SG11202007899QA - Ultra-sensitive detection of circulating tumor dna through genome-wide integration - Google Patents
Ultra-sensitive detection of circulating tumor dna through genome-wide integrationInfo
- Publication number
- SG11202007899QA SG11202007899QA SG11202007899QA SG11202007899QA SG11202007899QA SG 11202007899Q A SG11202007899Q A SG 11202007899QA SG 11202007899Q A SG11202007899Q A SG 11202007899QA SG 11202007899Q A SG11202007899Q A SG 11202007899QA SG 11202007899Q A SG11202007899Q A SG 11202007899QA
- Authority
- SG
- Singapore
- Prior art keywords
- genome
- ultra
- circulating tumor
- sensitive detection
- tumor dna
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N20/00—Machine learning
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N3/00—Computing arrangements based on biological models
- G06N3/02—Neural networks
- G06N3/08—Learning methods
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Theoretical Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Molecular Biology (AREA)
- Evolutionary Biology (AREA)
- Analytical Chemistry (AREA)
- Data Mining & Analysis (AREA)
- Organic Chemistry (AREA)
- Software Systems (AREA)
- Pathology (AREA)
- Evolutionary Computation (AREA)
- Artificial Intelligence (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- General Engineering & Computer Science (AREA)
- Databases & Information Systems (AREA)
- Epidemiology (AREA)
- Bioethics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Computing Systems (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862636135P | 2018-02-27 | 2018-02-27 | |
PCT/US2019/019905 WO2019169042A1 (fr) | 2018-02-27 | 2019-02-27 | Détection ultrasensible d'adn tumoral circulant par intégration à l'échelle du génome |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202007899QA true SG11202007899QA (en) | 2020-09-29 |
Family
ID=67806402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202007899QA SG11202007899QA (en) | 2018-02-27 | 2019-02-27 | Ultra-sensitive detection of circulating tumor dna through genome-wide integration |
Country Status (10)
Country | Link |
---|---|
US (1) | US20210043275A1 (fr) |
EP (1) | EP3759237A4 (fr) |
JP (2) | JP2021519607A (fr) |
KR (1) | KR20210009299A (fr) |
CN (1) | CN112601826A (fr) |
AU (1) | AU2019229273B2 (fr) |
CA (1) | CA3092343A1 (fr) |
IL (1) | IL276891A (fr) |
SG (1) | SG11202007899QA (fr) |
WO (1) | WO2019169042A1 (fr) |
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US10395772B1 (en) * | 2018-10-17 | 2019-08-27 | Tempus Labs | Mobile supplementation, extraction, and analysis of health records |
US11742064B2 (en) * | 2018-12-31 | 2023-08-29 | Tempus Labs, Inc. | Automated quality assurance testing of structured clinical data |
