CN111208041A - Preparation method of ginkgo leaf dripping pills - Google Patents
Preparation method of ginkgo leaf dripping pills Download PDFInfo
- Publication number
- CN111208041A CN111208041A CN202010027416.8A CN202010027416A CN111208041A CN 111208041 A CN111208041 A CN 111208041A CN 202010027416 A CN202010027416 A CN 202010027416A CN 111208041 A CN111208041 A CN 111208041A
- Authority
- CN
- China
- Prior art keywords
- viscosity
- standard deviation
- moving window
- viscometer
- window
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/10—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material
- G01N11/16—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material by measuring damping effect upon oscillatory body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a preparation method of a ginkgo leaf dripping pill, which comprises the following steps: heating and melting folium Ginkgo extract and polyethylene glycol 4000, mixing well to obtain mixed solution, performing viscosity detection on the mixed solution, and further preparing folium Ginkgo dripping pill according to the preparation method of dripping pill after the viscosity is qualified; the method for detecting the viscosity of the mixture liquid comprises the following steps: 1) installing an online viscometer in the mixed feed liquid; 2) the viscosity value of the mixed feed liquid was measured by an on-line viscometer. 3) Calculating the viscosity value according to a moving window standard deviation method, and when the standard deviation of the viscosity value in a moving window is less than 35 in 20-40 min, considering that the mixed material liquid reaches the standard; the method is simple to operate, economical, practical, green and environment-friendly, provides a new method for judging the end point of the auxiliary material mixing process in the drug production process, and has good economic benefit, social benefit and environmental benefit.
Description
Technical Field
The invention relates to a preparation method of a medicinal preparation, in particular to a preparation method of a ginkgo leaf dripping pill, and particularly discloses a method for controlling and measuring the viscosity of a ginkgo leaf extract mixed with polyethylene glycol 4000 to ensure the quality.
Background
Folium Ginkgo dripping pill is a commercially available medicine, has effects of promoting blood circulation, removing blood stasis and dredging collaterals, and is used for treating thoracic obstruction, cardialgia, apoplexy, hemiplegia, stiff tongue, coronary atherosclerotic heart disease, stable angina pectoris, cerebral infarction, etc. caused by blood stasis and obstruction of collaterals. The prescription component of the ginkgo biloba extract and the auxiliary material of the polyethylene glycol 4000 are listed in the pharmacopoeia of the people's republic of China in 2015 edition, and the mixing ratio of the ginkgo biloba extract and the polyethylene glycol 4000 is known technology.
However, in the production process, in order to ensure the product quality, the two are required to be mixed and the viscosity is controlled within a certain range, and an important step in the existing production process of the ginkgo leaf dripping pill is to heat and melt the ginkgo leaf extract and the polyethylene glycol 4000 and uniformly mix the ginkgo leaf extract and the polyethylene glycol to prepare mixed feed liquid. Polyethylene glycol 4000 a set point
The melt has certain viscosity, and the viscosity values of the melt at different temperatures and in a molten state have certain differences, so that the quality control is lack of standards, and the product quality defect is easily caused.
At present, no literature reports a method for measuring and controlling viscosity values of materials of polyethylene glycol 4000 and ginkgo biloba extract after mixing, and the invention researches a method for controlling and measuring the viscosity of ginkgo biloba extract and polyethylene glycol 4000 for ensuring quality according to the viscosity change trend in the mixing process of polyethylene glycol 4000 and ginkgo biloba extract.
The viscosity detecting instrument for liquid materials is mainly divided into three types, namely a capillary viscometer, a rotary viscometer and a vibration viscometer. The capillary viscometer is a common viscometer, and the sample time is calculated by utilizing the characteristic that the sample viscosity is in direct proportion to the flow time, so that the sample viscosity is further reflected; the rotary viscometer utilizes the characteristic that the torque applied by the torsion spring is in direct proportion to the viscosity of a measured sample to realize the measurement of the viscosity of the measured sample, the method has higher requirement on the state of the measured sample, and the measurement result is greatly influenced when the sample is in a flowing or stirring process, so that the rotary viscometer is difficult to realize the online measurement of the viscosity of the material liquid in the stirring and mixing process.
