CA2085810A1 - Pharmaceutical and feedstuff premixes - Google Patents
Pharmaceutical and feedstuff premixesInfo
- Publication number
- CA2085810A1 CA2085810A1 CA002085810A CA2085810A CA2085810A1 CA 2085810 A1 CA2085810 A1 CA 2085810A1 CA 002085810 A CA002085810 A CA 002085810A CA 2085810 A CA2085810 A CA 2085810A CA 2085810 A1 CA2085810 A1 CA 2085810A1
- Authority
- CA
- Canada
- Prior art keywords
- active substance
- carrier
- active
- preparation
- bran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000013543 active substance Substances 0.000 claims abstract description 20
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- 235000013339 cereals Nutrition 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 3
- 235000019752 Wheat Middilings Nutrition 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 7
- AQAZEGOUFUGKBP-UHFFFAOYSA-N 2-[3,5-dichloro-4-(4-methylsulfonylphenoxy)phenyl]-1-methyl-1,2,4-triazinane-3,5-dione Chemical compound CN1CC(=O)NC(=O)N1C(C=C1Cl)=CC(Cl)=C1OC1=CC=C(S(C)(=O)=O)C=C1 AQAZEGOUFUGKBP-UHFFFAOYSA-N 0.000 claims description 5
- 239000003224 coccidiostatic agent Substances 0.000 claims description 4
- 229950009695 sulazuril Drugs 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 2
- 230000000507 anthelmentic effect Effects 0.000 claims description 2
- 239000000921 anthelmintic agent Substances 0.000 claims description 2
- 229940124339 anthelmintic agent Drugs 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 8
- 208000003495 Coccidiosis Diseases 0.000 claims 1
- 206010023076 Isosporiasis Diseases 0.000 claims 1
- 235000019728 animal nutrition Nutrition 0.000 claims 1
- 238000009826 distribution Methods 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 239000003674 animal food additive Substances 0.000 abstract description 5
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 description 15
- 238000000926 separation method Methods 0.000 description 11
- 239000000428 dust Substances 0.000 description 10
- 239000000969 carrier Substances 0.000 description 7
- 230000000704 physical effect Effects 0.000 description 2
- LVASCWIMLIKXLA-CABCVRRESA-N 7-bromo-6-chloro-3-[3-[(2r,3s)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one Chemical compound O[C@H]1CCCN[C@@H]1CC(=O)CN1C(=O)C2=CC(Cl)=C(Br)C=C2N=C1 LVASCWIMLIKXLA-CABCVRRESA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 241001455617 Sula Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- PERZMHJGZKHNGU-JGYWJTCASA-N bambermycin Chemical compound O([C@H]1[C@H](NC(C)=O)[C@@H](O)[C@@H]([C@H](O1)CO[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@@H]1O[C@@H]([C@H]([C@H](O)[C@H]1NC(C)=O)O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@H](O1)C(=O)NC=1C(CCC=1O)=O)O)C)[C@H]1[C@@H](OP(O)(=O)OC[C@@H](OC\C=C(/C)CC\C=C\C(C)(C)CCC(=C)C\C=C(/C)CCC=C(C)C)C(O)=O)O[C@H](C(O)=O)[C@@](C)(O)[C@@H]1OC(N)=O PERZMHJGZKHNGU-JGYWJTCASA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- ITCAUAYQCALGGV-UHFFFAOYSA-M sodium;1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylate Chemical compound [Na+].C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C([O-])=O ITCAUAYQCALGGV-UHFFFAOYSA-M 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Physiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
ABSTRACT OF THE DISCLOSURE:
Pharmaceutical and feedstuff premixes The invention relates to an active substance preparation which comprises one or more active substances (pharmaceutical additives and feed additives) and coarsely-particulate cereal bran as carrier substance.
This active substance preparation is a pharmaceutical or feedstuff premix.
The invention furthermore relates to a process for manufacturing this active substance preparation which comprises intimately mixing the active substance and the carrier.
Pharmaceutical and feedstuff premixes The invention relates to an active substance preparation which comprises one or more active substances (pharmaceutical additives and feed additives) and coarsely-particulate cereal bran as carrier substance.
This active substance preparation is a pharmaceutical or feedstuff premix.
The invention furthermore relates to a process for manufacturing this active substance preparation which comprises intimately mixing the active substance and the carrier.
