EA202190070A1 - Бициклические ингибиторы гистондеацетилазы - Google Patents
Бициклические ингибиторы гистондеацетилазыInfo
- Publication number
- EA202190070A1 EA202190070A1 EA202190070A EA202190070A EA202190070A1 EA 202190070 A1 EA202190070 A1 EA 202190070A1 EA 202190070 A EA202190070 A EA 202190070A EA 202190070 A EA202190070 A EA 202190070A EA 202190070 A1 EA202190070 A1 EA 202190070A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- bicyclic
- histone deacetylase
- deacetylase inhibitors
- histodeacetylase
- hdac
- Prior art date
Links
- 229940121372 histone deacetylase inhibitor Drugs 0.000 title 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
В настоящей заявке представлены соединения формулы (I) и ее фармацевтически приемлемые соли и композиции, которые являются применимы для лечения различных патологических состояний, связанных с гистодеацетилазами (HDAC).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862697497P | 2018-07-13 | 2018-07-13 | |
| PCT/US2019/041587 WO2020014602A1 (en) | 2018-07-13 | 2019-07-12 | Bicyclic inhibitors of histone deacetylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202190070A1 true EA202190070A1 (ru) | 2021-10-26 |
Family
ID=67480367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202190070A EA202190070A1 (ru) | 2018-07-13 | 2019-07-12 | Бициклические ингибиторы гистондеацетилазы |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20210276977A1 (ru) |
| EP (1) | EP3820863A1 (ru) |
| JP (2) | JP7381578B2 (ru) |
| KR (1) | KR20210031703A (ru) |
| CN (1) | CN112805275A (ru) |
| AR (1) | AR115770A1 (ru) |
| AU (1) | AU2019301761A1 (ru) |
| CA (1) | CA3106354A1 (ru) |
| EA (1) | EA202190070A1 (ru) |
| IL (2) | IL310297A (ru) |
| MA (1) | MA53128A (ru) |
| MX (1) | MX2021000469A (ru) |
| SG (1) | SG11202012918PA (ru) |
| TW (1) | TW202019910A (ru) |
| WO (1) | WO2020014602A1 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017007756A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc | Hetero-halo inhibitors of histone deacetylase |
| ES2909086T3 (es) | 2017-01-11 | 2022-05-05 | Alkermes Inc | Inhibidores bicíclicos de histona desacetilasa |
| HRP20220648T1 (hr) | 2017-08-07 | 2022-09-02 | Alkermes, Inc. | Biciklički inhibitori histonske deacetilaze |
| CN115243023A (zh) * | 2022-07-20 | 2022-10-25 | 展讯通信（上海）有限公司 | 一种图像处理方法、装置、电子设备及存储介质 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2692153A1 (en) * | 2007-06-27 | 2009-01-08 | Richard W. Heidebrecht, Jr. | Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors |
| WO2012149540A1 (en) * | 2011-04-28 | 2012-11-01 | The Broad Institute Inc | Inhibitors of histone deacetylase |
| US20170349540A1 (en) * | 2014-07-28 | 2017-12-07 | The General Hospital Corporation | Histone deacetylase inhibitors |
| WO2017007756A1 (en) * | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc | Hetero-halo inhibitors of histone deacetylase |
-
2019
- 2019-07-12 CN CN201980046528.3A patent/CN112805275A/zh active Pending
- 2019-07-12 MA MA053128A patent/MA53128A/fr unknown
- 2019-07-12 AR ARP190101974A patent/AR115770A1/es unknown
- 2019-07-12 WO PCT/US2019/041587 patent/WO2020014602A1/en unknown
- 2019-07-12 EA EA202190070A patent/EA202190070A1/ru unknown
- 2019-07-12 AU AU2019301761A patent/AU2019301761A1/en active Pending
- 2019-07-12 US US17/260,192 patent/US20210276977A1/en active Pending
- 2019-07-12 IL IL310297A patent/IL310297A/en unknown
- 2019-07-12 SG SG11202012918PA patent/SG11202012918PA/en unknown
- 2019-07-12 KR KR1020217002883A patent/KR20210031703A/ko unknown
- 2019-07-12 JP JP2021523577A patent/JP7381578B2/ja active Active
- 2019-07-12 MX MX2021000469A patent/MX2021000469A/es unknown
- 2019-07-12 IL IL279920A patent/IL279920B1/en unknown
- 2019-07-12 EP EP19746298.9A patent/EP3820863A1/en active Pending
- 2019-07-12 CA CA3106354A patent/CA3106354A1/en active Pending
- 2019-07-12 TW TW108124684A patent/TW202019910A/zh unknown
-
2023
- 2023-11-01 JP JP2023187395A patent/JP2024012457A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| TW202019910A (zh) | 2020-06-01 |
| JP2021531335A (ja) | 2021-11-18 |
| IL279920B1 (en) | 2024-02-01 |
| KR20210031703A (ko) | 2021-03-22 |
| AR115770A1 (es) | 2021-02-24 |
| CN112805275A (zh) | 2021-05-14 |
| MA53128A (fr) | 2021-05-19 |
| SG11202012918PA (en) | 2021-02-25 |
| CA3106354A1 (en) | 2020-01-16 |
| MX2021000469A (es) | 2021-06-23 |
| JP2024012457A (ja) | 2024-01-30 |
| JP7381578B2 (ja) | 2023-11-15 |
| IL279920A (en) | 2021-03-01 |
| EP3820863A1 (en) | 2021-05-19 |
| IL310297A (en) | 2024-03-01 |
| US20210276977A1 (en) | 2021-09-09 |
| AU2019301761A1 (en) | 2021-01-14 |
| WO2020014602A1 (en) | 2020-01-16 |
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