansing compositions typically include anti-plaque and / or anti-gums, anti-microbial agents and flavorings tar64.061 / BE ····. · · ... .. φ.

• · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · . ·· ···· · · · · · · · φ φ ·, φ · they are harmful. The antimicrobial effect can prevent plaque formation by reducing the number of bacteria that can accumulate in the mouth / denture or killing bacteria in the film, thus preventing their further growth and metabolism. Flavoring agents reduce the problem by deodorizing the breath. Some antimicrobial agents, such as menthol, may act as deodorants for breath. However, the efficacy of the antimicrobial agents largely depends on the length of time they remain in the mouth / denture, in particular the plaque-forming surface of the tooth or denture.

A typical disadvantage of the known dentifrice formulations is that the time available for tooth cleaning or mouth rinsing is relatively short to exert the effect of the antimicrobial agent. The problem is compounded by the fact that dental care products are rarely used by most people once or at most twice a day. The time between tooth brushing usually creates optimum conditions for plaque formation.

For many other personal care and household applications, it would be desirable to increase the amount of material remaining on the surface. For detergents, for example, it would be advantageous to increase the amount of perfume remaining on the fabric so that the garment remains fragrant after washing, even during use. Increased antibacterial activity is required due to bad odor associated with sweat or other impurities. Perfume fragrance retention would also be desirable in fine perfumes and perfume-containing cosmetics. It would also be desirable to improve the cooling effect of cough suppressant / cooling products.

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Therefore, it is desirable to develop a lipophilic composition which provides improved retention, action and / or antimicrobial activity on the treated surface.

However, the use of lipophilic compounds, such as perfumes, flavoring agents in bleaching compositions may raise further problems. In particular, the problem is that the amount or intensity of the perfume or flavoring agent is reduced by interaction with the bleaching agent. In addition, the efficacy of the bleaching agent may be reduced. For this reason, it would be desirable to improve the stability and efficacy of bleach containing bleach-sensitive components.

Dental care compositions are known to be associated with silicones that are said to coat the tooth and prevent puncture and staining. For example, GB-A-689679 discloses an organopolysiloxane-containing mouthwash for preventing or removing adherence of tar, dirt, tartar and food particles. Mouthwashes may also contain disinfectants such as thymol as well as flavoring and perfuming agents.

US-A-2 806 814 discloses dentifrice compositions comprising a longer-chain aliphatic acylamide active ingredient derived from an aminocarboxylic acid and a silicone compound. The silicone compound is used to prevent or facilitate removal of tars, stains, tartar and similar impurities on the tooth. It is claimed that the silicone compound is synergistically

64.06 l / BE improves the antimicrobial and antacid properties of the active ingredient. Particularly preferred are dimethylpolysiloxane compounds. The composition may also contain flavoring oils and / or menthol.

U.S. Pat. No. 3,624,120 discloses cyclic siloxane polymer quaternary ammonium salts useful as cationic surfactants, bactericides and anticancer agents.

SUMMARY OF THE INVENTION The present invention relates to a flavoring agent, perfume, refrigerant, antimicrobial agent or other lipophilic composition which exhibits improved retention, action and / or efficacy on the treated surface.

The present invention also provides bleaching agents which contain an inorganic persal bleach and a lipophilic compound, such as a flavoring agent and / or perfume, and exhibit improved stability.

The present invention relates to a flavoring agent, perfume, refrigerant, antimicrobial agent or other lipophilic composition comprising an alkyl and alkoxydimethicone copolyol of formula (I):

X is hydrogen, alkyl of about 1 to 16 carbon atoms, pseudoxy and acyl;

Y is alkyl and alkoxy of about 8 to 22 carbon atoms.

group; n is about 0 - 200; m is about 1 - 40; q is about 1 - 100;

The molecular weight of the group - (C ₂ H ₄ O-) _x (C ₃ H ₈ O-) _y X is from about 50 to about 2000, preferably from about 250 to about 1000; and x and y are such that the weight ratio of the oxyethylene / oxypropylene groups is from about (100: 0) to (0: 100), preferably from about (100: 0) to (20: 80).

The present invention also relates to the use of a dimethicone copolyol with a lipophilic compound, such as a flavoring agent, physiological refrigerant, antimicrobial agent and mixtures thereof, which is an alkyl and alkoxydimethicone compound of formula (I).

