SG44510A1 - Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring - Google Patents
Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ringInfo
- Publication number
- SG44510A1 SG44510A1 SG1996001200A SG1996001200A SG44510A1 SG 44510 A1 SG44510 A1 SG 44510A1 SG 1996001200 A SG1996001200 A SG 1996001200A SG 1996001200 A SG1996001200 A SG 1996001200A SG 44510 A1 SG44510 A1 SG 44510A1
- Authority
- SG
- Singapore
- Prior art keywords
- compound
- formula
- pct
- disclosed
- imidazolyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80978191A | 1991-12-18 | 1991-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG44510A1 true SG44510A1 (en) | 1997-12-19 |
Family
ID=25202205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1996001200A SG44510A1 (en) | 1991-12-18 | 1992-12-17 | Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring |
Country Status (20)
Country | Link |
---|---|
US (1) | US5463074A (fr) |
EP (1) | EP0618913B1 (fr) |
JP (1) | JPH07121939B2 (fr) |
KR (1) | KR0142802B1 (fr) |
AT (1) | ATE141269T1 (fr) |
AU (1) | AU671092B2 (fr) |
CA (1) | CA2129679C (fr) |
DE (1) | DE69212844T2 (fr) |
DK (1) | DK0618913T3 (fr) |
ES (1) | ES2090956T3 (fr) |
GR (1) | GR3021464T3 (fr) |
HK (1) | HK31397A (fr) |
IL (1) | IL104125A (fr) |
MX (1) | MX9207393A (fr) |
MY (1) | MY110108A (fr) |
NZ (1) | NZ246441A (fr) |
SG (1) | SG44510A1 (fr) |
TW (1) | TW268950B (fr) |
WO (1) | WO1993012108A1 (fr) |
ZA (1) | ZA929788B (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5633250A (en) * | 1991-12-18 | 1997-05-27 | Schering Corporation | Imidazoylalkyl substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms |
FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
EP0842172A1 (fr) * | 1995-06-29 | 1998-05-20 | Novo Nordisk A/S | Nouveaux composes azacycliques et azabicycliques substitues |
JP2000507597A (ja) * | 1996-04-03 | 2000-06-20 | メルク エンド カンパニー インコーポレーテッド | ファルネシルタンパク質トランスフェラーゼ阻害剤 |
EP0891360A4 (fr) * | 1996-04-03 | 2002-05-15 | Merck & Co Inc | Inhibiteurs de la farnesyl-proteine transferase |
US6072057A (en) * | 1996-06-06 | 2000-06-06 | Gliatech Inc. | 1H-4(5)-cyclo-substituted imidazole derivatives as histamine H3 receptor agents |
US6407132B1 (en) | 1997-07-25 | 2002-06-18 | James Black Foundation Limited | Substituted imidazole derivatives and their use as histamine H3 receptor ligands |
US5990147A (en) * | 1997-11-07 | 1999-11-23 | Schering Corporation | H3 receptor ligands of the phenyl-alkyl-imidazoles type |
US6034251A (en) * | 1997-11-07 | 2000-03-07 | Schering Corporation | Phenyl-alkyl-imidazoles |
AU1296799A (en) * | 1997-11-07 | 1999-05-31 | Schering Corporation | Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom |
US6028095A (en) * | 1998-10-15 | 2000-02-22 | Warner-Lambert Company | Treatment of inflammatory bowel disease using histamine H3 -receptor agonists |
US6133291A (en) * | 1998-10-16 | 2000-10-17 | Schering Corporation | N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists |
US6100279A (en) * | 1998-11-05 | 2000-08-08 | Schering Corporation | Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom |
AU3033100A (en) | 1999-01-18 | 2000-08-01 | Boehringer Ingelheim International Gmbh | Substituted imidazoles, their preparation and use |
US6908926B1 (en) | 1999-04-16 | 2005-06-21 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
GB9924941D0 (en) * | 1999-10-22 | 1999-12-22 | Univ Manchester | Treatment of dyskinesia |
US6610721B2 (en) | 2000-03-17 | 2003-08-26 | Novo Nordisk A/S | Imidazo heterocyclic compounds |
