SG11202008470WA - Methods of making and using guidance and navigation control proteins - Google Patents
Methods of making and using guidance and navigation control proteinsInfo
- Publication number
- SG11202008470WA SG11202008470WA SG11202008470WA SG11202008470WA SG11202008470WA SG 11202008470W A SG11202008470W A SG 11202008470WA SG 11202008470W A SG11202008470W A SG 11202008470WA SG 11202008470W A SG11202008470W A SG 11202008470WA SG 11202008470W A SG11202008470W A SG 11202008470WA
- Authority
- SG
- Singapore
- Prior art keywords
- guidance
- making
- methods
- navigation control
- control proteins
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862648880P | 2018-03-27 | 2018-03-27 | |
US201862648888P | 2018-03-27 | 2018-03-27 | |
PCT/US2019/024111 WO2019191125A1 (fr) | 2018-03-27 | 2019-03-26 | Procédés de production et d'utilisation de protéines de contrôle de guidage et de navigation |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202008470WA true SG11202008470WA (en) | 2020-10-29 |
Family
ID=68060498
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202008474QA SG11202008474QA (en) | 2018-03-27 | 2019-03-26 | Guidance and navigation control proteins and method of making and using thereof |
SG11202008470WA SG11202008470WA (en) | 2018-03-27 | 2019-03-26 | Methods of making and using guidance and navigation control proteins |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202008474QA SG11202008474QA (en) | 2018-03-27 | 2019-03-26 | Guidance and navigation control proteins and method of making and using thereof |
Country Status (12)
Country | Link |
---|---|
US (2) | US20210024630A1 (fr) |
EP (2) | EP3773621A4 (fr) |
JP (3) | JP2021519072A (fr) |
KR (2) | KR20200135935A (fr) |
CN (4) | CN111566127A (fr) |
AU (2) | AU2019243448A1 (fr) |
CA (2) | CA3094996A1 (fr) |
IL (2) | IL271348A (fr) |
RU (1) | RU2020108448A (fr) |
SG (2) | SG11202008474QA (fr) |
TW (2) | TW201945013A (fr) |
WO (2) | WO2019191125A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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CN116199785A (zh) * | 2017-06-25 | 2023-06-02 | 西雅图免疫公司 | 多特异性抗体及其制备和使用方法 |
CN110831972B (zh) * | 2017-06-25 | 2023-05-12 | 西雅图免疫公司 | 抗pd-l1抗体及其制备和使用方法 |
CN110799540B (zh) * | 2017-06-25 | 2024-02-13 | 西雅图免疫公司 | 多特异性抗体及其制备和使用方法 |
JP7323513B2 (ja) * | 2017-06-25 | 2023-08-08 | システィミューン, インク. | 抗4-1bb抗体とその作製及び使用方法 |
CN111566127A (zh) * | 2018-03-27 | 2020-08-21 | 西雅图免疫公司 | 制导和导航控制蛋白及其制备和使用方法 |
EP4054649A4 (fr) * | 2019-11-06 | 2023-12-06 | Systimmune, Inc. | Protéines de régulation de guidage et de navigation et leurs procédés de production et d'utilisation |
TW202200618A (zh) * | 2020-03-17 | 2022-01-01 | 美商西雅圖免疫公司 | 微型導引和導航控制(miniGNC)類抗體蛋白及其製造和使用方法 |
WO2022165171A1 (fr) | 2021-01-28 | 2022-08-04 | Regeneron Pharmaceuticals, Inc. | Compositions et méthodes de traitement du syndrome de libération de cytokines |
BR112023024724A2 (pt) * | 2021-05-28 | 2024-02-15 | Dana Farber Cancer Inst Inc | Construtos de anticorpos multiespecíficos contra o muc1-c/domínio extracelular (muc1-c/ecd) |
WO2023198635A1 (fr) * | 2022-04-11 | 2023-10-19 | Astrazeneca Ab | Protéines de liaison à des lymphocytes t |
US20230357446A1 (en) | 2022-04-11 | 2023-11-09 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
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EP1354600A1 (fr) * | 2002-04-19 | 2003-10-22 | Affimed Therapeutics AG | Combinaison d'anticorps utilisable pour la thérapie de tumeurs |
AU2011336470B8 (en) * | 2010-12-01 | 2017-09-14 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
UA117289C2 (uk) * | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифічне антитіло |
EP2930188A1 (fr) * | 2014-04-13 | 2015-10-14 | Affimed Therapeutics AG | Molécule de liaison à l'antigène trifonctionnel |
CN107124884B (zh) * | 2014-07-25 | 2022-11-01 | 纪念斯隆-凯特林癌症中心 | 双特异性her2和cd3结合分子 |
WO2016019969A1 (fr) * | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Anticorps bispécifiques administrés par voie sous-cutanée, destinés à être utilisés dans le traitement du cancer |
EP2990416B1 (fr) * | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Récepteur d'antigène chimérique universel exprimant des cellules immunitaires pour le ciblage de divers antigènes multiples et son procédé de fabrication et son utilisation pour le traitement du cancer, des infections et des troubles auto-immuns |
WO2016105450A2 (fr) * | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Anticorps trispécifiques |
