SG194926A1 - Viscous nutritional composition - Google Patents
Viscous nutritional composition Download PDFInfo
- Publication number
- SG194926A1 SG194926A1 SG2013083878A SG2013083878A SG194926A1 SG 194926 A1 SG194926 A1 SG 194926A1 SG 2013083878 A SG2013083878 A SG 2013083878A SG 2013083878 A SG2013083878 A SG 2013083878A SG 194926 A1 SG194926 A1 SG 194926A1
- Authority
- SG
- Singapore
- Prior art keywords
- viscosity
- composition
- nutritional composition
- shear rate
- shear
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 383
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 199
- 238000010438 heat treatment Methods 0.000 claims abstract description 92
- 239000002671 adjuvant Substances 0.000 claims abstract description 69
- 238000005243 fluidization Methods 0.000 claims abstract description 44
- 238000004519 manufacturing process Methods 0.000 claims abstract description 34
- 235000013325 dietary fiber Nutrition 0.000 claims description 116
- 239000002562 thickening agent Substances 0.000 claims description 84
- 238000011282 treatment Methods 0.000 claims description 82
- 238000000265 homogenisation Methods 0.000 claims description 63
- 229920002472 Starch Polymers 0.000 claims description 57
- 235000019698 starch Nutrition 0.000 claims description 57
- 239000008107 starch Substances 0.000 claims description 55
- 238000005259 measurement Methods 0.000 claims description 43
- 239000003995 emulsifying agent Substances 0.000 claims description 41
- 102000004169 proteins and genes Human genes 0.000 claims description 37
- 108090000623 proteins and genes Proteins 0.000 claims description 37
- 229920001525 carrageenan Polymers 0.000 claims description 36
- 239000000679 carrageenan Substances 0.000 claims description 36
- 229940113118 carrageenan Drugs 0.000 claims description 36
- 235000010469 Glycine max Nutrition 0.000 claims description 35
- 239000007864 aqueous solution Substances 0.000 claims description 30
- 244000068988 Glycine max Species 0.000 claims description 29
- 230000001965 increasing effect Effects 0.000 claims description 28
- 239000000835 fiber Substances 0.000 claims description 19
- 238000005338 heat storage Methods 0.000 claims description 19
- 235000000346 sugar Nutrition 0.000 claims description 19
- 150000002632 lipids Chemical class 0.000 claims description 15
- 238000003825 pressing Methods 0.000 claims description 14
- 238000003860 storage Methods 0.000 claims description 11
- 235000013339 cereals Nutrition 0.000 claims description 9
- 240000004584 Tamarindus indica Species 0.000 claims description 5
- 235000004298 Tamarindus indica Nutrition 0.000 claims description 5
- 229920002907 Guar gum Polymers 0.000 claims description 4
- 229920000161 Locust bean gum Polymers 0.000 claims description 4
- 235000010417 guar gum Nutrition 0.000 claims description 4
- 239000000665 guar gum Substances 0.000 claims description 4
- 229960002154 guar gum Drugs 0.000 claims description 4
- 235000010420 locust bean gum Nutrition 0.000 claims description 4
- 239000000711 locust bean gum Substances 0.000 claims description 4
- 235000010451 Plantago psyllium Nutrition 0.000 claims description 3
- 244000090599 Plantago psyllium Species 0.000 claims description 3
- 235000021056 liquid food Nutrition 0.000 abstract description 49
- 238000000034 method Methods 0.000 abstract description 15
- 238000002156 mixing Methods 0.000 abstract description 5
- 238000011049 filling Methods 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 239000007858 starting material Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 description 67
- 238000004659 sterilization and disinfection Methods 0.000 description 45
- 230000001954 sterilising effect Effects 0.000 description 41
- 235000018102 proteins Nutrition 0.000 description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 32
- 239000012530 fluid Substances 0.000 description 28
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 25
- 235000013305 food Nutrition 0.000 description 20
- 229920001353 Dextrin Polymers 0.000 description 18
- 239000005018 casein Substances 0.000 description 18
- 239000004375 Dextrin Substances 0.000 description 17
- 235000019425 dextrin Nutrition 0.000 description 17
- 235000013336 milk Nutrition 0.000 description 16
- 239000008267 milk Substances 0.000 description 16
- 210000004080 milk Anatomy 0.000 description 16
- 239000000126 substance Substances 0.000 description 16
- 229920001817 Agar Polymers 0.000 description 15
- 239000008272 agar Substances 0.000 description 15
- 235000010419 agar Nutrition 0.000 description 15
- 235000010418 carrageenan Nutrition 0.000 description 15
- 150000002148 esters Chemical class 0.000 description 15
- 239000002253 acid Substances 0.000 description 14
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 14
- 239000000047 product Substances 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 12
- 235000021240 caseins Nutrition 0.000 description 12
- -1 organic acid esters Chemical class 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 11
- 239000002994 raw material Substances 0.000 description 11
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 10
- 235000021307 Triticum Nutrition 0.000 description 10
- 241000209140 Triticum Species 0.000 description 10
- 206010012735 Diarrhoea Diseases 0.000 description 9
- 229920000881 Modified starch Polymers 0.000 description 9
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 9
- 150000001720 carbohydrates Chemical class 0.000 description 9
- 235000014633 carbohydrates Nutrition 0.000 description 9
- 239000001913 cellulose Substances 0.000 description 9
- 229920002678 cellulose Polymers 0.000 description 9
- 230000007423 decrease Effects 0.000 description 9
- 239000007857 degradation product Substances 0.000 description 9
- 235000021245 dietary protein Nutrition 0.000 description 9
- 229920001282 polysaccharide Polymers 0.000 description 9
- 239000005017 polysaccharide Substances 0.000 description 9
- 150000004804 polysaccharides Chemical class 0.000 description 9
- 150000008163 sugars Chemical class 0.000 description 9
- 229920002245 Dextrose equivalent Polymers 0.000 description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 8
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 239000000194 fatty acid Substances 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 150000007524 organic acids Chemical class 0.000 description 8
- 239000011734 sodium Substances 0.000 description 8
- 229910052708 sodium Inorganic materials 0.000 description 8
- 241000196324 Embryophyta Species 0.000 description 7
- 229930006000 Sucrose Natural products 0.000 description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 235000019197 fats Nutrition 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000005720 sucrose Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 102000014171 Milk Proteins Human genes 0.000 description 6
- 108010011756 Milk Proteins Proteins 0.000 description 6
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 6
- 244000046052 Phaseolus vulgaris Species 0.000 description 6
- 102000007544 Whey Proteins Human genes 0.000 description 6
- 108010046377 Whey Proteins Proteins 0.000 description 6
- 240000008042 Zea mays Species 0.000 description 6
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 description 6
- 235000021239 milk protein Nutrition 0.000 description 6
- 239000011707 mineral Substances 0.000 description 6
- DNISEZBAYYIQFB-PHDIDXHHSA-N (2r,3r)-2,3-diacetyloxybutanedioic acid Chemical compound CC(=O)O[C@@H](C(O)=O)[C@H](C(O)=O)OC(C)=O DNISEZBAYYIQFB-PHDIDXHHSA-N 0.000 description 5
- 241000195493 Cryptophyta Species 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 240000007594 Oryza sativa Species 0.000 description 5
- 235000007164 Oryza sativa Nutrition 0.000 description 5
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 5
- 238000007796 conventional method Methods 0.000 description 5
- 235000005822 corn Nutrition 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 235000013312 flour Nutrition 0.000 description 5
- 235000011194 food seasoning agent Nutrition 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 5
- 235000009566 rice Nutrition 0.000 description 5
- 229930003231 vitamin Natural products 0.000 description 5
- 235000013343 vitamin Nutrition 0.000 description 5
- 239000011782 vitamin Substances 0.000 description 5
- 229940088594 vitamin Drugs 0.000 description 5
- 229920002261 Corn starch Polymers 0.000 description 4
- 102000002322 Egg Proteins Human genes 0.000 description 4
- 108010000912 Egg Proteins Proteins 0.000 description 4
- 229920002488 Hemicellulose Polymers 0.000 description 4
- 244000017020 Ipomoea batatas Species 0.000 description 4
- 235000002678 Ipomoea batatas Nutrition 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 229940099112 cornstarch Drugs 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229920001592 potato starch Polymers 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 239000001384 succinic acid Substances 0.000 description 4
- 239000006188 syrup Substances 0.000 description 4
- 235000020357 syrup Nutrition 0.000 description 4
- 230000008719 thickening Effects 0.000 description 4
- 235000021119 whey protein Nutrition 0.000 description 4
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 3
- WOKDXPHSIQRTJF-UHFFFAOYSA-N 3-[3-[3-[3-[3-[3-[3-[3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)CO WOKDXPHSIQRTJF-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 244000075850 Avena orientalis Species 0.000 description 3
- 235000007319 Avena orientalis Nutrition 0.000 description 3
- 244000077995 Coix lacryma jobi Species 0.000 description 3
- 241001428166 Eucheuma Species 0.000 description 3
- 229920002581 Glucomannan Polymers 0.000 description 3
- 240000005979 Hordeum vulgare Species 0.000 description 3
- 235000007340 Hordeum vulgare Nutrition 0.000 description 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000003434 Sesamum indicum Nutrition 0.000 description 3
- 235000002595 Solanum tuberosum Nutrition 0.000 description 3
- 244000061456 Solanum tuberosum Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000008120 corn starch Substances 0.000 description 3
- 230000001804 emulsifying effect Effects 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 229940046240 glucomannan Drugs 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 235000015110 jellies Nutrition 0.000 description 3
- 239000008274 jelly Substances 0.000 description 3
- 239000000787 lecithin Substances 0.000 description 3
- 235000010445 lecithin Nutrition 0.000 description 3
- 229940067606 lecithin Drugs 0.000 description 3
- 238000000691 measurement method Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- WZYRMLAWNVOIEX-MOJAZDJTSA-N (2s)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyacetaldehyde Chemical compound O=C[C@@H](O)[C@@H]1OC[C@H](O)[C@H]1O WZYRMLAWNVOIEX-MOJAZDJTSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical group OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- 108010085238 Actins Proteins 0.000 description 2
- 102000007469 Actins Human genes 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical group OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241001474374 Blennius Species 0.000 description 2
- 241000219198 Brassica Species 0.000 description 2
- 235000011331 Brassica Nutrition 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- 235000007354 Coix lacryma jobi Nutrition 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 244000239348 Echinochloa crus galli var. praticola Species 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241000220485 Fabaceae Species 0.000 description 2
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 2
- 240000008620 Fagopyrum esculentum Species 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 229920001503 Glucan Polymers 0.000 description 2
- 108010068370 Glutens Proteins 0.000 description 2
- 239000005913 Maltodextrin Substances 0.000 description 2
- 229920002774 Maltodextrin Polymers 0.000 description 2
- 240000003183 Manihot esculenta Species 0.000 description 2
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 2
- 108060008487 Myosin Proteins 0.000 description 2
- 102000003505 Myosin Human genes 0.000 description 2
- 235000007199 Panicum miliaceum Nutrition 0.000 description 2
- 240000008114 Panicum miliaceum Species 0.000 description 2
- 235000006089 Phaseolus angularis Nutrition 0.000 description 2
- 235000010582 Pisum sativum Nutrition 0.000 description 2
- 240000004713 Pisum sativum Species 0.000 description 2
- 235000019484 Rapeseed oil Nutrition 0.000 description 2
- 244000040738 Sesamum orientale Species 0.000 description 2
- 240000005498 Setaria italica Species 0.000 description 2
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 2
- 244000062793 Sorghum vulgare Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- 235000010711 Vigna angularis Nutrition 0.000 description 2
- 240000007098 Vigna angularis Species 0.000 description 2
- 240000004922 Vigna radiata Species 0.000 description 2
- 235000010721 Vigna radiata var radiata Nutrition 0.000 description 2
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 description 2
- 239000005862 Whey Substances 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 210000000991 chicken egg Anatomy 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 239000011362 coarse particle Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 235000008504 concentrate Nutrition 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 210000002969 egg yolk Anatomy 0.000 description 2
- 235000013345 egg yolk Nutrition 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical class CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000012041 food component Nutrition 0.000 description 2
- 229930182830 galactose Natural products 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 229920005610 lignin Polymers 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 229940035034 maltodextrin Drugs 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 235000002252 panizo Nutrition 0.000 description 2
- 239000001814 pectin Substances 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 229920001277 pectin Polymers 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920000223 polyglycerol Polymers 0.000 description 2
- 235000012015 potatoes Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- AVZIYOYFVVSTGQ-RBWRNIRVSA-N (z)-octadec-9-enoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O AVZIYOYFVVSTGQ-RBWRNIRVSA-N 0.000 description 1
- PHDVPEOLXYBNJY-KTKRTIGZSA-N 2-(2-hydroxyethoxy)ethyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCOCCO PHDVPEOLXYBNJY-KTKRTIGZSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 108010043137 Actomyosin Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 244000291564 Allium cepa Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 241000219318 Amaranthus Species 0.000 description 1
- 244000247812 Amorphophallus rivieri Species 0.000 description 1
- 235000001206 Amorphophallus rivieri Nutrition 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 240000005528 Arctium lappa Species 0.000 description 1
- 235000003130 Arctium lappa Nutrition 0.000 description 1
- 235000008078 Arctium minus Nutrition 0.000 description 1
- 244000028550 Auricularia auricula Species 0.000 description 1
- 235000000023 Auricularia auricula Nutrition 0.000 description 1
- 241000209764 Avena fatua Species 0.000 description 1
- 235000007558 Avena sp Nutrition 0.000 description 1
- 229920002749 Bacterial cellulose Polymers 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 240000005589 Calophyllum inophyllum Species 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 235000014036 Castanea Nutrition 0.000 description 1
- 241001070941 Castanea Species 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 241001147468 Chondrus ocellatus Species 0.000 description 1
- 235000010523 Cicer arietinum Nutrition 0.000 description 1
- 244000045195 Cicer arietinum Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 240000001980 Cucurbita pepo Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 208000035944 Duodenal fistula Diseases 0.000 description 1
- 241000323792 Emus Species 0.000 description 1
- 101710145505 Fiber protein Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010065713 Gastric Fistula Diseases 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- 108010061711 Gliadin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001507124 Hypnea charoides Species 0.000 description 1
- 241001147493 Iridaea Species 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 235000003228 Lactuca sativa Nutrition 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 240000000599 Lentinula edodes Species 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 244000070406 Malus silvestris Species 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- 108010070551 Meat Proteins Proteins 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 240000005561 Musa balbisiana Species 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 108010001441 Phosphopeptides Proteins 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 101710109488 Salt stress-induced protein Proteins 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 244000000231 Sesamum indicum Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 235000010749 Vicia faba Nutrition 0.000 description 1
- 240000006677 Vicia faba Species 0.000 description 1
- 229930003270 Vitamin B Chemical group 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003316 Vitamin D Chemical group 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Chemical group C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 229930003448 Vitamin K Chemical group 0.000 description 1
- 229920002000 Xyloglucan Polymers 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 235000021016 apples Nutrition 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 239000005016 bacterial cellulose Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 235000021015 bananas Nutrition 0.000 description 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 150000001746 carotenes Chemical group 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 235000021185 dessert Nutrition 0.000 description 1
- FYGDTMLNYKFZSV-MRCIVHHJSA-N dextrin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](CO)OC(O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-MRCIVHHJSA-N 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- KOWVMYVNEXNXDF-UHFFFAOYSA-N dodecanoic acid propane-1,2,3-triol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.CCCCCCCCCCCC(O)=O KOWVMYVNEXNXDF-UHFFFAOYSA-N 0.000 description 1
- SELHWUUCTWVZOV-UHFFFAOYSA-N dodecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.CCCCCCCCCCCC(O)=O SELHWUUCTWVZOV-UHFFFAOYSA-N 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 230000005183 environmental health Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 1
- 229940107187 fructooligosaccharide Drugs 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000021255 galacto-oligosaccharides Nutrition 0.000 description 1
- 150000003271 galactooligosaccharides Chemical class 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 108010083391 glycinin Proteins 0.000 description 1
- 235000011868 grain product Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000000252 konjac Substances 0.000 description 1
- 235000010485 konjac Nutrition 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 150000003272 mannan oligosaccharides Chemical class 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000001087 myotubule Anatomy 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 235000013808 oxidized starch Nutrition 0.000 description 1
- 239000001254 oxidized starch Substances 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Chemical group CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical class CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 1
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 238000010583 slow cooling Methods 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003900 succinic acid esters Chemical class 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical class CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- JYKSTGLAIMQDRA-UHFFFAOYSA-N tetraglycerol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO JYKSTGLAIMQDRA-UHFFFAOYSA-N 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Chemical group 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Chemical group 0.000 description 1
- 150000003710 vitamin D derivatives Chemical group 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Chemical group 0.000 description 1
- 150000003721 vitamin K derivatives Chemical group 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 235000008939 whole milk Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229920001221 xylan Polymers 0.000 description 1
- 150000004823 xylans Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pediatric Medicine (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Jellies, Jams, And Syrups (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Provided is a liquid food which can be fed through free fall and has a physiologically preferable viscous property compared to a liquid food having an extremely low viscosity. With the use of an adjuvant that imparts a viscous property but not shear fluidization, a nutritional composition which sustains a viscosity facilitating the production thereof in processes from the blending of starting materials to the filling of containers, and which, after heating, has a viscosity suitable for tube feeding through free fall, can be provided.
