SI0835659T1 - Use of non-peptidic bradykinin antagonists in the preparation of medicaments for the treatment and prevention of Alzheimer's disease - Google Patents

Use of non-peptidic bradykinin antagonists in the preparation of medicaments for the treatment and prevention of Alzheimer's disease

Info

Publication number
SI0835659T1
SI0835659T1 SI9730694T SI9730694T SI0835659T1 SI 0835659 T1 SI0835659 T1 SI 0835659T1 SI 9730694 T SI9730694 T SI 9730694T SI 9730694 T SI9730694 T SI 9730694T SI 0835659 T1 SI0835659 T1 SI 0835659T1
Authority
SI
Slovenia
Prior art keywords
alkyl
aryl
alkoxy
alzheimer
disease
Prior art date
Application number
SI9730694T
Other languages
English (en)
Slovenian (sl)
Inventor
Holger Dr. Heitsch
Klaus Dr. Wirth
Gabriele Prof. Dr. Wiemer
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996142290 external-priority patent/DE19642290A1/de
Priority claimed from DE1997129140 external-priority patent/DE19729140A1/de
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of SI0835659T1 publication Critical patent/SI0835659T1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
SI9730694T 1996-10-14 1997-10-13 Use of non-peptidic bradykinin antagonists in the preparation of medicaments for the treatment and prevention of Alzheimer's disease SI0835659T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1996142290 DE19642290A1 (de) 1996-10-14 1996-10-14 Verwendung von nicht-peptidischen Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von Prävention der Alzheimer'schen Krankheit
DE1997129140 DE19729140A1 (de) 1997-07-08 1997-07-08 Verwendung von nicht-peptidischen Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimer'schen Krankheit
EP97117677A EP0835659B1 (de) 1996-10-14 1997-10-13 Verwendung von nicht-peptidischen Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimerischen Krankheit

Publications (1)

Publication Number Publication Date
SI0835659T1 true SI0835659T1 (en) 2005-06-30

Family

ID=26030327

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9730694T SI0835659T1 (en) 1996-10-14 1997-10-13 Use of non-peptidic bradykinin antagonists in the preparation of medicaments for the treatment and prevention of Alzheimer's disease

Country Status (9)

Country Link
US (1) US5952346A (ja)
EP (1) EP0835659B1 (ja)
JP (1) JP4189045B2 (ja)
AT (1) ATE284692T1 (ja)
DE (1) DE59712118D1 (ja)
DK (1) DK0835659T3 (ja)
ES (1) ES2230581T3 (ja)
PT (1) PT835659E (ja)
SI (1) SI0835659T1 (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19642289A1 (de) * 1996-10-14 1998-04-16 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimer'schen Krankheit
US6153652A (en) 1996-11-22 2000-11-28 Elan Pharmaceuticals, Inc. N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
DE19712960A1 (de) * 1997-03-27 1998-10-01 Hoechst Ag Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten
JPH10301492A (ja) 1997-04-23 1998-11-13 Sony Corp 暗号化装置および方法、復号装置および方法、並びに情報処理装置および方法
US20030083277A1 (en) * 2000-02-24 2003-05-01 Hersh Louis B. Use of insulin degrading enzyme (IDE) for the treatment of alzheimer's disease in patients
US20030165481A1 (en) * 2000-02-24 2003-09-04 Hersh Louis B. Amyloid peptide inactivating enzyme to treat Alzheimer's disease
EP1914236A1 (en) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
AU2002950217A0 (en) * 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
EP1660092A2 (en) * 2003-07-03 2006-05-31 Myriad Genetics, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
WO2006026426A2 (en) 2004-08-27 2006-03-09 University Of Kentucky Research Foundation Amyloid peptide inactivating enzyme to treat alzheimer’s disease peripherally
EP1833482A4 (en) 2005-01-03 2011-02-16 Myriad Genetics Inc COMPOUNDS AND ITS THERAPEUTIC USE
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
JP2009527562A (ja) * 2006-02-21 2009-07-30 アムゲン インコーポレイティッド ホスホジエステラーゼ１０阻害剤としてのシンノリン誘導体
JP2009529060A (ja) * 2006-03-08 2009-08-13 アムゲン インコーポレイティッド ホスホジエステラーゼ１０阻害剤としてのキノリン及びイソキノリン誘導体
DE102006015140A1 (de) * 2006-03-31 2007-10-11 Philipps-Universität Marburg Heterozyklische Verbindungen mit Wirkung gegen neurodegenerative Erkrankungen
EP2066659B1 (de) * 2006-09-29 2013-08-28 Grünenthal GmbH Substituierte sulfonamid-derivate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385915A (en) * 1990-05-16 1995-01-31 The Rockefeller University Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation
US5216165A (en) * 1990-10-03 1993-06-01 American Home Products Corporation N-substituted aminoquinolines as analgesic agents
US5212182A (en) * 1990-10-03 1993-05-18 American Home Products Corpooration Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics
US5438064A (en) * 1991-12-23 1995-08-01 American Home Products Corporation Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic agents
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
WO1996004251A1 (fr) * 1994-08-03 1996-02-15 Fujisawa Pharmaceutical Co., Ltd. Compose heterocyclique
CN1168667A (zh) * 1994-10-27 1997-12-24 藤沢药品工业株式会社 用作缓激肽拮抗剂的吡啶并嘧啶酮，喹啉和稠合的n-杂环化合物
WO1997032585A1 (en) * 1996-03-05 1997-09-12 Medinox, Inc. Combinational therapeutic methods employing nitric oxide scavengers and compositions useful therefor