US20200340064A1 (en) * | 2019-04-16 | 2020-10-29 | Grail, Inc. | Systems and methods for tumor fraction estimation from small variants |
WO2021016441A1 (fr) * | 2019-07-23 | 2021-01-28 | Grail, Inc. | Systèmes et procédés de détermination d'une fraction tumorale |
EP4025706A4 (fr) * | 2019-09-05 | 2023-10-18 | Fabric Genomics, Inc. | Procédés d'analyse de variants génétiques basés sur un matériau génétique |
CN110659599A (zh) * | 2019-09-19 | 2020-01-07 | 安徽七天教育科技有限公司 | 一种基于扫描试卷的离线笔迹鉴定系统以及使用方法 |
CN110808081B (zh) * | 2019-09-29 | 2022-07-08 | 深圳吉因加医学检验实验室 | 一种鉴定肿瘤纯度样本的模型构建方法及应用 |
EP4041924A1 (fr) * | 2019-10-08 | 2022-08-17 | Illumina, Inc. | Caractérisation de taille de fragment de mutations d'adn acellulaire provenant d'une hématopoïèse clonale |
US20240186001A1 (en) * | 2019-10-16 | 2024-06-06 | Icahn School Of Medicine At Mount Sinai | Systems and methods for detecting a disease condition |
CN110890132A (zh) * | 2019-11-19 | 2020-03-17 | 湖南大学 | 基于自适应高斯混合模型的癌症突变簇识别方法 |
AU2021208683A1 (en) * | 2020-01-16 | 2022-08-18 | Congenica Ltd. | Application of pathogenicity model and training thereof |
CN111310680B (zh) * | 2020-02-24 | 2022-11-04 | 电子科技大学 | 一种基于深度学习的辐射源个体识别方法 |
EP4118653A1 (fr) * | 2020-03-11 | 2023-01-18 | Guardant Health, Inc. | Procédés de classification de mutations génétiques détectées dans des acides nucléiques acellulaires en tant qu'origine tumorale ou non tumorale |
CN111341383B (zh) * | 2020-03-17 | 2021-06-29 | 安吉康尔(深圳)科技有限公司 | 一种检测拷贝数变异的方法、装置和存储介质 |
KR102309277B1 (ko) * | 2020-03-26 | 2021-10-07 | 주식회사 클리노믹스 | 이종생물 유래의 유전자 마커 매칭에 기반한 하나 혹은 그 이상의 모델생물의 유전자 마커와 그 패턴 정보를 목표하는 생물의 유전자 마커 정보로 이용하는 유전자 검사 서비스 제공 방법 |
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CN116157868A (zh) * | 2020-08-18 | 2023-05-23 | 德尔菲诊断公司 | 用于游离dna片段大小密度以评估癌症的方法和系统 |
CN112285565B (zh) * | 2020-09-21 | 2021-07-13 | 电子科技大学 | 基于rkhs域匹配的迁移学习预测电池soh方法 |
WO2022168195A1 (fr) * | 2021-02-03 | 2022-08-11 | 国立大学法人東北大学 | Système d'analyse d'informations génétiques et procédé d'analyse d'informations génétiques |
WO2022178337A1 (fr) * | 2021-02-19 | 2022-08-25 | Tempus Labs, Inc. | Diagnostics moléculaires longitudinaux détectant des mutations de réversion somatique |
CN113113085B (zh) * | 2021-03-15 | 2022-08-19 | 杭州杰毅生物技术有限公司 | 基于智能宏基因组测序数据肿瘤检测的分析系统及方法 |
CN112951418B (zh) * | 2021-05-17 | 2021-08-06 | 臻和(北京)生物科技有限公司 | 基于液体活检的连锁区域甲基化评估方法和装置、终端设备及存储介质 |
CN113496762B (zh) * | 2021-05-20 | 2022-09-27 | 山东大学 | 一种生物基因序列的概要数据生成方法及系统 |
CN113257350B (zh) * | 2021-06-10 | 2021-10-08 | 臻和(北京)生物科技有限公司 | 基于液体活检的ctDNA突变程度分析方法和装置、ctDNA性能分析装置 |
CN113096728B (zh) * | 2021-06-10 | 2021-08-20 | 臻和(北京)生物科技有限公司 | 一种微小残余病灶的检测方法、装置、存储介质及设备 |
CN113362894A (zh) * | 2021-06-15 | 2021-09-07 | 上海基绪康生物科技有限公司 | 一种对协同致死的癌症驱动基因进行预测的方法 |