The present invention further relates to a bleaching composition comprising an inorganic persal bleach, a lipophilic substance which may be a flavoring agent, a perfume, a physiological refrigerant, an antimicrobial agent and mixtures thereof, and an alkyl and alkoxydimethicone copolyol of formula (I). In the formula:

X is hydrogen, C 1 -C 16 alkyl, alkoxy and acyl;

Y is alkyl and alkoxy of about 8 to 22 carbon atoms;

n is from about 0 to about 200;

m is from about 1 to about 40;

q is from about 1 to about 100;

the moiety -— (C ₂ H ₄ O-) _x (C ₃ H ₆ O-) _y X has a molecular weight of from about 50 to about 2000, preferably from about 250 to about 1000; and x and y are such that the weight ratio of the oxyethylene / oxypropylene groups is from about (100: 0) to (0: 100), preferably from about (100: 0) to (20: 80).

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The present invention also relates to the use of a dimethicone copolyol with an inorganic persal bleach and a lipophilic compound such as a flavoring agent, a physiological refrigerant, an antimicrobial agent and mixtures thereof, which is an alkyl and alkoxydimethicone compound of formula (I).

The percentages described herein are by weight of the total composition unless otherwise stated.

The compositions of the present invention, as described above, comprise a dimethicone copolyol anti-plaque agent which may be a flavoring agent, a perfume, a physiological refrigerant, an antimicrobial agent, and mixtures thereof. Other compositions of the present invention may also be bleaching and / or detergent compositions comprising a dimethicone copolyol anti-plaque agent and a lipophilic material.

The dimethicone copolyol is generally an alkyl- and alkoxydimethicone copolyol of the formula I in which:

X is hydrogen, C 1 -C 16 alkyl, alkoxy and acyl;

Y is alkyl and alkoxy of about 8 to 22 carbon atoms.

group; n is from about 0 to about 200; m is from about 1 to about 40; q is from about 1 to about 100; the molecular weight of the group - (C ₂ H ₄ O-) _x (C ₃ H ₆ O-) _y X preferably about 250-1000; and

about

2000

The values of x and y of 64.06 l / BE are such that the weight ratio of the oxyethylene / oxypropylene groups is from about (100: 0) to (0: 100), preferably from about (100: 0) to (20: 80) .

In a preferred embodiment of the invention, the dimethicone copolyol may be a C12-20 alkyldimethicone copolyol and mixtures thereof. Very preferred is cetyl dimethicone copolyol under the trade name Name Abil EM90. The amount of dimethicone copolyol is generally from about 0.01% to about 25% by weight, preferably from about 0.1% to about 5% by weight, and more preferably from about 0.5% to about 1.5% by weight.

The oral compositions of the present invention preferably also contain a lipophilic compound. Lipophilic compounds useful in the compositions of the present invention are, in general, oily substances which are soluble or soluble in dimethicone copolyol at 25 ° C, preferably at least about 1% by weight, more preferably at least about 5% by weight. Preferred lipophilic materials include flavoring agents, perfumes, physiological refrigerants and antimicrobial agents. Dimethicone copolyol improves the adhesion of the lipophilic compound to the treated surface, thereby providing improved and / or sustained taste, odor, cooling and improved antimicrobial efficacy.

Lipophilic flavoring agents for use in the compositions of the present invention include one or more flavoring components selected from the group consisting of gaulteria oil, oreganol oil, bay leaf oil, peppermint oil, frankincense oil, clove oil, safflower oil, lemongrass oil, orange oil, orange oil, Citronella,

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Rosemary ContainsLavender Oil, Mustard Oil, Pine Oil, Pine Needle Oil, Oil, Thyme Oil, Cinnamon Leaf Oil and Mixtures thereof.

Suitable lakes for the compositions of the present invention include one or more known perfume components, which may be natural substances such as essential oils, real perfumes or resins, and synthetic perfume components such as hydrocarbons, alcohols, aldehydes, ketones, ethers, acids, esters, acetals, ketals or nitriles, including saturated and unsaturated compounds, aliphatic, carboxylic and heterocyclic compounds. Representative examples of these include: geranyl acetate, linalyl acetate, citronellyl acetate, dihydromyrcenyl acetate, terpinyl acetate, tricyclodecenyl acetate, tricyclodecenyl propionate, 2-phenylethyl acetate, benzyl acetate, benzyl acetate, salicylate, benzyl benzoate, styryl acetate, amyl salicylate, methyl dihydro-jasmonate, phenoxyethyl isobutyrate, neryl acetate, trichloromethylphenylcarbinyl acetate, p-tert-butyl cyclohexyl acetate, isonylonyl acetate, cedryl acetate, vetiveryl acetate, benzyl alcohol, 2-phenylethanol, linalool, tetrahydrolinalol, citronellol, dimethylbenzylcarbinol, dihydromyrcenol, tetrahydromyrcenol, terpineol, eugenol, geraniol, vetiverol, 3-isocamphylcyclohexanol, 2-methyl-3- (p-tert-butyl-phenyl) -propanol, 2-methyl-3- (p-isopropyl-phenyl) -propanol, 3- (p-tert-butyl) -phenyl) -propanol, nerol, alpha-n-amylcinnaldehyde, alpha-hexylcinnaldehyde, 4- (4-hydroxymethylpentyl) -3-cyclohexenecarbaldehyde, 4- (4-methyl-3-pentenyl) ) -3-cyclohexen-carboxylic baldehyde, 4-acetoxy-3-pentyl-tetrahydropyran, · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·. . · ··· ·