Description
~5~0 HOECHST AKTIENGESELLSCHAFT HOE 91/F 411 Dr.AB/sch Description Pharmaceutical and feedstuff premixes In livestock farming, in particular intensive livestoçk farming, premixes play an important role in the adminis-tration of pharmaceuticals and feed additives. Premixesare concentrated mixtures of the pharmaceutical, or of the feed additive, with one or more carriers. Before they are administered to the animals, they are extended by the user to the use concentration. To avoid separation of the mixtures, and thus inhomogeneity in the end mixture, during transport and mixing at the user's, the physical properties of the premix must meet high demands. The properties of the premiX, mainly flowability, mixability, separation behavior of the mixture, dust count and tendency to caking under pressure are determined by the carrier, or carriers, which generally make up more than 90 ~ of the premix. Selection of the suitable carrier is therefore of crucial importance for ~he quality of the premix.
The manufacturer of a stable premix will strive to optimize the range of demands with regard to ~uality, having had the problem that, for example, admixing coarse cereal particles improve the flowability properties, but adversely affect the stability of the mixture (IF~-Dienst No. 221, Institut fur Futtermittelforschung [Institute of Feedstuffs Research], 3raunschweig-Thune, January/February 1990).
This is ~o because separation of the mixture can take place when the carrier is cQmposed of particles of different sizes. This separation process of the mixture is favored the greater the~difference i~ particle size is, since ~he small particles are capable of falling through the interstices of the large paxticles. The predominant school of thought therefore proposes to produce premixes of carriers and active substances having 2~
the same small particle size. The tendency of the mixture to separate can be prevented in this manner, however, other negative properties such as reduced flowability and increased dust count, will have to be accepted.
Surprisingly, it has been found that coarsely-particulate carriers show no greater separation of the mixture than finely-particulate ones. Compared with premixes with finely-particulate carriers, premixes with coarsely-particulate carriers show markedly better physical properties. The 10wability is improved, there is no measurable development of dust, and caking under pressure is reduced.
This means that the use of coarsely-particulate carriers can solve the problems which occur in the manufacture of premixes in a satisfactory manner.
The invention relates to an active substance preparation which compri~es one or more active ~ubstance~ (pharma-ceutical additives and feed additives) and coarsely-particulate cereal bran as carrier. This active ~ubstance prepara~ion is a pharmaceutical or feed~tuff premix.
Moreover, the invention relates to a process for manufac-turing this active substance preparation which comprises intimately mixing the active substance and the carrier.
A suitable coarsely-particulate~cereal bran is preferably cereal bran~having a particle size fraction 2 250 ~m of at least 90 ~, in particular durum and aestivum wheat middlings bran, such as coarsely-particulate wheat ~; middlings bran WG 12.
The term active substance embraces pharmaceutical addi-tives and feed additives. These are known in principleand are described, for e~ample, in the Arzneimittelgesetz [Pharmaceutical Act] (~2) and in the Futtermi~telgesetz tFeedStl~ffS Act~ (~2).
.
o Substances which can be added to the carrier are, forexample, coccidiostats, anthelmintics, antibiotics, minerals, vitamins and performance promoters. Perfonmance promoters are to be understood as meaning those sub-stances which affect the growth, metabolism, body weight,tissue composition and/or feed conversion, for example sulazuril, halofuginon, salinomycin sodium and flavophos-pholipol, in particular sulazuril.
The examples which follow are intended to illustrate the invention, particularly in its preferred embodLments. The invention is furthermore determined by the contents of the patent claimæ. Unless otherwise indicated, per-centages are by weight.
1. ~est for separation behavior of the mixture The separation behavior of the mixture was tested by allowing the homogeneous premix to run along a vibration channel and forming a poured cone. Samples were taken from the tip and the foot of the cone and analyzed.
Deviations from the desired value of the homogeneous premix are indicators for separation of the mixture during transport along the vibration channel or during free fall.
In a plough-share mixer, 99 parts of carrier were mixed with one part of active substance (sula~uril). After 5, 10 and 15 minutes, samples were taken from different locations of the mixer and analyzed.
