SK278376B6 - Polycomponent disinfectant agent - Google Patents

Abstract

The preparation contains 15 up to 25 parts of weight of the mixture of monoethanol amine and triethanol amine with molar ration 0,1 up to 0,2 mole of monoethyl amine and 0,03 up to 0,1 mole of the triethanol amine, 6 up to 15 parts of weight of benzyldimethylaurylaminochloride. The above mentioned preparation is suitable to be applied in the medicine, pharmacy and in the food industry.

Description

Technical field

The invention relates to a poly-component disinfectant based on quaternized precursors and halogen-containing substances.

BACKGROUND OF THE INVENTION

In recent years, the development and production of disinfectants has been directed to mixture-based types based on various substances known to date with different mechanisms of action.

According to US Pat. 4,436,754 have wide application of 2-6 carbons, formaldehyde and diols of the formula RO / CH 2 CH 2 O / CH 2 CH 2 OH, where R = H, Cl 2 and n = 1-22. Glutaraldehyde in admixture with various substituted phenols, benzotriazole and other excipients / US Pat. 4,469,614 /. A mixture containing the reaction products of nonionic surfactants, glutaraldehyde and triethylene glycol (EP 0 251 743) is also used as a liquid sterilizing and disinfecting agent. The combination of glutaraldehyde 1a and other aldehydes / and quaternary ammonium compounds results in a synergistic biocidal effect with a wide range of applications. Quaternary ammonium compounds are represented by alkyl / C [4-50%, Cl ₂ -40%, and 10% Cis / dimethylbenzylammonium chloride / EP 0217339 /. DE pat. 3,528,208 utilizes the disinfecting efficacy of biquanidine and quanidine derivatives, quaternary ammonium compounds, and various cationic surfactants.

SUMMARY OF THE INVENTION

According to the invention, the principle of the poly-component disinfectant based on quaternized precursors and halogen-containing substances consists of 15 to 25 wt. parts by weight of a mixture of monoethanolamine and triethanolamine in a molar ratio of 0.1 to 0.2 moles of monoethanolamine and 0.03 to 0.1 moles of triethanolamine, 6 to 15 wt. parts by weight of sodium hypochlorite and 5 to 15 wt. parts of benzyldimethyllaurylammonium chloride. Up to 100 wt. The composition is supplemented with glycol, hydrochloric acid and water additives to enhance the antimicrobacterial activity and stability of the composition.

Addition of glutaraldehyde results in a synergistic biocidal effect that extends the spectrum of action and use of the formulation. As a result of the ongoing interaction mechanisms, syngenetic substances are produced which increase the resulting disinfection efficiency of the preparation.

The composition of the invention is compatible with anticorrosive additives, antifoams and other additives. Its preparation is technologically undemanding.

DETAILED DESCRIPTION OF THE INVENTION

Example 1

To 2.5 g of the monoethanolamine / triethanolamine mixture was added 20 g of hydrochloric acid (37%) with stirring. 1 g of monopropylene glycol and 0.6 g of sodium hypochlorite / 160 g of active chlorine are added at a temperature of 40 ° C. ¾ ¹ /. After homogenization and cooling to 25 ° C, 0.5 g of benzyldimethyllaurylammonium chloride, 0.4 g of glutaraldehyde (50%) are added and the mixture is made up to 75 g with water. The product is adjusted to pH 5 = 6.2 with hydrochloric acid.

Example 2

To 2 g of the mixture of monoethanolamine and triethanolamine was added 22 g of hydrochloric acid 10 (37%) with stirring. Furthermore, 0.6 g of monopropylene glycol and 1 g of sodium hypochlorite / 160 g of active chlorine are added at 30 ° C. ¾ ¹ /. After homogenization and cooling to 25 [deg.] C., 1.3 g of benzyldimethyllaurylammonium chloride, 0.5 g of glutaraldehyde are added and the mixture is filled with water (72.6 g) until 15. The product was adjusted to pH = 5.5 with hydrochloric acid (37%).

Example 3

To 1.7 g of the mixture of monoethanolamine and triethanolamine was added 23 g of hydrochloric acid (37%) with stirring. Further, 0.5 g of monopropylene glycol and 1.2 g of sodium hypochlorite / 160 g of active chlorine are added at 25 ° C. Γ ¹ /. After homogenization, 1.5 g of benzyldimethyllaurylammonium chloride, 0.6 g of glutaraldehyde are added to mixture 25 and the mixture is made up with water in an amount of

71,5 g. The product was adjusted to pH = 6.7 with hydrochloric acid (37%).

Example 4

24 g of hydrochloric acid (37%), 0.3 g of monopropylene glycol and 1.5 g of sodium hypochlorite (160 g of active chlorine) were added to 1.5 g of the mixture of monoethanolamine and triethanolamine while stirring at 30 ° C. Γ ¹ /. After homogenization and cooling to 25 ° C, 1 g of benzyldimethyllaurylammonium chloride, 0.7 g of glutaraldehyde is added to the mixture, and the mixture is made up to 71 g with water. The product was adjusted to pH = 7.5 with hydrochloric acid (37%).

For the evaluation of microbicidal activity, the compositions prepared according to the examples with a concentration of 0.5% by weight were used. The microbicidal efficacy was evaluated by the method of Knaj ílová J .: Standard Methods for Evaluation of the Disinfectant Effectiveness of Chemical Substances Annex AHEM no. 1.1985.

microorganisms Bstnvre • xpozižní ča = in min. ). Demyro K examples Eschsricr.ia coli 10 10 3 Pseudcmonas aerugínosa 10 1 1 Salmonella tyhinur 10 3 3 Proteus vulgaris 5 5 4 StaphyloooccLS aureus 5 5 4 Strepzococcus agalacticae 10 3 2

Industrial usability

The poly-component disinfectant of the invention has a broad antimicrobial spectrum of action. Its activity can be used for disinfection and chemosterilization in medicine, pharmacy and food industry.

Claims (1)

PATENT CLAIMS Polycomponent disinfectant based on quaternized precursors and halogen-containing substances, characterized in that it contains 15 to 25 wt. parts by weight of a mixture of monoethanolamine and triethanolamine in a molar ratio of 0.1 to 0.2 moles of monoethanolamine and 0.03 to 0.1 moles of triethanolamine, 6 to 15 wt. parts by weight of sodium hypochlorite and 5 to 15 wt. parts of benzyldimethyllaurylammonium chloride. 10