Description
Title of Invention: VISCOUS NUTRITIONAL COMPOSITION
[0001]
The present invention relates to a viscous nutritional composition. More specifically, the present invention relates to a nutritional composition having a flow characteristic that is preferable in managing the dosing rate.
[0002]
Liquid foods with low viscosity are known to cause gastroesophageal reflux in feeding by percutaneous endoscopic gastrostomy tube, by which food is directly administered into the stomach. As a countermeasure for this, a method of administering a semi-solid liquid food having a viscosity of 4000 to 20,000 mPa-s (12 rpm) in a short time is often implemented. In fact, there is an increasing number of patients who experience symptomatic improvement after attempts of such a feeding method, and it has also been widely recognized that direct feeding of liquid nto the stomach may not be physiologically preferable,
[0003]
On the other hand, the conventional technique of free-fall feeding is not applicable when such high-viscosity semi-solid liquid food is administered. In such cases, it is necessary to administer the composition through procedures such as injection by syringe which 1s burdensome and laborious. Accordingly, there was a problem that the burden imposed on nurses and caregivers was heavy. 10004]
In percutaneous endoscopic gastrostomy (PEG), which is one of the methods of enteral feeding, a dosing rate of 100 to 200 ml/hr is presumed to be desirable from the viewpoint of preventing diarrhea and reflux of liquid foods. In this regard, a technique involving pushing down a liquid food having an extremely high viscosity by hand is alternatively used.
However, the possibility of the risk of medical accidents is pointed out due to lack of a method defined by guidelines.
[0005]
In view of the above, there is a need for a liquid food that can be fed by free-fall feeding, which is a widely implemented technique, and has a more physiologically favorable viscous property than a liquid food having very low viscosity.
[0006]
However, there is a problem of the occurrence of diarrhea with feeding of a rich liquid food through a tube. Causes of diarrhea include dosing rate, osmotic pressure, bacterial infection, composition, and the like. It is also reported that even when a liquid food with high osmotic pressure is administered, occurrence of diarrhea can be prevented by adjusting the dosing rate (Non Patent Literature 1). As shown above, management of the dosing rate plays a key role in maintaining QOL in patients receiving liquid foods.
[0007]
It should be noted that Non Patent Literature 1 states that because the incidence rate of diarrhea is high at 400 ml/hour, which is faster than the standard rate, it is necessary to select a food containing a dietary fiber. However, this description is based on an assumption that tube feeding is given at a rate higher than the standard rate. Furthermore, the above description is directed to the addition of a dietary fiber with the intention to reduce the incidence rate of diarrhea, and therefore, the description is totally irrelevant to the changes in the flow characteristics of nutritional agents. Moreover, Non Patent Literature 1 lacks specific descriptions as to what type of dietary fiber should be added.
[0008]
With regard to a semi-solidifying agent for nutritional agents given to patients with
PEG by enteral feeding, JP Patent Publication (Kokai) No. 2010-065013 A (Patent Literature 1) describes a semi-solidifying agent for nutritional agents given to patients with PEG by enteral feeding, characterized by containing kappa carrageenan in which a part of the molecule 1s replaced by iota carrageenan. This literature discloses, as the definition of "semi-
solidified", that "Semi-solidified used herein refers to the state in which an agent is gel-like while standing but is formed into a homogeneous paste when deformed or subjected to a force”. The above literature discloses that the semi-solid nutritional agent for enteral feeding described therein is characterized in that when 25 ml of the semi-solid nutritional agent for enteral feeding is put in a 50 ml syringe with an inner diameter of 30 mm and the syringe is connected to a tube with an inner diameter of 4 mm and a length of 300 mm, and the agent is pushed down by 35 mm into the tube at a rate of 5 mm/second using a jig, the stress applied is 20000 N/m? or less.
[0009]
JP Patent Publication (Kokai) No. 2007-295877 A (Patent Literature 2) describes a milk protein-containing gel-like nutritional composition, characterized by containing a gelling agent and a multivalent metal salt and being subjected to heat-sterilization treatment.
[6010]
JP Patent Publication (Kokai) No. 2004-261063 A (Patent Literature 3) describes an emuisifier for a milk component-containing gel-like food, containing organic acid esters of glycerol such as citric and fatty acid esters of glycerol. This literature also describes a method for producing a milk component-containing gel-like food as exemplified by milk pudding, including the step of adding an emulsifier prior to the heat sterilization step and then applying heat sterilization, and then solidifying a milk component-containing gel-like food by slow cooling.
[0011]
IP Patent Publication (Kokai) No. 2007-289164 A (Patent Literature 4) describes, as a method for producing a liquid food, a method for producing a liquid food having a certain viscosity. According to this document, the method includes producing a preparation having a certain viscosity in which a thickening agent is homogeneously dispersed and then subjecting the solution thus prepared to retort sterilization by heating. In this literature, tamarind gum is primarily used as the thickening agent.
[0012]
JP Patent Publication (Kokat) No. 2000-262239 A (Patent Literature 5) describes a liquid seasoning prepared with a combination of an alpha starch, a polysaccharide thickener, and an insoluble plant fiber and a method for producing the same. According to this literature, a liquid obtained by subjecting the above liquid seasoning and a base to heat sterilization at 80 to 95°C for three to 90 minutes has a viscous property close to a Newtonian fluid (Claims 1 and 3, paragraph [0010]). In paragraph [0017], there is a description that unlike ordinary chemically modified starch, a seasoning having a viscous property close to a
Newtonian fluid was obtained without developing a paste-like viscosity by using a coarse- particle alpha starch in combination with a porous, insoluble plant fiber. That is, in the seasoning described in this literature, an alpha starch is an essential component. In Working
Examples, there is also a description that a liquid having a reduced thread-forming property was obtained. There is no description as to quantified physical property values or objective indexes of the Newtonian fluid properties of the seasoning disclosed therein.
[6013]
However, none of these Patent Literatures 1 to 5 either describes or suggests a flow characteristic that is preferable in managing the dosing rate.
[0014]
So far, as a food exhibiting the Newtonian fluidity. for example, foods in a solution state such as rapeseed oil (approximately 10% to 10° mPas), gum syrup (approximately 10° to 10° mPa-s), starch syrup (approximately 10° to 10° mPa-s), and glucose syrup (approximately 10° to 10° mPa-s) and a dispersion liquid food product with a low-density dispersion phase such as milk (approximately 0 to 10 mPas) are known (it is to be noted that the aforementioned viscosities were all measured under the conditions of a shear rate of 1 to 50s and 20°Cy. However, many liquid food products exhibit non-Newtonian fluid behavior.
For example, a dessert gel is known to exhibit pseudoplastic flow behavior (Non Patent
Literature 2).
[0015]
Newtonian fluids are known to have a constant viscosity irrespective of a shear rate.
In contrast, Non-Newtonian fluids have a high viscosity at a low shear rate but the viscosity decreases with an increase in the shear rate. In other words, the viscosity of Non-Newtonian fluids is not constant but varies according to the shear rate. In general, this phenomenon is called shear thinning. Due to shear thinning, the viscosity of a non-Newtonian liquid food decreases when it is dripped at high speed, resulting in a rapid dose increase. As a result, inconveniently, one becomes prone to develop diarrhea, and also, the chance of esophageal reflux is increased. On the other hand, when a button type mount with a bumper to be fixed inside the stomach is used for feeding a non-Newtonian liquid food via percutaneous endoscopic gastrostomy (PEG), the liquid food rapidly slows down after hitting a backflow prevention valve in the button, while the viscosity rapidly increases correspondingly. As a result, inconveniently, the flow of the liquid food inside the mount becomes sluggish. There were further problems that as the remaining dose decreased, the flow rate decreased correspondingly or dripping stopped, ete.
Patent Literature
[0016]
Patent Literature |: JP Patent Publication (Kokai) No. 2010-065013 A
Patent Literature 2: JP Patent Publication {Kokai} No. 2007-295877 A
Patent Literature 3: JP Patent Publication (Kokai) No. 2004-261063 A
Patent Literature 4: JP Patent Publication (Kokai) No. 2007-289164 A
Patent Literature 5: JP Patent Publication (Kokai) No. 2000-262239 A
Non Patent Literature
[0017]
Non Patent Literature 1: Nihon Ryudoshoku Kyokai (fapan Liquid Food Association), [online], [Searched on March 9. 2011], How to use liquid food, Intemet address <
URL:http://www.ryudoshoku.org/tukaikata 1p. htmi>
Non Patent Literature 2: Supervised by Toshiaki Nakae, "Chapter 3. Food Industry”, Rheology
Engineering and Applied Technology, published by FUHNTECHNOSYSTEM Co., Ltd., 450 to year 2001
[0018]
An objective of the present invention is to provide a nutritional composition having a low shear thinning characteristic. That is, an objective of the present invention is to provide a composition having a flow characteristic closer to a Newtonian fluid, in which the viscosity does not readily decrease even when the shear rate increases.
Solution to Problem 10019]
The present inventors achieved the objective above by preparing a nutritional composition with a rich nutritional formulation and emulsifying the resulting nutritional composition, and additionally using an adjuvant that imparts a viscous property but not a shear thinning characteristic in combination.
[0020]
While a nutritional composition having a rich nutritional formulation has a certain degree of viscosity by itself, when it is emulsified by homogenization treatment and the like, it attains a property such that it has a characteristic closer to a Newfonian fluid. However, designing a rich nutritional formulation alone is not enough to achieve a viscosity sufficient as a nutritional composition for nutritional agents given to patients with PEG by enteral feeding.
In light of the above, the present inventors found that the combined use of the aforementioned rich nutritional composition and an adjuvant that imparts a viscous property but not a shear thinning characteristic enables increasing the viscosity of a heat-treated nutritional composition, while maintaining a characteristic closer to a Newtonian fluid, whereby a composition suitable as a nutritional agent for enteral feeding was successfully obtained. The present inventors accomplished inventing the present invention based on the foregoing findings.
[0021]
That is, the present mvention enables a reduction in the amount of substance that imparts a shear thinning characteristic necessary for imparting a certain degree of viscosity (such as a thickening agent) by using a water-absorbing adjuvant that imparts a viscous property but not a shear thinning characteristic, which reduces free water in a composition.
Alternatively, the present invention enables an increase in the viscosity of a nutritional composition while maintaining a characteristic close to a Newtonian fluid by using, among the atorementioned adjuvants, one that imparts viscosity to an aqueous solution while having a characteristic closer to a Newtonian fluid. By doing so, a shear thinning characteristic (also called pseudoplastic fluidity) attributable to a thickening agent and the like contained in a composition can be suppressed, whereby the provision of a nutritional composition having a low shear thinning characteristic was made possible. It is also possible to adjust the viscosity of the aforementioned composition post heat treatment by adjusting the homogenization treatment pressure.
[0022]
Thus, the present invention is as follows.
[06023] 1. A nutritional composition having a fluidization characteristic comprising an adjuvant that imparts a viscous property but not a shear thinning characteristic, wherein the composition is prepared so that when results of measurement of shear stress and shear rate at any two or more measurement points in a shear rate range of shear rate of 0.1/s to 1000/s are expressed by the following viscous property formula:
P= ph? wherein, P represents a shear stress (Pa), D represents a shear rate (1/5), pu represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of nis 0.3 to 1.0 and the viscosity at a shear rate of 10/5 (25°C) is 150 mPa:s or more.
[0024] 2. A nutritional composition having a fluidization characteristic comprising an adjuvant that imparts a viscous property but not a shear thinning characteristic, wherein the composition is prepared so that when results of measurement of shear stress and shear rate at any two or more measurement points in a shear rate range of shear rate of 0.1/s to 100/s are expressed by the following viscous property formula:
P= pD" wherein, P represents a shear stress (Pa), D represents a shear rate (1/5), pu represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of nis 0.4 to 0.8 and the viscosity at a shear rate of 10/s (25°C) is 150 to 1000 mPa-s or more.
[6025] 3. The nutritional composition having a fluidization characteristic according to 1 or 2, wherein the adjuvant that imparts a viscous property but not a shear thinning characteristic is selected from the group consisting of a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, and a starch not having been subjected to pregelatinization treatment in advance. 10026] 4. The nutritional composition having a fluidization characteristic according to any of 1 to 3, comprising the adjuvant that imparts a viscous property but not a shear thinning characteristic according to any of 1 to 3 in an amount of 0.10 to 5.00% by weight relative to the nutritional composition, and having a property such that viscosity thereof is increased by heat treatment.
[0027] 5. The nutritional composition having a fluidization characteristic according to any of 1 to 4, wherein the adjuvant that imparts a viscous property but not a shear thinning characteristic is a water-absorbing dietary fiber.
[0028] 6. The nutritional composition having a fluidization characteristic according to any of 3 to 3, wherein the water-absorbing dietary fiber Is an insoluble dietary fiber.
[0029] 7. The nutritional composition having a fluidization characteristic according to any of 3 to 6, wherein the water-absorbing dietary fiber is an insoluble fiber of a fusima bran dietary fiber of a cereal.
[0030] 8. The nutritional composition having a fluidization characteristic according to any of 3 to 7, wherein the water-absorbing dietary fiber is an insoluble fiber of soybean dietary fiber and/or soybean fusuma bran.
[0031] 9. The nutritional composition having a fluidization characteristic according to any of 1 to 4, wheremn the adjuvant that imparts a viscous property but not a shear thinning characteristic is a thickening agent that does not have a network structure in an aqueous solution.
[0032] 10. The nutritional composition having a fluidization characteristic according to 9, wherein the thickening agent that does not have a network structure in an aqueous solution is a thickening agent selected from the group consisting of i1-carrageenan, A-carrageenan, locust bean gum, guar gum, psyllium seed gum, and tamarind seed gum.
[0033] 11. The nutritional composition having a fluidization characteristic according to any of | to 4, wherein the adjuvant that imparts a viscous property but not a shear thinning characteristic is a starch not having been subjected to pregelatinization treatment in advance.
[0034] 12. The nutritional composition having a fluidization characteristic according to any of 1 to 11, comprising one or more from the group consisting of protein, lipid, and sugar, wherein the specific weight of the composition is 1.06 to 1.5,
[0035] 13. The nutritional composition having a fluidization characteristic according to any of I to 12, comprising one or more from the group consisting of a thickening agent and an emulsifier.
