SI2985025T1 - Farmacevtska kombinacija - Google Patents
Farmacevtska kombinacija Download PDFInfo
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- SI2985025T1 SI2985025T1 SI200931819T SI200931819T SI2985025T1 SI 2985025 T1 SI2985025 T1 SI 2985025T1 SI 200931819 T SI200931819 T SI 200931819T SI 200931819 T SI200931819 T SI 200931819T SI 2985025 T1 SI2985025 T1 SI 2985025T1
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- Prior art keywords
- compound
- pharmaceutical combination
- amino
- methyl
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- 150000001875 compounds Chemical class 0.000 claims abstract 16
- 238000001959 radiotherapy Methods 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims abstract 2
- 238000002360 preparation method Methods 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims 11
- -1 (4-methyl-piperazin-1-yl) -methylcarbonyl Chemical group 0.000 claims 5
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 229960002989 glutamic acid Drugs 0.000 claims 4
- 208000006178 malignant mesothelioma Diseases 0.000 claims 4
- 201000005282 malignant pleural mesothelioma Diseases 0.000 claims 4
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims 4
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 3
- 201000002513 peritoneal mesothelioma Diseases 0.000 claims 2
- 238000011262 co‐therapy Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 238000011278 co-treatment Methods 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 201000000050 myeloid neoplasm Diseases 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
Claims (11)
- Farmacevtska kombinacija Patentni zahtevki1. Farmacevtska kombinacija, ki obsega spojino 3-Z-[ 1 -(4-(W-((4-metil-piperazin-1 -il)-metilkarbonil)-7V-metil-amino)-aniIino)-l-fenil-metilen]-6-metoksikarbonil-2-indolinon ali njegovo farmacevtsko sprejemljivo sol in spojino AL[4-[2-(2-amino-4,7-dihidro-4-okso- l//-pirolo[2,3-i/Jpirimidin-5-il)etil]benzoil]-L-glutaminska kislina ali njeno farmacevtsko sprejemljivo sol, za uporabo pri postopku zdravljenja malignega plevralnega ali peritonealnega mezotelioma.
- 2. Farmacevtska kombinacija za uporabo po zahtevku 1, pri čemer je farmacevtska kombinacija za uporabo pri postopku zdravljenja malignega plevralnega mezotelioma.
- 3. Farmacevtska kombinacija za uporabo po zahtevku 1 ali 2, v kateri je farmacevtsko sprejemljiva sol spojine 3-Z-[ 1 -(4-(7V-((4-metil-piperazin-1 -il)-metilkarbonil)-./V-metil-amino)-anilino)-1 -fenil-metilen]-6-metoksikarbonil-2-indolinon oblika njegove monoetansulfonatne soli.
- 4. Farmacevtska kombinacija za uporabo po zahtevku 1 ali 2, v kateri je farmacevtsko sprejemljiva sol spojine 7V-[4-[2-(2-amino-4,7-dihidro-4-okso-l//-pirolo[2,3-cf]pirimidin-5-il)etil]benzoil]-L-glutaminska kislina oblika njene dinatrijeve soli.
- 5. Farmacevtska kombinacija za uporabo po zahtevku 1 ali 2, ki obsega obliko monoetansulfonatne soli spojine 3-Z-[ 1 -(4-(7V-((4-metil-piperazin- 1-il)- metilkarbonil)-7V-metil-amino)-anilino)-l-fenil-metilen]-6-metoksikarbonil-2-indolinon in obliko dinatrijeve soli spojine N-[4-[2-(2-amino-4,7-dihidro-4-okso-li7-pirolo[2,3-i/]pirimidin-5-il)etil]benzoil]-L-glutaminska kislina.
- 6. Farmacevtska kombinacija za uporabo po katerem koli od zahtevkov 1-5, ki je v obliki kombiniranega pripravka za sočasno, ločeno ali zaporedno uporabo.
- 7. Farmacevtska kombinacija za uporabo po katerem koli od zahtevkov 1-5, ki je nadalje prilagojena za sočasno zdravljenje z radioterapijo.
- 8. Spojina 3-Z-[ 1 -(4-(Ar-((4-metil-piperazin-1 -il)-metilkarbonil)-Ar-metil-amino)- anilino)-l-fenil-metilen]-6-metoksikarbonil-2-indolinon ali njegova farmacevtsko sprejemljiva sol za uporabo pri postopku zdravljenja malignega plevralnega ali peritonealnega mezotelioma, ki obsega dajanje pacientu, ki to potrebuje, učinkovite količine navedene spojine pred, po ali sočasno z učinkovito količino spojine ΛΓ-[4-[2-(2-amino-4,7-dihidro-4-okso-l//-pirolo[2,3-i/]pirimidin-5-il)etil]benzoil]-L-glutaminska kislina ali njene farmacevtsko sprejemljive soli.
- 9. Spojina za uporabo po zahtevku 8, pri čemer je spojina za uporabo pri postopku zdravljenja malignega plevralnega mezotelioma.
