SI1000034T1 - Substituted 6-alkylphenanthridines - Google Patents

Substituted 6-alkylphenanthridines

Info

Publication number
SI1000034T1
SI1000034T1 SI9830300T SI9830300T SI1000034T1 SI 1000034 T1 SI1000034 T1 SI 1000034T1 SI 9830300 T SI9830300 T SI 9830300T SI 9830300 T SI9830300 T SI 9830300T SI 1000034 T1 SI1000034 T1 SI 1000034T1
Authority
SI
Slovenia
Prior art keywords
alkylphenanthridines
substituted
ipharmaceutically
compositions
compounds
Prior art date
Application number
SI9830300T
Other languages
English (en)
Slovenian (sl)
Inventor
Hermann Amschler
Dieter Flockerzi
Wolf-R�diger ULRICH
Thomas Br
Thomas Martin
Christian Schudt
Armin Hatzelmann
Rolf Beume
Dietrich H�FNER
Hildegard Boss
Hans-Peter Kley
Beate Gutterer
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of SI1000034T1 publication Critical patent/SI1000034T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI9830300T 1997-07-25 1998-07-18 Substituted 6-alkylphenanthridines SI1000034T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97112794 1997-07-25
EP98942571A EP1000034B1 (en) 1997-07-25 1998-07-18 Substituted 6-alkylphenanthridines
PCT/EP1998/004476 WO1999005112A1 (en) 1997-07-25 1998-07-18 Substituted 6-alkylphenanthridines

Publications (1)

Publication Number Publication Date
SI1000034T1 true SI1000034T1 (en) 2003-04-30

Family

ID=8227118

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9830300T SI1000034T1 (en) 1997-07-25 1998-07-18 Substituted 6-alkylphenanthridines

Country Status (11)

Country Link
US (1) US6214839B1 (https=)
EP (1) EP1000034B1 (https=)
JP (1) JP2001510826A (https=)
AT (1) ATE224372T1 (https=)
AU (1) AU9066498A (https=)
DE (1) DE69808099T2 (https=)
DK (1) DK1000034T3 (https=)
ES (1) ES2184318T3 (https=)
PT (1) PT1000034E (https=)
SI (1) SI1000034T1 (https=)
WO (1) WO1999005112A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1212089B1 (en) 1999-08-21 2006-03-22 ALTANA Pharma AG Synergistic combination of roflumilast and salmeterol
PT1303506E (pt) * 2000-07-14 2005-06-30 Altana Pharma Ag 6-heteroarilfenantridinas
WO2002005616A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Novel 6-phenylphenanthridines
CA2495827C (en) 2002-08-29 2012-05-08 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
ES2281658T3 (es) * 2002-08-29 2007-10-01 Nycomed Gmbh 3-hidroxi-6-fenilfenantridinas como inhibidores de pde-4.
MXPA05010373A (es) 2003-04-01 2005-12-05 Applied Research Systems Inhibidores de fosfodiesterasas en infertilidad.
AU2005212857B2 (en) 2004-02-18 2011-04-28 Takeda Gmbh Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors
CN104803974A (zh) 2004-03-03 2015-07-29 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
JP2007527901A (ja) * 2004-03-10 2007-10-04 アルタナ　ファルマ　アクチエンゲゼルシャフト アミド置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用
WO2006026725A2 (en) 2004-08-31 2006-03-09 C.R. Bard, Inc. Self-sealing ptfe graft with kink resistance
ES2337083T3 (es) 2005-03-02 2010-04-20 Nycomed Gmbh (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1.
JP2008543376A (ja) * 2005-06-08 2008-12-04 シー・アール・バード・インコーポレーテッド 無機生体適合性カルシウム塩を有するグラフト及びステント
JP2009501027A (ja) 2005-06-17 2009-01-15 シー・アール・バード・インコーポレイテツド 締付後のよじれ耐性を有する血管移植片
WO2007056761A2 (en) 2005-11-09 2007-05-18 C.R. Bard Inc. Grafts and stent grafts having a radiopaque marker
EP2079575B1 (en) 2006-10-12 2021-06-02 C.R. Bard, Inc. Methods for making vascular grafts with multiple channels

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1199773B (de) * 1962-02-23 1965-09-02 Hoffmann La Roche Verfahren zur Herstellung von 6-Methyl-8, 9-methylendioxy-1, 2, 3, 4, 4a, 5, 6, 10b-octahydrophenanthridin und dessen Salzen
US3243438A (en) 1962-02-23 1966-03-29 Hoffmann La Roche Octahydro phenanthridine compounds
US4309545A (en) * 1980-07-28 1982-01-05 Pfizer Inc. Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof

Also Published As

Publication number Publication date
WO1999005112A1 (en) 1999-02-04
DE69808099D1 (de) 2002-10-24
JP2001510826A (ja) 2001-08-07
ES2184318T3 (es) 2003-04-01
DK1000034T3 (da) 2003-01-27
DE69808099T2 (de) 2003-05-15
AU9066498A (en) 1999-02-16
EP1000034A1 (en) 2000-05-17
PT1000034E (pt) 2003-02-28
US6214839B1 (en) 2001-04-10
ATE224372T1 (de) 2002-10-15
EP1000034B1 (en) 2002-09-18

Similar Documents

Publication Publication Date Title
SI1000034T1 (en) Substituted 6-alkylphenanthridines
DE69831937D1 (de) Bicyclische protein-farnesyl-transferase inhibitoren
MY117896A (en) Quinazoline derivatives
NZ332762A (en) Isobutylgaba and its derivatives for the treatment of pain
HU9302335D0 (en) 9-|(substituted glycyl)-amido¨-6-desmethyl-6-desoxy-tetracyclines
AU1889392A (en) Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
NO970162L (no) Substituerte pyrimidinforbindelser og anvendelse derav
GR3033020T3 (en) Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses.
TR199900186T2 (xx) H�cre proliferasyonunun engellenmesine y�nelik ikameli/katk�l� bisindolilmaleimidler
NO972379L (no) Metalloproteinaseinhibitorer
BR9708068A (pt) Método de inibição da replicação de citomegalovìrus em um mamìfero, composição anti- citomegalovìrus e composto.
YU55200A (sh) Supstituisani bisindolmaleimidi za inhibiranje ćelijske proliferacije
IL136735A0 (en) Substituted 2-benzylamino-2-phenyl-acetamide compounds
NZ332834A (en) Glycosaminoglycan-related carbohydrate derivatives ( 5 saccharide groups ) having 4 to 6 sulphate groups
PL341539A1 (en) Heterocyclic toxins of topoisomerases
GR3032698T3 (en) Organic compounds
TR199900153T2 (xx) H�cre �o�almas�n� �nlemek i�in ikame edilmi� bisindolilmaleimitler.
BG103271A (en) Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
AU2287499A (en) Azetidinecarboxamide derivatives for treating cns disorders
MX9702089A (es) Carboxamidas biciclicas como antagonistas de 5-ht1a.
HU9600300D0 (en) Thiocarbamoyl derivatives using as antimicrobial agents and process for producing of these
AU2178099A (en) Azetidinecarboxamide derivatives for treating cns disorders
AP9400608A0 (en) "New nicotinic acid derivative".
ZA982808B (en) Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of dementia
PH31212A (en) 4-Amino-2-(hetero)aryl-butanamides useful as 5-HT1a-antagonists.