[0036] 14. The nutritional composition having a fluidization characteristic according to any of 1 to 13, wherein the viscosity of the composition is 5 to 300 mPa-s. wherein the viscosity of the cemposition 1s measured at 45 to 85°C and 12 rpm using a B-type viscometer,
[0037]
15. The nutritional composition having a fluidization characteristic according to any of 1 to 14, wherein homogenization treatment 1s performed by adjusting the homogenization treatment pressure to 10 to 100 MPa.
[0038] 16. The nutritional composition having a fluidization characteristic according to any of | to 15, wherein the viscosity of the composition reaches 300 to 3000 mPas by subjecting the composition to heat treatment and then storing the composition at a temperature equal to or below normal temperature for 1 to 90 days, wherein the viscosity of the composition is measured at 20°C and 12 rpm using a B-type viscometer.
[0039] 17. A nutritional composition having a fluidization characteristic comprising an adjuvant that imparts a viscous property but not a shear thinning characteristic, wherein the composition is prepared so that when results of measurement of shear stress and shear rate at any two or more measurement points in a shear rate range of shear rate of 0.1/s to 1000/s are expressed by the following viscous property formula:
P= uD" wherein, P represents a shear stress (Pa), D represents a shear rate (1/s), 1 represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of n1s 0.3 to 1.0 and the viscosity at a shear rate of 10/5 (25°C) is 150 mPa-s or more, and wherein the composition has been subjected to heat treatment and then stored at a temperature equal to or below normal temperature for 1 to 90 days.
[0046] 18. A nutritional composition having a fluidization characteristic comprising an adjuvant that imparts a viscous property but not a shear thinning characteristic, wherein the composition is prepared so that when results of measurement of shear stress and shear rate at any two or more measurement points in a shear rate range of shear rate of 0.1/s to 100/s are expressed by the following viscous property formula:
P=uD"
wherein, P represents a shear stress (Pa), D represents a shear rate (1/5), pu represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of nis 0.4 to 0.8 and the viscosity at a shear rate of 10/s (25°C) is 150 mPa-s or more, and wherein the composition has been subjected to heat treatment and then stored at a temperature equal to or below normal temperature for 1 to 90 days.
[0041] 15. A method for producing a viscous nutritional composition, comprising the steps of: i) preparing an adjuvant that imparts a viscous property but not a shear thinning characteristic selected from the group consisting of a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, and a starch not having been subjected to pregelatinization treatment in advance, wherein said adjuvant is 0.10 to 5.00% by weight relative to the nutritional composition, 11} applying pressure treatment for homogenization, and 111) applying heat treatment, wherein the viscosity of the composition prior to the heat treatment is 3 to 300 mPa-s, wherein the viscosity of the composition prior to the heat treatment is measured at 45 to 85°C and 12 rpm using a B-type viscometer, and the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is 300 to 3000 mPa-s, wherein the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is measured at 20°C and 12 rpm using a B-type viscometer.
[0042] 20. A method for producing a viscous nutritional composition, comprising the steps of: 1} preparing an adjuvant that imparts a viscous property but not a shear thinning characteristic selected from the group consisting of a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, and a starch not having been subjected to pregelatinization treatment in advance, wherein said adjuvant is 0.10 to 5.00% by weight relative to the nutritional composition, il
11) applying pressure treatment for homogenization, and 111) applying heat treatment, wherein the viscosity of the composition prior to the heat treatment is 5 to 300 mPa-s, wherein the viscosity of the composition prior to the heat treatment is measured at 45 to 85°C and 12 rpm using a B-type viscometer, and the homogenization treatment pressure in the step of applying pressure treatment for homogenization is 10 to 100 MPa, and the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is 300 to 3000 mPa-s, wherein the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for
I to 90 days is measured at 20°C and 12 rpm using a B-type viscometer.
[0043] 21. A method for producing a nutritional composition having a fluidization characteristic comprising an adjuvant that imparts a viscous property but not a shear thinning characteristic, wherein the composition is prepared so that when results of measurement of shear stress and shear rate at any two or more measurement points in a shear rate range of shear rate of 0.1/5 to 1000/s are expressed by the following viscous property formula:
P=uD" wherein, P represents a shear stress (Pa), D represents a shear rate (1/s), i represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of nis 0.3 to 1.0 and the viscosity at a shear rate of 10/5 (25°C) is 150 mPa-s or more, comprising the steps of: i} preparing an adjuvant that imparts a viscous property but not a shear thinning characteristic selected from the group consisting of a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, and a starch not having been subjected to pregelatinization treatment in advance, wherein said adjuvant is 0.10 to 5.00% by weight relative to the nutritional composition, it} applying pressure treatment for homogenization, and iii) applying heat treatment,
wherein the viscosity of the composition prior to the heat treatment is 5 to 300 mPa-s, wherein the viscosity of the composition prior to the heat treatment is measured at 45 to 85°C and 12 rpm using a B-type viscometer, and the homogenization treatment pressure in the step of applying pressure treatment for homogenization is 10 to 100 MPa, and the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is 300 to 3000 mPa-s, wherein the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days 1s measured at 20°C and 12 rpm using a B-type viscometer.
[0044] 22. A method for producing a nutritional composition having a fluidization characteristic, wherein the composition is prepared so that when results of measurement of viscosity at any two or more measurement points in a shear rate range of shear rate of 0.1/s to 100/s are expressed by the following viscous property formula:
P=puD" wherein, P represents a shear stress (Pa), D represents a shear rate (1/5). pi represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of nis 0.4 to 0.8 and the viscosity at a shear rate of 10/s (25°C) is 150 to 1000 mPa-s, comprising the steps of: i) preparing an adjuvant that imparts a viscous property but not a shear thinning characteristic selected from the group consisting of a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, and a starch not having been subjected to pregelatinization treatment in advance, wherein said adjuvant is 0.10 to 5.00% by weight relative to the nutritional composition, ii} applying pressure treatment for homogenization, and ii) applying heat treatment, wherein the viscosity of the composition prior to the heat treatment is 5 to 300 mPa-s, wherein the viscosity of the composition prior to the heat treatment is measured at 435 to 85°C and 12 rpm using a B-type viscometer. and the homogenization treatment pressure in the step of applying pressure treatment for homogenization is 10 to 100 MPa, and the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is 300 to 3000 mPa-s, wherein the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days 1s measured at 20°C and 12 rpm using a B-type viscometer.
[0045]
The present application encompasses the contents described in the specification and/or drawings of JP Patent Application No. 2011-108857, based on which the priority of the present application is claimed.
[0046]
The use of an adjuvant that imparts a viscous property but not a shear thinning characteristic enables the provision of a nutritional composition which maintains a viscosity at which the production thereof is facilitated from the step of mixing raw materials to the step of filling a container with the resulting mixture, and which, after heat treatment, has a viscosity suitable for tube feeding by free fall. In other words, the nutritional composition of the present invention can be easily produced and administered by tube. Also, compared to a composition in which the viscosity is increased primarily by a thickening agent, the viscosity of the nutritional composition of the present invention before heat treatment can be kept low, whereby the production thereof is facilitated. Further, a water-absorbing dietary fiber and a starch not having been subjected to pregelatinization treatment in advance contained in the aforementioned adjuvant that imparts a viscous property but not a shear thinning characteristic can reduce free water in the nutritional composition by virtue of their water-absorbing action, whereby the content of a substance that imparts a shear thinning characteristic necessary for imparting a certain degree of viscosity (such as a thickening agent) can be kept lower than that in conventional products. The thickening agent that does not have a network structure in an aqueous solution and starch not having been subjected to pregelatinization treatment in advance contained in the aforementioned adjuvant that imparts a viscous property but not a shear thinning characteristic do not have a network structure in an aqueous solution, thereby capable of imparting viscosity to the aqueous solution, while attaining a characteristic closer to a Newtonian fluid.
[0047]
Also, by preparing the nutritional composition with a rich nutritional formulation and emulsifying this by homogenization treatment and the like, the resulting nutritional composition attains a characteristic closer to a Newtonian fluid, while retaining a certain degree of viscosity.
[0048]
By virtue of the aforementioned characteristics, also when a composition having a similar degree of viscosity to conventional products 1s produced, a shear thinning characteristic attributable to a substance that imparts a shear thinning characteristic such as a thickening agent can be reduced. Accordingly, a nutritional composition having a low shear thinning characteristic and is closer to the Newtonian viscous property can be obtained by the present invention. That is, due to the characteristic closer to a Newtonian fluid, the decrease of viscosity of the nutritional composition of the present invention is relatively low despite increase of shear rate, and consequently, the problem of occurrence of diarrhea and esophageal reflux associated with rapid dose increase caused by increased dripping rate is less likely to occur. Further, even at a low shear rate, the viscosity does not increase very much, and therefore, problems such as clogging of the liquid food inside the feeding apparatus are less likely to occur. In other words, the present invention provides an advantage that variation in time required for dripping attributable to the method of feeding by dripping or dripping apparatus 1s less likely to occur, whereby the procedure and management of feeding can be simplified. Moreover, there are economic advantages that some of the raw materials can be cut down.
[0049] [Figure 1} Figure 1 shows the relationship between the shear rate and viscosity of the
Formulations 1, 2, 3, and 4 of the present invention and a commercially available liquid food
(the viscosity was measured under the conditions of a gap of I mm, 25°C, a shear rate of 1 to 100/s using the rheometer Physica MCR301 (Anton Paar) with a cone plate having a diameter of 25 mm). The commercially available liquid food is represented by black diamonds,
Formulation 1 by white squares, Formulation 2 by white triangles, Formulation 3 by x, and
Formulation 4 by white circles, respectively, {Figure 2} Figure 2 shows the relationship between the shear rate and sheer stress in the
Formulations 1, 2, 3, and 4 of the present invention and a commercially available liquid food.
The commercially available liquid food is represented by black diamonds, Formulation 1 by white squares, Formulation 2 by white triangles, Formulation 3 by x, and Formulation 4 by white circles, respectively. [Figure 3] Figure 3 shows a schematic diagram of the apparatus used in the dripping test. [Figure 4] Figure 4 shows the results of measurement of the dripping rate of the Formulations
I and 2 of the present invention and a commercially available liquid food. White squares, circles, and triangles represent the commercially available liquid food, Formulation 1, and
Formuiation 2, all were administered by tube, respectively. Black (solid) squares, circles, and triangles represent the commercially available liquid food, Formulation 1, and
Formulation 2, all were administered via button, respectively.
[0050]
The nutritional composition of the present invention is based on the novel finding that a low shear thinning characteristic is successfully obtained by using an adjuvant that imparts a viscous property but not a shear thinning characteristic. Further, the present invention is based on the novel finding that a nutritional composition having a high calorific value but a low shear thinning characteristic is successfully obtained by preparing a nutritional composition with a rich nutritional formulation and emulsifying this by means such as homogenization treatment with the use of an adjuvant that imparts a viscous property but not a shear thinning characteristic.
[6031]
The low shear thinning characteristic as used herein refers fo a characteristic of a liquid such that when it is expressed by the viscous property formula:
P=uD" wherein, P represents a shear stress (Pa), which is a value obtained by multiplying the viscosity value by the shear rate value, D represents a shear rate, pu represents a non-
Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity Index, and the viscosity (25°C, Pas) is measured under the conditions of a gap of 1 mm, 25°C, a shear rate of 0.1 to 1000/s, for example [ to 100/s, using the rheometer Physica MCR301 (Anton Paar) with a cone plate having a diameter of 25 mm, the non-Newtonian viscosity index n is relatively close to 1 and the liquid behaves in a manner similar to a Newtonian fluid. The non-Newtonian viscosity index n being close to 1 means that in comparison with n of conventional nutritional compositions, n of the nutritional composition of the present invention is closer to 1. For example, if n of a conventional nutritional composition is less than 0.3 while n of the nutritional composition of the present vention is 0.4 to 1.0, then it can be said that the non-Newtonian viscosity index n is relatively close to 1. Due to the shear thinning phenomenon, the viscosity of a non-
Newtonian fluid is not constant but varies according to the shear rate. Accordingly, in the present specification, the fluidization characteristic of the nutritional composition of the present invention was expressed by a range of non-Newtonian viscosity index n obtained from the relationship between at least two points of shear rate and the shear stress calculated from the viscosity at those shear rates. This expression is merely provided for sake of facilitating the understanding of the present invention. For example, merely for the sake of convenience, the range of shear rate in which measurement is made can be from 0.1 to 100/s or 1 to 100/s according to the device used. Those skilled in the art will understand that an effect achieved by an embodiment of the present invention is indicated by the non-Newtonian viscosity index n obtained from the relationship between the shear rate and shear stress and is not limited by the range of shear rate exemplified as above. Also, the shear stress (Pa) is calculated by multiplying the viscosity (Pas) by the shear rate (l/s). However, when a commercially available rheometer equipped with automatic calculation function is used, the shear stress value on the display may be used without any problem. It is also possible to use the value calculated by multiplying the viscosity (Pa-s) by the shear rate (1/5).
[0052]
Also, in the present invention, in the measurement of the viscosity, the shear rate and viscosity are measured using the rheometer Physica MCR301 {Anton Paar) with a cone plate having a diameter of 25 mm and a gap of | mm. However, this is no more than an example, and needless to say, any commercially available rheometer that can measure the shear stress or viscosity at a certain shear rate can be used.
[0053]
In the present specification, an adjuvant that imparts a viscous property but not a shear thinning characteristic refers to a substance that imparts a viscous property to the composition to which the substance is added without lowering the non-Newtonian viscosity index n very much. For example, the adjuvant that imparts a viscous property but not a shear thinning characteristic refers fo an adjuvant such that when it is added to a nutritional composition in an amount of 0.10 to 5.00% by weight of the composition, it does not lower the non-Newtonian viscosity index n of the nutritional composition below 0.3 after heat treatment and storage.
Examples of the adjuvant that imparts a viscous property but not a shear thinning characteristic of the present invention include, but are not limited to, a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, and a starch not having been subjected to pregelatinization treatment in advance. The adjuvant that imparts a viscous property but not a shear thinning characteristic of the present invention is preferably one in which water absorbency is increased by heat treatment. [00541
In the present specification, examples of heat treatment include not only heat sterilization to be described later, but also heat treatment at 70°C or higher for several minutes or longer or heat treatment at 80°C or higher for several minutes or longer. However, heat treatment 1s not limited to those mentioned above as long as the treatment is conducted under the conditions of a temperature and retention time that are as bactericidal as or more bactericidal than the aforementioned heat treatments or a temperature and retention time that are known to be effective as thermal history by heating.
[0055]
The adjuvant that imparts a viscous property but not a shear thinning characteristic of the present invention may be subjected to heat treatment with protein, lipid, sugar, or the like.
Alternatively, it is also possible to subject the adjuvant that imparts a viscous property but not a shear thinning characteristic of the present invention to heat treatment separately from protein, lipid, sugar, or the like, and then add the resulting adjuvant to heat-sterilized protein, lipid, sugar, or the like.
[0056]
According to an embodiment of the present invention, as the adjuvant that imparts a viscous property but not a shear thinning characteristic, a dietary fiber, particularly a water- absorbing dietary fiber can be used. A dietary fiber refers to a substance in food that is not hydrolyzed by human digestive enzymes, and is classified into a water-soluble dietary fiber and an insoluble dietary fiber based on its affinity to water. As the source of a dietary fiber, cell wall constituents (such as cellulose, hemicellulose, insoluble pectin, lignin, and chitin), non-cell wall constituents {such as water-soluble pectin, plant gum, adhesive materials, seaweed polysaccharides, and chemically modified polysaccharides) are known (edited by
Satoshi Innami et al., Dietary fiber, published by DAIICHI SHUPPAN Co. Ltd, 1982). An insoluble dietary fiber is a dietary fiber insoluble in water, and it swells by absorption of water.