-heptylcyclopentanone, 3-methyl-2-pentylcyclopentanone, decane, dodecanal, hydroxycitronellal, phenylacetaldehyde dimethylacetal, phenylacetaldehyde diethylacetal, geranonitrile, citronellonitrile, cedrylmethyl ether, isolate , aubepinitrile, aubepin, heliotropin, coumarin, vanillin, diphenyl oxide, ions, methyl ions, isomethyl ions, irons, cis-3-hexanol and its esters, indan musk, tetralin musk, isochroman musk, ketones, macrolactone musk, ethylene brazilate. aromatic nitro-musks and mixtures thereof.

Suitable lipophilic antibacterial compounds include thymol, menthol, triclosan, 4-hexyl-resorcinol, phenol, eucalyptol, benzoic acid, benzoyl peroxide, butyl paraben, methyl paraben, propyl paraben, salicyl amides and mixtures thereof.

Carboxamides, menthane esters and menthane ethers, and mixtures thereof, may be used as physiological refrigerant components of the compositions of the present invention.

Mentan esters suitable for use in the compositions of the present invention include compounds of formula (a) wherein

_R5 is an optionally hydroxy substituted, up to 25 carbon atoms, preferably 5 carbon atoms; and

X is hydrogen or hydroxy.

An example of such a material is Takasago, a commercial product manufactured by Takasago International Corporation. A particularly preferred such material for use in the compositions of the present invention is Takasago 10- [3-1-menthoxypropane-1,2-diol (MDP)]. The MDP

64.061 / BE ···; . ··. . . . · ···. . . _{························································································································································ that required which is that of mono-glycerol} and is an excellent cooling agent;

The most suitable carboxamides are U.S. Pat. No. 4,136,163 and U.S. Pat

The most preferred of these materials disclosed in US-A-4 230 688 are carboxamides.

The amount of lipophilic compound used in the compositions of the invention will generally be from about 0.01% to about 10% by weight of the composition, preferably from about 0.05% to about 5%, and more preferably from about 0.1% to about 3% by weight.

The compositions of the present invention optionally contain one or more surfactants. These substances serve primarily to solubilize the lipophilic material and improve efficacy in the lipophilic compositions of the invention. Such materials include non-soap, nonionic, cationic, double ionic and amphoteric organic synthetic detergents. Many of these materials are disclosed in US-A-4,051,234.

Suitable surfactants include:

C 6 -C 18 alkyl sulfates and alkyl ether sulfates ethoxylated with about 0.5 to about 20 moles of ethylene oxide per molecule; anionic sulfonates, including C 5-20 linear alkyl benzene sulfonates, alkyl ester sulfonates, C 6-22 primary or secondary alkane sulfonates, C 6-24 olefin sulfonates, sulfonated polycarboxylic acids, alkylglycerol sulfonates, alkylglycerol sulfonates; anionic carboxylates including primary and secondary C 6 -C 18 alkyl carboxylates, ethoxycarboxylate, and polyethoxy64.06 l / BE ···· · · · · · · · · · · · · ·· «···

carboxylate surfactants having an average ethoxylation degree of about 0 to about 10; C 5 -C 17 sarcosinates such as sodium cocooyl sarcosinate, sodium lauroyl sarcosinate (Hamposyl-95, W.R. Grace); ethylene and propylene oxide with fatty acids, fatty alcohols, fatty amines and polyhydric alcohols (e.g. sorbitan monostearate, sorbitan oleate), alkyl phenols (e.g. Tregitol) and propylene oxide or polyoxybutylene (e.g.

Pluronics); alkyl polysaccharides disclosed in US-A-4,565,647; amine oxides such as dimethyl coconut amine oxide, dimethyl laurylamine oxide and coconut alkyl dimethylamine oxide (Aromox); polysorbates, for example

Tween 40 and Tween 80 (Hercules); sorbitan stearates, sorbitan monooleate; cationic surfactants such as cetylpyridinium chloride, cetyltrimethylammonium bromide, diisobutylphenoxyethoxyethyldimethylbenzylammonium chloride and coconut alkyltrimethylammonium nitrate.

Nonionic surfactants are highly preferred for the solubilization of the lipophilic material in the compositions of the invention. One class of suitable nonionic surfactants is the compound of formula (II) wherein

R _x is C 8 -C 22, preferably C 10 -C 20 alk (en) yl, or alk (en) is C 8 -C 22, preferably C 10 -C 20 alk (en) ylphenyl; m and n are 0 to 80 and 2-80, respectively.