The viscometer is a vibration viscometer, utilizes the characteristic that the surface of a probe generates resonance shear waves with fixed micro-amplitude, and the current required by the increase of the viscosity during measurement is increased along with the increase of the viscosity, and finally converts a current signal into a real viscosity value, and judges the material mixing end point according to the change trend of the viscosity value. The method has the advantages of simple operation, economy and practicality. The method is firstly to set the continuous spectrum quantity value in the moving window, then to calculate the difference value between different spectrums, and finally to compare and analyze the difference value, so as to judge the change of the sample state truly and reliably. According to the invention, by using the calculation principle of a moving window standard deviation method, viscosity values at different time points are compared, a proper threshold value is set, and when the viscosity difference value is lower than the set threshold value, the material mixing is considered to be uniform.
Disclosure of Invention
The invention aims to provide a preparation method of a ginkgo leaf dripping pill, which comprises the following steps:
heating and melting folium Ginkgo extract and polyethylene glycol 4000, mixing well to obtain mixed solution, performing viscosity detection on the mixed solution, and further preparing folium Ginkgo dripping pill according to the preparation method of dripping pill after the viscosity is qualified.
The method for detecting the viscosity of the mixture liquid comprises the following steps:
1) installing an online viscometer in the mixed feed liquid;
2) the viscosity value of the mixed feed liquid was measured by an on-line viscometer.
3) And calculating the viscosity value according to a moving window standard deviation method, and when the standard deviation of the viscosity value is less than 35, considering that the mixed feed liquid reaches the standard.
Wherein the on-line viscometer is a vibrating on-line viscometer, and the vibrating on-line viscometer needs to be zeroed in clean and dry air during operation.
Wherein, the vibrating type on-line viscometer is arranged at a place where the external interference vibration of the mixed material liquid is small.
The heating and melting temperature is 80-120 ℃.
The detection method of the viscosity value comprises the steps of calculating the standard deviation of the viscosity value within a certain time interval by adopting a moving window standard deviation method, and detecting according to the change of the standard deviation within a moving window; the moving window time interval is 20-40 min, wherein the calculation formula of the standard deviation value in the moving window time interval is as follows:
in the formula, xiThe viscosity value of the mixed feed liquid at the ith time point is shown,
represents the average value of the viscosity over a selected time window and n represents the total number of time points over a moving window.
The threshold range of the standard deviation within the moving window time interval is 35.
Wherein the detection standard is represented by a difference threshold range, and when the standard difference of the viscosity value is less than 35 in a moving window of 20-40 min, the material mixing process is considered to reach the standard.
The present invention further provides an apparatus for preparing a mixed feed liquid, which is shown in fig. 2, wherein a linear viscometer is installed on a melting pot, and a probe of the viscometer extends into the melting pot and is completely immersed in the mixed feed liquid; the probe of the on-line viscometer can not contact with solids such as a stirring paddle and the like and can not contact with the inner wall of the melting pot.
The invention has the advantages that:
1. the on-line viscometer used in the invention utilizes a viscosity measurement method based on the torque micro-oscillation principle to achieve the purpose of judging the material mixing end point by measuring the change trend of the viscosity in the material mixing process.
2. The method is simple and convenient to operate, economical and practical, and can well monitor the material mixing end point.