CN113470746B (zh) * | 2021-06-21 | 2023-11-21 | 广州市金域转化医学研究院有限公司 | 降低高通量测序中人工引入错误突变的方法及应用 |
EP4359569A1 (fr) * | 2021-06-22 | 2024-05-01 | Foundation Medicine, Inc. | Systèmes et procédés d'évaluation d'une fraction tumorale |
CN113539355B (zh) * | 2021-07-15 | 2022-11-25 | 云康信息科技(上海)有限公司 | 预测cfDNA的组织特异性来源及相关疾病概率评估系统及应用 |
EP4385021A1 (fr) * | 2021-08-10 | 2024-06-19 | Cornell University | Biopsie liquide ultrasensible par séquençage du génome entier du plasma grâce à l'apprentissage profond |
CN118043670A (zh) * | 2021-08-25 | 2024-05-14 | X基因组公司 | 随机表观基因组采样 |
CN113903398A (zh) * | 2021-09-08 | 2022-01-07 | 南京世和基因生物技术股份有限公司 | 肠癌早筛标志物、检测方法、检测装置以及计算机可读取介质 |
WO2023043914A1 (fr) * | 2021-09-15 | 2023-03-23 | The Broad Institute, Inc. | Diagnostic et pronostic du syndrome de richter |
CN113903401B (zh) * | 2021-12-10 | 2022-04-08 | 臻和(北京)生物科技有限公司 | 基于ctDNA长度的分析方法和系统 |
WO2023133093A1 (fr) * | 2022-01-04 | 2023-07-13 | Cornell University | Enrichissement de signal guidé par apprentissage automatique pour surveillance de charge tumorale au plasma ultrasensible |
CN114446386B (zh) * | 2022-01-17 | 2024-02-02 | 中国人民解放军国防科技大学 | 一种血液ctDNA的检测方法 |
KR20230172174A (ko) * | 2022-06-15 | 2023-12-22 | 주식회사 지씨지놈 | 무세포 핵산의 단일염기변이를 이용한 암 진단 및 암 종 예측방법 |
US20240021267A1 (en) * | 2022-07-18 | 2024-01-18 | Grail, Llc | Dynamically selecting sequencing subregions for cancer classification |
US20240071565A1 (en) * | 2022-08-31 | 2024-02-29 | Saga Diagnostics Ab | Structural variant identification |
CN115294231B (zh) * | 2022-09-29 | 2023-02-03 | 浙江省肿瘤医院 | 一种胃癌错配修复基因缺陷的预测方法 |
CN115558716B (zh) * | 2022-09-29 | 2023-11-03 | 南京医科大学 | 一种用于预测癌症的cfDNA片段特征组合、系统及应用 |
WO2024086515A1 (fr) * | 2022-10-17 | 2024-04-25 | Foundation Medicine, Inc. | Procédés et systèmes de prédiction d'un site de maladie primaire cutanée |
WO2024089689A1 (fr) * | 2022-10-25 | 2024-05-02 | Clonal Ltd | Méthodes de détection du cancer du sein |
WO2024091545A1 (fr) * | 2022-10-25 | 2024-05-02 | Cornell University | Suppression d'erreur d'acide nucléique |
CN115406815B (zh) * | 2022-11-02 | 2023-02-03 | 杭州华得森生物技术有限公司 | 基于多源数据融合的肿瘤细胞检测设备及其方法 |
CN115595371B (zh) * | 2022-12-07 | 2023-04-11 | 元码基因科技(北京)股份有限公司 | 确定结直肠癌患者msi状态的方法及应用 |
CN115690109B (zh) * | 2023-01-04 | 2023-03-14 | 杭州华得森生物技术有限公司 | 基于计算生物的肿瘤细胞检测设备及其方法 |
CN116386903B (zh) * | 2023-06-06 | 2023-11-10 | 中国医学科学院肿瘤医院 | 一种小细胞肺癌肿瘤间和肿瘤内异质性解读方法 |
CN116863998B (zh) * | 2023-06-21 | 2024-04-05 | 扬州大学 | 一种基于遗传算法的全基因组预测方法及其应用 |
CN116895332B (zh) * | 2023-09-11 | 2023-12-05 | 臻和(北京)生物科技有限公司 | 一种酶切法打断建库中人工片段产生的假阳性突变的过滤方法 |
CN117253546B (zh) * | 2023-10-11 | 2024-05-28 | 北京博奥医学检验所有限公司 | 一种降低靶向二代测序背景噪音的方法、系统及可存储介质 |
CN117373678B (zh) * | 2023-12-08 | 2024-03-05 | 北京望石智慧科技有限公司 | 基于突变签名的疾病风险预测模型构建方法及分析方法 |