Shorter alkyl groups are generally not used because the formulations would be less effective at 64.06 l / BE and unreacted fatty alcohol in the surfactant would be a source of bad odor and occasionally skin irritation. It should be noted that surfactants of this type are generally mixtures of different degrees of ethoxylation / propoxylation, so that the values of m and n are weight averages of the number of ethoxylate and propoxylate groups. The nonionic surfactants of the general type described above are mixtures of alcoholates in which both m and n are from about 2 to about 80, preferably m is from about 2 to about 20 and more preferably from about 3 to about 10, and n is preferably from about 2 to about 60, more preferably from about 5 to about 50. One such material is PPG-5-ceteth-20 (manufactured by Croda Inc. under the tradename Procetil AWS). other suitable nonionic surfactants that may be used include:

polyethoxylated surfactants such as ethoxylated alkyl phenol ethers, in particular octyl and nonyl phenol ethers having from 8 to 16 EO; C8-C16 linear and branched, preferably 9 -15 EO, ethoxylated C8-20 aliphatic alcohols; and ethoxylated hydrogenated castor oils.

The weight ratio of surfactant to perfume, refrigerant or other oily material is about (50: 1) to (1:10), preferably about (20: 1) to (1: 2), and more preferably about (10: 1) to (1) : 1).

The bleaching compositions of the present invention may further comprise one or more bleaching agents and, optionally, organic peroxyacid precursors, effervescent agents and chelating agents.

64.06 l / BE 'ί. * ···. ···· ···

The bleaching agent is an inorganic persal and may be any well-known bleaching agent, such as alkali metal and ammonium persulfate, perborate, including mono- and tetrahydrates, percarbonates (which are optionally used in GB). They may also be coated materials as described in-A-1 466 799) and perphosphates as well as alkali metal and alkaline earth metal peroxides. Representative examples thereof are potassium, ammonium sodium and lithium persulfates and perborate mono- and tetrahydrates, sodium pyrophosphate peroxyhydrate and magnesium, calcium, strontium and zinc peroxides. Of these, alkali metal persulfates, perborates and mixtures thereof are preferred, and alkali metal perborates and percarbonates are very preferred.

The amount of bleaching agent is generally from about 5% to about 70%, preferably from about 10% to about 50% by weight, based on the total weight of the bleaching composition.

The bleaching composition also comprises a effervescent agent which, in preferred embodiments, is a solid-base material that, in the presence of water, generates carbon dioxide or oxygen during effervescence. Suitable effervescent agents for use in the compositions of the present invention may be active in acidic, neutral or alkaline pH media, but preferred are effervescent agents which contain a combination effective or most effective in an acidic or neutral medium and an alkaline medium.

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At least one alkali metal carbonate or bicarbonate, such as sodium bicarbonate, sodium carbonate, sodium sesquicarbonate, potassium bicarbonate, or at least one thereof, and mixtures thereof, containing at least one alkali metal carbonate or bicarbonate, are present in acidic or neutral media. toxic, physiologically acceptable organic acids such as tartaric acid, fumaric acid, citric acid, malic acid, maleic acid, gluconic acid, succinic acid, salicylic acid, adipic acid or sulfamic acid, sodium fumarate, acid sodium or potassium phosphates, betaines thereof. Of these, malic acid is preferred.

The effervescent effervescent agents active in the alkaline medium contain peracobates, such as alkali metal and alkaline earth metal peroxoborates, perborates, as described above.

persulphates, percarbonates, perphosphates and mixtures thereof. An example of such a material is a mixture of an alkali metal perborate (anhydrous, mono- or tetrahydrate) and monopersulphate, such as Caroat (Dupont deNemours Co.). This material contains a 2: 1: 1 weight ratio of monopersulphate: potassium sulphate: potassium bisulphate and has an active oxygen content of about 4.5% by weight.

In the preferred whitening composition of the invention for use in denture cleansers, the solid base material comprises a (hydrogen) carbonate / acid effervescent agent and optionally a perborate / persulfate oxygen effervescent agent. By combining the developers, you can create the optimal control and pH conditions required for optimum cleaning and antimicrobial activity. The amount of (hydrogen) carbonate components is generally from about 5% to about 65%, preferably from about 25% to about 55%, by weight of the total composition; and the amount of acid component is generally from about 5% to about 50%, preferably from about 10% to about 30%, by weight of the total composition.

The bleaching compositions of the present invention may be supplemented with other known components used in the preparation of such compositions. An especially preferred such component is, more broadly, an organic peroxyacid precursor having a titre of at least 1.5 mL of 0.1 N sodium thiosulfate in the peracid formation assay.

