SK287842B6 - Oxazole derivative, method for the preparation thereof and use, pharmaceutical compositions containing thereof - Google Patents

Oxazole derivative, method for the preparation thereof and use, pharmaceutical compositions containing thereof Download PDF

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Publication number
SK287842B6
SK287842B6 SK1385-2003A SK13852003A SK287842B6 SK 287842 B6 SK287842 B6 SK 287842B6 SK 13852003 A SK13852003 A SK 13852003A SK 287842 B6 SK287842 B6 SK 287842B6
Authority
SK
Slovakia
Prior art keywords
methyl
ethoxy
phenyl
oxazol
propionic acid
Prior art date
Application number
SK1385-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK13852003A3 (en
Inventor
Alfred Binggeli
Markus Boehringer
Uwe Grether
Hans Hilpert
Hans-Peter Maerki
Markus Meyer
Peter Mohr
Fabienne Ricklin
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of SK13852003A3 publication Critical patent/SK13852003A3/sk
Publication of SK287842B6 publication Critical patent/SK287842B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK1385-2003A 2001-05-15 2002-05-06 Oxazole derivative, method for the preparation thereof and use, pharmaceutical compositions containing thereof SK287842B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01111745 2001-05-15
PCT/EP2002/004962 WO2002092084A1 (fr) 2001-05-15 2002-05-06 Derives d'oxazole substitues par de l'acide carboxylique utiles en tant qu'activateurs ppar-alpha et gamma dans le traitement du diabete

Publications (2)

Publication Number Publication Date
SK13852003A3 SK13852003A3 (en) 2004-10-05
SK287842B6 true SK287842B6 (sk) 2011-12-05

Family

ID=8177436

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1385-2003A SK287842B6 (sk) 2001-05-15 2002-05-06 Oxazole derivative, method for the preparation thereof and use, pharmaceutical compositions containing thereof

Country Status (39)

Country Link
US (1) US6642389B2 (fr)
EP (1) EP1392295B1 (fr)
JP (2) JP4330883B2 (fr)
KR (1) KR100654516B1 (fr)
CN (1) CN100356917C (fr)
AR (1) AR035892A1 (fr)
AT (1) ATE327753T1 (fr)
AU (1) AU2002342244B2 (fr)
BG (1) BG66316B1 (fr)
BR (1) BRPI0209821B1 (fr)
CA (1) CA2445145C (fr)
CY (1) CY1105160T1 (fr)
CZ (1) CZ20033037A3 (fr)
DE (1) DE60211891T2 (fr)
DK (1) DK1392295T3 (fr)
EC (1) ECSP034848A (fr)
EG (1) EG25755A (fr)
ES (1) ES2264482T3 (fr)
GT (1) GT200200085A (fr)
HK (1) HK1067534A1 (fr)
HR (1) HRP20030889B1 (fr)
HU (1) HU230224B1 (fr)
IL (2) IL158589A0 (fr)
JO (1) JO2282B1 (fr)
MA (1) MA27025A1 (fr)
ME (1) ME01310B (fr)
MX (1) MXPA03010435A (fr)
MY (1) MY136761A (fr)
NO (1) NO333833B1 (fr)
NZ (1) NZ529033A (fr)
PA (1) PA8544901A1 (fr)
PE (1) PE20021152A1 (fr)
PL (1) PL208074B1 (fr)
PT (1) PT1392295E (fr)
RU (1) RU2278859C2 (fr)
SI (1) SI1392295T1 (fr)
SK (1) SK287842B6 (fr)
WO (1) WO2002092084A1 (fr)
ZA (1) ZA200308538B (fr)

