SI1328269T1 - Association of a cb1 receptor antagonist and sibutramin for treating obesity - Google Patents

Association of a cb1 receptor antagonist and sibutramin for treating obesity

Info

Publication number
SI1328269T1
SI1328269T1 SI200130139T SI200130139T SI1328269T1 SI 1328269 T1 SI1328269 T1 SI 1328269T1 SI 200130139 T SI200130139 T SI 200130139T SI 200130139 T SI200130139 T SI 200130139T SI 1328269 T1 SI1328269 T1 SI 1328269T1
Authority
SI
Slovenia
Prior art keywords
sibutramin
association
receptor antagonist
treating obesity
obesity
Prior art date
Application number
SI200130139T
Other languages
Slovenian (sl)
Other versions
SI1328269T2 (en
Inventor
Odile Piot-Grosjean
Philippe Picaut
Francois Petitet
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8854974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1328269(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of SI1328269T1 publication Critical patent/SI1328269T1/en
Publication of SI1328269T2 publication Critical patent/SI1328269T2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention concerns the association of the CB1 receptor antagonist and a sibutramin, pharmaceutical compositions containing same and use thereof for treating obesity.
SI200130139T 2000-10-04 2001-10-01 Association of a cb1 receptor antagonist and sibutramin for treating obesity SI1328269T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0012646A FR2814678B1 (en) 2000-10-04 2000-10-04 COMBINATION OF AN ANTAGONIST OF THE CB1 RECEPTOR AND SIBUTRAMINE, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE FOR THE TREATMENT OF OBESITY
EP01974413A EP1328269B2 (en) 2000-10-04 2001-10-01 Association of a cb1 receptor antagonist and sibutramin for treating obesity
PCT/FR2001/003022 WO2002028346A2 (en) 2000-10-04 2001-10-01 Association of the cb1 receptor antagonist and sibutramin, for treating obesity

Publications (2)

Publication Number Publication Date
SI1328269T1 true SI1328269T1 (en) 2004-10-31
SI1328269T2 SI1328269T2 (en) 2008-12-31

Family

ID=8854974

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130139T SI1328269T2 (en) 2000-10-04 2001-10-01 Association of a cb1 receptor antagonist and sibutramin for treating obesity

Country Status (29)

Country Link
EP (1) EP1328269B2 (en)
JP (1) JP4221221B2 (en)
KR (1) KR20030036885A (en)
CN (1) CN100409845C (en)
AT (1) ATE267595T1 (en)
AU (2) AU2001293936B2 (en)
BG (1) BG107739A (en)
BR (1) BR0114410A (en)
CA (1) CA2424934A1 (en)
DE (1) DE60103556T3 (en)
DK (1) DK1328269T5 (en)
EA (1) EA005924B1 (en)
EE (1) EE200300121A (en)
ES (1) ES2217191T5 (en)
FR (1) FR2814678B1 (en)
HR (1) HRP20030249A2 (en)
HU (1) HUP0302044A3 (en)
IL (1) IL155236A0 (en)
MX (1) MXPA03002845A (en)
NO (1) NO20031521L (en)
NZ (1) NZ524904A (en)
PL (1) PL362833A1 (en)
PT (1) PT1328269E (en)
SI (1) SI1328269T2 (en)
SK (1) SK4032003A3 (en)
TR (1) TR200401264T4 (en)
WO (1) WO2002028346A2 (en)
YU (1) YU26103A (en)
ZA (1) ZA200303015B (en)

