SG11202101014XA - Chimeric antigen receptor therapy t cell expansion kinetics and uses thereof - Google Patents

Chimeric antigen receptor therapy t cell expansion kinetics and uses thereof

Info

Publication number
SG11202101014XA
SG11202101014XA SG11202101014XA SG11202101014XA SG11202101014XA SG 11202101014X A SG11202101014X A SG 11202101014XA SG 11202101014X A SG11202101014X A SG 11202101014XA SG 11202101014X A SG11202101014X A SG 11202101014XA SG 11202101014X A SG11202101014X A SG 11202101014XA
Authority
SG
Singapore
Prior art keywords
antigen receptor
chimeric antigen
cell expansion
receptor therapy
expansion kinetics
Prior art date
Application number
SG11202101014XA
Other languages
English (en)
Inventor
John M Rossi
Adrian I Bot
Original Assignee
Kite Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kite Pharma Inc filed Critical Kite Pharma Inc
Publication of SG11202101014XA publication Critical patent/SG11202101014XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2301—Interleukin-1 (IL-1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
SG11202101014XA 2018-08-02 2019-08-01 Chimeric antigen receptor therapy t cell expansion kinetics and uses thereof SG11202101014XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862713994P 2018-08-02 2018-08-02
US201862756391P 2018-11-06 2018-11-06
PCT/US2019/044638 WO2020028647A1 (fr) 2018-08-02 2019-08-01 Cinétique d'expansion de lymphocytes t pour thérapie par récepteur d'antigène chimérique et ses utilisations

Publications (1)

Publication Number Publication Date
SG11202101014XA true SG11202101014XA (en) 2021-02-25

Family

ID=67770563

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202101014XA SG11202101014XA (en) 2018-08-02 2019-08-01 Chimeric antigen receptor therapy t cell expansion kinetics and uses thereof

Country Status (11)

Country Link
US (1) US20200038442A1 (fr)
EP (1) EP3830125A1 (fr)
JP (2) JP2021531813A (fr)
KR (1) KR20210038922A (fr)
CN (1) CN112533953A (fr)
AU (2) AU2019314452B2 (fr)
CA (2) CA3170491A1 (fr)
IL (1) IL280329B1 (fr)
SG (1) SG11202101014XA (fr)
TW (2) TWI807077B (fr)
WO (1) WO2020028647A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202144400A (zh) * 2020-02-20 2021-12-01 美商凱特製藥公司 嵌合抗原受體t細胞療法
CA3234494A1 (fr) * 2021-10-15 2023-04-20 Astrazeneca Ab Recepteurs antigeniques chimeriques anti-steap2 et leurs utilisations
WO2023159001A1 (fr) * 2022-02-15 2023-08-24 Kite Pharma, Inc. Prédiction d'événements indésirables à partir d'une immunothérapie
WO2024092145A1 (fr) * 2022-10-28 2024-05-02 Kite Pharma, Inc. Administration accélérée de lymphocytes modifiés

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
US6319494B1 (en) 1990-12-14 2001-11-20 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US6406699B1 (en) 1999-10-05 2002-06-18 Gary W. Wood Composition and method of cancer antigen immunotherapy
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
JP2004500095A (ja) 2000-02-24 2004-01-08 エクサイト　セラピーズ，　インコーポレイテッド 細胞の同時の刺激および濃縮
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
GB0700058D0 (en) 2007-01-03 2007-02-07 Scancell Aps Anti-tumor vaccine based on normal cells
EP3305798A1 (fr) 2010-12-09 2018-04-11 The Trustees of The University of Pennsylvania Utilisation de cellules t de récepteur modifié d'antigène chimérique pour traiter le cancer
CA2824997C (fr) 2011-01-18 2023-01-17 The Trustees Of The University Of Pennsylvania Compositions et procedes de traitement du cancer
CN106074601A (zh) 2011-03-23 2016-11-09 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
EP2532740A1 (fr) 2011-06-11 2012-12-12 Michael Schmück Préparations de lymphocytes T à mémoire centrale CD4+ et CD8+ spécifiques aux antigènes pour thérapie de lymphocyte T adoptif
KR20140060541A (ko) 2011-09-16 2014-05-20 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암을 치료하기 위한 rna 조작된 t 세포
WO2014055657A1 (fr) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Utilisation d'une approche trans-signalisation dans des récepteurs d'antigènes chimériques
KR20220119176A (ko) * 2014-02-04 2022-08-26 카이트 파마 인코포레이티드 B 세포 악성종양 및 다른 암을 치료하는데 유용한 자가 t 세포 및 그의 조성물의 생산 방법
WO2015142661A1 (fr) * 2014-03-15 2015-09-24 Novartis Ag Récepteur d'antigène chimèrique régulable
AU2015361261B2 (en) * 2014-12-08 2020-03-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-CD70 chimeric antigen receptors
WO2016130598A1 (fr) * 2015-02-09 2016-08-18 University Of Florida Research Foundation, Inc. Récepteur antigénique chimérique bispécifique et ses utilisations
JP2018513216A (ja) * 2015-04-15 2018-05-24 プロスペクト チャーターケア アールダブリュエムシー，エルエルシー ディ／ビー／エイ ロジャー ウィリアムズ メディカル センターＰｒｏｓｐｅｃｔ Ｃｈａｒｔｅｒｃａｒｅ Ｒｗｍｃ，Ｌｌｃ Ｄ／Ｂ／Ａ Ｒｏｇｅｒ Ｗｉｌｌｉａｍｓ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ Ｃａｒ−ｔ細胞の肝動脈注入
WO2017015427A1 (fr) * 2015-07-21 2017-01-26 Novartis Ag Méthodes pour améliorer l'efficacité et l'expansion de cellules immunitaires
CN110494451B (zh) * 2017-01-13 2023-12-01 塞尔达拉医疗有限责任公司 靶向tim-1的嵌合抗原受体

