SK1002003A3 - Photodynamic treatment and UV-B irradiation of a thrombocyte suspension - Google Patents
Photodynamic treatment and UV-B irradiation of a thrombocyte suspension Download PDFInfo
- Publication number
- SK1002003A3 SK1002003A3 SK100-2003A SK1002003A SK1002003A3 SK 1002003 A3 SK1002003 A3 SK 1002003A3 SK 1002003 A SK1002003 A SK 1002003A SK 1002003 A3 SK1002003 A3 SK 1002003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- suspension
- radiation
- platelet
- wavelength range
- photoactive
- Prior art date
Links
- 239000000725 suspension Substances 0.000 title claims abstract description 34
- 210000001772 blood platelet Anatomy 0.000 title abstract description 33
- 238000002428 photodynamic therapy Methods 0.000 title abstract description 6
- 241000700605 Viruses Species 0.000 claims abstract description 43
- 238000000034 method Methods 0.000 claims abstract description 29
- 230000005855 radiation Effects 0.000 claims description 23
- 239000000126 substance Substances 0.000 claims description 17
- 238000012545 processing Methods 0.000 claims description 13
- 210000004369 blood Anatomy 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 10
- 239000000975 dye Substances 0.000 claims description 10
- 229950000688 phenothiazine Drugs 0.000 claims description 7
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 229960000907 methylthioninium chloride Drugs 0.000 claims description 6
- 239000003634 thrombocyte concentrate Substances 0.000 claims description 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 3
- 239000000906 photoactive agent Substances 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000002617 apheresis Methods 0.000 claims description 2
- 229950003937 tolonium Drugs 0.000 claims description 2
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 claims description 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims 1
- 125000001484 phenothiazinyl group Chemical group C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 claims 1
- 239000004546 suspension concentrate Substances 0.000 claims 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 abstract description 9
- 230000000415 inactivating effect Effects 0.000 abstract description 6
- KUUVQVSHGLHAKZ-UHFFFAOYSA-N thionine Chemical compound C=1C=CC=CSC=CC=1 KUUVQVSHGLHAKZ-UHFFFAOYSA-N 0.000 description 25
- 238000002474 experimental method Methods 0.000 description 23
- 230000002779 inactivation Effects 0.000 description 15
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- XQAXGZLFSSPBMK-UHFFFAOYSA-M [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride;trihydrate Chemical compound O.O.O.[Cl-].C1=CC(=[N+](C)C)C=C2SC3=CC(N(C)C)=CC=C3N=C21 XQAXGZLFSSPBMK-UHFFFAOYSA-M 0.000 description 5
- 238000005286 illumination Methods 0.000 description 5
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- 230000003612 virological effect Effects 0.000 description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
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- PPBOKXIGFIBOGK-BDTUAEFFSA-N bvdv Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)C1=CN=CN1 PPBOKXIGFIBOGK-BDTUAEFFSA-N 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- LXWYCLOUQZZDBD-LIYNQYRNSA-N csfv Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(O)=O)C1=CC=C(O)C=C1 LXWYCLOUQZZDBD-LIYNQYRNSA-N 0.000 description 3
- 230000009849 deactivation Effects 0.000 description 3
- 238000010348 incorporation Methods 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 3
- MWDNZMWVENFVHT-UHFFFAOYSA-L (2-decoxy-2-oxoethyl)-[2-[2-[(2-decoxy-2-oxoethyl)-dimethylazaniumyl]ethylsulfanyl]ethyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCOC(=O)C[N+](C)(C)CCSCC[N+](C)(C)CC(=O)OCCCCCCCCCC MWDNZMWVENFVHT-UHFFFAOYSA-L 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 208000031886 HIV Infections Diseases 0.000 description 2
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000012980 RPMI-1640 medium Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 208000002672 hepatitis B Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000005087 mononuclear cell Anatomy 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000003253 viricidal effect Effects 0.000 description 2
- DDGMDTGNGDOUPX-UHFFFAOYSA-N 7-methyliminophenothiazin-3-amine;hydrochloride Chemical compound [Cl-].C1=C(N)C=C2SC3=CC(=[NH+]C)C=CC3=NC2=C1 DDGMDTGNGDOUPX-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000710777 Classical swine fever virus Species 0.000 description 1