EP3245227A4 (fr) * | 2015-01-14 | 2018-07-25 | Compass Therapeutics LLC | Constructions de liaison à des antigènes immunomodulateurs multispécifiques |
EP3288975A1 (fr) * | 2015-04-29 | 2018-03-07 | Institute for Research in Biomedicine | Neutralisation ultra-puissante de cytokines par des anticorps multispécifiques et utilisations associées |
WO2017011342A1 (fr) * | 2015-07-10 | 2017-01-19 | Abbvie Inc. | Protéines de liaison modifiées par igm ou ige et leurs utilisations |
EP3156417A1 (fr) * | 2015-10-13 | 2017-04-19 | Affimed GmbH | Anticorps fv multivalents |
CN108779176A (zh) * | 2016-01-11 | 2018-11-09 | 印希比股份有限公司 | 多价和多特异性41bb结合融合蛋白 |
CN117327650A (zh) * | 2016-04-13 | 2024-01-02 | 维维雅生物技术公司 | 离体bite激活的t细胞 |
SG11201808911SA (en) * | 2016-04-13 | 2018-11-29 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
US10188749B2 (en) * | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
KR20230051602A (ko) * | 2016-04-15 | 2023-04-18 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
WO2018014260A1 (fr) * | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Protéines de liaison antigènes multi-spécifiques et leurs procédés d'utilisation |
CN106589129B (zh) * | 2016-12-30 | 2021-03-05 | 上海近岸生物科技有限公司 | 一种结合cd19、cd3和cd28的三功能分子及其应用 |
TW201904588A (zh) * | 2017-06-25 | 2019-02-01 | 美商西雅圖免疫公司 | 引導及導航控制蛋白質之製造及使用方法 |
CN110799540B (zh) * | 2017-06-25 | 2024-02-13 | 西雅图免疫公司 | 多特异性抗体及其制备和使用方法 |
CN116199785A (zh) * | 2017-06-25 | 2023-06-02 | 西雅图免疫公司 | 多特异性抗体及其制备和使用方法 |
CN111566127A (zh) * | 2018-03-27 | 2020-08-21 | 西雅图免疫公司 | 制导和导航控制蛋白及其制备和使用方法 |
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2019
- 2019-03-26 CN CN201980006846.7A patent/CN111566127A/zh active Pending
- 2019-03-26 WO PCT/US2019/024111 patent/WO2019191125A1/fr unknown
- 2019-03-26 KR KR1020207019088A patent/KR20200135935A/ko active Search and Examination
- 2019-03-26 JP JP2020551549A patent/JP2021519072A/ja active Pending
- 2019-03-26 CN CN201980006977.5A patent/CN111527108A/zh active Pending
- 2019-03-26 EP EP19775882.4A patent/EP3773621A4/fr active Pending
- 2019-03-26 CA CA3094996A patent/CA3094996A1/fr active Pending
- 2019-03-26 SG SG11202008474QA patent/SG11202008474QA/en unknown
- 2019-03-26 US US17/040,513 patent/US20210024630A1/en active Pending
- 2019-03-26 EP EP19776947.4A patent/EP3774918A4/fr active Pending
- 2019-03-26 AU AU2019243448A patent/AU2019243448A1/en active Pending
- 2019-03-26 JP JP2020551503A patent/JP2021519289A/ja active Pending
- 2019-03-26 CA CA3094997A patent/CA3094997A1/fr active Pending
- 2019-03-26 RU RU2020108448A patent/RU2020108448A/ru unknown
- 2019-03-26 US US17/040,519 patent/US20210008113A1/en active Pending
- 2019-03-26 AU AU2019243453A patent/AU2019243453A1/en active Pending
- 2019-03-26 CN CN202311257564.9A patent/CN117285641A/zh active Pending
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- 2019-03-26 WO PCT/US2019/024105 patent/WO2019191120A1/fr unknown
- 2019-03-26 SG SG11202008470WA patent/SG11202008470WA/en unknown
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- 2019-03-27 TW TW108110699A patent/TW201945013A/zh unknown
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2023
- 2023-12-22 JP JP2023216572A patent/JP2024045111A/ja active Pending
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Publication number | Publication date |
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CA3094996A1 (fr) | 2019-10-03 |
CN111566127A (zh) | 2020-08-21 |
AU2019243453A1 (en) | 2020-09-24 |
KR20200135935A (ko) | 2020-12-04 |
CN117285641A (zh) | 2023-12-26 |
RU2020108447A3 (fr) | 2022-04-27 |
KR20200139130A (ko) | 2020-12-11 |
SG11202008474QA (en) | 2020-10-29 |
EP3774918A4 (fr) | 2022-04-06 |
EP3773621A4 (fr) | 2022-03-23 |
WO2019191125A1 (fr) | 2019-10-03 |
US20210024630A1 (en) | 2021-01-28 |
US20210008113A1 (en) | 2021-01-14 |
CA3094997A1 (fr) | 2019-10-03 |
JP2024045111A (ja) | 2024-04-02 |
RU2020108448A (ru) | 2022-04-27 |
AU2019243448A1 (en) | 2020-09-24 |
CN111527108A (zh) | 2020-08-11 |
WO2019191120A1 (fr) | 2019-10-03 |
IL271325A (en) | 2020-01-30 |
EP3773621A1 (fr) | 2021-02-17 |
RU2020108447A (ru) | 2022-04-27 |
IL271348A (en) | 2020-01-30 |
CN117285642A (zh) | 2023-12-26 |
JP2021519289A (ja) | 2021-08-10 |
TW202003037A (zh) | 2020-01-16 |
RU2020108448A3 (fr) | 2022-04-27 |
JP2021519072A (ja) | 2021-08-10 |
EP3774918A1 (fr) | 2021-02-17 |
TW201945013A (zh) | 2019-12-01 |
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