SI8811284A - Device for injecting syringes - Google Patents

Abstract

The invention relates to an injection device injection, to prepare an emulsion or suspension solution sensitive drug in aqueous solution and for injection of the same. In the apparatus of the invention, uses a two-chamber cylindrical ampoule (1) which otherwise known for mixing aqueous medium (11) and medicaments (10), wherein the aqueous medium (11) is forced, that it flows peacefully from the bottom up through the medicine (10), to prevent shaking and stirring of air. Recommended is that mixing is carried out at a pressure higher than atmospheric. A device according to the invention for injection injections to prepare the injection solution, followed by injection of this solution has a front element (13) comprising a two-chamber cylinder (1), v wherein the dry drug (10) is separated from the liquid phase (11) and the last element (14) comprising the mechanism (22) for dispensing and dispensing. When these elements are screwed into each other, the liquid phase (11) is mixed with the dry phase (10) and dissolve it and the final solution is dissolved it can then be injected using the mechanism (22) for dosing and dispensing via a needle (17) arranged at the front end of the front member (13). It will be an invention for drugs sensitive to mechanical impact, allowed mixing dry matter and aqueous medium as well further manipulation of the prepared agent may performs so gently that the loss of quality of the medicines results mechanical effects minimized.

Description

INJECTION INJECTION DEVICE

Files: 3574 .-- P-12M / 38

KABIVITRUM AB Stockholm, Sweden

FIELD OF THE INVENTION

The invention falls within the field of apparatus for injecting agents into the body, and particularly relates to syringes for injection. Designation According to the International Patent Classification:

A 61 M 5/24.

Technical problem

The invention solves the problem of how to construct an injection device which will allow carrying ampoules with two-component medicaments and mixing them. usually sensitive components when injected.

The state of the art

The present invention relates to injection devices, especially for use in outpatient treatment. More specifically, the invention refers to a device by which a solution for injecting a substance, a substance, is prepared immediately before injection, or several doses are prepared before the first injection.

Injection injection devices in outpatient treatment where the medicament is in solution, a known force from before and have been widely used, for example, in the treatment of insulin malignancy. Such devices are usually designed so that the patient can easily assemble one cylindrical ampoule for one or more doses, one injection needle and dosing device in one convenient holder, after which he can easily give himself the injection required. Ampoules and needles can easily be replaced with new ones. In the assembled state are such devices. for injection often shaped like a fountain pen and the patient can easily carry them with them.

In addition, the so-called. two-chamber or container for mixing, or cylindrical ampoules for the preparation of a solution of sensitive substances just before injection. Such vessels are divided into two chambers separated by a single moving wall or plunger. The sensitive drug is located in the anterior chamber in a dry, usually freeze-dried state, and the anterior end of the anterior chamber is sealed with a single wall that can be punctured by the Injection Needle. The fluid to dissolve the sensitive substance prior to injection is located in the posterior chamber. The two chambers are separated by a front movable wall, .and the rear end of the rear chamber is sealed by the rear movable wall. In addition, a connection duct was constructed in the vessel wall that could connect the front and rear chambers.

In storage position before injection / no connection between front and rear chamber. The inlet as well as the outlet of the connecting duct ends in the front chamber.

When the container is to be prepared for injection, the rear displacement wall in the rear chamber moves forward, and due to fluid incompatibility, the front displacement wall will also move forward until it reaches a position opposite the connecting channel in the container wall. When, after that, the rear moving wall continues to move forward, the fluid will be pushed through the overflow duct into the anterior chamber where it will come into contact with the drug and dissolve it. On injection, these two walls will act together as one piston and squeeze the prepared injection solution through a single needle inserted through the front end wall into the anterior chamber.

In some cases, the medication may be so sensitive that special measures must be taken to protect the substance from mechanical influences at the time of dissolution as well as further handling of the solution, your own, for example, freezing of dried growth hormones where even simple shaking of the substance and mpj liquids lead to unacceptable biochemical changes.

Therefore, the preparation of the injection container must be carried out with the utmost care.

It would be highly desirable to have an injectable injection device that can be easily worn and used as a known simple cylindrical ampoule, in which the medicament is in liquid state as a solution, suspension or emulsion, and which can be used simultaneously the advantages of mixing containers for the injection of sensitive substances. This object was achieved by the present invention.

Description of solution to a technical problem

According to the invention, a device for preparing a solution for the injection of one or more substances sensitive to decaying properties, and for injecting that solution, is provided.