US6437147B1 (en) | 2000-03-17 | 2002-08-20 | Novo Nordisk | Imidazole compounds |
PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
WO2002072093A2 (fr) | 2001-02-08 | 2002-09-19 | Schering Corporation | Utilisation d'antagonistes doubles h3 et m2 dans le traitement de troubles cognitifs |
US6849621B2 (en) * | 2001-03-13 | 2005-02-01 | Schering Corporation | Piperidine compounds |
FR2827863A1 (fr) * | 2001-07-27 | 2003-01-31 | Sanofi Synthelabo | Derives d'aminoalkylimidazole, leur preparation et leur utilisation en therapeutique |
US7332508B2 (en) * | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
GB0505969D0 (en) | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
EP1707203A1 (fr) | 2005-04-01 | 2006-10-04 | Bioprojet | Utilization des allkylamines sans imidazoles comme ligandes du recepteur histamine H3 pour le traitement de la maladie de Parkinson, de l'apnee obstructive du sommeil, de la demence vasculaire et de la demence avec corps de Lewy |
EP1717235A3 (fr) | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines et leur utilisation comme ligands du récepteur histaminique H3 |
EP1717233A1 (fr) * | 2005-04-29 | 2006-11-02 | Bioprojet | Ligands du récepteur histaminique H3 et leur application thérapeutique |
GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
JP5306821B2 (ja) | 2005-12-30 | 2013-10-02 | ノバルティス アーゲー | レニン阻害剤としての3,5−置換ピペリジン化合物 |
ES2543641T3 (es) | 2007-06-25 | 2015-08-20 | Novartis Ag | Derivados de N5-(2-etoxietil)-N3-(2-piridinil)-3,5-piperidinadicarboxamida para uso como inhibidores de renina |
WO2013151982A1 (fr) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Méthodes et composés utiles pour traiter le prurit, et procédés d'identification desdits composés |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2987522A (en) * | 1958-03-17 | 1961-06-06 | Petrolite Corp | Amidine products |
US3491098A (en) * | 1967-05-29 | 1970-01-20 | Sterling Drug Inc | 1-((imidazolyl)-lower-alkyl)-4-substituted-piperazines |
US3470197A (en) * | 1967-08-30 | 1969-09-30 | Miles Lab | 1-substituted derivatives of 3-ethyl-4 - (1-methylimidazolyl-(5)-methyl)-2-pyrrolidinone |
US4011238A (en) * | 1972-07-26 | 1977-03-08 | Gruppo Lepetit S.P.A. | 2-imidazolidione derivatives |
DE2862340D1 (en) * | 1978-02-01 | 1983-11-24 | Wellcome Found | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof |
GR73560B (fr) * | 1979-02-24 | 1984-03-15 | Pfizer | |
DK151884C (da) * | 1979-03-07 | 1988-06-13 | Pfizer | Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
US4404382A (en) * | 1980-09-17 | 1983-09-13 | The Upjohn Company | Piperazinyl-substituted imidazoles |
US4404387A (en) * | 1980-09-17 | 1983-09-13 | The Upjohn Company | Aminoalkyl-substituted imidazoles |
US4431653A (en) * | 1982-03-18 | 1984-02-14 | Hoffmann-La Roche Inc. | Penicillanic acid derivatives |
DE3313073A1 (de) * | 1983-04-12 | 1984-10-18 | Bayer Ag, 5090 Leverkusen | 1-azolyl-3-pyrazolyl-2-propanol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
US4581370A (en) * | 1983-07-12 | 1986-04-08 | Schering A.G. | Antiarrhythmic imidazoliums |
DK704488D0 (da) * | 1988-12-19 | 1988-12-19 | Novo Industri As | Nye n-substituerede azaheterocykliske carboxylsyrer |
FR2579596B1 (fr) * | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
FR2586562B1 (fr) * | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
US5010075A (en) * | 1987-04-24 | 1991-04-23 | Syntex Pharmaceuticals Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
