SI0770613T1 - Substituted Imidazolidin-2,4-dione derivatives as immunomodulators - Google Patents

Substituted Imidazolidin-2,4-dione derivatives as immunomodulators

Info

Publication number
SI0770613T1
SI0770613T1 SI9630066T SI9630066T SI0770613T1 SI 0770613 T1 SI0770613 T1 SI 0770613T1 SI 9630066 T SI9630066 T SI 9630066T SI 9630066 T SI9630066 T SI 9630066T SI 0770613 T1 SI0770613 T1 SI 0770613T1
Authority
SI
Slovenia
Prior art keywords
immunomodulators
dione derivatives
substituted imidazolidin
imidazolidin
substituted
Prior art date
Application number
SI9630066T
Other languages
English (en)
Slovenian (sl)
Inventor
Oswald Dr. Zimmer
Horst Dr. B�hlke
Stephan Dr. Wnendt
Cornelia Dr. Geist-Rudolf
Kai Dr. Zwingenberger
Original Assignee
Grnenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grnenthal Gmbh filed Critical Grnenthal Gmbh
Publication of SI0770613T1 publication Critical patent/SI0770613T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
SI9630066T 1995-10-27 1996-10-08 Substituted Imidazolidin-2,4-dione derivatives as immunomodulators SI0770613T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19540027A DE19540027A1 (de) 1995-10-27 1995-10-27 Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe
EP96116069A EP0770613B1 (de) 1995-10-27 1996-10-08 Substituierte Imidazolidin-2,4-dion-Verbindungen als Immunodulatoren

Publications (1)

Publication Number Publication Date
SI0770613T1 true SI0770613T1 (en) 1999-10-31

Family

ID=7775931

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630066T SI0770613T1 (en) 1995-10-27 1996-10-08 Substituted Imidazolidin-2,4-dione derivatives as immunomodulators

Country Status (23)

Country Link
US (1) US6004963A (xx)
EP (1) EP0770613B1 (xx)
JP (1) JPH09188677A (xx)
KR (1) KR100445539B1 (xx)
CN (1) CN1097050C (xx)
AR (1) AR004517A1 (xx)
AT (1) ATE181072T1 (xx)
AU (1) AU707751B2 (xx)
CA (1) CA2188908A1 (xx)
CO (1) CO4750655A1 (xx)
DE (2) DE19540027A1 (xx)
DK (1) DK0770613T3 (xx)
ES (1) ES2135148T3 (xx)
GR (1) GR3030558T3 (xx)
HK (1) HK1010367A1 (xx)
HU (1) HU222120B1 (xx)
IL (1) IL119488A (xx)
MX (1) MX9605023A (xx)
PE (1) PE20011055A1 (xx)
PL (1) PL184446B1 (xx)
RU (1) RU2163603C2 (xx)
SI (1) SI0770613T1 (xx)
ZA (1) ZA968956B (xx)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19732928C2 (de) * 1997-07-31 2000-05-18 Gruenenthal Gmbh Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel
DE19917961A1 (de) 1999-04-21 2000-10-26 Degussa Verfahren zur Herstellung von Aminosäurederivaten
WO2001007048A1 (en) * 1999-07-21 2001-02-01 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
ES2284641T3 (es) 2000-05-31 2007-11-16 Tanabe Seiyaku Co., Ltd. Inhibidores de la adhesion celular mediada por alfa-l-beta-2.
US7354933B2 (en) 2003-01-31 2008-04-08 Aventis Pharma Sa Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
FR2850652B1 (fr) * 2003-01-31 2008-05-30 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
WO2005090316A1 (en) * 2004-03-12 2005-09-29 Wyeth HYDANTOINS HAVING RNase MODULATORY ACTIVITY
EP1621536A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621535A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
FR2896504B1 (fr) * 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
FR2896503B1 (fr) * 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
AU2012241184B2 (en) * 2006-03-27 2016-01-07 The Regents Of The University Of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
AU2016201061B2 (en) * 2006-03-27 2017-03-02 The Regents Of The University Of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
AU2013205325B2 (en) * 2006-03-27 2016-03-24 The Regents Of The University Of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
EP3412290B1 (en) * 2006-03-27 2021-03-03 The Regents of The University of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
CN101460467B (zh) * 2006-03-29 2012-09-19 加利福尼亚大学董事会 二芳基硫代乙内酰脲化合物
WO2008021309A1 (en) * 2006-08-15 2008-02-21 Wyeth Imidazolidin-2-one derivatives useful as pr modulators
US7649007B2 (en) * 2006-08-15 2010-01-19 Wyeth Llc Oxazolidine derivatives as PR modulators
WO2008021337A1 (en) 2006-08-15 2008-02-21 Wyeth Oxazinan-2-one derivatives useful as pr modulators
TW200815428A (en) 2006-08-15 2008-04-01 Wyeth Corp Oxazolidone derivatives as PR modulators
CA2661315C (en) * 2006-09-08 2015-11-24 Actelion Pharmaceuticals Ltd Pyridin-3-yl derivatives as immunomodulating agents
JP5535925B2 (ja) 2007-10-26 2014-07-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アンドロゲン受容体調節物質としてのジアリールヒダントイン化合物
SG192439A1 (en) * 2008-06-27 2013-08-30 Novartis Ag Organic compounds
RS53075B (en) 2009-05-12 2014-04-30 Janssen Pharmaceuticals Inc. 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
SI3124481T1 (en) 2010-02-16 2018-06-29 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and their use
MY180834A (en) 2012-09-26 2020-12-10 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
AU2018351714A1 (en) 2017-10-16 2020-04-30 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091596B1 (de) * 1982-04-08 1991-09-11 Shell Internationale Researchmaatschappij B.V. Neue Hydantoine, ihre Herstellung und Verwendung
US4746669A (en) * 1985-12-23 1988-05-24 Merck & Co., Inc. Substituted thiazoles as immunoregulants
JPH02101065A (ja) * 1988-10-06 1990-04-12 Tanabe Seiyaku Co Ltd イミダゾリン誘導体及びその製法
EP0557408A4 (en) * 1990-11-06 1993-10-27 Smith-Kline Beecham Corporation Imidazolidinone compounds
IL110296A (en) * 1993-07-16 1999-12-31 Smithkline Beecham Corp Imidazole compounds process for their preparation and pharmaceutical compositions containing them
US7466669B2 (en) * 2003-11-14 2008-12-16 Telefonaktiebolaget Lm Ericsson (Publ) Reverse link scheduler for CDMA networks

