SG158108A1 - Production of beta-lactam antibiotics by genetically modified non- naturally producing microorganisms - Google Patents

Production of beta-lactam antibiotics by genetically modified non- naturally producing microorganisms

Info

Publication number
SG158108A1
SG158108A1 SG200908083-9A SG2009080839A SG158108A1 SG 158108 A1 SG158108 A1 SG 158108A1 SG 2009080839 A SG2009080839 A SG 2009080839A SG 158108 A1 SG158108 A1 SG 158108A1
Authority
SG
Singapore
Prior art keywords
beta
production
genetically modified
lactam
modified non
Prior art date
Application number
SG200908083-9A
Other languages
English (en)
Inventor
Marco Alexander Van Den Berg
Roelof Ary Lans Bovenberg
Hendrik Jan Noorman
Bastiaan Romein
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of SG158108A1 publication Critical patent/SG158108A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG200908083-9A 2004-12-10 2005-12-08 Production of beta-lactam antibiotics by genetically modified non- naturally producing microorganisms SG158108A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04106471 2004-12-10

Publications (1)

Publication Number Publication Date
SG158108A1 true SG158108A1 (en) 2010-01-29

Family

ID=34930032

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200908083-9A SG158108A1 (en) 2004-12-10 2005-12-08 Production of beta-lactam antibiotics by genetically modified non- naturally producing microorganisms

Country Status (8)

Country Link
US (1) US20080131925A1 (zh)
EP (1) EP1819813A2 (zh)
KR (1) KR20070085955A (zh)
CN (1) CN101098963A (zh)
BR (1) BRPI0518399A2 (zh)
MX (1) MX2007006780A (zh)
SG (1) SG158108A1 (zh)
WO (1) WO2006061425A2 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008040731A2 (en) * 2006-10-05 2008-04-10 Dsm Ip Assets B.V. Production of beta-lactam antibiotics
EP2080801A1 (en) * 2008-01-21 2009-07-22 Technical University of Denmark Production of non-ribosomal peptides in Saccharomyces
EP2123772A1 (en) * 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-lactam antibiotic producing strains
EP2376619A4 (en) 2008-12-15 2012-07-04 Greenlight Biosciences Inc METHODS FOR CONTROLLING FLOWS IN METABOLIC PATHWAYS
WO2010074760A1 (en) * 2008-12-22 2010-07-01 Greenlight Biosciences Compositions and methods for the production of a compound
KR20130071433A (ko) 2010-05-07 2013-06-28 그린라이트 바이오사이언시스, 아이엔씨. 효소의 재배치를 통한 대사 경로에서의 흐름의 제어 방법
KR101988063B1 (ko) 2010-08-31 2019-09-30 그린라이트 바이오사이언시스, 아이엔씨. 프로테아제 조작을 통한 대사 경로에서 유동의 제어 방법
WO2013036787A2 (en) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Cell-free preparation of carbapenems
EP3460069B1 (en) 2013-08-05 2021-10-20 Greenlight Biosciences, Inc. Therapeutically active compounds and their methods of use
KR20180002636A (ko) 2015-03-30 2018-01-08 그린라이트 바이오사이언시스, 아이엔씨. 리보핵산의 무세포 생산
KR20230079463A (ko) 2016-04-06 2023-06-07 그린라이트 바이오사이언시스, 아이엔씨. 리보핵산의 무세포 생산
CN110300800A (zh) 2017-01-06 2019-10-01 绿光生物科技股份有限公司 糖的无细胞生产
KR102571743B1 (ko) 2017-10-11 2023-08-29 그린라이트 바이오사이언시스, 아이엔씨. 뉴클레오시드 트리포스페이트 및 리보핵산 생산을 위한 방법 및 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1327170C (en) * 1987-03-04 1994-02-22 Stephen Wyatt Queener Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase and deacetylcephalosporin c synthetase
US6258555B1 (en) * 1987-12-09 2001-07-10 Beecham Group P.L.C. DNA encoding ACV synthetase
GB8728811D0 (en) * 1987-12-09 1988-01-27 Beecham Group Plc Novel substance
US5882879A (en) * 1990-02-28 1999-03-16 Gist-Brocades, N.V. Method for influencing β-lactam antibiotic production and for isolation of large quantities of ACV synthetase

Also Published As

Publication number Publication date
WO2006061425A3 (en) 2006-08-03
MX2007006780A (es) 2007-08-06
CN101098963A (zh) 2008-01-02
EP1819813A2 (en) 2007-08-22
WO2006061425A2 (en) 2006-06-15
US20080131925A1 (en) 2008-06-05
KR20070085955A (ko) 2007-08-27
BRPI0518399A2 (pt) 2008-11-18

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