~¢~10 Content vf active substance sulazuril (INN):
Sampling site 5 min 10 min 15 min . _ a b a b a b 0.98 0.99 1.00 1.01 0.99 1.0 2 0.99 0.99 0.99 1.00 0.99 0.99 3 1.00 1.01 0.~9 1.01 0.99 1.00 a) Fine wheat middlings bran (70 ~ < 250 ~m) b) WG 12 Separation of the mixture of the transport along vibra-tion channel:
Vibration channel: length 45 cm, pouring height: 15 cm Active substance content: Fine wheat middlings bran WG 12 Tip of the cone 1.03 1.00 Foot of the cone 1.02 0.99 Separation of the mixture after tamping:
250 ml tamping cylinder, 1250 strokes Active substance content Fine wheat middlings bran WG 12 Surface 1.03 1.01 Bottom 1.02 0.99 Neither during transport along the vi~ration channel nor during tamping, does the use of coarse wheat middlings bran result in separation of the premix.
2. Determination of the dust count The dust count was detexmined :using an automated dust counter. The apparatus is composed of the gauging box with a dust box inside. A downpipe 50 cm in length with an extending feed tube and hopper is attached to the box.
_ 5 ~5~3~Lo At the bottom, the feed tube is separated from the down-pipe by means of a flap to be opened magnetically. On opening, the entire cross-section of the tube is uncsvered for 2 seconds. In the gauging box, an illumi-nation (12 V, 15 W) and a selenium photocell (S 60, manufactured by Bruno Lange) are attached collaterally and offset with regard to the direction of falling, both of which as well as the magnetic flap are connected to the apparatus by separate leads. The apparatus is designed for a supply voltage of 220 V, and the voltage is stabilized to + 0.1 %.
On measuring, a peak value memory records the peak value, stores it and, after a measuring period of 30 seconds, adds it to the momentary value. This is the end of the measurement. The dust count is the total of the peak value and the value after 30 seconds.
The dust count of fine wheat middlings bran was: 1.6/1.4;
the dust count of the coarse wheat middlings bran (WG 12) was 0.
3. Test for caking The test method for determining the caking tendency is described by Ru6sow et al. in Chem. Ing.-Techn. 40th volume 1968/No. 4, page 191.
` The data were 4.1/3.8 kg in the case of fine wheat middlings bran and 1.4/2.0 kg in the case of coarse wheat middlings bran ~WG 12) (2 detenminations).
The manufacturer of a stable premix will strive to optimize the range of demands with regard to ~uality, having had the problem that, for example, admixing coarse cereal particles improve the flowability properties, but adversely affect the stability of the mixture (IF~-Dienst No. 221, Institut fur Futtermittelforschung [Institute of Feedstuffs Research], 3raunschweig-Thune, January/February 1990).
This is ~o because separation of the mixture can take place when the carrier is cQmposed of particles of different sizes. This separation process of the mixture is favored the greater the~difference i~ particle size is, since ~he small particles are capable of falling through the interstices of the large paxticles. The predominant school of thought therefore proposes to produce premixes of carriers and active substances having 2~
the same small particle size. The tendency of the mixture to separate can be prevented in this manner, however, other negative properties such as reduced flowability and increased dust count, will have to be accepted.
Surprisingly, it has been found that coarsely-particulate carriers show no greater separation of the mixture than finely-particulate ones. Compared with premixes with finely-particulate carriers, premixes with coarsely-particulate carriers show markedly better physical properties. The 10wability is improved, there is no measurable development of dust, and caking under pressure is reduced.
This means that the use of coarsely-particulate carriers can solve the problems which occur in the manufacture of premixes in a satisfactory manner.
The invention relates to an active substance preparation which compri~es one or more active ~ubstance~ (pharma-ceutical additives and feed additives) and coarsely-particulate cereal bran as carrier. This active ~ubstance prepara~ion is a pharmaceutical or feed~tuff premix.
Moreover, the invention relates to a process for manufac-turing this active substance preparation which comprises intimately mixing the active substance and the carrier.
A suitable coarsely-particulate~cereal bran is preferably cereal bran~having a particle size fraction 2 250 ~m of at least 90 ~, in particular durum and aestivum wheat middlings bran, such as coarsely-particulate wheat ~; middlings bran WG 12.
The term active substance embraces pharmaceutical addi-tives and feed additives. These are known in principleand are described, for e~ample, in the Arzneimittelgesetz [Pharmaceutical Act] (~2) and in the Futtermi~telgesetz tFeedStl~ffS Act~ (~2).