The test solution is prepared by dissolving the following in 1000 ml of water:

Sodium pyrophosphate (Na ₄ P ₂ O _7. 10H ₂ O) 2.5 g Sodium perborate (NaBO _2. H ₂ O _2. 3 H ₂ O) with a liberated oxygen content of 10.4% by weight, 0.615 g of sodium dodecyl. benzenesulfonate 0.5 g.

To this solution is added enough activator at 60 ° C so that each oxygen atom present is equivalent to one molecule of introduced activator.

After the addition of the activator, the resulting mixture was stirred vigorously and kept at 60 ° C. After 5 minutes, add 100 ml of the solution and pipette immediately into a mixture of 250 g of crushed ice and 15 ml of glacial acetic acid. Then 0.4 g of potassium iodide was added immediately with 0.1 N sodium thiosulphate in the presence of starch until the first disappearance of the blue color.

Ralja. Sodium thiosulphate consumption [ml] is the titre of the bleach activator.

Organic peracid precursors are typically compounds containing one or two acyl groups prone to hydrolysis. Preferred activators are compounds of the N-acyl or O-acyl type containing an R-CO acyl group in which R is a hydrocarbon or substituted hydrocarbon group preferably having from about 1 to about 20 carbon atoms. Suitable peracid precursors include the following:

1) A RCONR _{X R2} acyl organoamidok formula I wherein RCO represents a carboxylic acid acyl, R] is acyl and

R ₂ is an organic group as described in US-A-3 117 148. Representative examples of such compounds are the following:

a) N, N-diacetylaniline and N-acetylphthalimide;

b) N-acylhydantoin, such as N, N'-diacetyl-5,5-dimethylhydantoin;

c) Polyacylated alkylene diamines such as N, N, N ', N'-tetraacetyl ethylenediamine (TAED) and the corresponding hexamethylene diamine (TAHD) derivatives, as described in GB-A-907 356, GB- A-907 357 and GB-A-907 358;

d) Acylated glycouryl derivatives such as tetraacetyl glycouryl as disclosed in GB-A-1 246 338, GB-A-1 246 339 and GB-A-1 247 429;

2) Acylated sulfonamides such as N-methyl-N-benzoylmethanesulfonamide and N-phenyl-N-acetylmethanesulfonamide as disclosed in GB-A-3 183 266;

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3) Carboxylic acid esters as described in GB-A-836 988, GB-A-963 135 and

GB-A-1 147 871. Representative examples thereof are phenylacetate, sodium acetoxybenzosulfonate, trichloroethyl acetate, sorbitol hexaacetate, fructose pentaacetate, p-nitrobenzaldehyde diacetate, isopropenyl acetate, acetylacetahydroxamic acid and acetyl. salicylic acid. Other examples are phenol esters and alpha-chlorinated lower aliphatic carboxylic acid substituted phenolic compounds such as chloroacetylphenol and chloroacetylsalicylic acid as disclosed in US-A-3 130 165.

4) Carboxylic acid esters of the formula AcL in which

Ac is an acyl group derived from an organic carboxylic acid containing an optionally substituted linear or branched C 6-20 alkyl or alkenyl group or a C 6-20 alkyl substituted group; and L is a leaving group; the conjugated acid has a pK _{a of} 4 to 13, such as oxybenzenesulfonate or oxybenzoate. Preferred compounds of this type include:

a) Ac is a group of the formula R ₃ -CO and R ₃ is a linear or branched alkyl group

6-20, preferably 6-12 carbon atoms and more preferably 7-9 carbon atoms, and the longest length of the alkyl chain attached to the carbonyl group together with the carbonyl carbon atoms of 5 to 18 carbon atoms, preferably 5-10 carbon atoms, R ₃ is optionally substituted (preferably the karbonil64 .061 / BE

········· in the alpha group) substituted with chlorine or bromine or OCH ₃ or OC ₂ H ₅ . Examples of this group include: sodium 3,5,5-trimethylhexanoyloxybenzenesulfonate, sodium 3,5,5-trimethylhexanoyloxybenzoate, sodium 2-ethylhexanoyloxybenzenesulfonate , sodium nonanoyloxybenzenesulfonate and sodium octanoyloxybenzenesulfonate; the acyloxy group is preferably in the p position in each compound.

b) Ac is R ₃ (AO) _m XA and R ₃ is a linear or branched alkyl or alkylaryl group containing from 6 to 20 carbon atoms in the alkyl group, preferably from 6 to 15 carbon atoms; R _{3 is} optionally substituted with chloro or bromo or OCH ₃ or OC ₂ H ₅ ; AO is oxyethylene or oxypropylene; m is from 0 to 100; X is O or NR ₄ or CO-NR ₄ ; and A is CO,

