SG11202012918PA - Bicyclic inhibitors of histone deacetylase - Google Patents
Bicyclic inhibitors of histone deacetylaseInfo
- Publication number
- SG11202012918PA SG11202012918PA SG11202012918PA SG11202012918PA SG11202012918PA SG 11202012918P A SG11202012918P A SG 11202012918PA SG 11202012918P A SG11202012918P A SG 11202012918PA SG 11202012918P A SG11202012918P A SG 11202012918PA SG 11202012918P A SG11202012918P A SG 11202012918PA
- Authority
- SG
- Singapore
- Prior art keywords
- histone deacetylase
- bicyclic inhibitors
- bicyclic
- inhibitors
- deacetylase
- Prior art date
Links
- 102000003964 Histone deacetylase Human genes 0.000 title 1
- 108090000353 Histone deacetylase Proteins 0.000 title 1
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862697497P | 2018-07-13 | 2018-07-13 | |
| PCT/US2019/041587 WO2020014602A1 (en) | 2018-07-13 | 2019-07-12 | Bicyclic inhibitors of histone deacetylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202012918PA true SG11202012918PA (en) | 2021-02-25 |
Family
ID=67480367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202012918PA SG11202012918PA (en) | 2018-07-13 | 2019-07-12 | Bicyclic inhibitors of histone deacetylase |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20210276977A1 (ko) |
| EP (1) | EP3820863A1 (ko) |
| JP (2) | JP7381578B2 (ko) |
| KR (1) | KR20210031703A (ko) |
| CN (1) | CN112805275A (ko) |
| AR (1) | AR115770A1 (ko) |
| AU (1) | AU2019301761A1 (ko) |
| CA (1) | CA3106354A1 (ko) |
| EA (1) | EA202190070A1 (ko) |
| IL (2) | IL310297A (ko) |
| MA (1) | MA53128A (ko) |
| MX (1) | MX2021000469A (ko) |
| SG (1) | SG11202012918PA (ko) |
| TW (1) | TW202019910A (ko) |
| WO (1) | WO2020014602A1 (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3319959T1 (sl) | 2015-07-06 | 2022-02-28 | Alkermes, Inc. | Hetero-halo inhibitorji histonske deacetilaze |
| KR102526032B1 (ko) | 2017-01-11 | 2023-04-25 | 로딘 테라퓨틱스, 인크. | 히스톤 데아세틸라제의 바이시클릭 억제제 |
| US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
| WO2023102162A1 (en) | 2021-12-03 | 2023-06-08 | Tango Therapeutics, Inc. | Tgonovel hdac inhibitors and therapeutic use thereof |
| CN115243023A (zh) * | 2022-07-20 | 2022-10-25 | 展讯通信（上海）有限公司 | 一种图像处理方法、装置、电子设备及存储介质 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010531358A (ja) * | 2007-06-27 | 2010-09-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ヒストン脱アセチル化酵素阻害剤としてのピリジル及びピリミジニル誘導体 |
| EP2701699B1 (en) * | 2011-04-28 | 2019-10-16 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| US20170349540A1 (en) * | 2014-07-28 | 2017-12-07 | The General Hospital Corporation | Histone deacetylase inhibitors |
| SI3319959T1 (sl) * | 2015-07-06 | 2022-02-28 | Alkermes, Inc. | Hetero-halo inhibitorji histonske deacetilaze |
-
2019
- 2019-07-12 KR KR1020217002883A patent/KR20210031703A/ko not_active Application Discontinuation
- 2019-07-12 AR ARP190101974A patent/AR115770A1/es unknown
- 2019-07-12 MX MX2021000469A patent/MX2021000469A/es unknown
- 2019-07-12 WO PCT/US2019/041587 patent/WO2020014602A1/en unknown
- 2019-07-12 IL IL310297A patent/IL310297A/en unknown
- 2019-07-12 AU AU2019301761A patent/AU2019301761A1/en active Pending
- 2019-07-12 EP EP19746298.9A patent/EP3820863A1/en active Pending
- 2019-07-12 CN CN201980046528.3A patent/CN112805275A/zh active Pending
- 2019-07-12 TW TW108124684A patent/TW202019910A/zh unknown
- 2019-07-12 EA EA202190070A patent/EA202190070A1/ru unknown
- 2019-07-12 IL IL279920A patent/IL279920B2/en unknown
- 2019-07-12 SG SG11202012918PA patent/SG11202012918PA/en unknown
- 2019-07-12 MA MA053128A patent/MA53128A/fr unknown
- 2019-07-12 CA CA3106354A patent/CA3106354A1/en active Pending
- 2019-07-12 US US17/260,192 patent/US20210276977A1/en active Pending
- 2019-07-12 JP JP2021523577A patent/JP7381578B2/ja active Active
-
2023
- 2023-11-01 JP JP2023187395A patent/JP2024012457A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021531335A (ja) | 2021-11-18 |
| CN112805275A (zh) | 2021-05-14 |
| WO2020014602A1 (en) | 2020-01-16 |
| JP2024012457A (ja) | 2024-01-30 |
| KR20210031703A (ko) | 2021-03-22 |
| MA53128A (fr) | 2021-05-19 |
| TW202019910A (zh) | 2020-06-01 |
| IL279920B2 (en) | 2024-06-01 |
| EA202190070A1 (ru) | 2021-10-26 |
| AU2019301761A1 (en) | 2021-01-14 |
| IL310297A (en) | 2024-03-01 |
| EP3820863A1 (en) | 2021-05-19 |
| CA3106354A1 (en) | 2020-01-16 |
| IL279920B1 (en) | 2024-02-01 |
| US20210276977A1 (en) | 2021-09-09 |
| JP7381578B2 (ja) | 2023-11-15 |
| AR115770A1 (es) | 2021-02-24 |
| IL279920A (en) | 2021-03-01 |
| MX2021000469A (es) | 2021-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL267953A (en) | Bicyclic histone deacetylase inhibitors | |
| SI3319959T1 (sl) | Hetero-halo inhibitorji histonske deacetilaze | |
| HK1252489A1 (zh) | 組蛋白去乙酰化酶抑制劑及其組合物和使用方法 | |
| IL279920A (en) | Bicyclic histone deacetylase inhibitors | |
| ZA201805066B (en) | Use of histone deacetylase inhibitors for enhancing immunotherapies | |
| IL272479B1 (en) | Bicyclic histone deacetylase inhibitors | |
| IL279940A (en) | Histone deacetylase inhibitors | |
| IL267465A (en) | Histone deacetylase inhibitors | |
| HK1252487A1 (zh) | 組蛋白去乙酰化酶抑制劑及其組合物和使用方法 | |
| GB201803361D0 (en) | Histone deacetylase inhibitors | |
| GB201912813D0 (en) | Histone deacetylase inhibitors | |
| GB201907955D0 (en) | Histone deacetylase inhibitors |