The object of the invention is to provide a solution, emulsion or suspension in water of one or more sensitive medicaments for one or more successive injections, using a known multi-chamber cylindrical ampoule, comprising an anterior space containing a sensitive medicament and sealed at its front the end with a single membrane that can be punctured by the injection needle, which is bounded on the back by a front moving wall, then a back space containing a single aqueous phase and bounded on the front end by a front moving wall, and bounded on the back by a rear moving wall , as well as one connecting channel made in the wall of the ampoule between the posterior and anterior space, with the rear displacement wall moving forward and moving the water phase and the front displacement wall until they reach the overflow channel so that the liquid phase on further movement into the front of the rear moveable wall flows past the front moveable wall into the front it dissolves, emulsifies or suspends the drug. What is characteristic of the device is that the aqueous phase flows quietly from below through the medicament, avoiding shaking and stirring of air.

The device according to the invention is characterized by the fact that it comprises

a) a container for the components of an injection solution, in which these components are kept separate but may be limited by the action outside to mix and dissolve, which is made in the form of a tube sealed at its front end by a single membrane breakable, with solid components of the injection solution held in one space between the breakable wall and one front moving wall, and liquid components of the injection solution held in the space between the front moving wall and one rear moving wall, while a conduit is arranged in the tubular wall so that when the sliding moving wall moves forward along with the fluid and the front moving wall, the fluid can flow past the front moving wall and mix with the solid components and form a solution;

b) A holder in which a container can be secured so that the components of the injection solution are brought into .dadir and mixed, and which is made of two tubular'elements that can be threaded and enclosed by the container so that when these elements are threaded. the front end of the container is exposed with a permeable membrane exposed at the front end of the holder to be punctured by the injection needle, with the rear moving wall at the rear end of the container moving forward together with the fluid and the front moving wall so that the fluid is forced. to flow through the junction channel into the space of the solid components, in order to mix the same with the former solution;

c) an injection needle holder adapted to be mounted on the front end of the container holder so that the needle can be connected to the interior of the container through a permeable membrane, and

d) a dosage device coupled to a container holder, the action of which the rear movable wall in the container moves in forward discharging at a predetermined dose of the injection solution, the dosing device being brought to the initial dosing position when the parts of the container holder are threaded.

• The invention also encompasses a more universally usable device for preparing injection solutions from components placed in the container according to a).

The invention will now be described in more detail with reference to the accompanying drawings.

One embodiment of the device according to the invention is shown in the drawings.

Figure 1 shows a two-chamber cylindrical ampoule having two chambers for administration in an injection device.

Figure 2 represents the general layout. injection devices according to the invention.

Figure 3 shows the same device in disassembled state. Figure 4 is a cross-section of the device in disassembled state. Figure 5 shows the injection device. Figure 6 shows, schematically, the layout of the first embodiment of the device according to the invention in the position before preparing the injection solution.

Figure 7 shows, schematically, the layout of the device with

D. 6 after preparation of the injection solution.

Figure 8 is, schematically, a layout of the apparatus shown in Figures 6 and 7 when injecting the prepared solution into a needle for injection.

Figure 9 shows, schematically, a layout of another embodiment of the invention in position before preparing the injection solution. '

Figure 10 shows, schematically, the layout of the apparatus of Figure 9 after preparation of the injection solution.

FIG. 11 shows, schematically, the layout of the apparatus of FIGS. 9 and 10 with the tube, cannula fitted, prepared for injection.

A cross-section of a two-chamber cylindrical ampoule used in the injection device of the invention is shown in Figure 1. The ampoule consists of a tube 1, preferably glass or plastic, which is made with a flanged neck 2 at its front end. The front end is sealed with a membrane 3 made of rubber or a suitable plastic material, which is secured by a metal capsule 4. The capsule 4 has an opening 5 in its middle region, so that the membrane 3 'is uncovered. The edge portion of the capsule is wound around the flange 2 so that the membrane 3 is attached to the front opening of the ampoule.

The ampoule is divided into the front space 6 and the rear space 7 by means of a movable partition 8. The rear end of the ampoule is sealed by a movable wall 9 which, at friction, also seals the rear chamber 7. The two movable walls 8 and 9 can be moved forward in the ampoule providing a seal against the wall of the ampoule, wherein the ampoule has a circularly cylindrical shape for this purpose.

The anterior chamber 6 of the ampoule contains one or more medicaments 10 in the dry state, preferably freeze-dried. Sensitive substances also have relatively good stability in this form. The rear chamber 7 contains a liquid phase 11 which is intended to dissolve the dry substance for injection. This liquid phase usually consists of water or saline, and such additional substances, which are common in pharmacological practice and may be added to the solution.