CO-CO-, R-CO, _CO-R6-CO, or _{CO-NR4 -R6} -CO group, R ₄ is C 1-4 alkyl; and R _{6 in} the alkylene or alkenylene group is C 1 -C 8 alkylene, alkenylene, arylene or alkarylene. Bleach activator compounds of this type include carboxylic acid derivatives of formula R ₃ (AO) _m OCOL, succinic acid derivatives of formula R ₃ OCO (CH ₂ ) ₂ COL,

R ₃ OCH ₂ COL glycollic acid derivatives, R ₃ OCH ₂ CH ₂ COL hydroxypropionic acid derivatives, R ₃ OCOCOL oxalic acid derivatives, R ₃ OCOCH = CHCOL maleic acid and fumaric acid derivatives, R ₃ CONR 1 (CH ₂ ) ₆ COL general

64061 / BE »· · • • ···· acyl aminocaproic acid derivatives of the formula ···, RjCONRxCf ^ COL, acyl glycine derivatives and N {R _r R ₃₎ CO _{(CH2) 4} COL general formula amino-6-oxo-caproic acid derivatives of the formula wherein m is preferably 0 to 10; and R ₃ is when m is 0, C 6 -C 12 alkyl, and when m is not

C 0-9 alkyl. The meaning of the L fissionable group is as defined above.

5) Acyl cyanurates, such as triacetyl or tribenzoyl cyanurates, as disclosed in U.S. Patent 3,332,882.

6) Optionally substituted benzoic or phthalic anhydrides such as benzoic anhydride, m-chlorobenzoic anhydride and phthalic anhydride.

Of the above, organic peracid precursors of types le) and 4a) are preferred.

Preferably, the amount of peroxyacid bleach precursor used in the compositions of the present invention is preferably from about 0.1% to about 10%, more preferably from about 0.5% to about 5% by weight of the total composition and is generally added to the composition as a bleaching precursor agglomerate.

Preferably, the bleach precursor useful in the composition of the present invention comprises a binder or an agglomerating agent in an amount of from about 5 to about 40% by weight, more preferably from about 10 to about 30% by weight. Suitable agglomerating agents include polyvinylpyrrolidone, polyoxyethylene having a molecular weight of from 20,000 to 500,000, and from about 1,000 to 50,000.

Polyethylene glycols having a molecular weight of 64,061 / BE, Carbowax having a molecular weight of 4,000 to 20,000, nonionic surfactants, sodium carboxymethylcellulose, gelatin, fatty alcohols, phosphates and polyphosphates, clays, aluminum. silicates and polymeric polycarboxylates. Of the above, polyethylene glycols are very preferred, especially those having a molecular weight of about 1000 to 30,000, preferably 2000 to about 10,000.

Preferred bleach precursors for optimum solubility and pH characteristics are from about 10 to about 75%, preferably from about 20 to about 60% by weight of the peroxyacid bleaching precursor, from about 5 to about 60%, preferably from about 5 to about 50% by weight, and more preferably from about 10% to about 40% by weight of a (hydrogen) carbonate / acid effervescent couple, from about 0% to about 20% by weight of peroxyborate and from about 5% to about 40%, preferably from about 10% to about 30% by weight of agglomerating agent.

Desirably, the final bleach precursor has an average particle size of about 500 to 1500, preferably about 500 to 1000, for optimum dissolution and aesthetic properties. The bleach precursor is present in an amount of from about 1% to about 20% by weight of the composition, preferably from about 5% to about 15% by weight.

The bleaching compositions of the present invention may be in the form of pastes, liquids, tablets, granules or powders, however, tablet formulations are highly preferred. Tablet formulations may be in the form of monolayer or multilayer tablets.

The bleaching composition of the present invention may also contain other components conventionally used in such compositions, which may be, for example, the compounds known in the art.

topical surfactants, chelating agents, enzymes, dyes, sweeteners, tablet binders and fillers, antifoams such as dimethylpolysiloxanes, foam stabilizers such as fatty acid sugar esters, preservatives, lubricants such as talc, magnesium stearate and fine. pyrogenic silicas.

Suitable binders and fillers for use in the compositions of the present invention include polyvinylpyrrolidone, polyoxyethylene having a molecular weight of 20,000 to 500,000, polyethylene glycols having a molecular weight of about 1,000 to 50,000,

Carbowax of 4000 to 20,000 molecular weight, nonionic surfactants, fatty acids, sodium carboxymethylcellulose, gelatin, fatty alcohols, clays, polymeric polycarboxylates, sodium carbonate, calcium carbonate, calcium hydroxide, magnesium hydroxide, carbonate, sodium sulfate, proteins, cellulose ethers, cellulose esters, polyvinyl alcohol, alginic acid esters and pseudocolloid vegetable fats. Of the above, polyethylene glycols are very preferred, especially those having a molecular weight of about 1000 to 30,000, preferably about 12,000 to 30,000.