In contrast, a water-soluble dietary fiber is a dietary fiber soluble in water, and it turns into a gel-like form by inclusion of water.
[0057]
A water-absorbing dietary fiber that can be used in the present invention refers to a dietary fiber having water-absorbing property. It is particularly preferable that water- absorbing capacity of such water absorbing dietary fiber can be enhanced through heat treatment. When a water-absorbing dietary fiber is used in the nutritional composition of the present invention, free water in the composition decreases due to the water-absorbing action of the fiber, and consequently, the concentration of a thickening agent, emulsifier, or the like will be increased relatively in the solution part of the composition. As a result, the viscosity attributable to a thickening agent, emulsifier, or the like will be increased. Moreover, when a dietary fiber whose water absorbency is increased by heat treatment is used, the viscosity attributable to a thickening agent, emulsifier, or the like will be further increased by heat treatment. Examples of the dietary fiber whose water absorbency is increased by heat treatment include fibrous cellulose and crystalline cellulose.
[6058]
As the water-absorbing dietary fiber of the present invention, an insoluble dietary fiber 1s preferably used. Examples of the aforementioned insoluble dietary fiber include cellulose, hemicellulose (such as xylan, mannan, galactan, glucan, glucomannan, and xyloglucan), holocellulose, matrix polysaccharide, an insoluble fiber of a dietary fiber derived from plants (such as vegetables (such as lettuce, celery, onions, burdock, radish, green peas, dried gourd, and tomatoes), fruits (such as apples and bananas), cereals (such as barley, wheat, common wild oat, corn, and Amaranthus), tubers (sweet potatoes, potatoes, and konjac potato), beans (such as peas, soybeans, adzuki beans, garbanzo beans, common beans, pinto beans, and mung beans), mushrooms (such as the Jew's ear and shiitake mushroom), chestnuts, almonds, peanuts, and sesames), an insoluble fiber of a dietary fiber derived from other natural products (such as animals, seaweed, and microorganisms), the aforementioned insoluble fiber derived from natural products that has been subjected to chemical modification, partial degradation, or purification, chemically synthesized edible insoluble fiber, soybean fusuma bran, wheat
Jusuma bran, barley fuswma bran, maize fusuma bran, oat fusuma bran, rye fusuma bran, job's tears (C. lacryma-jobi var. ma-yuen) fusuma bran, rice nuka bran, fusuma bran of rmiscellaneous cereals such as proso millet, foxtail millet, barnyard millet, and Sorghum,
Leguminosae fusuma bran, fusuma bran of pseudocereals such as buckwheat fusuma bran, sesame fusuma bran, and okara (soy pulp). Preferable examples thereof include an insoluble fiber of soybean dietary fiber and soybean fuswma bran. Also, as the aforementioned insoluble dietary fiber, one from which hydrophobic components such as lignin have been removed, one having many side chains, and one that is amorphous can be favorably used.
The aforementioned water-absorbing dietary fiber can be used alone or as a combination of plural types thereof, and it is also possible to use a food product containing a large amount of the aforementioned water-absorbing dietary fiber or additive containing a large amount of the aforementioned water-absorbing dietary fiber. Also, in the present invention, other dietary fibers can also be partly used in combination with the aforementioned water-absorbing dietary fiber. For example, at least an insoluble fiber of soybean dietary fiber and/or soybean fusuma bran can be contained in the water-absorbing dietary fiber to be used in the composition of the present invention. The insoluble fiber of soybean dietary fiber used in Examples of the present invention can be obtained by, for example, defatting sovbean, extracting the defatted soybean with water, and drying the insoluble matters thus produced.
Further, the insoluble fiber of soybean dietary fiber used in Examples of the present invention can also be obtained by drying soy pulp.
[0060]
According to STANDARD TABLES OF FOOD COMPOSITION IN JAPAN, 3* revised and enlarged edition (Ministry of Education, Culture, Sports, Science and Technology: http://www.mext.go.jp/b_menuw/shingi/giiyutw/gijyutu3/toushin/05031802 htm), the total amount of dietary fibers, the amount of a water-soluble dietary fiber, and the amount of an soluble dietary fiber contained in soybean (dry) is 17.1 g/100 edible part, 1.8 g/100 edible part, and 15.3 g/100 edible part, respectively. Also, the total amount of dietary fibers, the amount of a water-soluble dietary fiber, and the amount of an insoluble dietary fiber contained in soy pulp (old production method) is 9.7 g/100 edible part, 0.3 2/100 edible part, and 9.4 g/100 edible part, respectively, and the total amount of dietary fibers, the amount of a water- soluble dietary fiber, and the amount of an insoluble dietary fiber contained in soy pulp (new production method) is 11.5 g/100 edible part. 0.4 g/100 edible part, and 11.1 g/100 edible part, respectively.
[0061]
Also, the water-absorbing dietary fiber of the present invention does not contain a water-soluble dietary fiber, which increases the shear thinning characteristic (that is, reduces the non-Newtonian viscosity index) such as a soybean-derived polysaccharide thickener and indigestible dextrin. A water-soluble dietary fiber may be used in combination partly in the nutritional composition of the present invention. 10062]
The term "fusuma bran" refers to the residue remaining after milling of cereals and preparation of cereal products. For example, soybean fisuma bran refers to the residue after grinding soybean. and wheat fuswma bran, which is also called wheat feed, refers to the residue after the production of flour by grinding wheat. In the case of Poaceae, fusuma bran may also be called "nuka” (i.e. rice bran). Nuka refers to a part such as pericarp, seed coat, and germ that are obtained when cereals are polished. Fusuma Bran and nuka are used synonymously with each other in the present specification. Also, fusuma bran is used for cereals in general, and it is not limited to specific cereals such as wheat, corn, and oat.
Fusuma bran that can be used in the present invention is not limited and examples thereof include chemically synthesized edible insoluble fiber, soybean fusuma bran, wheat fusuma bran, barley fusuma bran, corn fusuma bran, oat fusuma bran, rye fusuma bran, job's tears (C lacryma-jobi var. ma-yuen) fusuma bran, rice nuka bran, fusuma bran of miscellaneous cereals such as proso millet, foxtail millet, barnyard millet, and Sorghum, Leguminosae fusuma bran,
Susuma bran of pseudocereals such as buckwheat fusuma bran, sesame fusuma bran, and okara {soy pulp).
[0063]
The amount of a water-absorbing dietary fiber to be used in the nutritional composition of the present invention can be appropriately adjusted according to, for example, the viscosity of the nutritional composition to be produced, the type of the water-absorbing dietary fiber, the types and contents of other components such as a thickening agent, an emulsifier, and a starch, and homogenization treatment pressure. However, only for the sake of example, a water- absorbing dietary fiber can be used in an amount of 0.10 to 5.00% by weight (w/w%), preferably 0.10 to 3.00% by weight (Ww/w%), preferably 0.10 to 2.50% by weight (w/w), preferably 0.10 to 2.20% by weight (w/w%), preferably 0.10 to 2.00% by weight (w/w%), preferably 0.10 to 1.50% by weight (w/w%), preferably 0.20 to 1.0% by weight, and more preferably 0.20 to 0.80% by weight of the nutritional composition. In the present invention,
when the aforementioned lower and upper limit values are set at any of the values specified above, the amount of a water-absorbing dietary fiber used can be described as "(lower limit value) to (upper limit value)."
[0064]
Also, the larger the water-absorbing dietary fiber particle, the better the water absorbency (edited by Satoshi Innami et al., Dietary fiber, published by DAI-ICHI SHUPPAN
Co. Ltd., 1982). The size of the dietary fiber that can be preferably used in the present invention can be appropriately adjusted according to, for example. the viscosity of the nutritional composition to be produced, the type and content of the water-absorbing dietary fiber, the types and contents of other components such as a thickening agent, an emulsifier, and a starch, and homogenization treatment pressure. However, only for the sake of example, the size of a dry water-absorbing dietary fiber before absorbing water can be a size such that the fiber passes through a 20 mesh but not a 100 mesh, more preferably a size such that the fiber passes through a 60 mesh but not a 100 mesh.
[0065]
Soybean dietary fiber contains cellulose, hemicellulose, and the like, and depending on the degree of polymerization and three dimensional structure, soybean dietary fiber exists as a water-soluble dietary fiber or an insoluble dietary fiber. Since a water-soluble dietary fiber has a thickening property on its own, it is utilized as a thickening and stabilizing agent in practical applications. Meanwhile, an insoluble dietary fiber composed mainly of cellulose and hemicellulose hardly exhibits a thickening property on its own. Among insoluble dietary fibers of soybean dietary fiber, those having large three dimensional structures are excellent in water absorbency and have a property such that its water absorbency is increased by heating.
Soybean fusuma bran is known to be a material rich in an insoluble dietary fiber of soybean dietary fiber.
[0066]
According to an embodiment of the present invention, as the adjuvant that imparts a viscous property but not a shear thinning characteristic, a thickening agent, for example a thickening agent that does not have a network structure in an aqueous solution can be used.
Examples of a thickening agent (also called a gelling agent, a stabilizer, a thickening and stabilizing agent, and a starch adhesive) that can be arbitrarily used in the present invention such as a thickening agent that does not have a network structure in an aqueous solution include locust bean gum, psyllium seed gum, 1-carrageenan, J-carrageenan, K-carrageenan in which a part of the molecule is replaced by 1-carrageenan, carrageenan in which a part of a- carrageenan is replaced by t-carrageenan, low-strength agar, guar gum, tamarind gum, and tamarind seed gum. Preferable examples thereof include a thickening agent composed mainly of polysaccharides. The aforementioned thickening agent can be used alone or as a combination of plural types thereof. Also, other thickening agents can be partly used in combination with the aforementioned thickening agent. For example, i-carrageenan and/or low-strength agar can be contained in the thickening agent used in the composition of the present invention. The amount of a thickening agent to be used in the nutritional composition of the present invention can be appropriately adjusted according to, for example, the viscosity of the nutritional composition to be produced, the type of a thickening agent, the types and contents of other components such as a water-absorbing dietary fiber, a non- pregelatinized starch, and an emulsifier, and homogenization treatment pressure. However, only for the sake of example, the thickening agent can be used in an amount of 0.01 to 5.00% by weight (w/w%), preferably 0.01 to 3.00% by weight (w/w%), preferably 0.01 to 2.0% by weight (w/w), preferably 0.02 to 1.0% by weight, and more preferably 0.05 to 0.5% by weight of the nutritional composition. In the present invention, when the aforementioned tower and upper limit values are set at any of the values specified above, the amount of a thickening agent used can be described as "(lower limit value) to (upper limit value)". A thickening agent that have a network structure in an aqueous solution can also be used in combination partly in the nutritional composition of the present invention.
[0067]
Carrageenan refers to salts of sulfuric acid esters of polysaccharides composed of galactose and anhydrogalactose, and is obtained by extracting the whole body of the algae
Hypnea charoides, Fucheuma muricatum, Iridaea, Gigarting tenella, and chondrus ocellatus with water or an alkaline aqueous solution, and then performing purification (purified carrageenan). Carrageenan may also be pronounced or expressed as carra-gee-nan, cara-ghe- nan, cara-ghe-nin, and Carrageenan. Carrageenan can also be used in the form of Fucheuma powder or processed Eucheuma algae, which is obtained by drying the whole body of the algae Eucheuma muricatum or subjecting the whole body of the algae Eucheuma muricarum to alkaline treatment, and then neutralizing and drying the algae. Depending on the ratio between galactose and anhydrogalactose and the number of sulfuric acid ester, carrageenan exists mainly in the following types; k-carrageenan, 1-carrageenan, and A-carrageenan. Also, besides x-carrageenan in which a part of the molecule is replaced by i-carrageenan and carrageenan in which a part of A-carrageenan is replaced by i-carrageenan, degraded carrageenan having non-dietary usage also exists. The x- and type carrageenan has a gelling property, and in an aqueous solution, the degree of viscosity is k-carrageenan < 1- carrageenan. When these aqueous solutions are cooled, k-carrageenan forms a hard but fragile gel, while t-carrageenan forms a viscoelastic gel. Also, x- and t-type carrageenan forms a strong gel by reacting with salt and milk protein (Toru Hidaka et al., Food Additive
Encyclopedia, FOOD CHEMICAL NEWSPAPER, Inc., published in 1997, p. 74 and
Handbook of Natural Materials, 147 edition, SHOKUHIN TO KAGAKU (Food Science), published in 1998, p. 110 to 111).
[0068]
According to an embodiment of the present invention, as the adjuvant that imparts a viscous property but not a shear thinning characteristic, a thickening agent, for example a thickening agent that does not have a network structure in an agueous solution can be used.
The thickening agent that does not have a network structure in an aqueous solution as used here encompasses low-strength agar. That is, although low-strength agar has a weak network structure in an aqueous solution due to partial cleavage of the molecule, a small amount of low-strength agar can be used as the adjuvant that imparts a viscous property but not a shear thinning characteristic of the present invention. Low-strength agar refers to agar that is adjusted to have a jelly strength (Nikkansui method) of 10 to 250 g/cm” at an agar concentration of 1.5% by cleaving the molecules of agar components by subjecting agar to heat treatment. Low-strength agar has a lower jelly strength than agar. Low-strength agar can be produced by, for example, the method described in JP Patent No. 3414954. It should be noted that jelly strength (Nikkansui method) refers to the maximum weight (g) that can be supported for 20 seconds per em? of the surface of a gel obtained by preparing a 1.5% agar solution and solidifying this by leaving it at 20°C for 15 hours.
[6069]
According to an embodiment of the present invention, as the adjuvant that imparts a viscous property but not a shear thinning characteristic, a starch not having been subjected to pregelatinization treatment in advance can be used. It is known that when a starch not having been subjected to pregelatinization treatment in advance is heated in an aqueous solution, the starch itself imparts a viscous property to the aqueous solution and its water absorbency increases. In the present specification, starch in a naturally occurring crystalline state is called 3 starch and starch in which sugar chains are freed by destruction of hydrogen bonds therebetween is called a starch. Starch is known to be pregelatinized by destruction of hydrogen bonds by heating, for example by a heat treatment step. Addition of a pregelatinized starch to the nutritional composition before heat treatment results in an unfavorable increase in the viscosity of the composition before heat treatment. Accordingly, a pregelatinized starch is excluded from the adjuvant that imparts a viscous property but not a shear thinning characteristic of the present invention. The amount of a starch not having been subjected to pregelatinization treatment in advance to be used in the nutritional composition of the present invention can be appropriately adjusted according to, for example, the viscosity of the nutritional composition to be produced, the types and contents of other components such as a thickening agent and an emulsifier, and homogenization treatment pressure. However, only for the sake of example, the starch not having been subjected to pregelatinization treatment in advance can be used in an amount of 0.10 to 5.00% by weight (w/w%}, 0.50 to 5.00% by weight (w/w%), preferably 0.10 to 3.00% by weight (w/w%), preferably 0.10 to 2.50% by weight (w/w%), preferably 0.10 to 2.20% by weight (w/w%), preferably 0.10 to 2.60% by weight (w/w%), preferably 0.10 to 1.50% by weight (w/w%), preferably 0.20 to 1.0% by weight, and more preferably 0.20 to 0.80% by weight of the nutritional composition. In the present invention, when the aforementioned lower and upper limit values are set at any of the values specified above, the amount of a starch not having been subjected to pregelatinization treatment in advance used can be described as "(lower limit value) to (upper limit value)".
[0070]
Examples of the type of a starch to be used in the present invention include wheat flour, rice flour, rye flour, corn starch, waxy corn starch, com flour, potato starch (bareisho starch), bean starch, sweet potato starch (kansho starch), tapioca starch, potato starch (jagaimo starch), and sweet potato starch (satsumaimo starch). Also, when necessary, two or more of the aforementioned starches can be combined, and a processed starch can also be used as long as it is not a non-pregelatinized starch.