In the wall of the ampoule there is a conduit, in the form of a recess, which is mounted and extends in the longitudinal direction of the ampoule. The overflow duct 12 is positioned so that it is completely in the anterior space 6 before the ampoule is prepared for injection and its length is such that it allows flow past the movable wall 8.

Figure 2 shows the injection device according to the invention in a folded state so that the patient can carry it easily with him. The apparatus is usually shaped as a fountain pen and consists of a qd front housing 13 comprising a two-chamber cylindrical ampoule according to Figure 1 for the injectable agent, a rear housing 14 comprising one mechanism for dispensing and administering the agent, and one protective cap 15 over injection needles. The mechanism for dosing and administration of the agent is made in one of the known ways and will not be described in more detail herein. It usually works in such a way that the control knob 16 on the rear end of the device rotates so that one index is placed against a single scale to determine one suitable dose.

When administering the medication, the control knob is pressed allowing one particular dose to be discharged through the needle. Many different embodiments of such a single drug dosing and administration mechanism are known from the prior art and can be used in the injection devices of the present invention.

Figure 3 shows the disassembled injection device. The protective cap 15 is also removed here so that the front part 17 of the needle with its holder 18 is shown. The needle can be screwed to the front end of the front housing 13 with the aid .. ~ of the holder. And can be replaced though. Thereafter, the protective cap 1.5 must be kept in place and maintained at all times to maintain sterility.

and should not be removed until just before injection. Na *

the front housing 13 has an opening 19 through which the user can check to see if an ampoule is inserted and how much solution is left for injection.

The rear housing 14 can be screwed into the front housing 13 by means of anvoy 20. At the same time as the twist, a double-chamber cylindrical injection ampoule is prepared, which will be described in more detail below.

Figure 4 is a partial view, in longitudinal section, of the disassembled injection device of Figure 3.

It is apparent here that a two-chamber cylindrical capsule of the type shown in Figure 1 is inserted into the front housing 13 and is so forward that its membrane 3 is exposed to be punctured by the needle. The rear housing 14 has a dosing and discharging mechanism schematically shown and marked with 22. This mechanism has a forward working rod 23. By activating the same, a two-component cylindrical ampoule is first prepared for injection, and then doses of the injection agent are determined thereafter. can distribute the help of the control knob 16.

The rear housing 14 may be screwed into the front housing 13 by means of an outer thread 20 which is connected to the inner thread 24.

Figure 5 shows the device assembled and ready for injection. Here the rear sliding wall 9 is so displaced. that it came in contact with the front movable wall 8. This one was displaced so much that it came opposite the joint duct 12 and the liquid phase flowed past the front movable wall 8 and mixed with the dry medicament. The protruding rear end 21 of the needle also penetrated through the membrane 3. The two movable walls 8 and 9 were moved in contact with each other so that all the air from the front space 6 was expelled through the needle. The unit is ready for injection.

The operation of the unit after it has been prepared for injection is as follows:

In the rear housing 14, the working bar 23 and the control knob 16 of the dosing mechanism 22 and the positioning arrangement are first set to the starting or zero positions. This is done in a manner determined by the construction of a mechanism otherwise known. The rear housing 14 is then screwed into the front housing 13 until the working bar 23 rests properly against the rear movable wall 9 in the two-chamber cylindrical ampoule. ,

If the rear housing is still screwed in, the operating lever will push the rear displacement wall 9 forward in the cylindrical ampoule, and since fluid 11 in the rear space 7 is substantially. non-destructive, the front movable wall 8 will also be pushed forward. In the front chamber 6, some overpressure occurs because the air cannot escape.

When the front movable wall 8 is pushed sufficiently to hopefully overflow channel 12, a fluid connection is made between the front and rear chambers. By moving further forward of the rear fisherman 9, the fluid will be pushed into the front chamber 6 through overflow channel 1.2. At this stage, or stage, the front sliding wall 8 will not move.

When all the fluid is pushed into the anterior space, the rear displacement wall 9 comes into mechanical contact with the anterior displacement wall 8. The fluid will dissolve the dry medicament 10 and form a ready-to-use injection solution. The holder 18 with the needle attached 17 then inserts into the front housing 13, wherein the diaphragm 3 of the cylindrical ampoule is pierced by the rear tip 21 of the needle and the overpressure in the front chamber is discharged.