US5091428A (en) * | 1987-04-24 | 1992-02-25 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
US4935417A (en) * | 1987-04-24 | 1990-06-19 | Syntex Pharmaceuticals Ltd. | Sustituted imidazolyl-alkyl-piperazine and -diazepine derivatives for treating cerebrovascular disease |
DE3811574A1 (de) * | 1988-03-31 | 1989-10-19 | Schering Ag | N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
FR2630328B1 (fr) * | 1988-04-22 | 1990-08-24 | Inst Nat Sante Rech Med | Derive de l'histamine, sa preparation et son application en therapeutique |
US4925851A (en) * | 1989-05-23 | 1990-05-15 | Sandoz Pharmaceuticals Corp. | 2- or 4-substituted-[2-(1H-imidazol-1-yl)ethyl]piperidines |
US5264449A (en) * | 1989-11-13 | 1993-11-23 | Allergan, Inc. | N-substituted derivatives of 3R,4R-ethyl-[(1-methyl-1H-imidazol-5-yl)methyl]-2-pyrrolidinone |
US5066663A (en) * | 1990-05-21 | 1991-11-19 | Warner-Lambert Company | Substituted-hetero-cyclopentanones and cyclopentenones and derivatives thereof acting at muscarinic receptors |
SK118794A3 (en) * | 1992-04-01 | 1995-06-07 | Univ Toledo | 4(4'-piperidinyl or 3'- pyrrolidinyl) substitutes imidazoles as h3-receptor |
-
1992
- 1992-12-17 SG SG1996001200A patent/SG44510A1/en unknown
- 1992-12-17 NZ NZ246441A patent/NZ246441A/en unknown
- 1992-12-17 MX MX9207393A patent/MX9207393A/es not_active IP Right Cessation
- 1992-12-17 AT AT93901329T patent/ATE141269T1/de not_active IP Right Cessation
- 1992-12-17 JP JP5511100A patent/JPH07121939B2/ja not_active Expired - Fee Related
- 1992-12-17 MY MYPI92002334A patent/MY110108A/en unknown
- 1992-12-17 WO PCT/US1992/010743 patent/WO1993012108A1/fr active IP Right Grant
- 1992-12-17 ES ES93901329T patent/ES2090956T3/es not_active Expired - Lifetime
- 1992-12-17 TW TW081110144A patent/TW268950B/zh active
- 1992-12-17 IL IL10412592A patent/IL104125A/xx not_active IP Right Cessation
- 1992-12-17 AU AU32773/93A patent/AU671092B2/en not_active Ceased
- 1992-12-17 EP EP93901329A patent/EP0618913B1/fr not_active Expired - Lifetime
- 1992-12-17 US US08/244,851 patent/US5463074A/en not_active Expired - Fee Related
- 1992-12-17 ZA ZA929788A patent/ZA929788B/xx unknown
- 1992-12-17 DE DE69212844T patent/DE69212844T2/de not_active Expired - Fee Related
- 1992-12-17 DK DK93901329.8T patent/DK0618913T3/da active
- 1992-12-17 CA CA002129679A patent/CA2129679C/fr not_active Expired - Fee Related
- 1992-12-27 KR KR94701079A patent/KR0142802B1/ko active
-
1996
- 1996-10-24 GR GR960402819T patent/GR3021464T3/el unknown
-
1997
- 1997-03-13 HK HK31397A patent/HK31397A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1993012108A1 (fr) | 1993-06-24 |
JPH06511009A (ja) | 1994-12-08 |
JPH07121939B2 (ja) | 1995-12-25 |
NZ246441A (en) | 1996-02-27 |
AU3277393A (en) | 1993-07-19 |
MY110108A (en) | 1998-01-27 |
ATE141269T1 (de) | 1996-08-15 |
DK0618913T3 (da) | 1996-10-14 |
DE69212844D1 (de) | 1996-09-19 |
GR3021464T3 (en) | 1997-01-31 |
AU671092B2 (en) | 1996-08-15 |
CA2129679A1 (fr) | 1993-06-24 |
KR0142802B1 (en) | 1998-07-15 |
ZA929788B (en) | 1993-06-22 |
EP0618913A1 (fr) | 1994-10-12 |
MX9207393A (es) | 1994-06-30 |
CA2129679C (fr) | 2000-05-09 |
IL104125A (en) | 2000-08-31 |
DE69212844T2 (de) | 1997-01-09 |
IL104125A0 (en) | 1993-05-13 |
ES2090956T3 (es) | 1996-10-16 |
EP0618913B1 (fr) | 1996-08-14 |
KR940703826A (fr) | 1994-12-12 |
US5463074A (en) | 1995-10-31 |
HK31397A (en) | 1997-03-21 |
TW268950B (fr) | 1996-01-21 |
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