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JP3591514B2 (ja) * 2000-05-26 2004-11-24 日本新薬株式会社 複素環誘導体
IL158589A0 (en) * 2001-05-15 2004-05-12 Hoffmann La Roche Carboxylic acid substituted oxazole derivatives for use as ppar-alpha and -gamma activators in the treatment of diabetes
US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
AU2002331064B2 (en) * 2001-08-10 2007-08-23 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
EP1480642B1 (fr) 2002-02-25 2008-11-26 Eli Lilly And Company Modulateurs des r cepteurs activ s par les prolif rateurs de peroxisomes
PT1537091E (pt) * 2002-08-30 2010-11-11 Hoffmann La Roche Novos compostos de 2-ariltiazole como agonistas de ppar-alfa e de ppar-gama
AR041481A1 (es) * 2002-10-07 2005-05-18 Hoffmann La Roche Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar
BR0315713A (pt) * 2002-11-15 2005-09-13 Cadila Healthcare Ltd Composto, processo para a preparação do composto, composição farmacêutica, métodos para reduzir a glicose, para a prevenção ou para o tratamento de doenças e uso do composto
WO2004048371A1 (fr) * 2002-11-25 2004-06-10 F.Hoffmann-La Roche Ag Derives d'indolyle
US7268157B2 (en) * 2002-11-26 2007-09-11 Shenzhen Chipscreen Biosciences, Ltd. Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity
FR2849849B1 (fr) * 2003-01-13 2006-08-04 Merck Sante Sas Nouveaux acides carboxyliques et derives pour le traitement et la prevention du diabete et des dyslipemies
US7968548B2 (en) * 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7262303B2 (en) * 2003-09-29 2007-08-28 Hoffman-La Roche Inc. Process for the production of chiral propionic acid derivatives
JP2007509998A (ja) * 2003-11-05 2007-04-19 エフ．ホフマン−ラ　ロシュ　アーゲー Ｐｐａｒ活性化剤としてのベンズ環付加された化合物
WO2005049573A1 (fr) * 2003-11-05 2005-06-02 F. Hoffmann-La Roche Ag Derives de phenyle utilises comme agonistes de ppar
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US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
KR100893449B1 (ko) 2004-05-03 2009-04-17 에프. 호프만-라 로슈 아게 간-ｘ-수용체 조절제로서의 인돌일 유도체
CN100344618C (zh) * 2004-05-24 2007-10-24 北京摩力克科技有限公司 作为hPPARα和hPPARγ激动剂的N－芳丙烯酰基取代的酪氨酸衍生物
CN100436430C (zh) * 2004-05-24 2008-11-26 北京摩力克科技有限公司 作为hPPARα和hPPARγ激动剂的烷酰基取代的酪氨酸衍生物
WO2006108491A1 (fr) * 2005-04-11 2006-10-19 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Procede ameliore de preparation de nitriles d'oxazole
US20060241073A1 (en) * 2005-04-20 2006-10-26 Wanders Ronaldus J A Means and methods for counteracting fatty acid accumulation
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
KR100847780B1 (ko) * 2006-10-26 2008-07-23 재단법인서울대학교산학협력재단 2-에톡시프로피온산 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 당뇨병 예방 및 치료제
GB2460784A (en) * 2007-03-07 2009-12-16 Dong A Pharmtech Co Ltd Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators,method of the same,and pharmaceutical composition
EP2100604B1 (fr) * 2008-03-10 2012-07-04 Nestec S.A. Acides dicarboxyliques à chaîne moyenne et leurs dérivés, et troubles du métabolisme
JP2011520890A (ja) * 2008-05-15 2011-07-21 メルク・シャープ・エンド・ドーム・コーポレイション オキサゾロベンゾイミダゾール誘導体
JP2012513626A (ja) 2008-12-23 2012-06-14 エフ．ホフマン−ラ ロシュ アーゲー 収集装置で作動する構造化収集手続の実装、実行、データ収集、及びデータ分析のための管理方法及びシステム
MX2011007381A (es) * 2009-01-23 2011-08-12 Hoffmann La Roche Composicion farmaceutica que contiene aleglitazar.
CN101805337B (zh) * 2009-02-13 2012-05-23 天津药物研究院 一类含脯氨酸和异恶唑骨架的化合物、其制备方法和用途
US8450496B2 (en) 2009-03-24 2013-05-28 Hoffman-La Roche Inc. Process for the preparation of propionic acid derivatives
CA2783448C (fr) 2009-12-07 2018-11-20 F. Hoffmann-La Roche Ag Procede pour la preparation de derives d'acide propionique
CN102351852B (zh) * 2011-08-23 2014-06-18 上海交通大学 苯并呋喃类化合物及其制备方法、用途
WO2013181384A1 (fr) 2012-05-31 2013-12-05 Ratiopharm Gmbh Formes à l'état solide d'aleglitazar sodique
MX2015002095A (es) * 2012-09-12 2015-05-11 Hoffmann La Roche Formas solidas de acido (s)-2-metoxi-3-{4-[2-(5-metil-2-fenil-oxaz ol-4-il)-etoxi]benzo[b]tiofen-7-il}propionico y de sales del mismo.
WO2017084989A1 (fr) 2015-11-18 2017-05-26 F. Hoffmann-La Roche Ag Aleglitazar pour traiter la néphropathie diabétique
WO2018002215A1 (fr) 2016-06-30 2018-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement de cardiomyopathies
WO2020156683A1 (fr) 2019-02-01 2020-08-06 F. Hoffmann-La Roche Ag Aleglitazar destiné à être utilisé dans le traitement ou la prévention d'accidents cardiaques majeurs
WO2020201263A1 (fr) 2019-04-01 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement et la prévention du remodelage cardiaque
CA3227149A1 (fr) * 2021-08-13 2023-02-16 Alebund Pharmaceuticals (Hong Kong) Limited Composes deuteres
WO2024100051A1 (fr) 2022-11-08 2024-05-16 Genfit Agoniste ppar-alpha/gamma destiné à être utilisé dans le traitement de l'insuffisance hépatique
CN118480034A (zh) * 2023-02-13 2024-08-13 礼邦医药(香港)有限公司 氘代化合物的晶型或盐

