SG11202108227RA - Method and apparatus for isolating desired cells from suspensions with non-magnetic biological materials - Google Patents
Method and apparatus for isolating desired cells from suspensions with non-magnetic biological materialsInfo
- Publication number
- SG11202108227RA SG11202108227RA SG11202108227RA SG11202108227RA SG11202108227RA SG 11202108227R A SG11202108227R A SG 11202108227RA SG 11202108227R A SG11202108227R A SG 11202108227RA SG 11202108227R A SG11202108227R A SG 11202108227RA SG 11202108227R A SG11202108227R A SG 11202108227RA
- Authority
- SG
- Singapore
- Prior art keywords
- suspensions
- biological materials
- desired cells
- isolating desired
- magnetic biological
- Prior art date
Links
- 239000012620 biological material Substances 0.000 title 1
- 239000000725 suspension Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/005—Pretreatment specially adapted for magnetic separation
- B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/025—High gradient magnetic separators
- B03C1/031—Component parts; Auxiliary operations
- B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
- B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/30—Combinations with other devices, not otherwise provided for
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/10—Rotating vessel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19155839.4A EP3693739A1 (en) | 2019-02-06 | 2019-02-06 | Method and device for isolating desired cells from a sample of nonmagnetic biological material |
| PCT/EP2020/053013 WO2020161252A1 (en) | 2019-02-06 | 2020-02-06 | Method and apparatus for isolating desired cells from suspensions with non-magnetic biological materials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202108227RA true SG11202108227RA (en) | 2021-08-30 |
Family
ID=65529234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202108227RA SG11202108227RA (en) | 2019-02-06 | 2020-02-06 | Method and apparatus for isolating desired cells from suspensions with non-magnetic biological materials |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220184634A1 (en) |
| EP (2) | EP3693739A1 (en) |
| CN (1) | CN113424061A (en) |
| AU (1) | AU2020217874A1 (en) |
| CA (1) | CA3127947A1 (en) |
| SG (1) | SG11202108227RA (en) |
| WO (1) | WO2020161252A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI802111B (en) | 2020-11-27 | 2023-05-11 | 財團法人工業技術研究院 | Cell activation reactor and cell activation method |
| DE202021105458U1 (en) | 2021-10-08 | 2023-01-24 | Sanolibio Co., Ltd. | Device for the magnetic purification of biological samples |
| DE102022200663A1 (en) | 2022-01-21 | 2023-07-27 | Robert Bosch Gesellschaft mit beschränkter Haftung | Microfluidic device and method of its operation |
| WO2023180465A1 (en) * | 2022-03-23 | 2023-09-28 | University Of Twente | A magnetic micro-needle to isolate single immunomagnetically labeled cells |
| DE102022210777A1 (en) | 2022-10-13 | 2024-04-18 | Robert Bosch Gesellschaft mit beschränkter Haftung | Microfluidic cartridge, microfluidic device and method for its operation |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US662398A (en) | 1899-10-11 | 1900-11-27 | Franklin B Giesler | Malting-drum. |
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| NO155316C (en) | 1982-04-23 | 1987-03-11 | Sintef | PROCEDURE FOR MAKING MAGNETIC POLYMER PARTICLES. |
| US4664796A (en) | 1985-09-16 | 1987-05-12 | Coulter Electronics, Inc. | Flux diverting flow chamber for high gradient magnetic separation of particles from a liquid medium |
| US5597531A (en) | 1985-10-04 | 1997-01-28 | Immunivest Corporation | Resuspendable coated magnetic particles and stable magnetic particle suspensions |
| US4884088A (en) | 1988-11-21 | 1989-11-28 | Polaroid Corporation | Kit for converting 35 mm camera for use with self-developing transparency film |
| WO1990007380A2 (en) | 1988-12-28 | 1990-07-12 | Stefan Miltenyi | Methods and materials for high gradient magnetic separation of biological materials |