[0071]
Examples of the emulsifier that can be used in the present invention include fatty acid esters of glycerol (such as pentaglycerol monolaurate, hexaglycerol monolaurate, decaglycerol monolaurate, tetraglycerol monostearate, decaglycerol monostearate, decaglveerol distearate, diglycerol monooleate, decaglycerol monooleate, and erucic acid esters of decaglycerol), organic acid (such as acetic acid, lactic acid, citric acid, succinic acid, and diacetyl tartaric acid) monoglyceride, fatty acid esters of polyglycerol, fatty acid esters of propylene glycol, condensed ricinoleic acid esters of polyglycerol, fatty acid esters of sorbitan, fatty acid esters of sucrose (such as erucic acid esters of sucrose, stearic acid esters of sucrose, and myristic acid esters of sucrose), (Brassica, egg yolk, fractionated, milk, and the like} lecithin, and enzymatically degraded lecithin (such as enzymatically degraded Brassica lecithin).
Preferable examples thereof include organic acid monoglyceride. The aforementioned emulsifier can be used alone or as a combination of plural types thereof, and it is also possible to use a hydrophilic emulsifier in combination with other emulsifiers. Also, in the present invention, the aforementioned emulsifier can partly contain an emulsifier other than those listed above, for example, in an amount less than that of the aforementioned emulsifier. For example, at least succinic acid monoglyceride and/or diacetyl tartaric acid monoglyceride can be contained in the emulsifier to be used in the composition of the present invention, and at least organic acid monoglyceride can be contained in the emulsifier to be used in the composition of the present invention. The amount of an emulsifier to be added can be appropriately adjusted according to, for example, the viscosity of the nutritional composition to be produced, the type of emulsifier, the contents of other ingredients such as a dietary fiber and a thickening agent, and homogenization treatment pressure. However, only for the sake of example, the amount of an emulsifier to be added can be 0.02 to 2.0% by weight {w/w%), preferably 0.05 to 1.5% by weight, and more preferably 0.1 to 1.0% by weight of the nutritional composition. In the present invention, when the aforementioned lower and upper limit values are set at any of the values specified above, the amount of an emulsifier used can be described as "(lower limit value) to (upper limit value)".
[0072]
Monoglyceride refers to glycerol with fatty acid bound to one of its hydroxyl groups.
Organic acid monoglyceride refers to the aforementioned monoglyceride with organic acid bound to the hydroxyl group thereof by ester linkage.
[0073]
Diacetyl tartaric acid monoglyceride refers to the aforementioned monoglyceride with a compound in which the hydroxyl group of tartaric acid is acetylated bound to the hydroxyl group thereof by ester linkage. Diacetyl tartaric acid monoglyceride is alternatively called
TMG or diacetyl] tartaric (acid) ester of monoglyceride (DATEM). Diacetyl tartaric acid monoglyceride may be used for O/W type emulsification.
[0074]
Succinic acid monoglyceride refers to the aforementioned monogiyceride with succinic acid bound to the hydroxyl group thereof by ester linkage. Also, succinic acid monoglyceride is alternatively called succinic acid esters of monoglyceride (SMG). Suecinic acid monoglyceride may be used for O/W type emulsification.
[0075]
In the present mvention, examples of fatty acid constituting organic acid monoglyceride include, but are not limited to, saturated fatty acid and unsaturated fatty acid such as caprylic acid, capric acid. lauric acid, myristic acid, palmitic acid, stearic acid, and oleic acid.
[0076]
In the present invention, food protein can be used as all or a part of protein. Examples of food protein that can be used in the present invention include milk-derived protein (such as casein, casein sodium, Milk Protein Concentrate (MPC), a-casein, B-casein, and x-casein and degradation products thereof), soy-derived protein (such as glycinin and f-conglycinin), wheat-derived protein (such as gluten, gliadin, and glutelin), meat-derived protein (such as muscle constituting protein, myosin, and actin), fish meat (such as muscle fiber protein, actomyosin, myosin, and actin), chicken egg-derived protein (such as egg white albumin and egg yolk lipoprotein), and pig skin-derived protein (such as gelatin). Preferable examples thereof include casein sodium. In the present invention, food protein can be used alone or as a combination of plural types thereof. Also, in the present invention, other food proteins can also be partly used in combination with protein having a gelling property. For example, at least casein sodium can be contained in the food protein to be used in the composition of the present invention. The amount of food protein to be used in the nutritional composition of the present invention can be appropriately adjusted according to, for example, the viscosity of the nutritional composition to be produced, the type of food protein, the types and contents of other components such as a dietary fiber, a thickening agent, and an emulsifier, and homogenization treatment pressure. However, only for the sake of example, food protein can be used in an amount of 2.0 to 12.0% by weight (w/w%), preferably 4.0 to 10.0% by weight, and more preferably 5.0 to 8.0% by weight of the nutritional composition.
[0077]
The nutritional composition of the present invention can contain sugars. Examples of sugars that can be used in the present invention include polysaccharides such as a starch (preferably one that is not pregelatinized), dextrin, cellulose, glucomannan, and glucan, chitins, fructooligosaccharide. galactooligosaccharide, mannan oligosaccharide, low molecular weight polysaccharides. low molecular weight dextrin, low molecular weight cellulose, and low molecular weight glucomannan. For example, those that have a DE value of 12 to 50, 15 to 40. and 20 to 40 can be used. Also, sugars can be derived from any source such as plants, animals, and microorganisms, or can be chemically synthesized. For example, sugars derived from, for example, plants (such as potatoes, rice, sweet potatoes, corn, wheat, beans {such as vicia faba, mung beans, and adzuki beans, and cassava), animals (such as Crustaceans, insects, and shell fish), and microorganisms (such as mushrooms and fungi) can be directly used, or sugars obtained by subjecting the above sugars to partial or entire degradation or modification by a means of enzymatic reaction, microbial reaction, heat, and chemical reaction may also be used. The amounts and types of sugars to be used in the nutritional composition of the present invention can be appropriately adjusted and selected according to, for example, the viscosity of the nutritional composition to be produced and the types and contents of other ingredients such as an emulsifier, a thickening agent, protein, and lipid.
[0078]
Dextrin refers to a product obtained by subjecting a starch to, for example, degradation by heat, acid, enzyme, and the like, and if necessary, performing purification. Dextrin is alternatively called or expressed as British gum, starch gum, or dextrine. Various types of dextrins exist depending on the production method, degree of degradation, and the like.
Examples of the various types of dextrins include maltodextrin, indigestible dextrin (water- soluble dietary fiber}, cyclodextrin, soluble starch, and branched corn syrup. Dextrin can be evaluated based on dextrose equivalent (DE). Those skilled in the art can determine DE by a conventional method. For example, the dextrose equivalent of maltodextrin is assumed to be 3t0 20. The dextrose equivalent (DE) of dextrin used in the present invention is normally 12 to 50, preferably 15 to 40, and more preferably 20 to 40. The above dextrin can be used in combination with dextrin having a DE outside the above-specified values.
[0079]
In the nutritional composition of the present invention, in addition to the aforementioned water-absorbing dietary fiber, a thickening agent, a non-pregelatinized starch, an emulsifier, food protein, and sugars, water, protein, carbohydrate, lipid, vitamins, minerals, organic acid, organic base, fruit juice, flavors, pH adjusters, and the like can be used.
Examples of the protein include animal and plant-derived proteins and degradation products thereof such as milk-derived protein, enzyme degradation products of protein, whole milk powder, nonfat dry milk powder, casein, degradation products of casein, whey powder, whey protein, whey protein concentrates, degradation products of whey protein, hydrolyzed products of whey protein, o-casein, f-casein, x-casein, S-lactoglobulin, o-Jactalbumin, lactoferrin, soybean protein. chicken egg protein, and meat protein; and various types of milk-derived components such as butter, milk serum mineral, cream, whey, non-protein nitrogen, sialic acid, phospholipid, and lacrosse. The nutritional composition of the present invention can contain peptide and amino acid such as casein phosphopeptide and lysine. Examples of the carbohydrate include sugars, processed starches (dextrin as well as soluble starch, British starch, oxidized starch, starch ester, starch ether, and the like), and a dietary fiber. Among those listed above, examples of substances that can be preferably used include a non- pregelatinized starch. Examples of the lipid include animal-derived fat such as lard and fish oil, and fractionated oil, hydrogenated oil, and ester-exchanged oil thereof: and plant-derived o1l such as palm oil, safflower oil, com oil, rapeseed oil, and coconut oil, and fractionated oil, hydrogenated oil, and ester-exchanged oil thereof. Examples of the vitamins include vitamin
A, carotenes, vitamin B group, vitamin C, vitamin D group, vitamin E, vitamin K group, vitamin P, vitanun Q, niacin, nicotinic acid, pantothenic acid, biotin, inositol, choline, and folic acid. Examples of the minerals include calcium, potassium, magnesium, sodium, copper, ron, manganese, zine, and serine. Examples of the organic acid include malic acid, citric acid, lactic acid, tartaric acid, and ervthorbic acid. A combination of two or more of these components can be used, and a synthesized product and/or food containing large amounts of these components can also be used.
[0080]
The heat quantity(calorie) of the nutritional composition of the present invention can be adjusted by appropriately adding protein, lipid, and carbohydrate. The nutritional composition of the present invention can contain, for example, protein in an amount of 3 to 10 g/100g, preferably 4 to 8 g/100 g. and more preferably 5 to 7 ¢/100 g in terms of protein equivalent. The nutritional composition of the present invention can contain, for example, lipid mm an amount equivalent to 2 to 10 g/100 ¢, preferably 3 to 8 g/100 g, and more preferably 3 to 6 g/100 g. The nutritional composition of the present invention can contain, for example, carbohydrate in an amount equivalent to 13 to 30 g/100 g, preferably 15 to 27
2/100 g, and more preferably 20 to 23 ¢/100 ¢. The nutritional composition of the present invention can contain the aforementioned amounts of protein, lipid, and carbohydrate while retaining certain fluidization characteristics as described above.
[6081]
The specific weight of the nutritional composition of the present invention can be adjusted according to the usage. The specific weight of the nutritional composition of the present invention can be set at, for example, 1.06 or more, 1.07 or more, 1.08 or more, 1.09 or more, 1.1 or more, less than 1.5, less than 1.4, less than 1.3, and less than 1.2, for example, 10610 1.5, 1.07t0 1.5, 1.080 14, 1.0910 1.3, 1.10 1.2, 1.1 to 1.15, 1.12 t0 1.15, 1.13 to 1.15, preferably 1.135 to 1.145. Those skilled in the art can determine the specific weight of the composition by appropriately adjusting each component. Although the specific weight may vary depending on the temperature, for the sake of convenience, the specific weight refers to a value obtained at 20°C in the present specification. The specific weight of the composition can be calculated from the weight and volume of each component or by a conventional method, for example by using a density and specific weight meter.
[0082]
In the present specification, a rich nutritional composition refers to a composition that appropriately contains protein, lipid, carbohydrate, and the like and has a specific weight of 1.06 or more, for example 1.06 to 1.5, for example 1.07 to 1.5, for example 1.08 to 1.4, for example 1.09 to 1.3, for example 1.1 to 1.2, for example 1.1 to 1.13, for example 1.12 to 1.15, for example 1.13 to 1.15, and 1.135 to 1.145. Such a rich nutritional composition can be prepared as an emulsion by appropriately using the aforementioned emulsifier. A rich nutritional composition can also be prepared as an emulsion by appropriately performing homogenization treatment. Although homogenization treatment can be conducted before or after the addition of the aforementioned emulsifier, it is preferably conducted after the addition of an emulsifier. Homogenization will be described in detail below. Accordingly, in the present specification, an emulsion of a rich nutritional composition refers to a composition that appropriately contains protein, lipid, carbohydrate, and the like and has a certain specific weight as described above, and is emulsified by homogenization treatment. According to an embodiment of the present invention, a rich nutritional composition having a flow characteristic close to that of a Newtonian fluid can be obtained by using an emulsion of a rich nutritional composition in combination with an adjuvant that imparts a viscous property but not a shear thinning characteristic.
[0083]
As a substance that imparts a shear thinning characteristic to a composition, the aforementioned raw materials, gum arabic, alginic acid, casein, k-carrageenan, xanthan gum, guar gum, gellan gum (native form, deacylated form, and the like). gelatin, tragacanth gum, bacterial cellulose, hydroxyethyleellulose, polyethylene glycol, locust bean gum, agar, fine crystathine cellulose, and the like are known. These materials can also be contained partly in the composition of the present invention.
[6084]
By using an adjuvant that imparts a viscous property but not a shear thinning characteristic in the composition of the present invention, the concentrations of a thickening agent necessary for imparting the intended viscosity, an emulsifier, or a substance that imparts a shear thinning characteristic can be kept low, whereby the shear thinning characteristic attributable to these substances can be suppressed. As a result, the composition of the present invention can attain a low shear thinning characteristic and a viscous property close to the
Newtonian viscous property, while maintaining high viscosity.
[0085]
The composition of the present invention is advantageous in that the dripping rate in drip feeding can readily be adjusted due to said composition having a viscous property close to the Newtonian viscous property.
[0086]
The shear thinning characteristic as used in the present specification has the meaning as commonly used in the field of the present invention, and a shear thinning fluid refers to a fluid in which an apparent viscous rate or consistency decreases with an increase in the shear deformation rate.
[10087]
After mixing some or all of the aforementioned raw materials, homogenization is performed as needed. Homogenization refers to homogenizing the mixed components by thorough mixing and mechanically miniaturizing fat globules and coarse particles of other components to prevent floatation and aggregation of fat and the like, while making the nutritional composition into a uniform emulsion. An emulsified nutritional composition can have a flow characteristic close to a Newtonian fluid even when it is rich with a certain degree of viscosity. By increasing homogenization treatment pressure in homogenization process, viscosity afier heat treatment can be reduced and generation of sediment (settling particles) can be reduced. That is, the viscosity of the nutritional composition and the generation of sediment can be controlled by adjusting the homogenization treatment pressure.
Homogenization treatment is normally performed by shearing an adjusted solution using a conventional homogenizer under certain pressure. In the present invention, homogenization treatment can be preferably performed at a homogenization pressure of 10, 25, 40, 60, 100
MPa, and the like; however, treatment pressure is not limited to those exemplified above.
That 1s, the viscosity (B-type viscometer, 20°C, 12 rpm) of the composition after heat treatment and storage at a temperature equal to or below normal temperature for a certain period of ime, for example 7 days, can also be adjusted to 300 to 3000 mPa-s, for example 400 to 3000 mPa-s by applying homogenization treatment at a homogenization treatment pressure of 10 to 100 MPa in addition to using, for example, an adjuvant that imparts a viscous property but not a shear thinning characteristic, a thickening agent, an emulsifier, or a substance that imparts a shear thinning characteristic as described above.
[0088]
Homogenization treatment after mixing the raw materials can be performed at any appropriate temperature. Homogenization treatment can be performed, for example, at room temperature of around 20°C. Homogenization treatment can also be performed at a temperature higher than this, for example at 20 to 85°C, for example at 45 to 80°C, preferably at 43 to 70°C, more preferably at around 50°C to 60°C. Homogenization treatment is preferably performed at around 50°C to 60°C.
[0689]
In the production of the nutritional composition of the present invention, heat treatment or heat sterilization is performed. For heat sterilization conditions, sterilization conditions generally applied to food product can be used, and heat sterilization can be performed using a conventional device. For example, sterilization at 62 to 65°C for 30 minutes, 72°C or higher for 15 seconds or more, 72°C or higher for 15 minutes or more, or 120 to 150°C for 1 to 3 seconds, or disinfection at 121 to 124°C for 5 to 20 minutes, at 105 to 140°C, retort (autoclave) sterilization, high pressure steam disinfection, and the like can be used; however, heat sterilization is not limited to those exemplified above. Heat sterilization can be performed preferably under pressure. Further, by using an adjuvant that imparts a viscous property but not a shear thinning characteristic having a property such that its water absorbency is increased by heating, for example a water-absorbing dietary fiber or a starch not having been subjected to pregelatinization treatment in advance, the nutritional composition can be sterilized by heat treatment, and also the viscosity of the composition can be increased.