By further pushing the control knob 16, the operating rod 23 is activated by moving the walls 8 and 9 further forward and the air in the cylindrical ampoule will flow through the needle 17. The device is now ready for injection as shown in Figure 5.

When preparing the appliance, it is necessary to hold it vertically, with the needle pointing upwards, and the thread connection must not be made too quickly. In this way, the liquid will calmly climb through the substance and dissolve it, without strong mixing. Such strong mixing is unsuitable for many sensitive substances as it can adversely affect the substance.

This is one preferred embodiment in which the two-chamber cylindrical ampoule 1 is inserted into the front housing 13 and the solid maedicament is dissolved before the needle 21 pierces the membrane of the 3 ampoules. As overpressure occurs, the tendency for foaming and blistering is reduced when the fluid and solid material are mixed, which is less harmful to the drug. However, for. medicaments that are not so sensitive, the needle holder 18 can be threaded to the front of the 13 housing before the cylindrical ampoule is inserted and both cases are screwed together. The last tip of the needle will then. pierce membrane 3 before solids and liquids are mixed £>

without overpressure in the mixing chamber.

When the device is to be used to administer the drug by injection, the protective needle cap is first removed. The desired dose is then determined using the control knob 16 and the dose is released through the needle by pressing the control knob. Subsequently, sleet doses can be given as long as there is a solution for injection in a cylindrical ampoule. After each discharge, the needle is usually replaced with a new lucky needle. This can be easily done by unscrewing the needle retainer 18 from the front end of the injection device and then inserting the new needle retainer. At the same time, the last pointed end of the needle will pierce the diaphragm and connect the fluid to the inside of the ampoule.

The embodiment shown in Fig. 6 comprises one holder in which container 1 can be fitted. The holder consists of two tubular elements that can be threaded, namely the front tubular element 24 and the rear tubular element 28. The front tubular element 24 has a narrowing 25 at its front end into which a flange 2 of the ampoule head can be fitted 1. At its rear end, the front tubular element is provided with an inner thread 28 into which an external thread 27 can be screwed onto the rear tubular element 28. At its rear end, the rear tubular element 28 has a closed rear wall 29 for which a fixed piston in the rear tubular element 28 is attached from the inside, wherein the pistons have a diameter smaller than the inner diameter of the ampoule and extend towards the ampoule 1.

When preparing the injection solution. the rear tubular member 28 is screwed into the front tubular member 24, wherein it is advisable to hold the holder vertically so that the tapered throat 25 faces upwards. When the rear tubular element 28 is screwed into the front tubular element 24, the fixed piston 30 moves the rear tubular wall upwards and compresses the fluid 11 in the rear space 7. The fluid will exert pressure on the front wall 8 so that it moves upwards to the exact position opposite to the joint. channel 12, in which position the fluid 11 can flow smoothly through the connecting channel 12 into the anterior space 6 and mix with the medicament 10. While the two tubular elements 24 and 28 are screwed into each other, a very quiet fluid flow into the anterior space is performed 6, which is closed by a membrane at the anterior end of the ampoule. When the fluid enters the anterior space 8, a pressure higher than atmospheric pressure occurs therein, so that a small pocket 31 of compressed gas is formed in the upper end of the ampoule, shown in Figure 7, which shows the holder in the position when the tubular elements 24 and 28 completely screwed into each other, and all the liquid overflowed into the front space 6. Thanks to the quiet contact of the liquid in the upper space 6 with the formed pressure higher than atmospheric, the foam formation during mixing was prevented. Of course, the device can then be rotated several times, if necessary, to completely dissolve the drug in the liquid.

When the injection solution prepared in this manner is discharged, the apparatus rotates to the position shown in Figure 8, with the front end of ampoule 1 facing down so that gas in the front space 6 of ampoule 1 is collected at the upper end and not near the diaphragm . The injection solution can be taken with the aid of a tube, the cannula 32 which is introduced through the membrane ϊ transferred to the usual injection syringe 33 in a known manner. , so that at least initially the solution will flow under its own pressure through the tube, the cannula 32 into the syringe 33 for subcutaneous injection.