Drawings
FIG. 1 is a schematic diagram of the operation steps of determining the mixing end point by the moving window time interval standard deviation method
FIG. 2 is a schematic view of an in-line viscometer installation
FIG. 3 is a schematic diagram showing the viscosity-time change of a material mixing process
FIG. 4 is a schematic diagram showing the standard deviation of viscosity and the change of time within a time interval of 25min in a moving window in a material mixing process
FIG. 5 is a schematic diagram showing the standard deviation of viscosity and the change of viscosity with time within a time interval of 30min in a moving window in a material mixing process
FIG. 6 is a schematic diagram showing the change of viscosity with time in the process of mixing materials
FIG. 7 is a schematic diagram showing the standard deviation of viscosity and the change of time within a time interval of 25min for a moving window in the material mixing process
FIG. 8 is a schematic diagram showing the standard deviation of viscosity and the change of viscosity with time within a time interval of 30min in a moving window in a material mixing process
FIG. 9 is a schematic diagram of viscosity-time variation in a material mixing process
FIG. 10 is a schematic diagram showing the standard deviation of viscosity and the change of time within a time interval of 25min for a moving window in the material mixing process
FIG. 11 is a schematic diagram showing the standard deviation of viscosity and the change of time within a time interval of 30min in a moving window in a material mixing process
Detailed Description
The following examples are further illustrative of the present invention, but the present invention is not limited thereto.
The on-line viscometer of the invention is a vibrating on-line viscometer, and the detection principle is that the surface of a probe generates resonance shear waves with fixed micro-amplitude, the current required by the increase of the viscosity during measurement is increased along with the increase of the viscosity, and then the current signal is converted into a real viscosity value finally.
In the embodiment of the invention, the on-line viscometers are fixed on the melting pot, and the probe of the viscometer extends into the melting pot and is immersed in the mixed feed liquid.
In the embodiment of the invention, the polyethylene glycol in the material is polyethylene glycol 4000.
In the embodiment of the invention, the online viscometer needs to be zeroed in dry and clean air. The heating temperature of the melting pot is 80-120 ℃.
Example 1
(1) Vibrating type on-line viscometer installation and zero setting
A vibrating on-line viscometer is fixed on a melting pot, a probe of the viscometer extends into the melting pot and is immersed in the mixed liquid, and the installation schematic diagram is shown in figure 2. The vibratile in-line viscometer was zeroed in clean, dry air.
(2) Material mixing process viscosity measurement and mixing end point judgment method
Adding appropriate amount of polyethylene glycol 4000 into melting pot, heating to 80 deg.C, adding appropriate amount of folium Ginkgo extract after melting completely, stirring, and reading viscosity value during material mixing process, wherein the viscosity-time curve is shown in FIG. 3. And drawing a viscosity value standard deviation-time curve graph by taking 25min and 30min as moving window time intervals respectively, as shown in figures 4 and 5. And when the standard deviation of the viscosity in the moving window is less than 35, the mixing process is considered to reach the end point, and the mixing is stopped.
Example 2
(1) Vibrating type on-line viscometer installation and zero setting
The same procedure as in step (1) of example 1.
(2) Material mixing process viscosity measurement and mixing end point judgment method
Adding appropriate amount of polyethylene glycol 4000 into melting pot, heating to 100 deg.C, adding appropriate amount of folium Ginkgo extract after melting completely, stirring, and reading viscosity value during material mixing process, wherein the viscosity-time curve is shown in FIG. 6. And drawing a viscosity value standard deviation-time curve graph by taking 25min and 30min as moving window time intervals respectively, as shown in figures 7 and 8. And when the standard deviation of the viscosity in the moving window is less than 35, the mixing process is considered to reach the end point, and the mixing is stopped.
Example 3
(1) Vibrating type on-line viscometer installation and zero setting
The same procedure as in step (1) of example 1.
(2) Material mixing process viscosity measurement and mixing end point judgment method
Adding appropriate amount of polyethylene glycol 4000 into melting pot, heating to 120 deg.C, adding appropriate amount of folium Ginkgo extract after melting completely, stirring, and reading viscosity value during material mixing process, wherein the viscosity-time curve is shown in FIG. 9. And drawing a viscosity value standard deviation-time curve graph by taking 25min and 30min as moving window time intervals respectively, as shown in figures 10 and 11. And when the standard deviation of the viscosity in the moving window is less than 35, the mixing process is considered to reach the end point, and the mixing is stopped.
While some embodiments of the present invention have been described, the present invention is not limited to the embodiments, and those skilled in the art can make various equivalent changes or substitutions without departing from the spirit of the present invention, and the equivalent changes or substitutions are included in the scope of the claims of the present application.
