SG11202103232WA - Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions - Google Patents

Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions

Info

Publication number
SG11202103232WA
SG11202103232WA SG11202103232WA SG11202103232WA SG11202103232WA SG 11202103232W A SG11202103232W A SG 11202103232WA SG 11202103232W A SG11202103232W A SG 11202103232WA SG 11202103232W A SG11202103232W A SG 11202103232WA SG 11202103232W A SG11202103232W A SG 11202103232WA
Authority
SG
Singapore
Prior art keywords
automatic
real
raman spectroscopic
time predictions
maintenance
Prior art date
Application number
SG11202103232WA
Other languages
English (en)
Inventor
Aditya Tulsyan
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG11202103232WA publication Critical patent/SG11202103232WA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48Automatic or computerized control
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J3/44Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00Machine learning
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00Computing arrangements using knowledge-based models
    • G06N5/04Inference or reasoning models
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84Systems specially adapted for particular applications
    • G01N2021/8411Application to online plant, process monitoring
    • G01N2021/8416Application to online plant, process monitoring and process controlling, not otherwise provided for
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/12Circuits of general importance; Signal processing
    • G01N2201/127Calibration; base line adjustment; drift compensation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/12Circuits of general importance; Signal processing
    • G01N2201/129Using chemometrical methods

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Software Systems (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mathematical Physics (AREA)
  • Computing Systems (AREA)
  • Evolutionary Computation (AREA)
  • Data Mining & Analysis (AREA)
  • Artificial Intelligence (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Computational Linguistics (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Computer Hardware Design (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
SG11202103232WA 2018-10-23 2019-10-23 Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions SG11202103232WA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862749359P 2018-10-23 2018-10-23
US201962833044P 2019-04-12 2019-04-12
US201962864565P 2019-06-21 2019-06-21
PCT/US2019/057513 WO2020086635A1 (en) 2018-10-23 2019-10-23 Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions

Publications (1)

Publication Number Publication Date
SG11202103232WA true SG11202103232WA (en) 2021-05-28

Family

ID=70331744

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202103232WA SG11202103232WA (en) 2018-10-23 2019-10-23 Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions

Country Status (13)

Country Link
US (1) US20220128474A1 (pt)
EP (1) EP3870957A1 (pt)
JP (1) JP2022512775A (pt)
KR (1) KR20210078531A (pt)
CN (1) CN112912716A (pt)
AU (1) AU2019365102A1 (pt)
BR (1) BR112021007611A2 (pt)
CA (1) CA3115296A1 (pt)
CL (1) CL2021001024A1 (pt)
IL (1) IL281977A (pt)
MX (1) MX2021004510A (pt)
SG (1) SG11202103232WA (pt)
WO (1) WO2020086635A1 (pt)

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CN114207593A (zh) * 2019-06-10 2022-03-18 沃特世科技爱尔兰有限公司 用于分析仪器性能诊断的技术
WO2022072198A1 (en) * 2020-10-01 2022-04-07 Amgen Inc. Predictive modeling and control of cell culture
US20220138557A1 (en) * 2020-11-04 2022-05-05 Adobe Inc. Deep Hybrid Graph-Based Forecasting Systems
DE102021100531B3 (de) * 2021-01-13 2022-03-31 BioThera Institut GmbH Apparatur zum Steuern eines Prozesses sowie zugehöriges Steuerungsverfahren
EP4352200A1 (en) * 2021-06-09 2024-04-17 Amgen Inc. Assessing packed cell volume for cell cultures
AR127458A1 (es) 2021-10-27 2024-01-24 Amgen Inc Predicción basada en aprendizaje profundo usando espectroscopia
US20230279332A1 (en) * 2022-03-01 2023-09-07 Amgen Inc. Hybrid Predictive Modeling for Control of Cell Culture
WO2024049725A1 (en) * 2022-08-29 2024-03-07 Amgen Inc. Predictive model to evaluate processing time impacts
WO2024046603A1 (en) * 2022-08-29 2024-03-07 Büchi Labortechnik AG Methods for providing a predictive model for spectroscopy and calibrating a spectroscopic device
US20240085864A1 (en) 2022-09-14 2024-03-14 Amgen Inc. Just-In-Time Learning With Variational Autoencoder For Cell Culture Process Monitoring And/Or Control
WO2024129650A1 (en) * 2022-12-12 2024-06-20 Genentech, Inc. Real-time automated monitoring and control of ultrafiltration/diafiltration (uf/df) conditioning and dilution processes

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US5862060A (en) * 1996-11-22 1999-01-19 Uop Llc Maintenance of process control by statistical analysis of product optical spectrum
NZ507381A (en) 1998-04-21 2003-12-19 Micromet Ag CD19xCD3 specific polypeptides and uses thereof
US7398119B2 (en) * 1998-07-13 2008-07-08 Childrens Hospital Los Angeles Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
KR101304718B1 (ko) 2002-12-20 2013-09-05 암겐 인코포레이티드 미오스타틴을 저해하는 결합제
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WO2016004322A2 (en) * 2014-07-02 2016-01-07 Biogen Ma Inc. Cross-scale modeling of bioreactor cultures using raman spectroscopy
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US20170127983A1 (en) * 2015-11-10 2017-05-11 Massachusetts Institute Of Technology Systems and methods for sampling calibration of non-invasive analyte measurements
EA039859B1 (ru) 2016-02-03 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3

Also Published As

Publication number Publication date
AU2019365102A1 (en) 2021-04-29
KR20210078531A (ko) 2021-06-28
US20220128474A1 (en) 2022-04-28
IL281977A (en) 2021-05-31
MX2021004510A (es) 2021-06-08
BR112021007611A2 (pt) 2021-07-27
CN112912716A (zh) 2021-06-04
TW202033949A (zh) 2020-09-16
EP3870957A1 (en) 2021-09-01
JP2022512775A (ja) 2022-02-07
CA3115296A1 (en) 2020-04-30
CL2021001024A1 (es) 2021-09-24
WO2020086635A1 (en) 2020-04-30

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