Also Published As

Publication number Publication date
CO4750655A1 (es) 1999-03-31
HU222120B1 (hu) 2003-04-28
KR100445539B1 (ko) 2004-12-30
EP0770613A1 (de) 1997-05-02
ZA968956B (en) 1997-05-29
IL119488A0 (en) 1997-01-10
IL119488A (en) 2001-01-11
HK1010367A1 (en) 1999-06-17
DE19540027A1 (de) 1997-04-30
KR970021076A (ko) 1997-05-28
MX9605023A (es) 1997-06-28
HUP9602932A3 (en) 1998-08-28
CN1152573A (zh) 1997-06-25
ATE181072T1 (de) 1999-06-15
AR004517A1 (es) 1998-12-16
AU707751B2 (en) 1999-07-22
EP0770613B1 (de) 1999-06-09
RU2163603C2 (ru) 2001-02-27
CN1097050C (zh) 2002-12-25
AU6818196A (en) 1997-05-01
GR3030558T3 (en) 1999-10-29
DE59602155D1 (de) 1999-07-15
PL316706A1 (en) 1997-04-28
ES2135148T3 (es) 1999-10-16
PL184446B1 (pl) 2002-10-31
HU9602932D0 (en) 1996-12-30
DK0770613T3 (da) 1999-12-13
CA2188908A1 (en) 1997-04-28
HUP9602932A2 (hu) 1998-07-28
PE20011055A1 (es) 2001-12-29
JPH09188677A (ja) 1997-07-22
US6004963A (en) 1999-12-21

Similar Documents

Publication Publication Date Title
HK1010367A1 (en) Substituted imidazolidin-2,4-dione derivatives as immunomodulators
AU1157095A (en) Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives
AU4754093A (en) Substituted 1-H-3-aryl-pyrrolidine-2,4-dione derivatives
AU1416695A (en) 1-H-3-aryl-pyrrolidine-2,4-dione derivatives as pesticides
AU7649191A (en) 1-h-3-aryl-pyrrolidine-2,4-dione derivatives
ZA924746B (en) Substituted 1h-3-aryl-pyrrolidine-2,4-dione derivatives
EG25227A (en) Heterocyclic compounds.
ZA965935B (en) Heterocyclic compounds.
ZA964725B (en) Heterocyclic ring-fused pyrimidine derivatives.
ZA97912B (en) Heterocyclic compounds.
AU3926697A (en) Substituted diamino-1,3,5-triazine derivatives
ZA9811599B (en) Ortho-anthranilamide derivatives as anti-coagulants.
ZA97521B (en) 19-Nor-pregnene derivatives.
CY2380B1 (en) Pde IV inhibiting 2-cyanoiminoimidazole derivatives.
HK1018457A1 (en) Alkylaminobenzothiazole and-benzoxazole derivatives.
AU2231397A (en) Thiazolidine-2,4-dione derivatives
ZA98755B (en) Substituted hydroxy-anilino derivatives of cyclobutane-3,4-diones.
ZA974953B (en) Substituted pyrazolylpyrazole derivatives.
ZA979617B (en) Novel heterocyclic compounds.
PL327681A1 (en) Novel derivatives of hexahydro-1,4-diazepin or their salts
ZA982436B (en) Thiazolimine derivatives.
ZA9810039B (en) Azoline derivatives
ZA937988B (en) Substituted 1-H-3-aryl-pyrrolidine-2,4-dione derivatives
AU9457898A (en) 4-aryl-4-substituted pyrazolidine-3,5-dione derivatives
ZA967997B (en) Urea derivatives.

Legal Events

Date Code Title Description
KO00 Lapse of patent

Effective date: 20080528