In the present specification, disinfection and sterilization can be used synonymously. Also, retort sterilization can be used as one aspect of heat sterilization.
[0060]
The viscosity (B-type viscometer, 20°C, 12 rpm) of the nutritional composition of the present Invention gradually increases by storing the composition at a temperature equal to or below room temperature following heat treatment, and after the elapse of a certain period of time, the viscosity is almost stabilized. The storage period of the composition can be appropriately selected according to the desired viscosity, for example, several hours to half a day, 1 day, 2 days, 3 days, 4 days, 3 days, 6 days, 7 days, 10 days, 14 days, 20 days, 30 days, 40 days, 50 days, 60 days, 70 days, 80 days, and 90 days. That is, the storage period of the composition of the present invention after heat treatment can be, for example, 1 to 90 days, preferably 5 to 60 days, more preferably 7 to 30 days, and even more preferably 7 days. The viscosity (B-type viscometer, 20°C, 12 rpm) of a nutritional composition according to a preferable embodiment of the present invention is almost stabilized approximately 7 days after (approximately one week alter) storage at a temperature equal to or below normal temperature following heat treatment. Those skilled in the art can appropriately determine the time required for stabilization of a heat-treated composition by a conventional technique.
[0091]
Also, preferably, the viscosity (B-type viscometer, 20°C, 12 rpm) of the nutritional composition of the present invention that has been subjected to heat treatment and then stored at normal temperature (15 to 25°C) or below for a certain period of time, for example 7 days, is 300 to 6500 mPa-s, preferably 300 to 3000 mPa-s, preferably 400 to 3000 mPa-s, preferably 400 to 2000 mPa-s, and more preferably 500 to 1500 mPas. The heat-treated nutritional composition of the present invention is preferably stored at 0°C to normal temperature or below. By adjusting the viscosity to the aforementioned values, conventional free-fall tube feeding can be employed for feeding a liquid nutritional compaosition to those who consume it.
As a result, gastroesophageal reflux, which is a problem associated with tube feeding of a low- viscosity nutritional composition, and cumbersome operation such as injection by syringe, which is a problem associated with feeding of a semi-solid nutritional composition with high viscosity (B-type viscometer, 20°C, 12 rpm, for example 4000 to 20000 mPa-s), are solved, whereby simple feeding is made possible. Altematively, a composition having the same degree of viscosity (B-type viscometer, 20°C, 12 rpm) as a semi-solid liquid food of 4000 mPa-s or more can be obtained by appropriately adjusting the types and contents of a water- absorbing dietary fiber, a thickening agent, and a non-pregelatinized starch, the contents and types of other ingredients such as an emulsifier, homogenization treatment pressure, and the like.
[0092]
In the present specification, when the viscosity (B-type viscometer, 20°C, 12 rpm) of the nutritional composition of the present invention that has been subjected to heat treatment and then stored for a certain period of time at a temperature equal to or below normal temperature is expressed as 300 to 3000 mPa-s, it is intended to indicate a range from not lower than the lower limit to less than the upper limit. That is, "300 to 3000 mPa-s" means 300 mPa-s or more to less than 3000 mPa-s. 10093]
The viscosity of the nutritional composition of the present invention can be measured by a conventional method. As an example, when the measurement is made at a constant shear rate, the viscosity can be measured with a B-type viscometer (for example, measurement is made with a B-type viscometer at 20 to 85°C and 12 rpm). Also, when the measurement is made at varied shear rates, as an example, the measurement can also be made under the conditions of a gap of 1 mm, 25°C, a shear rate of 1 to 100/s using the rheometer Physica
MCR301 (Anton Paar) with a cone plate having a diameter of 25 mm. Those skilled in the art can select an appropriate viscosity measurement device and determine measurement conditions according to the desired requirements.
[0094]
When the viscosity 1s measured under the conditions of a shear rate of 10/s, the viscosity of the nutritional composition of the present invention can be adjusted to 150 to 1000 m-Pas, 200 to 800 m-Pas, or 300 to 500 m-Pas. Examples of the measurement method of the aforementioned viscosity include a measurement method performed under the conditions of a gap of I mm and 25°C using the rheometer Physica MCR301 (Anton Paar) with a cone plate having a diameter of 25 mm.
[0095]
The measurement of the viscosity {B-type viscometer, 20°C. 12 rpm) of the nutritional composition of the present invention can be performed in accordance with, for example, "Standard for labeling approval of foods for special dietary uses: Test method for foods for the elderly 3, Viscosity ("How to handle the labeling approval for foods for the elderly”, (February 23, 1994, Notice No. 15 by the chief of the Office ot Health Policy on Newly Developed
Foods, Food Sanitation Division, Environmental Health Bureau, the Ministry of Health,
Labour and Welfare of Japan)) ". Specifically, using a B-type rotating viscometer, the reading is taken two minutes after rotating a rotor. Subsequently, the value thus obtained is multiplied by a coefficient corresponding to this value, and the resulting value is expressed as mPa-s. The measurement is performed at 20 + 2°C.
[0096]
Also, as other examples, the viscosity can be measured properly or continuously during the production step using an inline viscometer such as a torsional vibration viscometer, an ultrasonic viscometer, and a rotating viscometer.
[0097]
By virtue of the effect of an adjuvant that imparts a viscous property but not a shear thinning characteristic, the amounts of a thickening agent necessary for imparting a certain degree of viscosity to a composition, an emulsifier, a substance that imparts a shear thinning characteristic, and the like in the nutritional composition of the present invention can be reduced. Since the use of a substance that imparts a shear thinning characteristic such as a thickening agent can be reduced, the nutritional composition of the present invention achieves an increasing effect on the viscosity of the composition after heat treatment and storage at a temperature equal to or below normal temperature for a certain period of time, for example to 90 days, for example 7 days. In light of the above, the viscosity of the nutritional composition of the present invention before heat treatment can be kept lower that of a composition in which the viscosity 1s increased primarily by a thickening agent. That is, the present invention provides a nutritional composition that can be easily produced and fed by tube. Meanwhile, as will be demonstrated in. for example, Comparative Example 1 in
Example 1 to be described later, the viscosity of a nutritional composition produced by adding an emulsifier, not an adjuvant that imparts a viscous property but not a shear thinning characteristic, did not increase even after heat treatment and further storage at a temperature equal to or below normal temperature for 7 days, in comparison with the viscosity (B-type viscometer, 20°C, 12 rpm) before heat treatment.
[0098]
Here, the effect of an adjuvant that imparts a viscous property but not a shear thinning characteristic means that. in the production of a nutritional composition having a viscosity (B- type viscometer, 20°C, 12 rpm} of 360 to 3000 mPa-s after heat treatment and then storage at a temperature equal to or below normal temperature for a certain period of time, for example 1 to 90 days, for example 7 days. regardless of the fact that the viscosity of the composition before heat treatment is markedly lower than the viscosity of a composition in which the viscosity is increased primarily by a thickening agent, the viscosity of the composition can be brought to equal to or more than the viscosity of the nutritional formulation in which the viscosity is increased primarily by a thickening agent by heat treatment and further storage at a temperature equal to or below normal temperature for a certain period of time, for example 1 to 90 days, for example 7 days.
[0099]
By appropriately adjusting the formulation ratio of an adjuvant that imparts a viscous property but not a shear thinning characteristic, a thickening agent, and an emulsifier to be contained in the nutritional composition of the present invention and subjecting the composition to heat treatment and then to storage at a temperature equal to or below normal temperature for a certain period of time, for example 1 to 90 days, for example 7 days, a nutritional composition having a certain viscosity can be obtained. Since the viscosity of the composition is affected by factors such as the contents and types of protein and fat contained in the nutritional composition and particle diameter of fat globules before sterilization, the formulation ratio of a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, a non-pregelatinized starch, and an emulsifier can be appropriately adjusted.
[0100]
Further, the present invention can also provide a nutritional composition having a low shear thinning characteristic. The present invention enables a reduction in {ree water by virtue of the water-absorbing action of the adjuvant that imparts a viscous property but not a shear thinning characteristic used in the present vention, whereby it was made possible to reduce the amount of substances such as a thickening agent necessary for imparting a certain degree of viscosity. As a result, a shear thinning characteristic attributable to a thickening agent and the like can be reduced. In light of the above, the nutritional composition of the present invention is characterized by having a low shear thinning characteristic and fluidity closer to the Newtonian viscous property.
[0101]
The nutritional composition having a Jow shear thinning characteristic as used in the present specification refers to a nutritional composition having a reduced shear thinning characteristic. In other words, the nutritional composition having a low shear thinning characteristic as used in the present specification refers to a composition in which n, which 1s the non-Newtonian fluid index as defined in the description of the viscous property formula as above, is 0.3 or more, preferably 0.35 or more, preferably 0.4 or more, preferably 0.45 or more, preferably (0.5 or more, preferably 0.55 or more, preferably 0.6 or more, and less than 1.0, less than 0.9. for example less than 0.85, less than 0.8, less than 0.75, and less than 0.7. In the present invention, when the aforementioned lower and upper limit values are set at any of the values specified above, n can be described as "(lower limit value) to (upper limit vaiue)”,
That is, according to a further embodiment, the nutritional composition having a low shear thinning characteristic of the present invention refers to a composition having a non-
Newtonian fluid index n of, for example, 0.3 t0 1.0, 0.3t0 0.9, 0.4 t0 0.8, 0.4 t0 0.7, 0.5 to 0.8, 0.510 0.7,0.6t00.8, and 0.6 10 0.7.
[6102]
It should be noted that although Examples in the present specification describe the compositions having large n values as non-limiting examples of preferable formulation, those skilled in the art understand that in order to reduce the n value, the proportion of a substance that increases the shear thinning characteristic such as a thickening agent to be added to the composition may be increased.
[0103]
By virtue of the present invention, a nutritional composition suitable for managing the dosing rate in tube feeding through gastric fistula, duodenal fistula, and the like can be provided.
[0104]
With conventional compositions having shear thinning characteristics, a phenomenon in which the viscosity of the composition decreases with an increase in the shear rate occurs, controlling the dripping rate is difficult. In this regard, it was necessary to appropriately adjust the composition and viscosity of a composition, the type of gastrostomy tube, and the container or package for storage of the nutritional composition in accordance with the desired dripping rate.
[0165]
In contrast, the dripping rate of the nutritional composition of the present invention can readily be controlled since the viscosity of said composition of the present invention is less affected by the dripping rate. Accordingly, the nutritional composition of the present invention can be used with any gastrostomy tube and container or package for storage of the nutritional composition, irrespective of the type of gastrostomy tube (tube type, button type, balloon type, bumper type. and the like) as well as the size, form, and type of the container or package for storage of the nutritional composition. Further, diarrhea and the like can be prevented by adjusting the dosing rate even when the nutritional composition has high osmotic pressure; therefore, it is also possible to maintain the quality of life (QOL) of patients receiving nutritional compositions.
[0106] (Examples)
Example 1 Soybean dietary fiber
The effect of a water-absorbing dietary fiber on the viscosity of a nutritional composition was tested by adding a certain amount of a water-absorbing dietary fiber to the composition. Raw materials were stirred and mixed in accordance with the recipe in the upper table in Table 1 to formulate various nutritional compositions {Production Examples 1 and 2, and the like). The resulting nutritional compositions were subjected to homogenization treatment under the conditions of 50 to 60°C and a homogenization treatment pressure of 20 MPa, followed by homogenization treatment at 50 to 60°C and 30 MPa. The specific gravities of Production Examples 1 to 2 and Comparative Example 1 were all measured to be 1.14 by a density and specific weight meter at 20°C. After the viscosity of these nutritional compositions was measured [before retort sterilization], they were filled and sealed in containers and then subjected to retort sterilization under the conditions of 121 to 123.5°C for 5 to 20 minutes. The nutritional compositions after retort sterilization were stored at 15°C for one week, and the viscosity was measured again [after retort sterilization].
It should be noted that the viscosity was measured using a B-type viscometer under the conditions of 12 rpm, 20°C or 50°C. Also, the milk-derived protein used in the present
Example was a combination of 1.9% by weight of MPC, 3.8% by weight of casein sodium, and 1.5% of degradation products of milk protein, the water-absorbing dietary fiber used in the present Example was an insoluble fiber of soybean dietary fiber, and the emulsifier used in the present Example was diacetyl tartaric (acid) ester of monoglyceride (DATEM). A thickening agent was not used. Also, the composition of Production Examples 1 and 2 and Comparative
Example 1 is shown in Table 1-2. [Table 1-1} ~ Production Example 1 | Production Example 2 | Comparative Example 1 - Formulation ratio Formulation ratio | Formulation ratio ' Raw material a (wha) (wiw%) (wh)
Mitk-derived protein | ~~ 72 72 12
Dextrin oo 22: I =) 225
Dietary fiber
Indigestible dextrin 0.73 11 0
Insoluble soybean dietary fiber | 147 al 0
Sucrose | 1 6] 1.6 1.6
Mineral mixture oo 1.3 +3 13 pH Adjuster 3 as] 0.16 018
Prepared fat oo 4 4B] I
Vitamin mixture } LC 018! 0.18 | Co 018
Fragrance i 018 AL: G18
Diacetyl tariaric (acid) Diacety! tartaric {acid} | Diacetyl tartaric (acid)
Emus | ester of manoglyceride | ester of monoglyceride | ester of monoglyceride mulsifier
OATEM) | (pATEM) | (DATEM)
Lo 084 084 084
Thickening agent __ None Nore More
Water Best ®,s RO
Viscosity prior to retort ye 270{20°C} IB 120{20=C) 65(20°C)
Viscosity post refort = 1600 | 940 52
Table 1-2]
Composition | at Example 1. | Comparative example 1
POON | Production Example2 | oon
Protein esgiong 83g1o0g pid | aagioog| 44g/100g (Carbohydrate | 246g100g | 2279/1009
Detail Sugar | 22.7g/100g | 22.7g/100g
[0107]
The results of measurement of viscosity before and after heat treatment are shown in the lower table in Table 1. The viscosity of the nutritional composition of Production
Example 1 was 270 mPas (20°C) before retort sterilization, whereas it was markedly increased to 1600 mPa-s (20°C) after retort sterilization. The viscosity of Comparative
Example 1 without insoluble soybean dietary fiber was 65 mPas (20°C) before retort sterilization, and after retort sterilization, it was only slightly changed to 52 mPa-s (20°C).
That is, even in the absence of a thickening agent (Production Examples 1 and 2}, the viscosity of a composition containing a certain amount of a water-absorbing dietary fiber after retort sterilization was approximately 5.9 to 7.8 times as high as that before retort sterilization.
[0108]
From the above results, it was found that by using a water-absorbing dietary fiber in the nutritional composition of the present invention, the viscosity of the composition after retort sterilization could be dramatically increased even in the absence of a thickening agent or in the presence of only a small amount of a thickening agent.
[0109]
Example 2 Starch not having been pregelatinized in advance
The effect of a starch not having been pregelatinized in advance on the viscosity of a nutritional composition was tested by adding a certain amount of a starch not having been pregelatinized in advance to the composition. Raw materials were stirred and mixed in accordance with the recipe in Table 2-1 to formulate various nutritional compositions
(Formulations 3 and 4), and the resulting nutritional compositions were subjected to homogenization treatment under the conditions of 50 to 60°C and a homogenization treatment pressure of 20 MPa, followed by homogenization treatment at 50 to 60°C and 30 MPa. Also, the specific gravities of Formulations 3 and 4 were both measured to be 1.14 by a density and specific weight meter at 20°C. After the viscosity of these nutritional compositions was measured [before retort sterilization], they were filled and sealed in containers and then subjected to retort sterilization under the conditions of 121 to 123.5°C for 5 to 20 minutes.