Preferably, the chelating agents promote the cleaning and bleaching effect by keeping metal ions such as calcium, magnesium and heavy metal ions in solution. Suitable chelating agents include sodium tripolyphosphate, sodium pyrophosphate, tetrasodium pyrophosphate, aminopolycarboxylate such as nitrilotriacetic acid and ethylenediaminetetraacetic acid and their salts, ethylenediamine-N, N'-dibasic acid. these

Salts thereof, as well as polyphosphonates and amino polyphosphonates such as hydroxyethane diphosphonic acid and ethylenediaminetetramethylene phosphonic acid, diethylenetriamine pentamethylene phosphonic acid and their salts. The chelating agent used is not critical, but must be compatible with the other denture cleanser components, both in the dry state and in aqueous solution. The amount of chelating agent is preferably from about 0.1 to about 60% by weight of the composition, and preferably from about 0.5 to about 30% by weight. However, the phosphonic acid chelating agent is preferably used in an amount of from about 0.1% to about 1% by weight of the composition, and more preferably from about 0.1% to about 0.5% by weight.

Suitable enzymes for use in the compositions of the present invention include proteases, alkalases, amylases, fungal and bacterial lipases, dextranases, mutanases, glucanases, esterases, cellulases, pectinases, lactases and peroxidases. Suitable enzymes are described in US-A-3 519 570.

The following examples illustrate the invention in more detail.

- Examples 5:

The following examples illustrate representative denture cleansing tablets of the present invention. The percentages refer to the total weight of the tablet. Tablets were prepared by the following granular components compressing pressure of about 10 ⁵ kPa in a molding device.

64 061 / BE

Examples

Ingredients 1 2 3 [wt%] 4 5 Malic acid 12 10 15 - 14 Citric acid - 10 - 15 - Sodium carbonate 10 8 10 6 10 sulphamic 5 - - 3 3 PEG 20,000 - 3 7 8 5 PVP 40,000 6 3 - - - Sodium bicarbonate 23 24 25 23 24 Sodium perborate monohydrate 15 12 16 30 15 Potassium monopersulfate 15 18 13 - 14 Pyrogenic silica - 3 1 1 - talc 2 - - - - EDTA - - 1 - 3 EDTMP ¹ 1 - - 1 - flavoring 2 1 2 1 2 Abil EM90 ⁴ 1 1.5 0.5 2 1 Bleaching precursor agglomerate 9 8 10 12 10 Bleaching precursor agglomerate: 1 2 3 4 5 TAED ² 2 - 4 5 2.5 TMHOS ³ 2 3 - - - sulphamic 2 2 2 2 3.5 Sodium bicarbonate 0.5 0.2 0.2 0.5 2 PEG 6000 2.5 2 2.4 2.5 1.5 coloring - 0.8 1.4 2 0.5

^X Ethylenediamine tetramethylene phosphonic acid

Tetraacetyl ethylenediamine ³ Sodium 3,5,5-trimethylhexanoyloxybenzenesulfonate

Cetyldimethicone copolyol ^{5 5} Peppermint based flavoring.

64.06 l / BE

1-5 above. Each of the tablets described in Examples 1 to 4 has a total weight of 3 g and a diameter of 25 mm.

1-5 above. The dentifrice cleaners of Examples 1 to 4 show an improved anti-plaque, excellent cleaning and anti-bacterial, adhesion and other beneficial physical and utility effects.

- Examples 9:

The following examples illustrate representative perfume, flavoring, refrigerant and antimicrobial compositions of the present invention. The percentages refer to the total weight of the composition.

Examples

Ingredients 6789 [% by weight]

PPG-5-ceteth-20 3.0 3.0 4.5 3.0 PEG-40-hydrogenated castor oil - 1.8 4.5 3.0 Trideceth 12 2.0 - - Trideceth 9 - 2.0 3.0 Flavoring ⁵ 2.0 - 3.0 Perfume ⁶ - 3.0 - Trimethyl butane amide 0.3 0.5 - Abil EM90 ⁴ 1.0 1.5 5.0 1.0 Trichlosan - 1.0 0, 5 Water supplement to 100

⁶ Perfume is a compound additive used mainly for its fragrance effect.

64.061 / BE ·· ·

6-9 above. The perfume, flavoring, refrigerant, and antimicrobial compositions of Examples 1 to 5 show improved surface adherence, affect, and efficacy.