CN117976045B (zh) * | 2024-03-29 | 2024-06-14 | 鲁东大学 | 一种基于基因突变数据的癌症转移相关基因预测方法 |
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US10236078B2 (en) * | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
EP2891099A4 (fr) * | 2012-08-28 | 2016-04-20 | Broad Inst Inc | Détection de variants dans des données de séquençage et un étalonnage |
ES2923602T3 (es) * | 2014-12-31 | 2022-09-28 | Guardant Health Inc | Detección y tratamiento de enfermedades que muestran heterogeneidad celular de enfermedad y sistemas y métodos para comunicar los resultados de las pruebas |
US10815522B2 (en) * | 2015-02-20 | 2020-10-27 | The Johns Hopkins University | Genomic alterations in the tumor and circulation of pancreatic cancer patients |
US10364468B2 (en) * | 2016-01-13 | 2019-07-30 | Seven Bridges Genomics Inc. | Systems and methods for analyzing circulating tumor DNA |
US10095831B2 (en) * | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
WO2017161175A1 (fr) * | 2016-03-16 | 2017-09-21 | Dana-Farber Cancer Institute, Inc. | Procédés pour la caractérisation de génomes |
GB201607629D0 (en) * | 2016-05-01 | 2016-06-15 | Genome Res Ltd | Mutational signatures in cancer |
JP6963009B2 (ja) * | 2016-05-19 | 2021-11-05 | オンコスカー エルエルシーOncoscar Llc | 臨床的に難治性の悪性腫瘍の診断及び治療標的化の方法 |
CN107447258A (zh) * | 2016-06-01 | 2017-12-08 | 大连医科大学 | 循环肿瘤dna靶向基因高通量检测文库及其检测方法和应用 |
CN105950750A (zh) * | 2016-06-08 | 2016-09-21 | 福州市传染病医院 | 用于肝癌诊断及预后评估的基因群及试剂盒 |
-
2019
- 2019-02-27 JP JP2020567471A patent/JP2021519607A/ja active Pending
- 2019-02-27 EP EP19761020.7A patent/EP3759237A4/fr active Pending
- 2019-02-27 US US16/976,056 patent/US20210043275A1/en active Pending
- 2019-02-27 WO PCT/US2019/019905 patent/WO2019169042A1/fr unknown
- 2019-02-27 CA CA3092343A patent/CA3092343A1/fr active Pending
- 2019-02-27 AU AU2019229273A patent/AU2019229273B2/en active Active
- 2019-02-27 CN CN201980028168.4A patent/CN112601826A/zh active Pending
- 2019-02-27 KR KR1020207027663A patent/KR20210009299A/ko not_active Application Discontinuation
- 2019-02-27 SG SG11202007899QA patent/SG11202007899QA/en unknown
-
2020
- 2020-08-24 IL IL276891A patent/IL276891A/en unknown
-
2023
- 2023-11-30 JP JP2023202317A patent/JP2024019413A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3759237A1 (fr) | 2021-01-06 |
IL276891A (en) | 2020-10-29 |
CN112601826A (zh) | 2021-04-02 |
WO2019169042A1 (fr) | 2019-09-06 |
KR20210009299A (ko) | 2021-01-26 |
AU2019229273B2 (en) | 2023-04-27 |
CA3092343A1 (fr) | 2019-09-06 |
AU2019229273A1 (en) | 2020-09-10 |
JP2021519607A (ja) | 2021-08-12 |
EP3759237A4 (fr) | 2022-06-01 |
JP2024019413A (ja) | 2024-02-09 |
US20210043275A1 (en) | 2021-02-11 |
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