SK375592A3 - Drug and fodder premixtures - Google Patents

Abstract

The invention relates to an active compound composition which is characterised in that it contains one or more active compounds (drug and feed additives) and coarsely particulate cereal bran as carrier. This active compound composition is drug and fodder premixes. The invention further relates to a process for preparing this active compound composition which is characterised in that the active compound and the carrier are intimately mixed together.

Description

Technical field

The invention relates to formulations for the preparation of medicament-containing premixes and to methods for making such premixes.

BACKGROUND OF THE INVENTION

In animal husbandry, especially in the case of large-scale farming, premixes play an important role in the application of medicaments and feed additives. Premixtures are concentrated drug mixes of optional feed additives with one or more carriers. The user is mixed to the application concentration prior to administration to the animals. In order to prevent separation and thus the formation of inhomogeneities in the final mixtures during transport and mixing by the user, the physical properties of the premixture are subject to high demands. The properties of the premix, in particular flowability, miscibility, susceptibility to separation, dust fraction and sintering tendency under the effect of compressive forces, are determined by the carrier or carriers which generally have a proportion of more than 90% in premixtures. Thus, the selection of suitable carriers is of decisive importance for the quality of the premix.

Stable premix manufacturers are trying to optimize different quality requirements, with the problem that exemplary admixtures

-2-grain grains improve the flowability, but the stability of the mix deteriorates. (IFF-Dienst No. 221, Institute for Futtermittelforschung, Braunschweig-Thune, January / February 1990).

Indeed, if the carrier consists of particles with different grain sizes, separation may occur. This separation process is made easier by the larger the grain size difference, since the small particles then have the possibility to fall through the free spaces between the large particles. According to the prevailing opinion, it is therefore recommended to make premixes from carriers and active substances with as small a grain size as possible. In this way, although the tendency to separate can be avoided, other negative properties, such as reduced flowability and increased dust content, must also be accepted.

SUMMARY OF THE INVENTION

Surprisingly, it has now been found that they do not show coarse-grained carriers! higher separation than fine grains. Compared to the fine-grained carrier premixes, the coarse-grained premixes exhibit significantly more favorable physical properties. The flowability is better, there is no measurable dust formation and sintering under the effect of compressive forces is reduced.

Thus, the problems encountered in the production of premixes can be satisfactorily solved by using coarse-grained carriers.

BACKGROUND OF THE INVENTION 1. Field of the Invention by containing one or more active substances (medicaments or feed additives) and, as a carrier, coarse grain bran. These active ingredient formulations are premixes of medicaments and feed additives.

The invention furthermore relates to a process for the production of these active ingredient formulations which are characterized by: in that the active ingredient and the carrier are intensively mixed with each other.

Suitable coarse grain bran is preferably a grain bran with a grain size of > 250 μm of at least 90%, in particular bran of durum and soft wheat groats such as coarse-grained bran of wheat groats WG 12.

The term active ingredient includes medicaments and feed additives. These are known in principle and are exemplified in the Pharmaceuticals Act (§ 2) and the Feed Law (§ 2).

Thus, inter alia, anthelmintics, antibiotics, minerals, vitamins and performance enhancers can be added to the carrier. Performance enhancers are those which affect growth, metabolism, body weight, tissue composition and / or feed evaluation, for example, Sulazuril, Halofuginone, Salinomycin Sodium and Flavophospholipol, in particular Sularuzil, are added.

The following examples serve to illustrate the invention, in particular in preferred embodiments. Further, the invention is determined by the content of the claims. The percentages are by weight unless otherwise indicated.

EXAMPLES OF THE INVENTION

1. Examination of separation behavior

The tendency to separate was investigated, with the homogeneous premix passing through the vibrating trough and forming a loose cone. Samples were taken from the tip and base of the cone and analyzed. Deviations from the prescribed content of a homogeneous premix are indicators of separation during transport through a vibratory trough or free fall.

a portion of the carrier was mixed with one part of the active ingredient (Sulazuril) in a plowshaker mixer. After 5, 10 and 15 minutes, samples were taken from various mixer sites and analyzed.