Claims (9)
1. A preparation method of a ginkgo leaf dripping pill comprises the following steps: heating and melting folium Ginkgo extract and polyethylene glycol 4000, mixing well to obtain mixed solution, performing viscosity detection on the mixed solution, and further preparing folium Ginkgo dripping pill according to the preparation method of dripping pill after the viscosity is qualified; the method for detecting the viscosity of the mixture liquid is characterized by comprising the following steps:
1) installing an online viscometer in the mixed feed liquid;
2) the viscosity value of the mixed feed liquid was measured by an on-line viscometer.
3) And calculating the viscosity value according to a moving window standard deviation method, and when the standard deviation of the viscosity value in a moving window is less than 35 in 20-40 min, considering that the mixed material liquid reaches the standard.
2. The method of claim 1 wherein said in-line viscometer is a vibratile in-line viscometer.
3. The method of claim 1, wherein the vibrating in-line viscometer is mounted on the melting pot and the probe of the viscometer extends into the melting pot and is completely immersed in the feed mixture.
4. The method of claim 3, wherein the probe of the in-line viscometer does not contact a solid such as a stirrer or the like and does not contact the inner wall of the storage tank.
5. The method of claim 1, wherein the melting temperature is 80 to 120 ℃.
6. The process according to claim 1, wherein the standard deviation of the viscosity values in the window is calculated by a moving window standard deviation method using continuously recorded viscosity values over a certain time interval as a window.
7. The method of claim 6, wherein after the standard deviation of the current window is calculated, the moving window is moved forward along the time axis for a sampling interval to remove the viscosity value that entered the window earliest and to select a new viscosity value, and the standard deviation is calculated until the standard deviation falls within a predetermined threshold range and becomes stable. The standard deviation calculation formula is as follows:
in the formula, xiThe viscosity value of the mixed feed liquid at the ith time point is shown,
represents the average value of the viscosity over a selected time window and n represents the total number of time points over a moving window.
8. The method of claim 7, wherein the moving window time interval is 20 to 40 min.
9. The method of claim 8, wherein the standard deviation of viscosity values is less than 35 within 20-40 min of the moving window.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010027416.8A CN111208041A (en) | 2020-01-10 | 2020-01-10 | Preparation method of ginkgo leaf dripping pills |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010027416.8A CN111208041A (en) | 2020-01-10 | 2020-01-10 | Preparation method of ginkgo leaf dripping pills |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111208041A true CN111208041A (en) | 2020-05-29 |
Family
ID=70786039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010027416.8A Pending CN111208041A (en) | 2020-01-10 | 2020-01-10 | Preparation method of ginkgo leaf dripping pills |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111208041A (en) |
Citations (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5054313A (en) * | 1990-07-17 | 1991-10-08 | National Metal And Refining Company, Ltd. | Control circuitry for viscosity sensors |
| US6030621A (en) * | 1998-03-19 | 2000-02-29 | De Long; Xie | Ginkgo biloba composition, method to prepare the same and uses thereof |
