SG11202010451QA - Chimeric antigen receptors with modified linker domains and uses thereof - Google Patents

Chimeric antigen receptors with modified linker domains and uses thereof

Info

Publication number
SG11202010451QA
SG11202010451QA SG11202010451QA SG11202010451QA SG11202010451QA SG 11202010451Q A SG11202010451Q A SG 11202010451QA SG 11202010451Q A SG11202010451Q A SG 11202010451QA SG 11202010451Q A SG11202010451Q A SG 11202010451QA SG 11202010451Q A SG11202010451Q A SG 11202010451QA
Authority
SG
Singapore
Prior art keywords
chimeric antigen
antigen receptors
linker domains
modified linker
modified
Prior art date
Application number
SG11202010451QA
Other languages
English (en)
Inventor
Kanchana Bandara
Justin Coombs
Timothy Sadlon
Simon Barry
Jade Foeng
Shaun Mccoll
Original Assignee
Biosceptre Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2018901782A external-priority patent/AU2018901782A0/en
Application filed by Biosceptre Uk Ltd filed Critical Biosceptre Uk Ltd
Publication of SG11202010451QA publication Critical patent/SG11202010451QA/en

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    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • C07K14/70517—CD8
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    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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SG11202010451QA 2018-05-21 2019-05-20 Chimeric antigen receptors with modified linker domains and uses thereof SG11202010451QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2018901782A AU2018901782A0 (en) 2018-05-21 Chimeric Antigen Receptors with Modified Linker Domain and uses thereof
PCT/AU2019/050487 WO2019222796A1 (fr) 2018-05-21 2019-05-20 Récepteurs d'antigènes chimériques avec domaines de liaison modifiés et utilisations associées

Publications (1)

Publication Number Publication Date
SG11202010451QA true SG11202010451QA (en) 2020-11-27

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Application Number Title Priority Date Filing Date
SG11202010451QA SG11202010451QA (en) 2018-05-21 2019-05-20 Chimeric antigen receptors with modified linker domains and uses thereof

Country Status (11)

Country Link
US (1) US20220089718A1 (fr)
EP (1) EP3797164A4 (fr)
JP (1) JP2021524248A (fr)
KR (1) KR20210013691A (fr)
CN (1) CN112166193A (fr)
AU (1) AU2019275479B2 (fr)
BR (1) BR112020023489A8 (fr)
CA (1) CA3099712A1 (fr)
MX (1) MX2020012445A (fr)
SG (1) SG11202010451QA (fr)
WO (1) WO2019222796A1 (fr)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
CN111944062B (zh) * 2019-12-09 2023-11-07 深圳市体内生物医药科技有限公司 一种识别Fc片段的嵌合抗原受体及其应用
KR20220140800A (ko) * 2020-02-12 2022-10-18 에스에이비, 엘엘씨 항-흉선세포 글로불린
CN116194475A (zh) 2020-08-31 2023-05-30 Sab有限责任公司 对冠状病毒蛋白具有特异性的有蹄类动物源性多克隆免疫球蛋白和其用途
MX2023010646A (es) * 2021-03-11 2023-11-30 Biosceptre Aust Pty Ltd Novedoso sistema de terapia celular.
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CA3099712A1 (fr) 2019-11-28
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EP3797164A4 (fr) 2022-03-02
MX2020012445A (es) 2021-02-09
CN112166193A (zh) 2021-01-01
KR20210013691A (ko) 2021-02-05
BR112020023489A8 (pt) 2022-12-20
WO2019222796A1 (fr) 2019-11-28
AU2019275479A1 (en) 2020-11-19
EP3797164A1 (fr) 2021-03-31
US20220089718A1 (en) 2022-03-24

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