- 102100022641 Coagulation factor IX Human genes 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 108010076282 Factor IX Proteins 0.000 description 1
- 108010054218 Factor VIII Proteins 0.000 description 1
- 102000001690 Factor VIII Human genes 0.000 description 1
- 241000711549 Hepacivirus C Species 0.000 description 1
- 208000005176 Hepatitis C Diseases 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 1
- 241000710961 Semliki Forest virus Species 0.000 description 1
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 229940050528 albumin Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- PGWTYMLATMNCCZ-UHFFFAOYSA-M azure A Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 PGWTYMLATMNCCZ-UHFFFAOYSA-M 0.000 description 1
- KFZNPGQYVZZSNV-UHFFFAOYSA-M azure B Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(NC)=CC=C3N=C21 KFZNPGQYVZZSNV-UHFFFAOYSA-M 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 229950004398 broxuridine Drugs 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000001085 differential centrifugation Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000002900 effect on cell Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 229960004222 factor ix Drugs 0.000 description 1
- 229960000301 factor viii Drugs 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 210000004779 membrane envelope Anatomy 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 244000309711 non-enveloped viruses Species 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 150000002927 oxygen compounds Chemical class 0.000 description 1
- -1 oxygen. in fact Chemical class 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 108091069025 single-strand RNA Proteins 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003501 vero cell Anatomy 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0215—Disinfecting agents, e.g. antimicrobials for preserving living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0278—Physical preservation processes
- A01N1/0294—Electromagnetic, i.e. using electromagnetic radiation or electromagnetic fields
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Electromagnetism (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10031851A DE10031851B4 (de) | 2000-07-04 | 2000-07-04 | Photodynamische Behandlung und UV-B-Bestrahlung einer Thrombozyten-Suspension |
| PCT/DE2001/002410 WO2002002152A1 (de) | 2000-07-04 | 2001-07-04 | Photodynamische behandlung und uv-b- bestrahlung einer thrombozyten-suspension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK1002003A3 true SK1002003A3 (en) | 2003-06-03 |
Family
ID=7647321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK100-2003A SK1002003A3 (en) | 2000-07-04 | 2001-07-04 | Photodynamic treatment and UV-B irradiation of a thrombocyte suspension |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20040072139A1 (cs) |
| EP (1) | EP1307241B1 (cs) |
| CN (1) | CN1264577C (cs) |
| AT (1) | ATE296118T1 (cs) |
| AU (2) | AU2001279556B2 (cs) |
| BR (1) | BR0111958A (cs) |
| CA (1) | CA2415063C (cs) |
| CZ (1) | CZ300018B6 (cs) |
| DE (2) | DE10031851B4 (cs) |
| DK (1) | DK1307241T3 (cs) |
| EA (1) | EA004246B1 (cs) |
| ES (1) | ES2241850T3 (cs) |
| HU (1) | HU226418B1 (cs) |
| MX (1) | MXPA02012663A (cs) |
| PL (1) | PL363076A1 (cs) |
| PT (1) | PT1307241E (cs) |
| SK (1) | SK1002003A3 (cs) |
| WO (1) | WO2002002152A1 (cs) |
| ZA (1) | ZA200300257B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6843961B2 (en) * | 2000-06-15 | 2005-01-18 | Gambro, Inc. | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
| US9044523B2 (en) | 2000-06-15 | 2015-06-02 | Terumo Bct, Inc. | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
| DE60327166D1 (de) * | 2002-02-01 | 2009-05-28 | Caridianbct Biotechnologies Ll | Reduzierung von verunreinigungen in blut und blutprodukten durch verwendung von photoaktiven substanzen und bestrahlung mit licht eines engen wellelängenbereichs |
| EP1496114A1 (de) * | 2003-07-07 | 2005-01-12 | Margraf, Stefan, Dr.med. | Verfahren zur Inaktivierung von Mikroorganismen |
| DE102010017687A1 (de) * | 2010-07-01 | 2012-01-05 | Claas Selbstfahrende Erntemaschinen Gmbh | Verfahren zur Einstellung zumindest eines Arbeitsorganes einer selbstfahrenden Erntemaschine |