| JP2006317243A (en) * | 2005-05-12 | 2006-11-24 | Yamaguchi Univ | Method and device for determining mixed state |
| CN101444545A (en) * | 2009-01-03 | 2009-06-03 | 浙江万邦药业有限公司 | Folium ginkgo dripping pill and manufacturing method thereof |
| CN101780030A (en) * | 2010-03-09 | 2010-07-21 | 贵州大学 | Ginkgo flavone aglycone solid dispersion and preparation method thereof |
| CN101907551A (en) * | 2010-07-23 | 2010-12-08 | 浙江大学 | Ultrasonic detection device for Chinese medicament extract concentrated solution density and application |
| CN102183440A (en) * | 2011-03-01 | 2011-09-14 | 清华大学 | Vibrating type viscometer |
| CN102183538A (en) * | 2011-02-24 | 2011-09-14 | 张乃银 | Online monitoring method for softening point in production of terpene resin and special device |
| CN102252992A (en) * | 2011-04-28 | 2011-11-23 | 天津红日药业股份有限公司 | Method for performing near-infrared on-line detection in process of extracting Chinese medicines |
| CN103146354A (en) * | 2013-03-18 | 2013-06-12 | 江苏悦达墨特瑞新材料科技有限公司 | Ethylene glycol based heat transfer medium containing composite thermal conductive filler and preparation method thereof |
| US20130186184A1 (en) * | 2010-10-08 | 2013-07-25 | David Goodall | Viscosity measurement apparatus and method |
| CN103439288A (en) * | 2013-08-24 | 2013-12-11 | 浙江大学 | Real-time release detection method for ginkgo leaf medicinal material |
| CN103561591A (en) * | 2011-05-13 | 2014-02-05 | 株式会社明治 | Viscous nutritional composition |
| WO2014196436A1 (en) * | 2013-06-04 | 2014-12-11 | 日本ゼオン株式会社 | Porous film slurry composition for lithium ion secondary batteries, separator for lithium ion secondary batteries, electrode for lithium ion secondary batteries, and lithium ion secondary battery |
| US20150106036A1 (en) * | 2013-10-14 | 2015-04-16 | Exxonmobil Research And Engineering Company | Detection of corrosion rates in processing pipes and vessels |
| US20150114625A1 (en) * | 2013-10-29 | 2015-04-30 | Schlumberger Technology Corporation | Method of Acquiring Viscosity of A Downhole Fluid |
| CN105181526A (en) * | 2015-07-17 | 2015-12-23 | 江苏恒神股份有限公司 | Viscosity detection method in sizing agent production process |
| CN106470692A (en) * | 2014-03-29 | 2017-03-01 | 国立大学法人新泻大学 | Suppress compositionss and its manufacture method of the fatty liver and renal hypertrophy being caused by diabetes |
| JP2017078595A (en) * | 2015-10-19 | 2017-04-27 | 大陽工業株式会社 | Viscosity measurement device and viscosity measurement method |
| WO2017146286A1 (en) * | 2016-02-26 | 2017-08-31 | 에스케이케미칼주식회사 | Pharmaceutical composition of ginkgo biloba leaf extract using matrix of sustained-release hydrophilic polymer, and sustained-release oral preparation using same |
| CN107297191A (en) * | 2016-04-15 | 2017-10-27 | 江苏瑞美福实业有限公司 | Polymeric kettle |
| CN107576591A (en) * | 2017-08-03 | 2018-01-12 | 长安大学 | 60 DEG C of dynamic viscosity value quick determination methods of pitch |
| CN107811255A (en) * | 2017-11-14 | 2018-03-20 | 苏庆庆 | The nut processing method of complex again after a kind of crushing |
| WO2019039466A1 (en) * | 2017-08-25 | 2019-02-28 | 株式会社資生堂 | Method for evaluating skin feel of cosmetic and device for evaluating skin feel of cosmetic |
| CN109482249A (en) * | 2018-12-12 | 2019-03-19 | 西安交通大学 | Micro fluidic device and method for macromolecule content detection in non-newtonian fluid |
| CN109839328A (en) * | 2017-11-25 | 2019-06-04 | 深圳格林德能源集团有限公司 | The determination method of pulp of lithium ion battery dispersion effect |
| CN110208146A (en) * | 2019-07-08 | 2019-09-06 | 莆田市烛火信息技术有限公司 | A kind of detection method of epoxy resin viscosity |