Also Published As

Publication number Publication date
DK0835659T3 (da) 2005-04-18
JPH10130144A (ja) 1998-05-19
US5952346A (en) 1999-09-14
JP4189045B2 (ja) 2008-12-03
ATE284692T1 (de) 2005-01-15
DE59712118D1 (de) 2005-01-20
EP0835659B1 (de) 2004-12-15
EP0835659A1 (de) 1998-04-15
ES2230581T3 (es) 2005-05-01
PT835659E (pt) 2005-03-31

Similar Documents

Publication Publication Date Title
SI0835659T1 (en) Use of non-peptidic bradykinin antagonists in the preparation of medicaments for the treatment and prevention of Alzheimer's disease
HK1054927A1 (en) Tropane derivatives useful in therapy
SE0104332D0 (sv) Therapeutic agents
TW200510431A (en) Quinazoline derivatives
CA2425876A1 (en) Piperidine derivatives as antagonists of tachykinins
YU25299A (sh) Paraziticidni pirazoli
HU9401877D0 (en) Anti-rheumatic naphthyridine derivatives
BG107023A (en) 3-aminoquinazolin-2,4-dione antibacterial agents
WO2001032652A3 (en) N-substituted carbamoyloxyalkyl-azolium derivatives
TW200504085A (en) Derivatives of [2-(8,9-dioxo-2, 6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of use thereof
DE50306860D1 (de) Herbizide mittel enthaltend benzoylpyrazole und safener
WO2003053971A8 (en) Pyridoquinoxaline antivirals
NZ516454A (en) Titanium compounds, preparation and use thereof
GB9801851D0 (en) Parasiticidal agents
NZ515025A (en) Solvates of pymetrozine
CA2412596A1 (en) Cyclic gmp-specific phosphodiesterase inhibitors
NO20022123L (no) Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII
AU2983792A (en) Diaminomethyleneamino substituted substituted phenyl thiazoles
HU9503852D0 (en) Use of cephem derivatives as anti-metastatic agents
HU9503597D0 (en) Use of 1,2-alkylene-1,4-dihydro-pyridine derivatives as medicine
ATE255102T1 (de) Benzothiophenderivate, ihre herstellung und verwendung als urokinase-inhibitoren
EP1023062A4 (en) ANTIBACTERIAL CARBAPENEMAS, COMPOSITIONS AND METHODS OF TREATMENT
ES2158809A1 (es) Nuevos derivados sulfonados como inhibidores de la ciclooxigenasa ii.
IT1283283B1 (it) "arileterocicli ad attivita' erbicida"
IT1283011B1 (it) Arileterocicli ad attivita' erbicida