Also Published As

Publication number Publication date
TWI807077B (zh) 2023-07-01
EP3830125A1 (fr) 2021-06-09
CA3107938A1 (fr) 2020-02-06
IL280329B1 (en) 2024-05-01
CN112533953A (zh) 2021-03-19
JP2021531813A (ja) 2021-11-25
AU2019314452A1 (en) 2021-02-18
TW202216175A (zh) 2022-05-01
WO2020028647A1 (fr) 2020-02-06
JP2024016200A (ja) 2024-02-06
TW202019445A (zh) 2020-06-01
AU2023201286A1 (en) 2023-04-06
IL280329A (en) 2021-03-01
CA3107938C (fr) 2024-04-30
US20200038442A1 (en) 2020-02-06
AU2019314452B2 (en) 2022-12-08
CA3170491A1 (fr) 2020-02-06
KR20210038922A (ko) 2021-04-08

Similar Documents

Publication Publication Date Title
IL274921A (en) BCMA-directed chimeric antigen receptor and uses thereof
IL280718A (en) T cell structures and their uses
IL280329A (en) Treatment with receptor-antigen chimeric kinetics of T cell expansion and their uses
IL274617A (en) Chimeric antigen receptor-directed BCMA, chimeric antigen receptor-directed CD19, and combination therapies
SG10202012157QA (en) Chimeric antigen receptor and car-t cells that bind bcma
EP3564266A4 (fr) Nouveau récepteur chimère de l'antigène et utilisation correspondante
EP3630980A4 (fr) Préparation cellulaire de récepteurs antigéniques chimériques et utilisations de celle-ci
IL279063A (en) Chimeric antigen receptor T cells for cancer therapy
ZA202000852B (en) T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof
IL271751A (en) T cell receptors and immunotherapy using them
IL280029A (en) ROR-1 specific chimeric antigen receptors and their uses
EP4045539A4 (fr) Récepteur antigénique chimérique amélioré pour l'ingénierie de cellules effectrices immunitaires et son utilisation
SG11202010642TA (en) Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor
SG11202101169PA (en) Chimeric antigen receptor that binds hla-dr and car-t cell
EP3827025A4 (fr) Récepteur antigénique chimérique à base de gd2 et utilisation associée
EP3733839A4 (fr) Cellule t modifiée par récepteur d'antigène chimère modifié par anticorps et leurs utilisations
IL281232A (en) Chimeric antigen receptor for solid cancer and t cells expressing chimeric antigen receptor
ZA201906321B (en) Chimeric antigen receptor
EP3573660A4 (fr) Constructions améliorées de récepteur de lymphocytes t couplé à un anticorps et leurs utilisations thérapeutiques
IL281428A (en) chimeric antigen receptor
IL308227A (en) T-cell chemical antigen receptor therapy
SG11202001011XA (en) Chimeric antigen receptor and car-t cells that bind cxcr5
EP4105240A4 (fr) Récepteur antigénique chimérique et son utilisation
GB201709508D0 (en) Chimeric antigen receptor
GB2585607B (en) Chimeric antigen receptor and application thereof