SG11202108774XA - Microfluidic method and system for the isolation of particles - Google Patents

Microfluidic method and system for the isolation of particles

Info

Publication number
SG11202108774XA
SG11202108774XA SG11202108774XA SG11202108774XA SG11202108774XA SG 11202108774X A SG11202108774X A SG 11202108774XA SG 11202108774X A SG11202108774X A SG 11202108774XA SG 11202108774X A SG11202108774X A SG 11202108774XA SG 11202108774X A SG11202108774X A SG 11202108774XA
Authority
SG
Singapore
Prior art keywords
isolation
particles
microfluidic method
microfluidic
Prior art date
Application number
SG11202108774XA
Inventor
Gianni Medoro
Original Assignee
Menarini Silicon Biosystems Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Silicon Biosystems Spa filed Critical Menarini Silicon Biosystems Spa
Publication of SG11202108774XA publication Critical patent/SG11202108774XA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1894—Cooling means; Cryo cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424—Dielectrophoretic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1415—Control of particle position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Electrostatic Separation (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
SG11202108774XA 2019-02-26 2020-02-26 Microfluidic method and system for the isolation of particles SG11202108774XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102019000002777A IT201900002777A1 (en) 2019-02-26 2019-02-26 METHOD AND MICROFLUIDIC SYSTEM FOR THE ISOLATION OF PARTICLES
PCT/IB2020/051647 WO2020174422A1 (en) 2019-02-26 2020-02-26 Microfluidic method and system for the isolation of particles

Publications (1)

Publication Number Publication Date
SG11202108774XA true SG11202108774XA (en) 2021-09-29

Family

ID=66690772

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202108774XA SG11202108774XA (en) 2019-02-26 2020-02-26 Microfluidic method and system for the isolation of particles

Country Status (13)

Country Link
US (1) US20220143615A1 (en)
EP (1) EP3930899B1 (en)
JP (1) JP7551637B2 (en)
KR (1) KR20210145140A (en)
CN (1) CN113490549B (en)
AU (1) AU2020229471A1 (en)
CA (1) CA3130041A1 (en)
IL (1) IL285834A (en)
IT (1) IT201900002777A1 (en)
PL (1) PL3930899T3 (en)
SA (1) SA521430149B1 (en)
SG (1) SG11202108774XA (en)
WO (1) WO2020174422A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113996357B (en) * 2021-10-29 2023-05-23 北京理工大学 Method for controlling directional flow of liquid by heating condition in micro-fluidic chip pipeline

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1309430B1 (en) 1999-05-18 2002-01-23 Guerrieri Roberto METHOD AND APPARATUS FOR HANDLING PARTICLES BY MEANS OF ELECTROPHORESIS
ITBO20050481A1 (en) 2005-07-19 2007-01-20 Silicon Biosystems S R L METHOD AND APPARATUS FOR THE HANDLING AND / OR IDENTIFICATION OF PARTICLES
ITBO20050643A1 (en) 2005-10-24 2007-04-25 Si Bio S R L METHOD AND APPARATUS FOR HANDLING PARTICLES IN CONDUCTIVE SOLUTIONS
US20080302732A1 (en) * 2007-05-24 2008-12-11 Hyongsok Soh Integrated fluidics devices with magnetic sorting
PT2408562T (en) 2009-03-17 2018-06-06 Menarini Silicon Biosystems Spa Microfluidic device for isolation of cells
JP5920895B2 (en) 2010-09-14 2016-05-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Method and device for isolating cells from heterogeneous solutions using microfluidic capture vortices
IT1403518B1 (en) 2010-12-22 2013-10-31 Silicon Biosystems Spa MICROFLUID DEVICE FOR PARTICLE HANDLING
US9846150B2 (en) * 2011-06-02 2017-12-19 Industry-Academic Cooperation Foundation Yonsei University High efficiency particle separating apparatus and method
US10240186B2 (en) * 2011-07-14 2019-03-26 Fluxion Biosciences, Inc. Devices, systems, and methods for magnetic separation
CN103959037A (en) * 2011-10-25 2014-07-30 皇家飞利浦有限公司 Filtering particles from blood or other media
US20160016180A1 (en) * 2013-03-08 2016-01-21 Duke University Devices, systems, and methods for acoustically-enhanced magnetophoresis
EP3473700B1 (en) * 2013-10-22 2020-05-13 Berkeley Lights, Inc. Microfluidic devices having isolation pens and methods of testing biological micro-objects with same
CN109142717B (en) * 2013-10-22 2021-11-16 伯克利之光生命科技公司 Microfluidic device for determining biological activity
ES2637385T3 (en) * 2013-12-04 2017-10-13 Menarini Silicon Biosystems S.P.A. Method and kit to determine genome integrity and / or the quality of a library of DNA sequences obtained by complete genome amplification by deterministic restriction sites
EP3247998B1 (en) * 2015-01-21 2021-09-22 SBT Instruments A/S Microfluidic particle analysis device
DE102015218177B4 (en) * 2015-09-22 2022-09-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Isolation and enrichment of magnetically labeled cells in flow-through
US10717086B2 (en) 2016-08-29 2020-07-21 The Regents Of The University Of California Integrated system for isolation and emulsification of particles and cells

Also Published As

Publication number Publication date
CN113490549B (en) 2023-08-01
WO2020174422A1 (en) 2020-09-03
JP7551637B2 (en) 2024-09-17
KR20210145140A (en) 2021-12-01
SA521430149B1 (en) 2024-08-04
IL285834A (en) 2021-10-31
IT201900002777A1 (en) 2020-08-26
CN113490549A (en) 2021-10-08
JP2022521940A (en) 2022-04-13
CA3130041A1 (en) 2020-09-03
EP3930899B1 (en) 2024-02-21
AU2020229471A1 (en) 2021-09-16
EP3930899A1 (en) 2022-01-05
PL3930899T3 (en) 2024-06-24
US20220143615A1 (en) 2022-05-12

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