SG175968A1 - Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide - Google Patents
Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide Download PDFInfo
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- SG175968A1 SG175968A1 SG2011082492A SG2011082492A SG175968A1 SG 175968 A1 SG175968 A1 SG 175968A1 SG 2011082492 A SG2011082492 A SG 2011082492A SG 2011082492 A SG2011082492 A SG 2011082492A SG 175968 A1 SG175968 A1 SG 175968A1
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- Prior art keywords
- dimethyl
- phenyl
- butyramide
- morpholin
- compound
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- WMKGGPCROCCUDY-PHEQNACWSA-N dibenzylideneacetone Chemical compound C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 WMKGGPCROCCUDY-PHEQNACWSA-N 0.000 description 1
- LCSNDSFWVKMJCT-UHFFFAOYSA-N dicyclohexyl-(2-phenylphenyl)phosphane Chemical compound C1CCCCC1P(C=1C(=CC=CC=1)C=1C=CC=CC=1)C1CCCCC1 LCSNDSFWVKMJCT-UHFFFAOYSA-N 0.000 description 1
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- 238000009505 enteric coating Methods 0.000 description 1
- PCOBBVZJEWWZFR-UHFFFAOYSA-N ezogabine Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 PCOBBVZJEWWZFR-UHFFFAOYSA-N 0.000 description 1
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- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 description 1
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- QXFHPLPMTXEJPV-UHFFFAOYSA-N octane-1-sulfonic acid;sodium Chemical compound [Na].CCCCCCCCS(O)(=O)=O QXFHPLPMTXEJPV-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000000697 serotonin reuptake Effects 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200900597 | 2009-05-11 | ||
| PCT/DK2010/050101 WO2010130260A2 (fr) | 2009-05-11 | 2010-05-11 | Formes stables du n-(2,6-diméthyl-4-morpholin-4-ylphényl)-3,3-diméthylbutyramide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG175968A1 true SG175968A1 (en) | 2011-12-29 |
Family
ID=42237259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2011082492A SG175968A1 (en) | 2009-05-11 | 2010-05-11 | Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP2430008A2 (fr) |
| JP (1) | JP2012526152A (fr) |
| KR (1) | KR20120022934A (fr) |
| CN (1) | CN102459208A (fr) |
| AR (1) | AR076556A1 (fr) |
| AU (1) | AU2010246724B2 (fr) |
| BR (1) | BRPI1013930A2 (fr) |
| CA (1) | CA2761383A1 (fr) |
| CL (1) | CL2011002814A1 (fr) |
| CO (1) | CO6460741A2 (fr) |
| CR (1) | CR20110590A (fr) |
| DO (1) | DOP2011000351A (fr) |
| EA (1) | EA201171381A1 (fr) |
| GE (1) | GEP20146006B (fr) |
| IL (1) | IL216148A0 (fr) |
| MA (1) | MA33351B1 (fr) |
| MX (1) | MX2011011885A (fr) |
| NZ (1) | NZ596738A (fr) |
| SG (1) | SG175968A1 (fr) |
| TN (1) | TN2011000557A1 (fr) |
| TW (1) | TW201041857A (fr) |
| WO (1) | WO2010130260A2 (fr) |
| ZA (1) | ZA201108112B (fr) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI349666B (en) * | 2004-03-12 | 2011-10-01 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivatives |
| DK2061465T3 (da) * | 2006-08-23 | 2013-07-08 | Valeant Pharmaceuticals Int | Derivater af 4-(N-azacycloalkyl)anilider som kaliumkanalmodulatorer |
| NZ582942A (en) * | 2007-08-01 | 2011-09-30 | Lundbeck & Co As H | Use of kncq potassium channel openers for treating attention deficit hyperactivity disorder (adhd) or aggression |
-
2010
- 2010-05-06 TW TW099114459A patent/TW201041857A/zh unknown
- 2010-05-10 AR ARP100101588A patent/AR076556A1/es unknown
- 2010-05-11 EA EA201171381A patent/EA201171381A1/ru unknown
- 2010-05-11 CA CA2761383A patent/CA2761383A1/fr not_active Abandoned
- 2010-05-11 MX MX2011011885A patent/MX2011011885A/es not_active Application Discontinuation
- 2010-05-11 GE GEAP201012498A patent/GEP20146006B/en unknown
- 2010-05-11 JP JP2012510116A patent/JP2012526152A/ja active Pending
- 2010-05-11 KR KR1020117026958A patent/KR20120022934A/ko not_active Application Discontinuation
- 2010-05-11 EP EP10719726A patent/EP2430008A2/fr not_active Withdrawn
- 2010-05-11 WO PCT/DK2010/050101 patent/WO2010130260A2/fr active Application Filing
- 2010-05-11 SG SG2011082492A patent/SG175968A1/en unknown
- 2010-05-11 BR BRPI1013930A patent/BRPI1013930A2/pt not_active IP Right Cessation
- 2010-05-11 AU AU2010246724A patent/AU2010246724B2/en not_active Ceased
- 2010-05-11 CN CN2010800321765A patent/CN102459208A/zh active Pending
- 2010-05-11 NZ NZ596738A patent/NZ596738A/xx not_active IP Right Cessation
- 2010-05-11 MA MA34435A patent/MA33351B1/fr unknown
-
2011
- 2011-11-03 IL IL216148A patent/IL216148A0/en unknown
- 2011-11-04 ZA ZA2011/08112A patent/ZA201108112B/en unknown
- 2011-11-04 TN TNP2011000557A patent/TN2011000557A1/en unknown
- 2011-11-10 CL CL2011002814A patent/CL2011002814A1/es unknown
- 2011-11-11 CO CO11153611A patent/CO6460741A2/es not_active Application Discontinuation
- 2011-11-11 CR CR20110590A patent/CR20110590A/es unknown
- 2011-11-11 DO DO2011000351A patent/DOP2011000351A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2011002814A1 (es) | 2012-04-13 |
| NZ596738A (en) | 2013-04-26 |
| GEP20146006B (en) | 2014-01-10 |
| ZA201108112B (en) | 2013-01-30 |
| DOP2011000351A (es) | 2012-01-31 |
| KR20120022934A (ko) | 2012-03-12 |
| CN102459208A (zh) | 2012-05-16 |
| AU2010246724A1 (en) | 2011-12-08 |
| WO2010130260A3 (fr) | 2011-06-16 |
| AR076556A1 (es) | 2011-06-22 |
| CO6460741A2 (es) | 2012-06-15 |
| BRPI1013930A2 (pt) | 2019-09-24 |
| TW201041857A (en) | 2010-12-01 |
| IL216148A0 (en) | 2012-01-31 |
| WO2010130260A2 (fr) | 2010-11-18 |
| MA33351B1 (fr) | 2012-06-01 |
| MX2011011885A (es) | 2011-12-06 |
| EA201171381A1 (ru) | 2012-05-30 |
| WO2010130260A9 (fr) | 2012-10-18 |
| JP2012526152A (ja) | 2012-10-25 |
| AU2010246724B2 (en) | 2013-03-21 |
| TN2011000557A1 (en) | 2013-05-24 |
| EP2430008A2 (fr) | 2012-03-21 |
| CA2761383A1 (fr) | 2010-11-18 |
| CR20110590A (es) | 2012-02-22 |
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