| CN109966574A (zh) * | 2016-02-02 | 2019-07-05 | 汪相伯 | 一种基于核黄素光化学法的血液制品处理系统 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6348309B1 (en) * | 1989-09-13 | 2002-02-19 | Blutspendedienst Der Landesverbaende Des Deutschen Roten Kreuzes Niedersachsen, Oldenburg Und Bremen G.G.M.B.H. | Process for inactivating viruses in blood and blood products |
| DE3930510A1 (de) * | 1989-09-13 | 1991-03-21 | Blutspendedienst Dt Rote Kreuz | Verfahren zur inaktivierung von viren in blut und blutprodukten |
| US5545516A (en) * | 1990-05-01 | 1996-08-13 | The American National Red Cross | Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light |
| US6077659A (en) * | 1990-05-15 | 2000-06-20 | New York Blood Center, Inc. | Vitamin E and derivatives thereof prevent potassium ion leakage and other types of damage in red cells that are virus sterilized by phthalocyanines and light |
| WO1996008965A1 (en) * | 1994-09-22 | 1996-03-28 | Baxter International, Inc. | Photodynamic inactivation of viral and bacterial blood contaminants with halogenated coumarin and furocoumarin sensitizers |
| DE69637181T2 (de) * | 1995-07-14 | 2008-04-17 | Caf - Dcf Cvba - Scrl | Vorrichtung zur inaktivierung von viralen verunreinigungen in blutprodukten |
| US20010053547A1 (en) * | 1995-12-04 | 2001-12-20 | Slichter Sherrill J. | Method for preparing a platelet composition |
| JP2001514617A (ja) * | 1997-01-21 | 2001-09-11 | ジ・アメリカン・ナショナル・レッド・クロス | 両親媒性フェノチアジン−５−イウム染料と光による全血および血液成分の細胞内および細胞外汚染除去 |
| US6258577B1 (en) * | 1998-07-21 | 2001-07-10 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers |
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2000
- 2000-07-04 DE DE10031851A patent/DE10031851B4/de not_active Expired - Fee Related
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2001
- 2001-07-04 AU AU2001279556A patent/AU2001279556B2/en not_active Ceased
- 2001-07-04 PL PL01363076A patent/PL363076A1/xx not_active IP Right Cessation
- 2001-07-04 WO PCT/DE2001/002410 patent/WO2002002152A1/de active IP Right Grant
- 2001-07-04 EP EP01957701A patent/EP1307241B1/de not_active Expired - Lifetime
- 2001-07-04 PT PT01957701T patent/PT1307241E/pt unknown
- 2001-07-04 DE DE50106329T patent/DE50106329D1/de not_active Expired - Fee Related
- 2001-07-04 DK DK01957701T patent/DK1307241T3/da active
- 2001-07-04 AT AT01957701T patent/ATE296118T1/de not_active IP Right Cessation
- 2001-07-04 EA EA200300111A patent/EA004246B1/ru not_active IP Right Cessation
- 2001-07-04 CA CA002415063A patent/CA2415063C/en not_active Expired - Fee Related
- 2001-07-04 US US10/332,108 patent/US20040072139A1/en not_active Abandoned
- 2001-07-04 SK SK100-2003A patent/SK1002003A3/sk unknown
- 2001-07-04 HU HU0301717A patent/HU226418B1/hu not_active IP Right Cessation
- 2001-07-04 BR BR0111958-3A patent/BR0111958A/pt not_active IP Right Cessation
- 2001-07-04 AU AU7955601A patent/AU7955601A/xx not_active Withdrawn
- 2001-07-04 ES ES01957701T patent/ES2241850T3/es not_active Expired - Lifetime
- 2001-07-04 CN CNB018122973A patent/CN1264577C/zh not_active Expired - Fee Related
- 2001-07-04 MX MXPA02012663A patent/MXPA02012663A/es active IP Right Grant
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- 2003-01-03 CZ CZ20030015A patent/CZ300018B6/cs not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| DE10031851A1 (de) | 2002-01-24 |
| CN1264577C (zh) | 2006-07-19 |
| HU226418B1 (en) | 2008-12-29 |
| HUP0301717A2 (hu) | 2003-08-28 |
| EP1307241B1 (de) | 2005-05-25 |
| WO2002002152A1 (de) | 2002-01-10 |
| CZ200315A3 (cs) | 2003-05-14 |
| HUP0301717A3 (en) | 2005-12-28 |
| DK1307241T3 (da) | 2005-08-08 |
| EA004246B1 (ru) | 2004-02-26 |
| CZ300018B6 (cs) | 2009-01-14 |
| DE50106329D1 (de) | 2005-06-30 |
| EA200300111A1 (ru) | 2003-06-26 |
| AU7955601A (en) | 2002-01-14 |
| BR0111958A (pt) | 2003-07-01 |
| US20040072139A1 (en) | 2004-04-15 |
| PL363076A1 (en) | 2004-11-15 |
| ZA200300257B (en) | 2003-11-04 |
| MXPA02012663A (es) | 2004-07-30 |
| AU2001279556B2 (en) | 2006-07-06 |
| CA2415063A1 (en) | 2002-12-30 |
| ATE296118T1 (de) | 2005-06-15 |
| DE10031851B4 (de) | 2005-10-13 |
| CN1440297A (zh) | 2003-09-03 |
| ES2241850T3 (es) | 2005-11-01 |
| PT1307241E (pt) | 2005-08-31 |
| CA2415063C (en) | 2006-10-03 |
| EP1307241A1 (de) | 2003-05-07 |
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