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EP1496838B1 (en) 2002-03-12 2010-11-03 Merck Sharp & Dohme Corp. Substituted amides
WO2003082190A2 (en) 2002-03-26 2003-10-09 Merck & Co., Inc. Spirocyclic amides as cannabinoid receptor modulators
WO2003082191A2 (en) 2002-03-28 2003-10-09 Merck & Co., Inc. Substituted 2,3-diphenyl pyridines
CA2481313A1 (en) 2002-04-12 2003-10-23 Merck & Co., Inc. Bicyclic amides
RU2304580C2 (en) 2002-07-29 2007-08-20 Ф.Хоффманн-Ля Рош Аг Novel benzodioxols
PL378244A1 (en) 2003-01-02 2006-03-20 F. Hoffmann-La Roche Ag Pyrrolyl-thiazoles and their use as cb 1 receptor inverse agonists
WO2004060870A1 (en) 2003-01-02 2004-07-22 F. Hoffmann-La Roche Ag Novel cb 1 receptour inverse agonists
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US20040224962A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
US7485732B2 (en) 2003-06-11 2009-02-03 Merck & Co., Inc. Substituted 3-alkyl and 3-alkenyl azetidine derivatives
ES2303077T3 (en) 2003-06-20 2008-08-01 F. Hoffmann-La Roche Ag 2-AMINOBENZOTIAZOLES AS INVESTED AGONISTS OF THE CB1 RECEIVER.
EP1498123A1 (en) * 2003-07-18 2005-01-19 Aventis Pharma S.A. Emulsifying systems containing azetidine derivatives
EP1498122A1 (en) * 2003-07-18 2005-01-19 Aventis Pharma S.A. Semi-solid systems containing azetidine derivatives
EP1663215A1 (en) * 2003-09-02 2006-06-07 Solvay Pharmaceuticals GmbH Novel medical use of selective cb1- receptor antagonists
FR2861303A1 (en) * 2003-10-24 2005-04-29 Sanofi Synthelabo Use of pyrazole derivative as cannabinoid CB1 receptor antagonist, for treatment and prevention of metabolic syndrome, particularly cardiovascular risks, dyslipidemia and liver disease associated with obesity
WO2005049615A1 (en) * 2003-11-21 2005-06-02 Pfizer Products Inc. Pyrazolo`1,5-a!`1,3,5! triazin -4-one derivatives as cb1 receptor antagonists
CN100509808C (en) 2003-12-08 2009-07-08 霍夫曼-拉罗奇有限公司 Novel thiazole derivates
EP1716132B1 (en) 2004-01-28 2010-08-25 F. Hoffmann-La Roche AG Spiro-benzodioxoles and their use as cb1 antagonists
JP2007536298A (en) 2004-05-10 2007-12-13 エフ．ホフマン−ラ　ロシュ　アーゲー Pyrrole or imidazole amide for the treatment of obesity
US20060025448A1 (en) 2004-07-22 2006-02-02 Cadila Healthcare Limited Hair growth stimulators
WO2006039334A1 (en) * 2004-09-29 2006-04-13 Schering Corporation Combinations of substituted azetidonones and cb1 antagonists
FR2876689B1 (en) * 2004-10-14 2008-02-22 Aventis Pharma Sa NOVEL PROCESS AND INTERMEDIATES FOR PREPARING N- (1-BENZHYDRYL-AZETIDIN-3-YL) -N-PHENYL-METHYLSULFONAMIDE DERIVATIVES
CA2585175A1 (en) 2004-10-25 2006-05-04 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising cb1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type i, obesity and related conditions
ES2309812T3 (en) 2004-10-27 2008-12-16 F. Hoffmann-La Roche Ag NEW DERIVATIVES OF INDOL OR BENZIMIDAZOL.
EP1812418B1 (en) 2004-11-09 2010-10-27 F. Hoffmann-La Roche AG Dibenzosuberone derivatives
DE602006007563D1 (en) 2005-04-06 2009-08-13 Hoffmann La Roche AGONIST
US7906652B2 (en) 2005-11-28 2011-03-15 Merck Sharp & Dohme Corp. Heterocycle-substituted 3-alkyl azetidine derivatives
US20080027087A1 (en) * 2006-02-21 2008-01-31 Ampla Pharmaceuticals, Inc. CB1 antagonists and inverse agonists
WO2007110449A1 (en) * 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
WO2007118854A1 (en) 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and the use thereof
US8791264B2 (en) 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
US7629346B2 (en) 2006-06-19 2009-12-08 Hoffmann-La Roche Inc. Pyrazinecarboxamide derivatives as CB1 antagonists
WO2008038143A2 (en) * 2006-06-22 2008-04-03 Medichem, S.A. Novel solid forms of rimonabant and synthetic processes for their preparation
WO2008026219A2 (en) * 2006-09-01 2008-03-06 Hetero Drugs Limited Novel polymorphs of rimonabant
US7781593B2 (en) 2006-09-14 2010-08-24 Hoffmann-La Roche Inc. 5-phenyl-nicotinamide derivatives
CA2664310A1 (en) * 2006-09-25 2008-04-03 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
DE102007002260A1 (en) 2007-01-16 2008-07-31 Sanofi-Aventis Use of substituted pyranonic acid derivatives for the preparation of medicaments for the treatment of the metabolic syndrome
EP1953144A1 (en) * 2007-01-30 2008-08-06 Sandoz AG Novel polymorphic forms of N-piperidino-5-(4-chlorophenyl)-1-(2, 4-dichlorphenyl)-4-methyl-3-pyrazolecarboxamide
WO2008124118A1 (en) 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
US8765736B2 (en) 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
EA019315B1 (en) * 2007-12-18 2014-02-28 Санофи-Авентис Azetidine derivatives, their preparation and their application in therapy
WO2010079241A1 (en) 2009-01-12 2010-07-15 Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion Use of antagonists and/or inverse agonists of cb1 receptors for the preparation of drugs that increase motor neuron excitability
BRPI0902481B8 (en) 2009-07-31 2021-05-25 Soc Beneficente De Senhoras Hospital Sirio Libanes pharmaceutical composition comprising hemopressin and its use.
US8410107B2 (en) 2010-10-15 2013-04-02 Hoffmann-La Roche Inc. N-pyridin-3-yl or N-pyrazin-2-yl carboxamides
US8669254B2 (en) 2010-12-15 2014-03-11 Hoffman-La Roche Inc. Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents

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Also Published As

Publication number Publication date
MXPA03002845A (en) 2004-09-10
AU9393601A (en) 2002-04-15
ES2217191T5 (en) 2009-02-16
CN100409845C (en) 2008-08-13
HUP0302044A2 (en) 2003-11-28
EP1328269B2 (en) 2008-07-30
ATE267595T1 (en) 2004-06-15
CN1473040A (en) 2004-02-04
FR2814678B1 (en) 2002-12-20
ZA200303015B (en) 2004-02-26
PT1328269E (en) 2004-08-31
CA2424934A1 (en) 2002-04-11
DE60103556T2 (en) 2005-06-30
WO2002028346A2 (en) 2002-04-11
WO2002028346A3 (en) 2002-08-29
ES2217191T3 (en) 2004-11-01
AU2001293936B2 (en) 2007-01-25
EA200300441A1 (en) 2003-08-28
NO20031521D0 (en) 2003-04-03
KR20030036885A (en) 2003-05-09
BR0114410A (en) 2004-02-17
DK1328269T3 (en) 2004-09-20
FR2814678A1 (en) 2002-04-05
PL362833A1 (en) 2004-11-02
EA005924B1 (en) 2005-08-25
DK1328269T5 (en) 2009-03-16
BG107739A (en) 2004-01-30
HRP20030249A2 (en) 2005-02-28
EP1328269A2 (en) 2003-07-23
YU26103A (en) 2006-08-17
NZ524904A (en) 2004-11-26
DK1328269T4 (en) 2008-11-24
IL155236A0 (en) 2003-11-23
NO20031521L (en) 2003-04-24
SI1328269T2 (en) 2008-12-31
EP1328269B1 (en) 2004-05-26
HUP0302044A3 (en) 2005-05-30
TR200401264T4 (en) 2004-07-21
SK4032003A3 (en) 2003-09-11
JP2004512279A (en) 2004-04-22
DE60103556D1 (en) 2004-07-01
EE200300121A (en) 2005-04-15
DE60103556T3 (en) 2009-04-09
JP4221221B2 (en) 2009-02-12

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