SI2600869T1 - Kombinacija spojine pirolokinolin in beta-laktamskega protimikrobnega sredstva, mupirocina in klorheksidina - Google Patents

Kombinacija spojine pirolokinolin in beta-laktamskega protimikrobnega sredstva, mupirocina in klorheksidina

Info

Publication number
SI2600869T1
SI2600869T1 SI201131932T SI201131932T SI2600869T1 SI 2600869 T1 SI2600869 T1 SI 2600869T1 SI 201131932 T SI201131932 T SI 201131932T SI 201131932 T SI201131932 T SI 201131932T SI 2600869 T1 SI2600869 T1 SI 2600869T1
Authority
SI
Slovenia
Prior art keywords
mupirocin
chlorhexidine
beta
combination
antimicrobial agent
Prior art date
Application number
SI201131932T
Other languages
English (en)
Inventor
Yanmin Hu
Anthony R. M. Coates
Original Assignee
Helperby Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1013209.0A external-priority patent/GB201013209D0/en
Priority claimed from GBGB1013212.4A external-priority patent/GB201013212D0/en
Priority claimed from GBGB1013214.0A external-priority patent/GB201013214D0/en
Application filed by Helperby Therapeutics Limited filed Critical Helperby Therapeutics Limited
Publication of SI2600869T1 publication Critical patent/SI2600869T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/04—Antibacterial agents
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    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI201131932T 2010-08-05 2011-08-05 Kombinacija spojine pirolokinolin in beta-laktamskega protimikrobnega sredstva, mupirocina in klorheksidina SI2600869T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1013209.0A GB201013209D0 (en) 2010-08-05 2010-08-05 Novel combination
GBGB1013212.4A GB201013212D0 (en) 2010-08-05 2010-08-05 Novel combination
GBGB1013214.0A GB201013214D0 (en) 2010-08-05 2010-08-05 Novel combination
PCT/GB2011/001181 WO2012017215A1 (en) 2010-08-05 2011-08-05 Combination of a pyrroloquinoline compound and a beta-lactam antimicrobial agent, mupirocin or chlorhexidine
EP11746287.9A EP2600869B1 (en) 2010-08-05 2011-08-05 Combination of a pyrroloquinoline compound and a beta-lactam antimicrobial agent, mupirocin or chlorhexidine

Publications (1)

Publication Number Publication Date
SI2600869T1 true SI2600869T1 (sl) 2021-03-31

Family

ID=45558971

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201131932T SI2600869T1 (sl) 2010-08-05 2011-08-05 Kombinacija spojine pirolokinolin in beta-laktamskega protimikrobnega sredstva, mupirocina in klorheksidina

Country Status (10)

Country Link
US (1) US8940723B2 (sl)
EP (1) EP2600869B1 (sl)
JP (2) JP2013532716A (sl)
CA (1) CA2807075C (sl)
DK (1) DK2600869T3 (sl)
ES (1) ES2826884T3 (sl)
PL (1) PL2600869T3 (sl)
PT (1) PT2600869T (sl)
SI (1) SI2600869T1 (sl)
WO (1) WO2012017215A1 (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0522715D0 (en) * 2005-11-08 2005-12-14 Helperby Therapeutics Ltd New use
EP2624817A1 (en) * 2010-10-08 2013-08-14 Helperby Therapeutics Limited Novel composition
US10016375B2 (en) 2013-12-12 2018-07-10 Paul J. Rucinski Materials and methods for controlling infections
AU2014361828A1 (en) * 2013-12-12 2016-06-30 Innovation Technologies, Inc. Materials and methods for controlling infections
JP6804096B2 (ja) * 2015-04-11 2020-12-23 ヘルパービー セラピューティクス リミテッドＨｅｌｐｅｒｂｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 口腔用組成物
ES2856798T3 (es) * 2015-08-05 2021-09-28 Univ Rochester Composiciones antimicrobianas que comprenden mupirocina y neomicina
GB201518969D0 (en) * 2015-10-27 2015-12-09 Helperby Therapeutics Ltd Triple combination
GB2589286A (en) * 2019-07-22 2021-06-02 Helperby Therapeutics Ltd Method
WO2021183590A1 (en) * 2020-03-10 2021-09-16 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Antiseptic-antibiotic gumbos effective against gram-negative pathogens
GB202012797D0 (en) 2020-08-17 2020-09-30 Helperby Therapeautics Ltd Disinfectant composition

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2157996T3 (es) 1993-10-22 2001-09-01 Smithkline Beecham Corp Nueva composicion.
US6180604B1 (en) * 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
PT1129212E (pt) 1998-11-09 2004-11-30 Helperby Therapeutics Ltd Processo de triagem para agentes antibacterianos
US6974585B2 (en) 2001-08-01 2005-12-13 Medlogic Global Limited Durable multi-component antibiotic formulation for topical use
WO2005014585A1 (en) 2003-08-08 2005-02-17 Ulysses Pharmaceutical Products Inc. Halogenated quinazolinyl nitrofurans as antibacterial agents
KR20070091613A (ko) 2004-11-08 2007-09-11 그렌마크 파머수티칼스 엘티디. 항여드름 화합물 및 항생제 화합물을 함유하는 국소적 제약조성물
GB0522715D0 (en) * 2005-11-08 2005-12-14 Helperby Therapeutics Ltd New use
GB0709513D0 (en) * 2007-05-17 2007-06-27 Helperby Therapeutics Ltd Topical formulations
GB0705915D0 (en) 2007-03-28 2007-05-09 Helperby Therapeutics Ltd New use
HUE034298T2 (en) 2007-05-17 2018-02-28 Helperby Therapeutics Ltd Use of 4- (Pyrrolidin-1-yl) quinoline derivatives to kill clinically latent microorganisms

Also Published As

Publication number Publication date
WO2012017215A1 (en) 2012-02-09
JP6265395B2 (ja) 2018-01-24
PT2600869T (pt) 2020-10-08
CA2807075C (en) 2018-10-16
ES2826884T3 (es) 2021-05-19
US20130184230A1 (en) 2013-07-18
DK2600869T3 (da) 2020-11-16
EP2600869B1 (en) 2020-09-23
CA2807075A1 (en) 2012-02-09
US8940723B2 (en) 2015-01-27
JP2016188239A (ja) 2016-11-04
JP2013532716A (ja) 2013-08-19
EP2600869A1 (en) 2013-06-12
PL2600869T3 (pl) 2021-04-06

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