| CN110263488A (en) * | 2019-07-03 | 2019-09-20 | 昆明理工大学 | A kind of industrial Mooney Viscosity of Rubber Mix flexible measurement method based on integrated instant learning |
-
2020
- 2020-01-10 CN CN202010027416.8A patent/CN111208041A/en active Pending
Patent Citations (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5054313A (en) * | 1990-07-17 | 1991-10-08 | National Metal And Refining Company, Ltd. | Control circuitry for viscosity sensors |
| US6030621A (en) * | 1998-03-19 | 2000-02-29 | De Long; Xie | Ginkgo biloba composition, method to prepare the same and uses thereof |
| JP2006317243A (en) * | 2005-05-12 | 2006-11-24 | Yamaguchi Univ | Method and device for determining mixed state |
| CN101444545A (en) * | 2009-01-03 | 2009-06-03 | 浙江万邦药业有限公司 | Folium ginkgo dripping pill and manufacturing method thereof |
| CN101780030A (en) * | 2010-03-09 | 2010-07-21 | 贵州大学 | Ginkgo flavone aglycone solid dispersion and preparation method thereof |
| CN101907551A (en) * | 2010-07-23 | 2010-12-08 | 浙江大学 | Ultrasonic detection device for Chinese medicament extract concentrated solution density and application |
| US20130186184A1 (en) * | 2010-10-08 | 2013-07-25 | David Goodall | Viscosity measurement apparatus and method |
| CN102183538A (en) * | 2011-02-24 | 2011-09-14 | 张乃银 | Online monitoring method for softening point in production of terpene resin and special device |
| CN102183440A (en) * | 2011-03-01 | 2011-09-14 | 清华大学 | Vibrating type viscometer |
| CN102252992A (en) * | 2011-04-28 | 2011-11-23 | 天津红日药业股份有限公司 | Method for performing near-infrared on-line detection in process of extracting Chinese medicines |
| CN103561591A (en) * | 2011-05-13 | 2014-02-05 | 株式会社明治 | Viscous nutritional composition |
| CN103146354A (en) * | 2013-03-18 | 2013-06-12 | 江苏悦达墨特瑞新材料科技有限公司 | Ethylene glycol based heat transfer medium containing composite thermal conductive filler and preparation method thereof |
| WO2014196436A1 (en) * | 2013-06-04 | 2014-12-11 | 日本ゼオン株式会社 | Porous film slurry composition for lithium ion secondary batteries, separator for lithium ion secondary batteries, electrode for lithium ion secondary batteries, and lithium ion secondary battery |
| CN103439288A (en) * | 2013-08-24 | 2013-12-11 | 浙江大学 | Real-time release detection method for ginkgo leaf medicinal material |
| US20150106036A1 (en) * | 2013-10-14 | 2015-04-16 | Exxonmobil Research And Engineering Company | Detection of corrosion rates in processing pipes and vessels |
| US20150114625A1 (en) * | 2013-10-29 | 2015-04-30 | Schlumberger Technology Corporation | Method of Acquiring Viscosity of A Downhole Fluid |
| CN106470692A (en) * | 2014-03-29 | 2017-03-01 | 国立大学法人新泻大学 | Suppress compositionss and its manufacture method of the fatty liver and renal hypertrophy being caused by diabetes |
| CN105181526A (en) * | 2015-07-17 | 2015-12-23 | 江苏恒神股份有限公司 | Viscosity detection method in sizing agent production process |
| JP2017078595A (en) * | 2015-10-19 | 2017-04-27 | 大陽工業株式会社 | Viscosity measurement device and viscosity measurement method |
| WO2017146286A1 (en) * | 2016-02-26 | 2017-08-31 | 에스케이케미칼주식회사 | Pharmaceutical composition of ginkgo biloba leaf extract using matrix of sustained-release hydrophilic polymer, and sustained-release oral preparation using same |
| CN107297191A (en) * | 2016-04-15 | 2017-10-27 | 江苏瑞美福实业有限公司 | Polymeric kettle |
| CN107576591A (en) * | 2017-08-03 | 2018-01-12 | 长安大学 | 60 DEG C of dynamic viscosity value quick determination methods of pitch |
| WO2019039466A1 (en) * | 2017-08-25 | 2019-02-28 | 株式会社資生堂 | Method for evaluating skin feel of cosmetic and device for evaluating skin feel of cosmetic |