As stated earlier, another embodiment of the device according to the invention is shown in Figures 9 to 11, having the same components as the device shown in Figures 6 and 7. The main difference is in the towers, which is the device according to Figures 9 to 11 designed to be directly connected to one cannula, tube, at a tapered throat 25 of the front annular element 24. In addition, the rear wall 29 of the rear tubular element 28 is not closed but has a central opening 3.4 through which the working rod 35 passes. integrally connected to piston 30 in the rear tubular element, wherein the piston not connected to rear tubular element 28 is already limited in longitudinal direction by means of the operating lever 35. As with the device shown in Figures 6 to 8, the outer diameter of piston 30 is less than of the inner diameter of the ampoule 1, but at the same time 'larger than the diameter of the opening 34 in the rear wall 29, so that the piston 30 cannot be pulled out of the rear tubular member 28. Two tubular ele mints 24 and 28 are aligned with each other from the position shown in Figure 9, in which the components of the injection solution are completely separated from each other, in the same manner as described in connection with the first embodiment of embodiment 6 to 8, while 'complete mixing is not achieved and the device is in the position shown in Figure 10. In this and

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the cover 36 is placed on the tapered throat 25 of the front tubular element 24. In addition, the cannula, tube 32 is attached to the cap 35, piercing the membrane of the ampoule 1 when the cap is placed on the tapered throat 25. This is done vertically when 'throat 25 is facing up. The device is ready to be used as a syringe for injection, which is done by pushing it on the working bar 35 so that the plunger 30 moves the two jivals of the wall 8 and 9 forward into the front space 6 in the ampoule, so that the ampoule removes the gas, then the injection solution is discharged through the conduit 32 in a known manner. '·

A very practical and simple instrument for preparing injection solutions is provided by the apparatus of the invention. As stated above, the unit provides very quiet and safe mixing of the components of the injection solution.

If mixing is done too quickly, the result is the formation of particles and opalescence. Both are expressions of clumping. It is recommended that the device be made of plastic, in which case the price of the device will be very small, so the device can be used once. The thread pitch on the elements is not critical, but it is recommended that it be in the range of 0.5 to 10 mm.

It is most advantageous for the device according to the invention to be used for subcutaneous injections, but other procedures for 'administering injections according to current medical practice are possible,' such as, for example, intramuscular injection.

When the cylindrical ampoule is empty, the injection device is unscrewed and the empty capsule is removed. The dosing mechanism is reset to zero and the device can then be re-prepared for injection, as described above. It is easy for the user to carry with them a assembled and prepared device to use at convenient times.

It may be necessary to protect sensitive drugs, especially polypeptide types, against mechanical action when in dissolved form. Particularly critical moments are the conversion of the dried powder into a solution, on the one hand, and on the other, the further handling of the prepared solution. The latter will be especially important when it comes to preparations for multiple doses that must be repeatedly administered.

The use of conventional packs and syringes does not contribute to the protection against mechanical stresses, however, which the present invention provides. The establishment of the dry powder solution by the invention is carried out in a very careful manner by design, so that the medicament is spared. As the solution adheres to a certain overpressure, foaming and bubble formation are prevented at this stage. Further handling of the prepared solution will also be very gentle according to the invention. Practically all the air that was in contact with the solution was removed when the injection device was preparing to give the first injection from a newly installed two-chamber cylindrical ampoule. This avoids the interphase, which, when handling the solution container, has a negative effect on the sensitized drug, and can then be handled without the special sensitivity of the solution.

Therefore, it is possible to prepare one solution according to the present invention which can be used for a long or shorter time in a gentle way, and to transport the prepared solution without reducing the quality of the sensitive drug due to mechanical stress. Therefore, the invention makes it possible that sensitive medications may also be available for complex outpatient treatment.

The medicaments that may be used in the apparatus shown may consist of any substance or mixture of substances used in the two-chamber ampoules known so far, or suitable for this purpose. However, sensitive substances which cannot be stored for a long time in solution and which tend to change when dissolved are particularly suitable. Examples of such substances are · various polypeptide! such as hormones and interferon. It has been found that the invention is particularly suitable for the preparation and injection of growth hormone solutions. They are very sensitive and easily modified when a solution is prepared from them. By using in the present case the 'invention disclosed, such influence is greatly reduced'. This is extremely unexpected and could not be foreseen by experts.

Dry medicines are usually found in the freezing dried or lyophilized state of the preparation of the injection solution. The liquid used for the solutions usually consists of water to which osmotic pressure adjusting agents, preservatives, etc. are often added, and in accordance with current pharmacological practice. It is also possible that the liquid phase itself may contain dissolved substances which may have some pharmacological action which can then be used together with the action of the agent which is subsequently dissolved in the liquid.

