SI1888506T1 - Ločitev stereoizomernih N,N-dialkilamino-2-alkil-3-fenil-alkanov - Google Patents
Ločitev stereoizomernih N,N-dialkilamino-2-alkil-3-fenil-alkanovInfo
- Publication number
- SI1888506T1 SI1888506T1 SI200631593T SI200631593T SI1888506T1 SI 1888506 T1 SI1888506 T1 SI 1888506T1 SI 200631593 T SI200631593 T SI 200631593T SI 200631593 T SI200631593 T SI 200631593T SI 1888506 T1 SI1888506 T1 SI 1888506T1
- Authority
- SI
- Slovenia
- Prior art keywords
- stereoisomeric
- dialkylamino
- alkyl
- separation
- phenyl alkanes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005024824 | 2005-05-27 | ||
| DE102005033732.5A DE102005033732B4 (de) | 2005-05-27 | 2005-07-15 | Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane |
| EP06753942A EP1888506B1 (de) | 2005-05-27 | 2006-05-29 | Trennung stereoisomerer n,n-dialkylamino-2-alkyl-3-phenyl-alkane |
| PCT/EP2006/005101 WO2006125675A1 (de) | 2005-05-27 | 2006-05-29 | Trennung stereoisomerer n,n-dialkylamino-2-alkyl-3-phenyl-alkane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1888506T1 true SI1888506T1 (sl) | 2013-07-31 |
Family
ID=36829758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200631593T SI1888506T1 (sl) | 2005-05-27 | 2006-05-29 | Ločitev stereoizomernih N,N-dialkilamino-2-alkil-3-fenil-alkanov |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7649114B2 (sl) |
| EP (1) | EP1888506B1 (sl) |
| CN (1) | CN101228109B (sl) |
| DE (1) | DE102005033732B4 (sl) |
| ES (1) | ES2403418T3 (sl) |
| HK (1) | HK1119660A1 (sl) |
| IL (1) | IL187680A (sl) |
| PL (1) | PL1888506T3 (sl) |
| PT (1) | PT1888506E (sl) |
| SI (1) | SI1888506T1 (sl) |
| TW (1) | TWI374869B (sl) |
| WO (1) | WO2006125675A1 (sl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1397189B1 (it) | 2009-12-01 | 2013-01-04 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
| CA2790519A1 (en) | 2010-03-05 | 2011-09-09 | Actavis Group Ptc Ehf | Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
| US20130096347A1 (en) | 2010-04-05 | 2013-04-18 | Actavis Group Ptc Ehf | Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof |
| ITMI20100924A1 (it) * | 2010-05-21 | 2011-11-22 | Fidia Farmaceutici | Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol |
| EP2545028A4 (en) * | 2011-01-27 | 2013-07-03 | Symed Labs Ltd | STEREOSPECIFIC SYNTHESIS OF (-) (2S, 3S) -1-DIMETHYLAMINO-3- (3-METHOXYPHENYL) -2-METHYLPENTAN-3-OLE |
| WO2012146978A2 (en) | 2011-04-28 | 2012-11-01 | Actavis Group Ptc Ehf | A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof |
| WO2015075678A1 (en) | 2013-11-21 | 2015-05-28 | Unimark Remedies Ltd. | A novel process for the preparation of 1-phenyl-3-aminopropane derivatives |
| CN104151177B (zh) * | 2014-08-27 | 2015-11-18 | 殷江霞 | 一种他喷他多中间体的制备方法 |
| CN106349089B (zh) * | 2016-07-30 | 2021-04-02 | 湖南理工学院 | 一种采用酒石酸酯-多元酸配合物萃取分离美托洛尔对映体的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE124521C (sl) | ||||
| NL259249A (sl) * | 1959-12-28 | |||
| US4155935A (en) * | 1973-03-26 | 1979-05-22 | American Home Products Corporation | Benzylamine analgesics |
| DD124521A1 (sl) * | 1976-03-16 | 1977-03-02 | ||
| US4155936A (en) * | 1978-03-08 | 1979-05-22 | The Goodyear Tire & Rubber Company | Para-nitrodiphenylamines synthesis using Polyethers and macrocyclic esters as solubilizing agents |
| ZW6584A1 (en) * | 1983-04-18 | 1985-04-17 | Glaxo Group Ltd | Phenethanolamine derivatives |
| IT1213219B (it) * | 1984-09-28 | 1989-12-14 | Consiglio Nazionale Ricerche | Derivati amminoalchilnaftalenici ad attivita' farmacologica. |
| DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| PT778263E (pt) | 1994-08-22 | 2002-06-28 | Mitsubishi Pharma Corp | Composto de benzeno e sua utilizacao farmaceutica |
| DE19547766A1 (de) * | 1995-12-20 | 1997-06-26 | Gruenenthal Gmbh | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe |
| DE19601744C2 (de) * | 1996-01-19 | 1998-04-16 | Gruenenthal Gmbh | Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| DE19915602A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-4-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
| DE19963179B4 (de) * | 1999-12-27 | 2009-02-05 | Grünenthal GmbH | Substituierte 1- und 2-Naphthol-Mannichbasen |
| DE10108308A1 (de) * | 2001-02-21 | 2002-08-29 | Gruenenthal Gmbh | Verfahren zur Isolierung und Reinigung von (1RS,2RS)-2[(Dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol |
-
2005
- 2005-07-15 DE DE102005033732.5A patent/DE102005033732B4/de active Active
-
2006
- 2006-05-29 EP EP06753942A patent/EP1888506B1/de active Active
- 2006-05-29 WO PCT/EP2006/005101 patent/WO2006125675A1/de active Application Filing
- 2006-05-29 PL PL06753942T patent/PL1888506T3/pl unknown
- 2006-05-29 ES ES06753942T patent/ES2403418T3/es active Active
- 2006-05-29 TW TW095118941A patent/TWI374869B/zh active
- 2006-05-29 PT PT67539429T patent/PT1888506E/pt unknown
- 2006-05-29 CN CN2006800267181A patent/CN101228109B/zh active Active
- 2006-05-29 US US11/915,653 patent/US7649114B2/en active Active
- 2006-05-29 SI SI200631593T patent/SI1888506T1/sl unknown
-
2007
- 2007-11-27 IL IL187680A patent/IL187680A/en active IP Right Grant
-
2008
- 2008-10-29 HK HK08111902.6A patent/HK1119660A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101228109B (zh) | 2011-05-04 |
| US20080269524A1 (en) | 2008-10-30 |
| HK1119660A1 (en) | 2009-03-13 |
| ES2403418T3 (es) | 2013-05-17 |
| WO2006125675A1 (de) | 2006-11-30 |
| TWI374869B (en) | 2012-10-21 |
| DE102005033732A1 (de) | 2006-11-30 |
| US7649114B2 (en) | 2010-01-19 |
| TW200718675A (en) | 2007-05-16 |
| IL187680A0 (en) | 2008-08-07 |
| IL187680A (en) | 2013-02-28 |
| EP1888506B1 (de) | 2013-03-20 |
| PT1888506E (pt) | 2013-04-17 |
| CN101228109A (zh) | 2008-07-23 |
| DE102005033732B4 (de) | 2014-02-13 |
| EP1888506A1 (de) | 2008-02-20 |
| PL1888506T3 (pl) | 2013-06-28 |
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