- 10. Spojina za uporabo po zahtevku 8 ali 9, pri čemer je farmacevtsko sprejemljiva sol spojine 3-Z-[ 1 -(4-(AL((4-metil-piperazin-1 -il)-metilkarbonil)-7V-metil-amino)-anilino)-l-fenil-metilen]-6-metoksikarbonil-2-indolinon njegova monoetansulfonatna sol.
- 11. Spojina za uporabo po zahtevku 8 ali 9, pri čemer je farmacevtsko sprejemljiva sol spojine A^-[4-[2-(2-amino-4,7-dihidro-4-okso-l//-pirolo[2,3-cf]pirimidin-5-il)etil]benzoil]-L-glutaminska kislina njena dinatrijeva sol.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08157749 | 2008-06-06 | ||
| US7888208P | 2008-07-08 | 2008-07-08 | |
| EP15179438.5A EP2985025B1 (en) | 2008-06-06 | 2009-06-04 | Pharmaceutical combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2985025T1 true SI2985025T1 (sl) | 2018-04-30 |
Family
ID=40912046
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200931819T SI2985025T1 (sl) | 2008-06-06 | 2009-06-04 | Farmacevtska kombinacija |
| SI200931315T SI2293795T1 (sl) | 2008-06-06 | 2009-06-04 | Farmacevtska kombinacija |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200931315T SI2293795T1 (sl) | 2008-06-06 | 2009-06-04 | Farmacevtska kombinacija |
Country Status (34)
| Country | Link |
|---|---|
| US (5) | US20110178099A1 (sl) |
| EP (2) | EP2985025B1 (sl) |
| JP (2) | JP5993573B2 (sl) |
| KR (1) | KR101760657B1 (sl) |
| CN (1) | CN102056609B (sl) |
| AR (1) | AR072061A1 (sl) |
| AU (1) | AU2009254554B2 (sl) |
| CA (1) | CA2726644C (sl) |
| CO (1) | CO6280488A2 (sl) |
| CY (2) | CY1116877T1 (sl) |
| DK (2) | DK2985025T3 (sl) |
| EA (1) | EA020046B1 (sl) |
| EC (1) | ECSP10010716A (sl) |
| ES (2) | ES2662824T3 (sl) |
| HK (1) | HK1152640A1 (sl) |
| HR (2) | HRP20151186T1 (sl) |
| HU (2) | HUE025821T2 (sl) |
| IL (1) | IL208953B (sl) |
| LT (1) | LT2985025T (sl) |
| MA (1) | MA32384B1 (sl) |
| ME (1) | ME02273B (sl) |
| MX (1) | MX338047B (sl) |
| MY (1) | MY158929A (sl) |
| NZ (1) | NZ588957A (sl) |
| PE (1) | PE20100084A1 (sl) |
| PL (2) | PL2985025T3 (sl) |
| PT (2) | PT2293795E (sl) |
| RS (2) | RS57035B1 (sl) |
| SI (2) | SI2985025T1 (sl) |
| TW (1) | TWI447113B (sl) |
| UA (1) | UA102258C2 (sl) |
| UY (1) | UY31866A (sl) |
| WO (1) | WO2009147218A1 (sl) |
| ZA (1) | ZA201007594B (sl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| DK2299987T3 (en) * | 2008-06-06 | 2018-05-22 | Boehringer Ingelheim Int | Pharmaceutical Capsule Dosage Form Containing A Suspension Formulation Of An Indolinone Derivative |
| UA107560C2 (uk) * | 2008-06-06 | 2015-01-26 | Фармацевтична лікарська форма для негайного вивільнення похідної індолінону | |
| US20140350022A1 (en) * | 2013-05-10 | 2014-11-27 | Boehringer Ingelheim International Gmbh | Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment |
| NZ717528A (en) | 2013-07-31 | 2024-07-05 | Avalyn Pharma Inc | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| WO2017067685A1 (en) * | 2015-10-21 | 2017-04-27 | Capsugel Belgium N.V. | Printing process for oral dosage forms |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL96531A (en) * | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
| AU6890800A (en) * | 1999-08-23 | 2001-03-19 | Eli Lilly And Company | A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor |
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| DE10233500A1 (de) | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| DE10237423A1 (de) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| US20040204458A1 (en) * | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
| US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
| US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| EP1711209A4 (en) * | 2004-01-23 | 2007-09-26 | Sarissa Inc | METHOD FOR TREATING MESOTHELION WITH AN ANTISENSE OLIGONUCLEOTIDE AGAINST TYHMIDYLATE SYNTHASE |
| US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| US20060041013A1 (en) * | 2004-08-18 | 2006-02-23 | Brittain Jason E | Alanosine formulations and methods of use |
| PE20060777A1 (es) * | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| WO2007057397A1 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer |
| EP1870400A1 (en) | 2006-06-08 | 2007-12-26 | Boehringer Ingelheim Pharma GmbH & Co. KG | Salts and crystalline salt forms of an 2-indolinone derivative |
| JP2008543975A (ja) * | 2006-08-14 | 2008-12-04 | シコール インコーポレイティド | 高度に純粋なペメトレキセド二酸およびその調製方法 |
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