SI2154150T1 - Geni za biosintezo spojin tetraciklina in njihove uporabe - Google Patents

Geni za biosintezo spojin tetraciklina in njihove uporabe Download PDF

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Publication number
SI2154150T1
SI2154150T1 SI200931766T SI200931766T SI2154150T1 SI 2154150 T1 SI2154150 T1 SI 2154150T1 SI 200931766 T SI200931766 T SI 200931766T SI 200931766 T SI200931766 T SI 200931766T SI 2154150 T1 SI2154150 T1 SI 2154150T1
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Slovenia
Prior art keywords
polypeptide
tetracycline
seq
substituted
cell
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SI200931766T
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English (en)
Inventor
Hrvoje Petkovic
Peter Raspor
Urska Lesnik
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Univerza V Ljubljani
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Publication of SI2154150T1 publication Critical patent/SI2154150T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (7)

  1. Geni za biosintezo spojin tetraciklina in njihove uporabe Patentni zahtevki
    1. Gensko spremenjena celica, kjer je omenjena celica vrste Aktinomiceta, kjer je omenjena celica zmožna proizvajati spojino tetraciklina po modificirani poti biosinteze tetraciklina, kjer omenjena modificirana biosintetična pot tetraciklina vključuje polipeptide iz SEQ ID No: od 1 do 8, kjer je vsak izmed omenjenih polipeptidov iz SEQ ID No: od 1 do 8, lahko substituiran s polipeptidom, ki je vsak 80% enak in ima enako katalitsko funkcijo kot omenjeni substituirani polipeptid; in, kjer omenjena calica ni Amycolatopsis sulphurea sev NRRL2822.
  2. 2. Celica po zahtevku 1, kjer omenjena modificirana biosintetična pot tetraciklina vsebuje reakcijo katalizirano dodatnim polipeptidom izbranim iz skupine, ki vsebuje SEQ ID No: od 9 do 18, kjer je omenjeni dodatni polipeptid lahko substituiran s polipeptidom, kije vsaj 80% enak in ima enako katalitsko funkcijo kot omenjeni substituirani dodatni polipeptid.
  3. 3. Celica po zahtevku 2, kjer omenjena modificirana biosintetična pot tetraciklina vsebuje nadalje vsebuje vsaj eno reakcijo, katalizirano s polipeptidom izbranim iz skupine, ki vsebuje katerokoli izmed SEQ ID No: od 19 do 26 in polipeptid, ki je vsaj 80% enak in ima enako katalitsko funkcijo kot omenjeni polipeptid kateregakoli izmed SEQ ID No: od 19 do 26.
  4. 4. Genski grozd, ki kodira biosintetična pot tetraciklina, kjer omenjeni genski grozd vsebuje nukleinsko kislino, ki kodira vse polipeptide iz SEQ ID NO: od 1 do 8, kjer je vsak omenjeni polipeptid iz SEQ ID NO: od 1 do 8 lahko substituiran s polipeptidom, kije vsaj 80% enak in ima enako katalitsko funkcijo kot omenjeni substituirani polipeptid.
  5. 5. Genski grozd po zahtevku 4, kjer omenjeni genski grozd vsebuje nukleinsko kislino, ki kodira nadaljnji polipeptid izbran iz skupine, ki sestoji iz SEQ ID NO: od 8 do 18, kjer je omenjeni nadaljnji polipeptid lahko substituiran s polipeptidom, ki je vsaj 80% enak in ima enako katalitsko funkcijo kot omenjeni nadaljnji polipeptid.
  6. 6. Postopek biosintetične proizvodnje spojine tetraciklina, kjer omenjeni postopek obsega naslednje korake: zagotavljanje celice po kateremkoli zahtevku od 1 do 3; zagotavljanje substrata; inkubiranje omenjenega substrata z omenjeno celico pri dovoljenih pogojih, in pridobivanje omenjene spojine tetraciklina.
  7. 7. Postopek biosintetične proizvodnje spojine tetraciklina po zahtevku 6, kjer ima omenjena spojina zgradbo izbrano iz skupine, ki sestoji iz:
SI200931766T 2008-08-07 2009-08-07 Geni za biosintezo spojin tetraciklina in njihove uporabe SI2154150T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08014141A EP2154249A1 (en) 2008-08-07 2008-08-07 Genes for biosynthesis of tetracycline compounds and uses thereof
EP09010246.8A EP2154150B1 (en) 2008-08-07 2009-08-07 Genes for biosynthesis of tetracycline compounds and uses thereof

Publications (1)

Publication Number Publication Date
SI2154150T1 true SI2154150T1 (sl) 2018-01-31

Family

ID=39832012

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200932105T SI3309253T1 (sl) 2008-08-07 2009-08-07 Geni za biosintezo tetraciklinskih spojin in uporabe le-teh
SI200931766T SI2154150T1 (sl) 2008-08-07 2009-08-07 Geni za biosintezo spojin tetraciklina in njihove uporabe

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Application Number Title Priority Date Filing Date
SI200932105T SI3309253T1 (sl) 2008-08-07 2009-08-07 Geni za biosintezo tetraciklinskih spojin in uporabe le-teh

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US (2) US8361777B2 (sl)
EP (3) EP2154249A1 (sl)
SI (2) SI3309253T1 (sl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200392071A1 (en) 2017-12-22 2020-12-17 Helmholtz-Zentrum für Infektionsforschung GmbH Gene cluster for the biosynthetic production of tetracycline compounds in a heterologous host
CN110058011A (zh) * 2019-05-23 2019-07-26 广州元睿生物科技有限公司 一种四环素化学发光酶联免疫检测试剂盒

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3824285A (en) * 1967-09-13 1974-07-16 Pfizer 4-oxo-4-dedimethylaminotetracycline-4,6-hemiketals
US20070292403A1 (en) * 2006-05-11 2007-12-20 Avicena Group, Inc. Methods of treating a neurological disorder with creatine monohydrate

Also Published As

Publication number Publication date
EP2154150B1 (en) 2017-10-11
US20130196953A1 (en) 2013-08-01
US20100035847A1 (en) 2010-02-11
US8361777B2 (en) 2013-01-29
EP2154150A1 (en) 2010-02-17
EP3309253B1 (en) 2020-10-14
SI3309253T1 (sl) 2021-03-31
EP2154249A1 (en) 2010-02-17
EP3309253A1 (en) 2018-04-18
US9630911B2 (en) 2017-04-25

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