Another embodiment is wherein the liquid may consist of an injectable grease emulsion, such as that described in the Maier patent documents no. 4 .073 943 and 4 168 308. In this case, the dry injection substance is present. a water-soluble or hydrophilic agent that dissolves or disperses in the aqueous phase of an emulsion in a mixture.

The injection device is made of a suitable element such as metal, for example stainless steel or aluminum alloy or a suitable plastic material. The choice of metals is completely within the scope of work of the specialist.

In addition, it should be noted that the process and apparatus of the invention are shown in the drawings and detailed descriptions-7 are not merely examples, and that other embodiments are also possible within the scope of the claims. '

Claims (4)

An injection injection device for preparing a solution of substances susceptible to degradation and for injecting this solution, labeled with tea, to contain a) a reservoir (1) for the components of the injection solution, in which the components are held separately or can be externally combined to mix and dissolve, and which is formed as a tube (1) sealed at its front end with by means of a permeable membrane (3), in which solid components (10) of the injection solution are located in the space (6) between the permeable membrane and the front movable wall (8), while in the space (7) ) between the front sliding wall (8) and the rear sliding wall (9) there is a liquid component (11) of the injection solution and a connecting channel (12) is arranged in the tubular wall so that when the rear sliding wall (9) ) moves forward, together with the fluid (11) and the front movable wall (8), the fluid flows along the front movable wall (8) and is mixed with the solid components (10) until a solution is obtained; b) a holder in which the reservoir (1) can be fixed so that the components of the injection solution can be brought into contact and mixed, and which is made of two tubular elements (13, 15) that can be screwed together and surrounded the reservoir (1) such that, when the elements are joined by a thread, the front end of the reservoir with the permeable membrane (2) is exposed at the front end of the holder to be punctured by the injection needle (17, 21) and at the rear end, the rear movable wall (9) is moved forward together with the fluid (11) and the front movable wall (8) by forcing the fluid (11) to flow through the connecting channel (12) to the space (6) with solid components to mix with them and form a solution; ε) injection needle holder (18) (17), ready to be mounted on the front end of the reservoir holder (13) so that the needle (21) can be connected to the reservoir space (6) through a diaphragm (3) predreti; and -σd) a dosing device (27) connected to a reservoir holder (14), by means of which the movable wall (9) in the reservoir reservoir is moved in a controlled manner, thereby delivering certain doses of the injection solution, wherein the dosing device (22) is positioned in a starting position for dosing when it is fastened to the retainers (13, 14) by the screws. 2. Injection device for the preparation of a solution for injection of drugs from susceptible substances, characterized by tes> that the components of the solution for injection are stored in a reservoir (1) in which the components are separated but can be collected in order to mixed and dissolved by external action, which is made as a tube sealed at its front end (2) by means of a permeable membrane containing a space (6) between the permeable wall and the anterior a movable wall (8) in which the solid components (10) of the injection solution are located, while in the space (7) the movable wall (8) and the rear movable wall of the liquid component of the injection solution a tubular wall (12) is installed so that when the rear movable wall (9) moves forward together with the fluid (11) and the front movable wall (8), the fluid (11) can flow along the front movable wall (8) and be mixed with solid components (10 ) until a solution is obtained and n that the device comprises a holder (24, 28) in which the reservoir can be fixed so that the components (10, 11) of the injection solution can be contacted and mixed and which is made of two tubular elements (24, 28) which can be screwed into each other, with the front end (2) of the tank between the front (9) being located and having in -u> (1) with a permeable membrane exposed at the front end (25) of the holder and, at the rear end of the reservoir (1), the rear tubular wall (9) moves forward together with the fluid (11) and with the front movable the wall (8) by means of a piston (30) mounted at the rear end (28) of a holder that pushes the rear movable wall (9) of the container, of the reservoir (1) so that the fluid (11) can be discharged by flowing through the connecting channel (12) into the space (6) of the solid components (10) and mix with them until a solution is obtained. Apparatus according to claim 2, characterized in that the piston (30) is fixedly positioned at the rear end (28) of the holder and that the front end (24) of the holder is provided with an opening directly in front of the permeable membrane. the reservoir so that a tube, a cannula, can be inserted through an opening and a membrane that can be torn due to the extraction of the prepared injection solution for the syringe (33) for administration and care. Apparatus according to claim 2, characterized in that the piston (30) is provided with a working rod (35) extending through the rear wall (29) at the rear end (28) of the holder and the attachment to the cannula (35). 32) mounted at the front end (25) of the retainer, which can be adapted to the retainers (24, 25) and then pierce the membrane of the reservoir (1).