The nutritional compositions after retort sterilization were stored at 153°C for three days, and the viscosity was measured again [after retort sterilization]. It should be noted that the viscosity was measured using a B-type viscometer under the conditions of 12 rpm, 20°C or 50°C. Also, the starch not having been pregelatinized in advance used in the present
Example was waxy corn starch (trade name "Suehiro 200", the product of OIJI
CORNSTARCH Co., Ltd), the milk-derived protein used in the present Example was a combination of 1.9% by weight of MPC, 3.7% by weight of casein sodium, and 1.5% of degradation products of milk protein, and the emulsifier used in the present Example was diacetyl tartaric (acid) ester of monoglyeceride (DATEM). A thickening agent was not used.
Also, the composition of Formulations 3 and 4 is shown in Table 2-2. [Table 2-1]
1 Formulation 3 Formulation4
Formulation ratio Formulation ratio
Raw material (wiw%) (w/w) LL
Milk-derived protein Ta 7.9
Dextrin + 22, 22.1
Sucrose Cn 1.6 | 1.8
Mineral mixture 1.3 1.3 pH Adjuster + 0.16 0.16
Prepared fat | 4.17 4.15
Vitamin mixture 0.18 ee 0.18
Fragrance | 0.18 0.18
Diacetyl tartaric {acid) ester | Diacetyl tartaric (acid) ester
Emulsifier of monoglyceride (DATEM) | of monoglyceride (DATEM) 0.63 oo 0.63
Thickeningagent ~~ | ~~~ None po Nome
Water 61.08 8077
Viscosity prior to retort = a | —
Viscosity post retort
Lo 563(20°C) 1600(26°C) sterilization mPa-s oo © [Table 2-2]
Composition | Formulation 3 | Formutation 4
Protein 6.3g/100g | ~~ 6.3g/100g
Lipid 4.4g/100g 4.49/100g
Carbohydrate 24 2g/100qg | 24.59/100g
Detail Sugar 24.2g/100g | 24.5g/100g
Dietaryfiber | 0g/100g| 0g/100g
[0110]
The results of measurement of viscosity before and after heat sterilization are shown in
Table 2-1. After heat sterilization, the viscosity of Formulations 3 and 4 was dramatically increased compared to before heat sterilization. Particularly, the viscosity of Formulation 4 after heat sterilization was increased to approximately 24 times as high as the viscosity before heat sterilization.
[0111]
From the above results, it was found that the viscosity of the composition after retort sterilization could be dramatically increased even in the absence of a thickening agent or in the presence of only a small amount of a thickening agent by using a starch not having been pregelatinized in advance in the nutritional composition of the present invention.
[0112]
Further, based on the observation that these nutritional compositions had a certain degree of viscosity even in the absence of a thickening agent or in the presence of only a small amount of a thickening agent, it was speculated that the Newtoman fluidity was improved. In light of this, the following test was conducted to reveal the fluidization characteristics of these nutritional compositions.
[0113]
Example 3
The shear rate-dependent viscosity of the nutritional composition of the present invention was measured. Also, a dripping test was performed using a percutaneous endoscopic gastrostomy catheter.
[0114]
Nutritional composition
Formulations 1 to 4 were prepared in accordance with Table 2-1 (Example 2) and Table 3-1. The composition of Formulations 1 and 2 is shown in Table 3-2. The specific gravities of Formulations | to 4 were all measured to be 1.14 by a density and specific weight meter at 20°C. Also, as a Comparative Example, a commercially available liquid food (trade name "F2 Light", the product of TERUMO CORPORATION) was used. It should be noted that the milk-derived protein used in the present Example was a combination of 1.9% by weight of
MPC, 3.7% by weight of casein sodium, and 1.5% of degradation products of milk protein in
Formulations 3 and 4, while that was a combination of 1.9% by weight of MPC, 3.8% by weight of casein sodium, and 1.5% of degradation products of nulk protein in Formulations and 2, and the emulsifier used in the present Example was diacetyl tartaric (acid) ester of monoglyceride (DATEM]}, and as to carrageenan, »-carrageenan was used. For specific weight, an actual measurement value obtained by a hvdrometer was recorded.
[0115]
The commercially available liquid food is assumed to have the nutritional components and specific weight as shown in Table 3-3 based on the information of the nutritional components and physical property values of the trade name "F2 light" as listed in the pamphlet of this commercially available liquid food.
[0116]
For Formulations | to 4, the raw materials were stirred and mixed and homogenization treatment was performed under the conditions of 50 to 60°C and a homogenization treatment pressure of 20 MPa, followed by homogenization treatment at 50 to 60°C and 30 MPa.
Formulations 1 to 4 after homogenization treatment were each filled and sealed in containers and subjected to retort sterilization under the conditions of 121 to 123.5°C for 10 to 20 minutes. Thereafter, the resulting products were stored at 15°C for one week and then subjected to viscosity measurement and a dripping test.
[0117]
Measurement method for shear rate-dependent viscosity
The nutritional compositions of the present invention (Formulations I to 4 and
Production Examples 1 and 2, and a commercially available liquid food) were tested. When the viscosity was measured at varied shear rates, the measurement was made under the conditions of a gap of I mm, 25°C, a shear rate of 1 to 100/s using the rheometer Physica
MCR301 (Anton Paar) with a cone plate having a diameter of 25 mm.
[0118]
Dripping test method
The nutritional compositions of the present invention (Formulations 1 and 2. and a commercially available liquid food) were tested.
The following apparatus or samples were used in this experiment:
» Tube: Percutaneous endoscopic gastrostomy catheter (CORFLO-DUAL GT, catalog
No. 8144, shaft diameter (outside diameter) 8 mm, shaft length 22.5 cm, BOSTON
SCIENTIFIC CORPORATION) s Button : PEG feeding tube (bolus feeding tube, shaft diameter (outside diameter) 4 mm, shaft length 30.5 cm, BOSTON SCIENTIFIC CORPORATION) with a button-type percutaneous endoscopic gastrostomy catheter with a bumper (Button (TM), catalog No. 6828, shaft diameter (outside diameter) 6 mm, shaft length 2.4 cm, BOSTON SCIENTIFIC
CORPORATION) attached to its tip e | L Plastic graduated cylinder (cylinder diameter ¢70 mm x total height 420 mm) e Sample to be packed in a pouch: A soft pack container for liquid food (pouch with one outlet} having 300 ml of liquid foods filled and sealed therein is used as a sample (the size of the soft pack container used is 25.5 ¢m in length x 17 cm in width, the outside diameter of the tip of an attachment port (spout part) is 0.6 cm, and normally, the container is filled with a volume of 333 ml. Also. as shown in Figure 3, the attachment port is disposed at one of the bottom corners.)
A dripping test was performed using a device shown in Figure 3. A vat 6 is placed on a scale 7 shown in Figure 3, and a 1 L graduated cylinder 4 filled with water 5 (25 + 2°C drinkable water, tap water) is placed on top of the vat 6. A sample pouch 1, in which a feeding tube 3 or a tube with a button attached to its tip 3 is connected to a spout part 2, is mounted on a stand so that the sample pouch 1 is hung from the stand. Subsequently, the height of the stand is adjusted so that the tip of the aforementioned tube or button deposits in a depth of water d of 13 to 15 cm in the graduated cylinder 4. After confirming that the tube or button was filled with the sample content, the tube or button was fixed with a cramp so that dripping of the liquid food was stopped. This state was defined as the initial state of measurement. After confirming the initial weight of the scale, dripping 1s started by removing the cramp. Time elapsed until the amount of dripping reached 100 g was measured.
[0119]
It is assumed that human stomach is under an abdominal pressure of approximately 10 mmHg. Taking this into consideration, the experimental apparatus was designed so that the tip of the tube deposits at a depth of water of 14 cm. That is, the water pressure 1s approximately 10 mmHg at a depth of water of 14 cm, and this was assumed to serve as abdominal pressure. [Table 3-1] eee rm ee Formulation 1 P Formulation2 } Formulation ratio Formulation ratio
Raw material ww) Co (wiw%)
Milk-derived protein oo 2) 72
Dextrin 22.5 22.5 ge rr om
Indigestibledextrin | 22, 1.76
Insoluble soybean dietary fiber, 0. 0.44
Sucrose 16 16
Mineral mixture | 13 13 pHAduster 4 016 01s pepsesta 42s 28
Fragrance 0.18 0.18 grance, 0b UE YK
Diacetyl tartaric (acid) ester | Diacetyl tartaric (acid) ester ' Emulsifier of monoglyceride (DATEM) | of monogltyceride (DATEM) 4 0s 083
J.-Carrageenan | x-Carrageenan
Thickening agent ree
EU oer 0033
Water | se] 6077 [Table 3-2]
Composition | Formulation 1 | Formulation 2
Protein 8900s 63 100g lipid | 44g/100g 449/100g
Catvonydse | 2479/00s 246591008,
Detail Sugar | 22.79/100g 22.7g/100g Dietryfber | 201005 1950/1000] {Table 3-3]
TT
Commercially available liquid food (per pack) i Content (g) 400
Oe ye
EEE 300
Lpd@ 858 cavonyimies | 50.8
Sugar (g) 459
Rn
Dietary fiber{gy | ~~ 49 (Waeter(g) | 330
Viscosity (mPa's) 4,000 [Specificweight | 108]
[0120]
Shear rate-dependent viscosity
In Figure 1, the shear rate (1/8) and viscosity are expressed in logarithmic scale on the horizontal axis and vertical axis, respectively. The viscosity of the commercially available liquid food is extremely high at a low shear rate, while the viscosity is low at a high shear rate.
An ideal Newtonian fluid exhibits a horizontal linear line for having a constant viscosity, irrespective of the shear rate. Regarding formulations 1, 2, 3 and 4, which are the nutritional compositions of the present invention, the non-Newtonian fluidity characteristic is alleviated and a low viscosity is maintained even at a low shear rate (Formulation 2 exhibits a viscosity of approximately 1000 at a shear rate of 1.0), and even at a high shear rate the decrease of viscosity is relatively low (Formulation 2 exhibits a viscosity of approximately 200 at a shear rate of 100}.
Table 4]
Results of measurement Results of shear rate-dependent viscosity of dripping test -____ _ TTT TTT TTT
Non-Newtoniarn Co Time (minuies)
C Viscosity (mPa-s) | _
I viscosity for dripping of 100 g index (nvalue) | 1s 10/s 100/s | Tube Button
A em rT
Commercially available liquid food 0.288 2500 450 96 3.2 oo
Formulation 1 of the present invention | 0679 730 390 170 | 40 | 14
Formulation 2 of the present invention 0.677 1020 480 230 4.5 | 23
Formulation 3 of the present invention 0.761 648 474 240 = .
Formulation 4 of the present invention 0.812 2110 831 39 - | .
Production Example 1 of the present invention 0.761 2000 1050 3500
Production Example 2 of the present invention 0691 {1100 570 280 | ;
[0121]
The results are shown in Figure 4 and Table 4. Regarding the results of measurement of the shear rate-dependent viscosity, the viscosity of the commercially available liquid food varied greatly according to the shear rate. Meanwhile, in Formulations | and 2 of the present invention, the phenomenon of shear thinning is alleviated. Regarding the dripping test, when a feeding tube was used, time (minutes) required until the amount of dripping of the commercially available liquid food reached 100 g was 3.2 minutes, whereas that was 4.0 minutes and 4.5 minutes for Formulations 1 and 2 of the present invention, respectively.
Also, when a button was used, the time required for the commercially available liquid food was 170 minutes, whereas that was 14 minutes and 23 minutes for Formulations 1 and 2 of the present invention, respectively. In fact, when the commercially available liquid food was dripped using a button, dripping almost completely stopped after reaching a cumulative drip amount of 47.4 g, which occurred 20 minutes after initiation of dripping. Therefore, the aforementioned 170 minutes were obtained by approximation from the plot for the dripped weight (g) - dripping time (minutes) from 0 to 20 minutes. As shown above, particularly when a button is used, the viscosity of a commercially available product increases due to a decrease in the shear rate, resulting in a drastically reduced flow rate. Meanwhile, the aforementioned problem of shear thinning is improved and solved with the nutritional composition of the present invention as shown in Figure 2. The ratio of dripping rate between the use of a tube and the use of a button was 0.019 for the conventional product. 0.286 for Formula 1 of the present invention, and 0.196 for Formulation 2 of the present invention, revealing that the problem of shear thinning is markedly improved.
[0122]
Assessment of fluidity index
In the following viscous property formula:
P=uD" [wherein, P represents a shear stress(Pa), which is a value obtained by multiplying the viscosity value by the shear rate value, I) represents a shear rate, p represents a non-
Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index. The viscosity (25°C, Pas) is measured under the conditions of a gap of 1 mm, 25°C, a shear rate of 1 to 1000/s, for example 1 to 100/s, using the rheometer Physica MCR301 (Anton Paar) with a cone plate having a diameter of 25 mm] an ideal Newtonian fluid has n = 1 and when the shear rate (1/5) and shear stress (Pa) are expressed in logarithmic scale on the horizontal axis and vertical axis, respectively, an ideal
Newtonian fluid exhibits a linear line passing through the origin. In contrast, the slope of a non-Newtonian fluid is n, wherein n is a fluidity index of the non-Newtonian fluid. The relationship between the shear rate and shear stress of Formulations 1 to 4 of the present invention in comparison with that of a conventional product 1s shown in Figure 2. The viscosity (Pa-s) is a value obtained by dividing shear stress (Pa) by shear rate (1/5). As shown in Figure 2, the n of the commercially available liquid food is 0.288, whereas that of
Formulation 1 of the present invention is 0.679 and that of Formulation 2 of the present invention 1s 0.677. and as shown in Table 4, the n of Formulation 3 is 0.761 and that of
Formulation 4 is 0.612, revealing that the fluidity index of the Formulations of the present invention is relatively closer to 1 compared to the commercially available liquid food.
Further, similarly to Formulations 3 and 4, there was a tendency that the viscosity of the nutritional compositions of Production Examples | and 2, to which insoluble soybean dietary fiber was added but not a thickening agent, increased after retort heat sterilization. There was a tendency that in these nutritional compositions, the value of n approached closer to 1 compared to the commercially available liquid food (Table 4).
Reference Signs List
[0123] 1 Sample pouch 2 Spout part 3 Tube 4 Graduated cylinder
Water 6 Vat 7 Scale
All the publications, patents, and patent applications cited in the present specification are incorporated herein by reference in their entirety.