| US6020210A (en) | 1988-12-28 | 2000-02-01 | Miltenvi Biotech Gmbh | Methods and materials for high gradient magnetic separation of biological materials |
| US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
| US5186827A (en) | 1991-03-25 | 1993-02-16 | Immunicon Corporation | Apparatus for magnetic separation featuring external magnetic means |
| US20030127396A1 (en) * | 1995-02-21 | 2003-07-10 | Siddiqi Iqbal Waheed | Apparatus and method for processing magnetic particles |
| US5705059A (en) | 1995-02-27 | 1998-01-06 | Miltenyi; Stefan | Magnetic separation apparatus |
| US5725535A (en) | 1996-09-20 | 1998-03-10 | Hegde; Anant V. | Multiple balloon stent delivery catheter and method |
| US6551843B1 (en) * | 1999-01-29 | 2003-04-22 | Immunivest Corporation | Methods for enhancing binding interactions between members of specific binding pairs |
| WO2002071929A2 (en) | 2001-03-14 | 2002-09-19 | Burnstein Technologies, Inc. | Methods of decreasing non-specific binding in dual bead assays and system apparatus for detecting medical targets |
| US7135340B2 (en) | 2001-11-07 | 2006-11-14 | Stemcell Technologies Inc. | Tetrameric antibody complexes for blocking non-specific labeling of antigens |
| WO2005028663A2 (en) * | 2003-09-18 | 2005-03-31 | Immunivest Corporation | Operator independent programmable sample preparation and analysis system |
| DE102007043281A1 (en) | 2007-09-11 | 2009-05-28 | Sebastian Dr. med. Chakrit Bhakdi | Apparatus, materials and methods for high gradient magnetic separation of biological material |
| US20120132593A1 (en) * | 2010-11-30 | 2012-05-31 | General Electric Company | Systems and methods for magnetic separation of biological materials |
| US20140100102A1 (en) * | 2012-10-10 | 2014-04-10 | California Institute Of Technology | Devices and methods for cell lysis and sample preparation through centrifugation |
| EP3037170A1 (en) * | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Multisort cell separation method |
| WO2016179053A1 (en) * | 2015-05-01 | 2016-11-10 | BioLegend, Inc. | Stable nanomagnetic particle dispersions |
| CN104928280A (en) * | 2015-06-26 | 2015-09-23 | 关节动力安达（天津）生物科技有限公司 | Rotary magnetic cell separation method |
| DE102015013851B3 (en) | 2015-10-27 | 2016-10-13 | Stefan Schreier | Method for improved magnetic marking of biological materials |
| CN108220233B (en) * | 2016-12-21 | 2021-07-09 | 上海透景诊断科技有限公司 | Cell separation instrument surface treatment method, related instrument, and method for rapidly and efficiently separating peripheral blood rare cells or circulating tumor cells |
| CN108546676A (en) * | 2018-04-21 | 2018-09-18 | 深圳市红莓生物科技有限公司 | The method that tunnel magnetic field technology detaches and is enriched with rare cell in peripheral blood |
| CN108795869A (en) * | 2018-06-28 | 2018-11-13 | 亚能生物技术（深圳）有限公司 | A kind of circulating tumor cell positive enrichment method |
-
2019
- 2019-02-06 EP EP19155839.4A patent/EP3693739A1/en not_active Withdrawn
-
2020
- 2020-02-06 US US17/428,842 patent/US20220184634A1/en active Pending
- 2020-02-06 AU AU2020217874A patent/AU2020217874A1/en active Pending
- 2020-02-06 EP EP20702498.5A patent/EP3921645B1/en active Active
- 2020-02-06 CA CA3127947A patent/CA3127947A1/en active Pending
- 2020-02-06 SG SG11202108227RA patent/SG11202108227RA/en unknown
- 2020-02-06 WO PCT/EP2020/053013 patent/WO2020161252A1/en active Search and Examination
- 2020-02-06 CN CN202080012746.8A patent/CN113424061A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3921645B1 (en) | 2023-06-07 |
| CN113424061A (en) | 2021-09-21 |
| US20220184634A1 (en) | 2022-06-16 |
| WO2020161252A1 (en) | 2020-08-13 |
| AU2020217874A1 (en) | 2021-08-26 |
| EP3921645A1 (en) | 2021-12-15 |
| EP3921645C0 (en) | 2023-06-07 |
| CA3127947A1 (en) | 2020-08-13 |
| EP3693739A1 (en) | 2020-08-12 |
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