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Also Published As

Publication number Publication date
IL158589A0 (en) 2004-05-12
RU2003134150A (ru) 2005-06-10
ZA200308538B (en) 2005-04-26
HRP20030889B1 (en) 2011-10-31
MA27025A1 (fr) 2004-12-20
US6642389B2 (en) 2003-11-04
EP1392295B1 (fr) 2006-05-31
PE20021152A1 (es) 2003-02-07
JP2009138011A (ja) 2009-06-25
ME01310B (fr) 2011-10-10
CA2445145C (fr) 2008-10-14
PL208074B1 (pl) 2011-03-31
BR0209821A (pt) 2004-06-01
ATE327753T1 (de) 2006-06-15
PL367087A1 (en) 2005-02-21
RU2278859C2 (ru) 2006-06-27
BG108362A (bg) 2005-03-31
PT1392295E (pt) 2006-09-29
NO333833B1 (no) 2013-09-30
HK1067534A1 (en) 2005-04-15
AR035892A1 (es) 2004-07-21
DE60211891D1 (de) 2006-07-06
SI1392295T1 (sl) 2006-10-31
CA2445145A1 (fr) 2002-11-21
KR20030096397A (ko) 2003-12-24
NZ529033A (en) 2005-06-24
WO2002092084A1 (fr) 2002-11-21
MXPA03010435A (es) 2004-03-09
JP4330883B2 (ja) 2009-09-16
IL158589A (en) 2010-11-30
CY1105160T1 (el) 2009-11-04
US20030055265A1 (en) 2003-03-20
HRP20030889A2 (en) 2005-08-31
DK1392295T3 (da) 2006-10-02
HUP0400992A2 (hu) 2004-08-30
KR100654516B1 (ko) 2006-12-05
BRPI0209821B1 (pt) 2016-09-27
CN100356917C (zh) 2007-12-26
NO20035086L (no) 2003-11-14
CZ20033037A3 (cs) 2004-06-16
EG25755A (en) 2012-06-26
JP2004529174A (ja) 2004-09-24
BG66316B1 (bg) 2013-04-30
PA8544901A1 (es) 2003-01-24
AU2002342244B2 (en) 2005-06-16
DE60211891T2 (de) 2007-05-24
EP1392295A1 (fr) 2004-03-03
CN1509173A (zh) 2004-06-30
MY136761A (en) 2008-11-28
NO20035086D0 (no) 2003-11-14
SK13852003A3 (en) 2004-10-05
ES2264482T3 (es) 2007-01-01
JO2282B1 (en) 2005-09-12
HU230224B1 (hu) 2015-10-28
GT200200085A (es) 2003-01-16
ECSP034848A (es) 2003-12-24
HUP0400992A3 (en) 2007-11-28

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20200506