64 061 / BE

Claims (11)

Claims CLAIMS 1. A bleaching composition comprising an inorganic persal bleaching agent, a lipophilic compound which may be a flavoring agent, a perfume, a physiological refrigerant, an antimicrobial compound and mixtures thereof, and an alkyl and alkoxydimethicone copolyol of formula (I): : X is hydrogen, C 1 -C 16 alkyl, alkoxy and acyl; Y is alkyl and alkoxy of about 8 to 22 carbon atoms; n is about 0 - 200; m is about 1 - 40; q is about 1 - 100; the molecular weight of the group - (C ₂ H ₄ O-) _x (C ₃ H ₈ O-) _y X is from about 50 to about 2000; and x and y are such that the weight ratio of the oxyethylene / oxypropylene groups is about (100: 0) to (0: 100). A composition according to claim 1, wherein the dimethicone copolyol is a C 12-20 alkyldimethicone copolyol or a mixture thereof. Composition according to claim 1 or 2, characterized in that the dimethicone copolyol is cetyldimethicone copolyol. Composition according to any one of claims 1 to 3, characterized in that it contains from about 0.01% to about 25% by weight, preferably from about 0.1% to about 5% by weight of dimethicone copolyol. Composition according to any one of claims 1 to 4, characterized in that the inorganic persal contains one or more proteinaceous substances, which may be an alkali metal persulphate or perborate and mixtures thereof. Composition according to any one of claims 1 to 5, characterized in that the flavoring agent is gaulteria oil, oreganol oil, bay leaf oil, peppermint oil, clove oil, cayenne oil, safflower oil, lemon oil, orange oil, aniseed oil, cinnamon oil, cinnamon oil, cinnamon oil, , marjoram oil, citronella oil, lavender oil, mustard oil, fir oil, pine needle oil, rosemary oil, thyme oil, cinnamon leaf oil and mixtures thereof. Composition according to any one of claims 1 to 6, characterized in that the perfume contains one or more components which may be geranyl acetate, linalyl acetate, citronellyl acetate, dihydromyrcenyl acetate, terpinyl acetate, tricyclodecenyl acetate. , tricyclodecenyl propionate, 2-phenylethyl acetate, benzyl acetate, benzyl salicylate, benzyl benzoate, styrylallyl acetate, amyl salicylate, methyl dihydro-jasmonate, phenoxyethyl isobutyrate, neryl acetate, trichloromethyl -phenyl-carbinyl acetate, p-tert-butylcyclohexyl acetate, isonylonyl acetate, cedryl acetate, vetiveryl acetate, benzyl alcohol, 2-phenylethanol, linalool, tetrahydrolinal, citronellol, dimethylbenzyl -carbinol, dihydromyrcenol, tetrahydromyrcenol, terpineol, eugenol, geraniol, vetiverol, 3-isocamphylcyclohexanol, 2-methyl-3- (p-tert-butylphenyl) propanol, 2-methyl-3- ( p-isopropyl-phenyl) -propanol, 3- (p-tert-butyl-phenyl) -propanol, nerol, alpha-amylcinnaldehyde, alpha-hexylcinnamic aldehyde, 4- (4-hydroxyethyl) roxymethylpentyl) -3-cyclohexenecarbaldehyde, 4- (4-methyl-3-pentenyl) -364.06L / BE · · · -cyclohexenecarbaldehyde, 4-acetoxy-3-pentyl-tetrahydropyran, 2-heptylcyclopentanone, 3-methyl-2-pentylcyclopentanone, decanal, dodecanal, hydroxycitrone, phenylacetaldehyde dimethylacetal, phenylacetaldehyde -diethylacetal, geranonitrile, citronellonitrile, cedrylmethyl ether, isolongifolanone, aubepinitrile, aubepin, heliotropin, coumarin, vanillin, diphenyl oxide, ions, methyl ions, isomethyl ions, irons, cis-3-hexanol and esters thereof, indan musk, tetralin musk, isochroman musk, macrocyclic ketones, macrolactone musk, ethylene brassilate, aromatic nitro musk and mixtures thereof. 8. A composition according to any one of claims 1 to 7, further comprising an effervescent agent. 9. A composition according to any one of claims 1 to 8, further comprising an organic peroxyacid bleach precursor. Composition according to claim 9, characterized in that the organic peroxyacid bleach precursor can be acylated poly (alkyldiamine), in particular tetraacetyl ethylenediamine and a carboxylic acid ester of the formula AcL in which Ac is an acetyl group or optionally An organic carboxylic acid substituted with a C 6-20 linear or branched alkyl or alkenyl group or a C 6-20 alkyl substituted aryl group and L is a leaving group; and the conjugate acid pK _a is 4-13. 11. A process for the combined use of dimethicone copolyol with an inorganic perso, bleaching agent and a lipophilic substance which may be a flavoring agent, perfume, physiological refrigerant, antimicrobial agent and mixtures thereof, characterized in that the composition thus prepared has improved lipophilic stability. and the dimethicone copolyol is an alkyl or alkoxydimethicone copolyol of formula (I).