SK281977B6 - Spôsob prípravy arylpiperidínových derivátov metanolu a spôsob výroby paroxetínu - Google Patents

Spôsob prípravy arylpiperidínových derivátov metanolu a spôsob výroby paroxetínu Download PDF

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Publication number
SK281977B6
SK281977B6 SK1140-95A SK114095A SK281977B6 SK 281977 B6 SK281977 B6 SK 281977B6 SK 114095 A SK114095 A SK 114095A SK 281977 B6 SK281977 B6 SK 281977B6
Authority
SK
Slovakia
Prior art keywords
formula
compound
solution
diborane
alkyl
Prior art date
Application number
SK1140-95A
Other languages
English (en)
Slovak (sk)
Other versions
SK114095A3 (en
Inventor
Sidney Edward Callander
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of SK114095A3 publication Critical patent/SK114095A3/sk
Publication of SK281977B6 publication Critical patent/SK281977B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK1140-95A 1993-03-13 1994-03-08 Spôsob prípravy arylpiperidínových derivátov metanolu a spôsob výroby paroxetínu SK281977B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939305175A GB9305175D0 (en) 1993-03-13 1993-03-13 Novel process
PCT/EP1994/000694 WO1994021609A1 (en) 1993-03-13 1994-03-08 Process for preparing acryl-piperidine carbinols

Publications (2)

Publication Number Publication Date
SK114095A3 SK114095A3 (en) 1996-01-10
SK281977B6 true SK281977B6 (sk) 2001-09-11

Family

ID=10731995

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1140-95A SK281977B6 (sk) 1993-03-13 1994-03-08 Spôsob prípravy arylpiperidínových derivátov metanolu a spôsob výroby paroxetínu

Country Status (27)

Country Link
US (1) US5681962A (zh)
EP (1) EP0688317B1 (zh)
JP (1) JPH08507540A (zh)
KR (1) KR100296719B1 (zh)
CN (2) CN1041918C (zh)
AP (1) AP452A (zh)
AT (1) ATE207898T1 (zh)
AU (1) AU682497B2 (zh)
BR (1) BR9406035A (zh)
CA (1) CA2158175A1 (zh)
CZ (1) CZ235595A3 (zh)
DE (1) DE69428886T2 (zh)
DZ (1) DZ1758A1 (zh)
ES (1) ES2164700T3 (zh)
FI (1) FI954272A (zh)
GB (1) GB9305175D0 (zh)
HU (1) HUT72087A (zh)
IL (1) IL108946A (zh)
MA (1) MA23134A1 (zh)
NO (1) NO306717B1 (zh)
NZ (1) NZ262735A (zh)
PH (1) PH31434A (zh)
PL (1) PL176907B1 (zh)
RU (1) RU2141477C1 (zh)
SK (1) SK281977B6 (zh)
WO (1) WO1994021609A1 (zh)
ZA (1) ZA941716B (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444190B2 (en) 1995-08-03 2002-09-03 Fmc Corporation Reduction compositions and processes for making the same
ES2121685B1 (es) * 1996-04-10 1999-09-16 Vita Invest Sa Procedimiento para la obtencion de (+)-trans-4(4-fluoro-fenil)-3-hidroximetil-1-metilpiperidina.
JP3446468B2 (ja) 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
US5936090A (en) * 1996-05-24 1999-08-10 Fmc Corporation Processes for the reduction of imide ester functionality
EP1384720A1 (en) * 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Process for drying paroxetine hydrochloride
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process
GB9710004D0 (en) * 1997-05-17 1997-07-09 Knoll Ag Chemical process
BR9809687A (pt) * 1997-05-29 2000-07-11 Smithkline Beecham Corp Processo novo
ES2149687B1 (es) * 1998-04-08 2001-05-16 Medichem Sa Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas.
GB0003232D0 (en) * 2000-02-11 2000-04-05 Smithkline Beecham Plc Novel composition
US6720003B2 (en) * 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
HUP0401921A3 (en) * 2001-09-14 2008-03-28 Medichem Sa Intermediate compounds for the preparation of mirtazapine and the production methods thereof
JP5165951B2 (ja) * 2006-07-24 2013-03-21 住友化学株式会社 （±）−トランス−４−（４−フルオロフェニル）−３−ヒドロキシメチルピペリジンの製造方法
WO2008013248A1 (fr) * 2006-07-24 2008-01-31 Sumitomo Chemical Company, Limited Procédé de production de (±)-trans-4-(4- fluorophényl)-3-hydroxyméthylpipéridine
CN109020872B (zh) * 2018-06-26 2020-05-12 浙江邦富生物科技有限责任公司 一种盐酸帕罗西汀关键中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
JPS5470262A (en) * 1977-11-09 1979-06-05 Daiichi Kagaku Yakuhin Kk Manufacture of pyrrolidinee22methanol
FR2581242B1 (fr) * 1985-04-24 1988-08-26 Telemecanique Electrique Dispositif de commande electrique adaptable a un dispositif de commutation a deux etats
EP0223334B1 (en) * 1985-08-10 1991-07-10 Beecham Group Plc Process for the preparation of aryl-piperidine carbinols
DK716088D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Reduktion af piperidin-dion-derivater samt intermediat
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine

Also Published As

Publication number Publication date
IL108946A0 (en) 1994-06-24
HUT72087A (en) 1996-03-28
SK114095A3 (en) 1996-01-10
IL108946A (en) 1997-11-20
PL310469A1 (en) 1995-12-11
NO306717B1 (no) 1999-12-13
DZ1758A1 (fr) 2002-02-17
CN1041918C (zh) 1999-02-03
CN1055470C (zh) 2000-08-16
CN1203226A (zh) 1998-12-30
DE69428886T2 (de) 2002-04-25
KR100296719B1 (ko) 2001-10-24
DE69428886D1 (de) 2001-12-06
NZ262735A (en) 1996-10-28
BR9406035A (pt) 1996-01-02
EP0688317B1 (en) 2001-10-31
FI954272A0 (fi) 1995-09-12
PH31434A (en) 1998-11-03
AU6258794A (en) 1994-10-11
CA2158175A1 (en) 1994-09-29
GB9305175D0 (en) 1993-04-28
AU682497B2 (en) 1997-10-09
NO953598L (no) 1995-09-12
MA23134A1 (fr) 1994-10-01
US5681962A (en) 1997-10-28
JPH08507540A (ja) 1996-08-13
ES2164700T3 (es) 2002-03-01
RU2141477C1 (ru) 1999-11-20
AP9400624A0 (en) 1994-04-30
AP452A (en) 1996-01-19
ATE207898T1 (de) 2001-11-15
EP0688317A1 (en) 1995-12-27
ZA941716B (en) 1995-01-13
NO953598D0 (no) 1995-09-12
CN1119012A (zh) 1996-03-20
FI954272A (fi) 1995-09-12
CZ235595A3 (en) 1996-01-17
WO1994021609A1 (en) 1994-09-29
PL176907B1 (pl) 1999-08-31

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