.
o Substances which can be added to the carrier are, forexample, coccidiostats, anthelmintics, antibiotics, minerals, vitamins and performance promoters. Perfonmance promoters are to be understood as meaning those sub-stances which affect the growth, metabolism, body weight,tissue composition and/or feed conversion, for example sulazuril, halofuginon, salinomycin sodium and flavophos-pholipol, in particular sulazuril.
The examples which follow are intended to illustrate the invention, particularly in its preferred embodLments. The invention is furthermore determined by the contents of the patent claimæ. Unless otherwise indicated, per-centages are by weight.
1. ~est for separation behavior of the mixture The separation behavior of the mixture was tested by allowing the homogeneous premix to run along a vibration channel and forming a poured cone. Samples were taken from the tip and the foot of the cone and analyzed.
Deviations from the desired value of the homogeneous premix are indicators for separation of the mixture during transport along the vibration channel or during free fall.
In a plough-share mixer, 99 parts of carrier were mixed with one part of active substance (sula~uril). After 5, 10 and 15 minutes, samples were taken from different locations of the mixer and analyzed.
~¢~10 Content vf active substance sulazuril (INN):
Sampling site 5 min 10 min 15 min . _ a b a b a b 0.98 0.99 1.00 1.01 0.99 1.0 2 0.99 0.99 0.99 1.00 0.99 0.99 3 1.00 1.01 0.~9 1.01 0.99 1.00 a) Fine wheat middlings bran (70 ~ < 250 ~m) b) WG 12 Separation of the mixture of the transport along vibra-tion channel:
Vibration channel: length 45 cm, pouring height: 15 cm Active substance content: Fine wheat middlings bran WG 12 Tip of the cone 1.03 1.00 Foot of the cone 1.02 0.99 Separation of the mixture after tamping:
250 ml tamping cylinder, 1250 strokes Active substance content Fine wheat middlings bran WG 12 Surface 1.03 1.01 Bottom 1.02 0.99 Neither during transport along the vi~ration channel nor during tamping, does the use of coarse wheat middlings bran result in separation of the premix.
2. Determination of the dust count The dust count was detexmined :using an automated dust counter. The apparatus is composed of the gauging box with a dust box inside. A downpipe 50 cm in length with an extending feed tube and hopper is attached to the box.
_ 5 ~5~3~Lo At the bottom, the feed tube is separated from the down-pipe by means of a flap to be opened magnetically. On opening, the entire cross-section of the tube is uncsvered for 2 seconds. In the gauging box, an illumi-nation (12 V, 15 W) and a selenium photocell (S 60, manufactured by Bruno Lange) are attached collaterally and offset with regard to the direction of falling, both of which as well as the magnetic flap are connected to the apparatus by separate leads. The apparatus is designed for a supply voltage of 220 V, and the voltage is stabilized to + 0.1 %.
On measuring, a peak value memory records the peak value, stores it and, after a measuring period of 30 seconds, adds it to the momentary value. This is the end of the measurement. The dust count is the total of the peak value and the value after 30 seconds.
The dust count of fine wheat middlings bran was: 1.6/1.4;
the dust count of the coarse wheat middlings bran (WG 12) was 0.
3. Test for caking The test method for determining the caking tendency is described by Ru6sow et al. in Chem. Ing.-Techn. 40th volume 1968/No. 4, page 191.
` The data were 4.1/3.8 kg in the case of fine wheat middlings bran and 1.4/2.0 kg in the case of coarse wheat middlings bran ~WG 12) (2 detenminations).
Claims (9)
1. An active compound preparation which comprises one or more active compounds and coarsely-particulate cereal bran as carrier.
2. An active compound preparation as claimed in claim 1, wherein the carrier is composed of wheat mid-dlings bran.
3. An active compound preparation as claimed in claims l and 2, wherein the carrier is composed of wheat middlings bran having a particle size distribution > 250 µm of at least 90 %.
4. An active compound preparation as claimed in one or more of claims 1 to 3, wherein an active substance is selected from the group of the vitamins, minerals, antibiotics, anthelmintics, coccidiostats and performance promoters.
5. An active compound preparation as claimed in one or more of claims 1 to 4, wherein the active compound is a coccidiostat.
6. An active compound preparation as claimed in one or more of claims 1 to 5, wherein sulazuril is employed as active substance.