Content of the active substance Sulazuril (INN):

Consumption point min min min

1 I 0.98 0.99 s I 1.00 1.01 1 I 0.99 1.01 2 1 1 0/99 0.99 1 1 I 0.99 1.00 1 1 I 0.99 0.99 3 1 1 1.00 1.01 1 1 0.99 1.01 1 1 0.99 1.00

i.

-5 * 4th

a) fine bran wheat flour (70% <250 µm)

(b) WG 12

Separation after transport through vibrating trough: Vibratory trough: length 45 cm, feed height 15 cm Content effective substances Fine bran wheat groats WG 12 the tip of the cone 1.3 1.00 heel of the cone 1.02 0.99

Separation after tamping

250 ml ramming cylinder, 1250 ramming impact

Content effective Fine bran WG 12 substances wheat groats surface 1.3 1.01 the bottom 1.02 0.99

The use of coarse wheat semolina bran did not lead to separation of the premix when transported through the vibratory trough nor during tamping.

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6 •.

2. Measurement of dust fraction;

I i

The proportion of dust was measured by an automated instrument for measuring dust. The measuring apparatus consists of a measuring box with 1 µ

mounted dust box. The cabinet has a 50 cm long downpipe with an extension supply tube and a feed hopper. At the bottom, the supply tube is separated from the downcomer by a magnetically operated flap. When opened, the entire tube cross-section is released for 2 seconds. Illumination (12 V, t, t) is located laterally in the measuring cabinet

W) and selenium _; photocell (S 60 from Bruno Lange), which are the same as the magnetic flap connected by a special cable to the measuring device. The meter is powered by mains;

voltage 220 V and stabilized to ± 0.1%. f

The maximum value memory registers the maximum values during measurement, stores them and summarizes them after 30 seconds as an instantaneous value. The measurement is then complete. Dust 3 is the sum of the maximum values and the value after 30 seconds.

s

The dust fraction of fine bran wheat wheat meal is:

1.6 / 1.4; the dust fraction of coarse bran of wheat groats (WG 12) was 0.

3. Sinter test

A test method for determining susceptibility is described by Rusov et al. in Chem.Ing.-Techn.4 ^0:, Year 1968 / Workbook 4, page 191st

The value for fine bran wheat bran is:

-Ί | h. ·

4.1 / 3.8 kg and for coarse bran wheat groats (WG 12) 1.4 / 2.0 kg (2 determinations).

Industrial usability

The premixes produced by the process of the invention, which contain medicaments and feed additives, have increased resistance to component separation during handling.

Claims (9)

PATENT CLAIMS An active ingredient formulation comprising one or more active ingredients and coarse grain bran as a carrier. The active ingredient formulation according to claim 1, characterized in that the carrier consists of wheat meal bran. Active ingredient formulation according to claims 1 and 2, characterized in that the carrier substance consists of bran of wheat groats, which has at least a 90% grain size of> 250 μη. Active ingredient formulation according to one or more of Claims 1 to 3, characterized in that the active ingredient is selected from the group consisting of vitamins, minerals, antibiotics, anthelmintics, coccidiostats and performance enhancers. The active ingredient formulation according to one or more of claims 1 to 4, characterized in that the active ingredient is a coccidostatic. Active ingredient formulation according to one or more of claims 1 to 5, characterized in that Sulazuril is used as active ingredient. Active ingredient formulation according to one or more of claims 1 to 6 for use in the treatment and prophylaxis of parasitoses, in particular coccidiosis. Active ingredient formulation according to one or more of claims 1 to 7 for animal nutrition and health care, in particular as a coccidiostat. A process for the preparation of an active ingredient formulation according to one or more of claims 1 to 6, characterized in that the carrier substance is intensively mixed with the active substance.