SI1922350T1 - Postopki za pripravo polimernih reagentov - Google Patents

Postopki za pripravo polimernih reagentov

Info

Publication number
SI1922350T1
SI1922350T1 SI200631902T SI200631902T SI1922350T1 SI 1922350 T1 SI1922350 T1 SI 1922350T1 SI 200631902 T SI200631902 T SI 200631902T SI 200631902 T SI200631902 T SI 200631902T SI 1922350 T1 SI1922350 T1 SI 1922350T1
Authority
SI
Slovenia
Prior art keywords
methods
polymeric reagents
preparing polymeric
preparing
reagents
Prior art date
Application number
SI200631902T
Other languages
English (en)
Inventor
Antoni Kozlowski
Jon Mckannan
Samuel P. Mcmanus
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37600795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1922350(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of SI1922350T1 publication Critical patent/SI1922350T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B47/00—Formation or introduction of functional groups not provided for in groups C07B39/00 - C07B45/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
SI200631902T 2005-07-29 2006-07-31 Postopki za pripravo polimernih reagentov SI1922350T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70370905P 2005-07-29 2005-07-29
EP06789107.7A EP1922350B1 (en) 2005-07-29 2006-07-31 Methods for preparing polymeric reagents
PCT/US2006/029929 WO2007016560A2 (en) 2005-07-29 2006-07-31 Methods for preparing carbonate esters of poly(etylene glycol)

Publications (1)

Publication Number Publication Date
SI1922350T1 true SI1922350T1 (sl) 2015-04-30

Family

ID=37600795

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200631902T SI1922350T1 (sl) 2005-07-29 2006-07-31 Postopki za pripravo polimernih reagentov

Country Status (16)

Country Link
US (9) US7767784B2 (sl)
EP (1) EP1922350B1 (sl)
JP (1) JP5544085B2 (sl)
KR (1) KR101354244B1 (sl)
CN (1) CN101243120B (sl)
AU (1) AU2006275473B2 (sl)
CA (1) CA2615627C (sl)
DK (1) DK1922350T3 (sl)
ES (1) ES2529258T3 (sl)
HR (1) HRP20150247T1 (sl)
MX (1) MX2008001328A (sl)
PL (1) PL1922350T3 (sl)
PT (1) PT1922350E (sl)
RS (1) RS53847B1 (sl)
SI (1) SI1922350T1 (sl)
WO (1) WO2007016560A2 (sl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1922350T3 (en) 2005-07-29 2015-03-09 Nektar Therapeutics Methods for preparing polymerreagenser
CN101870767B (zh) * 2009-04-24 2012-09-12 石药集团中奇制药技术（石家庄）有限公司 一种聚乙二醇化的1,2-二脂肪酰磷脂酰乙醇胺的制备方法
EP3053977B1 (en) * 2013-09-30 2019-09-11 Fujimi Incorporated Polishing composition and method for producing same
CA3093645A1 (en) 2018-03-13 2019-09-19 Nof Corporation Heterobifunctional compound having monodispersed polyethylene glycol in main chain and side chain
CA3112834A1 (en) * 2018-10-11 2020-04-16 Nektar Therapeutics Method of making releasable polymeric reagents
EP3901193A1 (en) * 2020-04-24 2021-10-27 Pro-View Biotech Co. Ltd. Amino acid-modified polymer for adhesion prevention and application thereof
CN115400219B (zh) * 2021-05-26 2024-09-17 博唯弘展生技股份有限公司 用于预防组织沾粘的温度敏感组合物及其应用
CN115403760B (zh) * 2021-05-26 2023-10-03 博唯弘展生技股份有限公司 用于预防沾粘的氨基酸改质的聚合物及其应用
JP2023133194A (ja) 2022-03-09 2023-09-22 日油株式会社 ポリエチレングリコールの活性炭酸エステルの製造方法およびポリエチレングリコールの活性炭酸エステル

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5281698A (en) * 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
US5629384A (en) * 1994-05-17 1997-05-13 Consiglio Nazionale Delle Ricerche Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
PT1061954E (pt) * 1998-03-12 2004-10-29 Nektar Therapeutics Al Corp Derivados de poli(etileno glicol) com grupos reactivos proximos
US6348558B1 (en) * 1999-12-10 2002-02-19 Shearwater Corporation Hydrolytically degradable polymers and hydrogels made therefrom
DK1259563T4 (en) * 1999-12-22 2016-11-21 Nektar Therapeutics PROCEDURE FOR PREPARING 1-BENZOTRIAZOLYL CARBONATE ESTERS OF WATER SOLUBLE POLYMERS
US6413507B1 (en) * 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
SG159387A1 (en) * 2002-11-26 2010-03-30 Biocon Ltd In Modified natriuretic compounds, conjugates, and uses thereof
DK1922350T3 (en) 2005-07-29 2015-03-09 Nektar Therapeutics Methods for preparing polymerreagenser

Also Published As

Publication number Publication date
US20190375892A1 (en) 2019-12-12
CN101243120A (zh) 2008-08-13
CA2615627C (en) 2014-10-21
US20080064851A1 (en) 2008-03-13
ES2529258T3 (es) 2015-02-18
US20140323742A1 (en) 2014-10-30
US20120214952A1 (en) 2012-08-23
US8809489B2 (en) 2014-08-19
HRP20150247T1 (hr) 2015-04-10
JP5544085B2 (ja) 2014-07-09
DK1922350T3 (en) 2015-03-09
KR101354244B1 (ko) 2014-02-18
US7767784B2 (en) 2010-08-03
PT1922350E (pt) 2015-03-09
US10421838B2 (en) 2019-09-24
US20130253203A1 (en) 2013-09-26
AU2006275473B2 (en) 2012-07-05
WO2007016560A2 (en) 2007-02-08
US20210130546A1 (en) 2021-05-06
JP2009503201A (ja) 2009-01-29
WO2007016560A9 (en) 2007-05-31
US8461295B2 (en) 2013-06-11
CA2615627A1 (en) 2007-02-08
US20170283552A1 (en) 2017-10-05
US9334364B2 (en) 2016-05-10
PL1922350T3 (pl) 2015-07-31
EP1922350A2 (en) 2008-05-21
EP1922350B1 (en) 2015-01-07
MX2008001328A (es) 2008-04-09
WO2007016560A3 (en) 2007-04-12
US20160289382A1 (en) 2016-10-06
US9732189B2 (en) 2017-08-15
US8193306B2 (en) 2012-06-05
KR20080034485A (ko) 2008-04-21
AU2006275473A1 (en) 2007-02-08
US20100256310A1 (en) 2010-10-07
RS53847B1 (en) 2015-08-31
CN101243120B (zh) 2012-04-18

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