7. An active substance preparation as claimed in one or more of claims 1 to 6 for use in the treatment and prophylaxis of parasitoses, in particular coccidiosis .
8. Use of an active substance preparation as claimed in one or more of claims 1 to 7 in animal nutrition and for animal health, in particular as a coccidiostat.
9. A process for manufacturing an active substance preparation as claimed in one or more of claims 1 to 6, which comprises intimately mixing the carrier with the active substance.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4142633.9 | 1991-12-21 | ||
| DE4142633 | 1991-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2085810A1 true CA2085810A1 (en) | 1993-06-22 |
Family
ID=6447923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002085810A Abandoned CA2085810A1 (en) | 1991-12-21 | 1992-12-18 | Pharmaceutical and feedstuff premixes |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0549975A1 (en) |
| JP (1) | JPH05255122A (en) |
| KR (1) | KR930012037A (en) |
| AU (1) | AU3021092A (en) |
| BR (1) | BR9205071A (en) |
| CA (1) | CA2085810A1 (en) |
| CZ (1) | CZ375592A3 (en) |
| HU (1) | HUT63342A (en) |
| IL (1) | IL104164A0 (en) |
| NZ (1) | NZ245526A (en) |
| PL (1) | PL297065A1 (en) |
| RO (1) | RO109035B1 (en) |
| SK (1) | SK375592A3 (en) |
| ZA (1) | ZA929830B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015193724A1 (en) * | 2014-06-20 | 2015-12-23 | Laboratorios Virbac | Premix composition for cattle |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114557259A (en) * | 2022-03-03 | 2022-05-31 | 中国农业大学 | Vegetable seedling culture medium containing high-activity growth-promoting bacteria and preparation method and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS163505B1 (en) * | 1972-11-15 | 1975-09-15 | ||
| US4504471A (en) * | 1982-09-27 | 1985-03-12 | Fujisawa Pharmaceutical Co., Ltd. | Animal growth promotant and method of use for animal growth |
| HU209473B (en) * | 1990-12-22 | 1994-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of fodder-additives, premixes and fodders containing n-thiobenzoil-morpholine derivatives with weight-gain increasing action |
-
1992
- 1992-12-16 RO RO92-01567A patent/RO109035B1/en unknown
- 1992-12-17 AU AU30210/92A patent/AU3021092A/en not_active Abandoned
- 1992-12-17 JP JP4337546A patent/JPH05255122A/en not_active Withdrawn
- 1992-12-18 ZA ZA929830A patent/ZA929830B/en unknown
- 1992-12-18 IL IL104164A patent/IL104164A0/en unknown
- 1992-12-18 PL PL29706592A patent/PL297065A1/en unknown
- 1992-12-18 HU HU9204027A patent/HUT63342A/en unknown
- 1992-12-18 BR BR9205071A patent/BR9205071A/en not_active Application Discontinuation
- 1992-12-18 CZ CS923755A patent/CZ375592A3/en unknown
- 1992-12-18 EP EP92121559A patent/EP0549975A1/en not_active Withdrawn
- 1992-12-18 NZ NZ245526A patent/NZ245526A/en unknown
- 1992-12-18 CA CA002085810A patent/CA2085810A1/en not_active Abandoned
- 1992-12-18 SK SK3755-92A patent/SK375592A3/en unknown
- 1992-12-19 KR KR1019920024774A patent/KR930012037A/en not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015193724A1 (en) * | 2014-06-20 | 2015-12-23 | Laboratorios Virbac | Premix composition for cattle |
Also Published As
| Publication number | Publication date |
|---|---|
| IL104164A0 (en) | 1993-05-13 |
| PL297065A1 (en) | 1993-07-26 |
| SK375592A3 (en) | 1994-09-07 |
| RO109035B1 (en) | 1994-11-30 |
| NZ245526A (en) | 1995-07-26 |
| ZA929830B (en) | 1993-06-23 |
| JPH05255122A (en) | 1993-10-05 |
| KR930012037A (en) | 1993-07-20 |
| HUT63342A (en) | 1993-08-30 |
| AU3021092A (en) | 1993-06-24 |
| EP0549975A1 (en) | 1993-07-07 |
| CZ375592A3 (en) | 1994-02-16 |
| BR9205071A (en) | 1993-06-29 |
| HU9204027D0 (en) | 1993-04-28 |
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