Claims (1)
- [Claim 1] A nutritional composition having a fluidization characteristic comprising an adjuvant that imparts a viscous property but not a shear thinning characteristic, wherein the composition is prepared so that when results of measurement of shear stress and shear rate at any two or more measurement points in a shear rate range of shear rate 0.1/5 to 1000/s are expressed by the following viscous property formula: P= uD” wherein, P represents a shear stress (Pa), D represents a shear rate (1/s), pu represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of n is 0.3 to 1.0 and the viscosity at a shear rate of 10/s (25°C) 1s 150 mPa-s or more. {Claim 2] A nutritional composition having a fluidization characteristic comprising an adjuvant that imparts a viscous property but not a shear thinning characteristic, wherein the composition is prepared so that when results of measurement of shear stress and shear rate at any two or more measurement points in a shear rate range of shear rate of 0.1/5 to 100/s are expressed by the following viscous property formula: pP=puD" wherein, P represents a shear stress (Pa), D represents a shear rate (1/s), pt represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of n is 0.4 to 0.8 and the viscosity at a shear rate of 10/s (25°C) is 150 to 1000 mPa-s or more. [Claim 3} The nutritional composition having a fluidization characteristic according to claim 1 or 2, wherein the adjuvant that imparts a viscous property but not a shear thinning characteristic is selected from the group consisting of a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, and a starch not having been subjected to pregelatinization treatment ins advance.[Claim 4] The nutritional composition having a fluidization characteristic according to any of claims 1 to 3, comprising the adjuvant that imparts a viscous property but not a shear thinning characteristic according to any of claims 1 to 3 in an amount of 0.10 to 5.00% by weight of the nutritional composition, and having a property such that viscosity thereof is increased by heat treatment.[Claim 5] The nutritional composition having a fluidization characteristic according to any of claims I fo 4, wherein the adjuvant that imparts a viscous property but not a shear thinning characteristic 1s a water-absorbing dietary fiber.[Claim 6] The nutritional composition having a fluidization characteristic according to any of claims 3 to 5, wherein the water-absorbing dietary fiber is an insoluble dietary fiber.[Claim 7] The nutritional composition having a fluidization characteristic according to any of claims 3 to 6, wherein the water-absorbing dietary fiber is an insoluble fiber of a fusuma bran dietary fiber of a cereal.[Claim 8] The nutritional composition having a fluidization characteristic according to any of claims 3 to 7, wherein the water-absorbing dietary fiber is an insoluble fiber of soybean dietary fiber and/or soybean fusuma bran. [Claim 9} The nutritional composition having a fluidization characteristic according to any of claims 1 to 4, wherein the adjuvant that imparts a viscous property but not a shear thinning characteristic is a thickening agent that does not have a network structure in an aqueous solution. {Claim 10] The nutritional composition having a fluidization characteristic according to claim 9. wherein the thickening agent that does not have a network structure in an aqueous solution is a thickening agent selected from the group consisting of 1-carrageenan, A-carrageenan, locust bean gum, guar gum, psyllium seed gum, and tamarind seed gum. {Claim 11] The nutritional composition having a fluidization characteristic according to any of claims 1 to 4, wherein the adjuvant that imparts a viscous property but not a shear thinning characteristic is a starch not having been subjected to pregelatinization treatment in advance.[Claim 12] The nutritional composition having a fluidization characteristic according to any of claims 1 to 11, comprising one or more from the group consisting of protein, lipid. and sugar, wherein the specific weight of the composition is 1.06 to 1.5.[Claim 13] The nutritional composition having a fluidization characteristic according to any of claims 1 to 12, comprising one or more from the group consisting of a thickening agent and an emulsifier.[Claim 14] The nutritional composition having a fluidization characteristic according to any of claims 1 to 13, wherein the viscosity of the composition is 5 to 300 mPa-s, wherein the viscosity of the composition is measured at 45 to 85°C and 12 rpm using a B-type viscometer.[Claim 15] The nutritional composition having a fluidization characteristic according to any of claims 1 to 14, wherein homogenization treatment is performed by adjusting the homogenization treatment pressure to 10 to 100 MPa.[Claim 16] The nutritional composition having a fluidization characteristic according to any of claims 1 to 15, wherein the viscosity of the composition reaches 300 to 3000 mPas by subjecting the composition to heat treatment and then to storage at a temperature equal to or below normal temperature for 1 to 90 days, wherein the viscosity of the composition is measured at 20°C and 12 rpm using a B-type viscometer. [Claim 17}A nutritional composition having a fluidization characteristic comprising an adjuvant that imparts a viscous property but not a shear thinning characteristic according to any of claims 1 to 16, wherein the composition is prepared so that when results of measurement of shear stress and shear rate at any two or more measurement points in a shear rate range of shear rate of 0.1/s to 1000/s are expressed by the following viscous property formula: P= uD" wherein, P represents a shear stress (Pa), D represents a shear rate (1/5), pt represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of nis 0.3 to 1.0 and the viscosity at a shear rate of 10/5 (25°C) is 150 mPa-s or more, and wherein the composition has been subjected to heat treatment and then stored at a temperature equal to or below normal temperature for I to 90 days. {Claim 18] A nutritional composition having a fluidization characteristic comprising an adjuvant that imparts a viscous property but not a shear thinning characteristic according to any of claims 1 to 16, wherein the composition is prepared so that when results of measurement of shear stress and shear rate at any two or more measurement points in a shear rate range of shear rate of 0.1/s to 100/s are expressed by the following viscous property formula: P= uD" wherein, P represents a shear stress (Pa), D represents a shear rate (1/8), pt represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of n is 0.4 to 0.8 and the viscosity at a shear rate of 10/5 (25°C) 1s 150 mPa-s or more, and wherein the composition has been subjected to heat treatment and then stored at a temperature equal to or below normal temperature for 1 to 90 days.[Claim 19] A method for producing a viscous nutritional composition, comprising the steps of: 1) preparing an adjuvant that imparts a viscous property but not a shear thinning characteristic selected from the group consisting of a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, and a starch not having been subjected to pregelatinization treatment in advance, wherein said adjuvant is 0.10 to 5.00% by weight relative to the nutritional composition. it) applying pressure treatment for homogenization, and 11) applying heat treatment, wherein the viscosity of the composition prior to the heat treatment is 5 to 300 mPa-s, wherein the viscosity of the composition prior to the heat treatment is measured at 45 to 85°C and 12 rpm using a B-type viscometer, and the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is 300 to 3000 mPa-s, wherein the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is measured at 20°C and 12 rpm using a B-type viscometer. {Claim 20]A method for producing a viscous nutritional composition, comprising the steps of: i) preparing an adjuvant that imparts a viscous property but not a shear thinning characteristic selected from the group consisting of a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, and a starch not having been subjected to pregelatinization treatment in advance, wherein said adjuvant is 0.10 to 5.00% by weight relative to the nutritional composition, it} applying pressure treatment for homogenization, and 111) applying heat treatment, wherein the viscosity of the composition prior to the heat treatment is 5 to 300 mPa-s, wherein the viscosity of the composition prior to the heat treatment is measured at 45 to 85°C and 12 rpm using a B-type viscometer, and the homogenization treatment pressure in the step of applying pressure freatment for homogenization is 10 to 100 MPa, and the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is 300 to 3000 mPa-s, wherein the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is measured at 20°C and 12 rpm using a B-type viscometer.[Claim 21] A method for producing a nutritional composition having a fluidization characteristic comprising an adjuvant that imparts a viscous property but not a shear thinning characteristic, wherein the composition is prepared so that when results of measurement of shear stress and shear rate at any two or more measurement points in a shear rate range of shear rate of 0.1/s to 1000/s are expressed by the following viscous property formula: pP=uD" wherein, P represents a shear stress (Pa), D represents a shear rate (1/5), pu represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of nis 0.3 to 1.0 and the viscosity at a shear rate of 10/5 (25°C) is 150 mPa-s or more, comprising the steps of: i) preparing an adjuvant that imparts a viscous property but not a shear thinning characteristic selected from the group consisting of a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, and a starch not having been subjected to pregelatinization treatment in advance, wherein said adjuvant is 0.10 to 5.00% by weight relative to the nutritional composition, ii) applying pressure treatment for homogenization, and iii) applying heat treatment, wherein the viscosity of the composition prior to the heat treatment is 3 to 300 mPa-s, wherein the viscosity of the composition prior fo the heat treatment is measured at 45 to 85°C and 12 rpm using a B-type viscometer, and the homogenization treatment pressure in the step of applying pressure treatment for homogenization is 10 to 100 MPa, and the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is 300 to 3000 mPa:-s, wherein the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is measured at 20°C and 12 rpm using a B-type viscometer.[Claim 22] A method for producing a nutritional composition having a fluidization characteristic, wherein the composition is prepared so that when results of measurement of viscosity at any two or more measurement points in a shear rate range of shear rate of 0.1/s to 100/s are expressed by the following viscous property formula:P=uD"wherein, P represents a shear stress (Pa), D represents a shear rate (1/5), p represents a non-Newtonian viscosity coefficient, and n represents a non-Newtonian viscosity index, the value of nn is 0.4 to 0.8 and the viscosity at a shear rate of 10/5 (25°C) is 150 to 1000 mPa-s, comprising the steps of: i) preparing an adjuvant that imparts a viscous property but not a shear thinning characteristic selected from the group consisting of a water-absorbing dietary fiber, a thickening agent that does not have a network structure in an aqueous solution, and a starch not having been subjected to pregelatinization treatment in advance, wherein said adjuvant is 0.10 to 5.00% by weight relative to the nutritional composition, ii) applying pressure treatment for homogenization, and iii) applying heat treatment, wherein the viscosity of the composition prior to the heat treatment is 5 to 300 mPa-s, wherein the viscosity of the composition prior to the heat treatment is measured at 45 to 85°C and 12 rpm using a B-type viscometer, and the homogenization treatment pressure in the step of applying pressure treatment for homogenization is 10 to 100 MPa, and the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is 300 to 3000 mPa-s, wherein the viscosity of the composition after the heat treatment and storage at a temperature equal to or below normal temperature for 1 to 90 days is measured at 20°C and 12 rpm using a B-type viscometer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011108857 | 2011-05-13 | ||
PCT/JP2012/062184 WO2012157571A1 (en) | 2011-05-13 | 2012-05-11 | Viscous nutritional composition |
Publications (1)
Publication Number | Publication Date |
---|---|
SG194926A1 true SG194926A1 (en) | 2013-12-30 |
Family
ID=47176889
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2013083878A SG194926A1 (en) | 2011-05-13 | 2012-05-11 | Viscous nutritional composition |
Country Status (6)
Country | Link |
---|---|
JP (2) | JP6010025B2 (en) |
CN (1) | CN103561591B (en) |
HK (1) | HK1194257A1 (en) |
SG (1) | SG194926A1 (en) |
TW (1) | TWI573531B (en) |
WO (1) | WO2012157571A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201700058QA (en) * | 2014-07-04 | 2017-02-27 | Meiji Co Ltd | Dilute-type nutritional composition |
WO2016012403A1 (en) * | 2014-07-21 | 2016-01-28 | Nestec S.A. | Nutritional products to promote safe swallowing for individuals with dysphagia |
WO2017098022A1 (en) * | 2015-12-11 | 2017-06-15 | Nestec S.A. | Aseptic rtd peanut milk and method of making thereof |
CN106307518B (en) * | 2016-09-13 | 2019-11-12 | 上海民和生物科技有限公司 | A kind of water supply liquid food and preparation method thereof |
CN107279454B (en) * | 2017-06-20 | 2021-04-27 | 上海交通大学 | A novel viscous food composition and its preparation method |
EP3777560A4 (en) * | 2018-03-29 | 2021-12-01 | Fuji Oil Holdings Inc. | Method for manufacturing soybean paste food or gel food |
JP6842185B2 (en) * | 2018-07-17 | 2021-03-17 | 有限会社粉川 | Water / oil absorbent and its manufacturing method |
CN111208041A (en) * | 2020-01-10 | 2020-05-29 | 万邦德制药集团有限公司 | Preparation method of ginkgo leaf dripping pills |
KR102446554B1 (en) * | 2021-01-11 | 2022-09-22 | 에코클리어 주식회사 | the integrated prefabricated POSMACK water tank having outside enforcement earthquake-proof structure |
CN113115901A (en) * | 2021-03-18 | 2021-07-16 | 桂林全州县康乐粉业有限责任公司 | Method for simultaneously producing fresh wet rice noodles and dry rice noodles |
KR102446549B1 (en) * | 2021-03-22 | 2022-09-22 | 에코클리어 주식회사 | the prefabricated water tank having earthquake-proof structure |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003289830A (en) * | 2002-04-02 | 2003-10-14 | Asahi Kasei Corp | Thick fluid food product and method for producing the same |
JP2004065179A (en) * | 2002-08-08 | 2004-03-04 | Ezaki Glico Co Ltd | Method for producing paste-like seasoning sauce containing non-pregelatinized starch |
JP2007289164A (en) * | 2006-03-30 | 2007-11-08 | Nof Corp | Method for preparation of liquid diet |
JP2010104307A (en) * | 2008-10-31 | 2010-05-13 | House Foods Corp | Viscose fluid food |
JP2010189353A (en) * | 2009-02-20 | 2010-09-02 | Dai Ichi Kogyo Seiyaku Co Ltd | Emulsion stabilizing composition for dense liquid diet, and dense liquid diet containing the same |
JP2011004702A (en) * | 2009-06-29 | 2011-01-13 | Asahi Kasei Pharma Kk | Dietary fiber-containing nutrient composition |
JP2011120571A (en) * | 2009-11-13 | 2011-06-23 | Q P Corp | Oil-in-water emulsion seasoning and production method thereof |
JP2011147444A (en) * | 2009-12-25 | 2011-08-04 | Kaneka Corp | Emulsified food composition |
JPWO2012086593A1 (en) * | 2010-12-22 | 2014-05-22 | 株式会社明治 | Viscous nutritional composition |
-
2012
- 2012-05-11 TW TW101116955A patent/TWI573531B/en active
- 2012-05-11 SG SG2013083878A patent/SG194926A1/en unknown
- 2012-05-11 WO PCT/JP2012/062184 patent/WO2012157571A1/en active Application Filing
- 2012-05-11 CN CN201280023339.2A patent/CN103561591B/en active Active
- 2012-05-11 JP JP2013515129A patent/JP6010025B2/en active Active
-
2014
- 2014-08-01 HK HK14107879.5A patent/HK1194257A1/en not_active IP Right Cessation
-
2016
- 2016-09-15 JP JP2016180073A patent/JP6556678B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2012157571A1 (en) | 2012-11-22 |
JPWO2012157571A1 (en) | 2014-07-31 |
TWI573531B (en) | 2017-03-11 |
CN103561591A (en) | 2014-02-05 |
CN103561591B (en) | 2016-09-07 |
JP6010025B2 (en) | 2016-10-19 |
JP6556678B2 (en) | 2019-08-07 |
TW201249351A (en) | 2012-12-16 |
JP2017038602A (en) | 2017-02-23 |
HK1194257A1 (en) | 2014-10-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6556678B2 (en) | Viscous nutritional composition | |
TWI548349B (en) | Nutritional compositions with sticky properties | |
JP6015669B2 (en) | Acidic protein food with freezing tolerance | |
US20140287128A1 (en) | Emulsified liquid seasoning | |
CN107105704A (en) | Composition for preparing frozen confection | |
JP6367892B2 (en) | Viscous nutritional composition | |
TWI434659B (en) | Induced viscosity nutritional emulsions comprising a carbohydrate-surfactant complex | |
Tahmouzi et al. | Application of guar (Cyamopsis tetragonoloba L.) gum in food technologies: A review of properties and mechanisms of action | |
Alam et al. | Exploring the versatility of diverse hydrocolloids to transform techno-functional, rheological, and nutritional attributes of food fillings | |
JP5854994B2 (en) | Acid oil-in-water emulsified food | |
JP6413381B2 (en) | Gel nutrition composition | |
JP6061263B2 (en) | Gel-like food and method for producing the same | |
Prabsangob | Plant-based cellulose nanomaterials for food products with lowered energy uptake and improved nutritional value-a review | |
JP5684496B2 (en) | Water-in-oil emulsified fat composition for butter cream | |
JP2005040024A (en) | Milk fat-containing acidic milk beverage | |
Liu | Exploring commercial exploration of yellow mustard (sinapis alba l.) gum: stabilization and emulsification in vegetarian mayonnaise and non-dairy fat whipping cream | |
JP7245489B2 (en) | Shape retention agent | |
Kumar et al. | Processed Meat Products | |
JP2016063767A (en) | Multilayer cake and method for producing the same | |
JP2023131691A (en) | Texture modifier for frozen confectionery | |
JP2010051240A (en) | Stabilizer for oil and fat and/or milk component-containing drink |