HK1119660A1 - Separation of stereoisomeric n,n-dialkylamino-2-alkyl-3-phenyl alkanes - Google Patents

Separation of stereoisomeric n,n-dialkylamino-2-alkyl-3-phenyl alkanes

Info

Publication number
HK1119660A1
HK1119660A1 HK08111902.6A HK08111902A HK1119660A1 HK 1119660 A1 HK1119660 A1 HK 1119660A1 HK 08111902 A HK08111902 A HK 08111902A HK 1119660 A1 HK1119660 A1 HK 1119660A1
Authority
HK
Hong Kong
Prior art keywords
stereoisomeric
dialkylamino
alkyl
separation
phenyl alkanes
Prior art date
Application number
HK08111902.6A
Other languages
English (en)
Inventor
Helmut Heinrich Buschmann
Wolfgang Hell
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of HK1119660A1 publication Critical patent/HK1119660A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10Separation; Purification; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
HK08111902.6A 2005-05-27 2008-10-29 Separation of stereoisomeric n,n-dialkylamino-2-alkyl-3-phenyl alkanes HK1119660A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005024824 2005-05-27
DE102005033732.5A DE102005033732B4 (de) 2005-05-27 2005-07-15 Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane
PCT/EP2006/005101 WO2006125675A1 (de) 2005-05-27 2006-05-29 Trennung stereoisomerer n,n-dialkylamino-2-alkyl-3-phenyl-alkane

Publications (1)

Publication Number Publication Date
HK1119660A1 true HK1119660A1 (en) 2009-03-13

Family

ID=36829758

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08111902.6A HK1119660A1 (en) 2005-05-27 2008-10-29 Separation of stereoisomeric n,n-dialkylamino-2-alkyl-3-phenyl alkanes

Country Status (12)

Country Link
US (1) US7649114B2 (xx)
EP (1) EP1888506B1 (xx)
CN (1) CN101228109B (xx)
DE (1) DE102005033732B4 (xx)
ES (1) ES2403418T3 (xx)
HK (1) HK1119660A1 (xx)
IL (1) IL187680A (xx)
PL (1) PL1888506T3 (xx)
PT (1) PT1888506E (xx)
SI (1) SI1888506T1 (xx)
TW (1) TWI374869B (xx)
WO (1) WO2006125675A1 (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1397189B1 (it) 2009-12-01 2013-01-04 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
CA2790519A1 (en) 2010-03-05 2011-09-09 Actavis Group Ptc Ehf Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
US20130096347A1 (en) 2010-04-05 2013-04-18 Actavis Group Ptc Ehf Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof
ITMI20100924A1 (it) * 2010-05-21 2011-11-22 Fidia Farmaceutici Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol
EP2545028A4 (en) * 2011-01-27 2013-07-03 Symed Labs Ltd STEREOSPECIFIC SYNTHESIS OF (-) (2S, 3S) -1-DIMETHYLAMINO-3- (3-METHOXYPHENYL) -2-METHYLPENTAN-3-OLE
WO2012146978A2 (en) 2011-04-28 2012-11-01 Actavis Group Ptc Ehf A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
WO2015075678A1 (en) 2013-11-21 2015-05-28 Unimark Remedies Ltd. A novel process for the preparation of 1-phenyl-3-aminopropane derivatives
CN104151177B (zh) * 2014-08-27 2015-11-18 殷江霞 一种他喷他多中间体的制备方法
CN106349089B (zh) * 2016-07-30 2021-04-02 湖南理工学院 一种采用酒石酸酯-多元酸配合物萃取分离美托洛尔对映体的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE124521C (xx)
NL259249A (xx) * 1959-12-28
US4155935A (en) * 1973-03-26 1979-05-22 American Home Products Corporation Benzylamine analgesics
DD124521A1 (xx) * 1976-03-16 1977-03-02
US4155936A (en) * 1978-03-08 1979-05-22 The Goodyear Tire & Rubber Company Para-nitrodiphenylamines synthesis using Polyethers and macrocyclic esters as solubilizing agents
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
IT1213219B (it) * 1984-09-28 1989-12-14 Consiglio Nazionale Ricerche Derivati amminoalchilnaftalenici ad attivita' farmacologica.
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
PT778263E (pt) 1994-08-22 2002-06-28 Mitsubishi Pharma Corp Composto de benzeno e sua utilizacao farmaceutica
DE19547766A1 (de) * 1995-12-20 1997-06-26 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe
DE19601744C2 (de) * 1996-01-19 1998-04-16 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE19915602A1 (de) * 1999-04-07 2000-10-19 Gruenenthal Gmbh 3-Amino-4-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung
DE19963179B4 (de) * 1999-12-27 2009-02-05 Grünenthal GmbH Substituierte 1- und 2-Naphthol-Mannichbasen
DE10108308A1 (de) * 2001-02-21 2002-08-29 Gruenenthal Gmbh Verfahren zur Isolierung und Reinigung von (1RS,2RS)-2[(Dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol

Also Published As

Publication number Publication date
CN101228109B (zh) 2011-05-04
US20080269524A1 (en) 2008-10-30
ES2403418T3 (es) 2013-05-17
WO2006125675A1 (de) 2006-11-30
TWI374869B (en) 2012-10-21
DE102005033732A1 (de) 2006-11-30
US7649114B2 (en) 2010-01-19
TW200718675A (en) 2007-05-16
IL187680A0 (en) 2008-08-07
IL187680A (en) 2013-02-28
EP1888506B1 (de) 2013-03-20
SI1888506T1 (sl) 2013-07-31
PT1888506E (pt) 2013-04-17
CN101228109A (zh) 2008-07-23
DE102005033732B4 (de) 2014-02-13
EP1888506A1 (de) 2008-02-20
PL1888506T3 (pl) 2013-06-28

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