| CN107811255A (en) * | 2017-11-14 | 2018-03-20 | 苏庆庆 | The nut processing method of complex again after a kind of crushing |
| CN109839328A (en) * | 2017-11-25 | 2019-06-04 | 深圳格林德能源集团有限公司 | The determination method of pulp of lithium ion battery dispersion effect |
| CN109482249A (en) * | 2018-12-12 | 2019-03-19 | 西安交通大学 | Micro fluidic device and method for macromolecule content detection in non-newtonian fluid |
| CN110263488A (en) * | 2019-07-03 | 2019-09-20 | 昆明理工大学 | A kind of industrial Mooney Viscosity of Rubber Mix flexible measurement method based on integrated instant learning |
| CN110208146A (en) * | 2019-07-08 | 2019-09-06 | 莆田市烛火信息技术有限公司 | A kind of detection method of epoxy resin viscosity |
Non-Patent Citations (8)
| Title |
|---|
| 崔向龙 等: "质量源于设计在银杏叶片制粒工艺中的应用(Ⅲ):基于设计空间的过程控制策略", 《中国中药杂志》 * |
| 李艺青: "聚合物驱油螺旋型静态混合器流场仿真与实验研究" * |
| 林兆洲 等: "中药混合过程终点在线判定方法研究", 《中国中药杂志》 * |
| 申基琛 等: "设计空间法优化银杏叶滴丸滴制工艺", 《中国中药杂志》 * |
| 谢金生: "银杏叶滴丸的制备与含量测定研究", 《中国药业》 * |
| 高婧 等: "基于主成分分析研究山楂叶 4 种提取物对血瘀证相关指标的影响", 《中草药》 * |
| 龚益飞 等: "近红外光谱法在线判断滴丸料液混合终点" * |
| 龚益飞 等: "近红外光谱法在线判断滴丸料液混合终点", 《中国药学杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5357783A (en) | Dynamic shear rheometer and method | |
| CN111855498B (en) | Asphalt mixture mixing temperature determination method based on surface energy theory | |
| Carnicer et al. | Microfluidic rheology: A new approach to measure viscosity of ceramic suspensions at extremely high shear rates | |
| CN110907246B (en) | Preparation device and use method suitable for contact angle test sample of asphalt high-viscosity substance | |
| TW201300758A (en) | Mixer sensors and methods for using same | |
| CN111208041A (en) | Preparation method of ginkgo leaf dripping pills | |
| Pu et al. | Assessment of a solid-state bulk acoustic wave sensor to measure viscosity of Newtonian and Non-Newtonian fluids under static and flow conditions | |
| JPS6312936A (en) | Viscosity measuring method | |
| CN205426721U (en) | A rotary viscosimeter for detecting composite thickening agent viscosity | |
| Labout et al. | Micromethod for determining viscosity of high viscosity materials | |
| CN108613900A (en) | Road rubber powder viscosity detecting device and method | |
| US5773712A (en) | Method for measuring viscosity and viscosimeter | |
| US5964526A (en) | Kneader and rheometric analysis method in a kneader | |
| Patil et al. | Characterization of the superconcentration and granulation steps of a disruptive spray-drying free process for the manufacture of dairy powders | |
| CN107991445B (en) | Online detection method for ethanol concentration in traditional Chinese medicine alcohol precipitation process | |
| Prentice | Precision and accuracy in viscometric measurements on foods | |
| Griffith et al. | Relation of empirical tests to fundamental viscosity of asphalt cement | |
| JPH0361835A (en) | Evaluation of quality of gelatinized starch gel | |
| CN214224954U (en) | Automatic measuring device for magnesium oxide activity | |
| CN104458837B (en) | A kind of examination of glucose concentration device and detection method | |
| JP2001059806A (en) | Method for measuring viscoelasticity of liquid | |
| Vivar-Vera et al. | Rheological and structural changes of chocolate mass | |
| CN106383085A (en) | Ball-three-plate friction test method for identifying surfactant type warm mix asphalt (WMA) | |
| CN110274964A (en) | A kind of evaluation method and device of pour-point depressant | |
| CN111272705A (en) | Quick detection method for dextrin solubility |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |