SG11202005254RA - 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors - Google Patents

1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors

Info

Publication number
SG11202005254RA
SG11202005254RA SG11202005254RA SG11202005254RA SG11202005254RA SG 11202005254R A SG11202005254R A SG 11202005254RA SG 11202005254R A SG11202005254R A SG 11202005254RA SG 11202005254R A SG11202005254R A SG 11202005254RA SG 11202005254R A SG11202005254R A SG 11202005254RA
Authority
SG
Singapore
Prior art keywords
inhibitors
histone deacetylase
oxadiazole derivatives
oxadiazole
derivatives
Prior art date
Application number
SG11202005254RA
Other languages
English (en)
Inventor
González Elena Carceller
Muñoz Alberto Ortega
Solana Jorge Salas
Original Assignee
Oryzon Genomics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oryzon Genomics Sa filed Critical Oryzon Genomics Sa
Publication of SG11202005254RA publication Critical patent/SG11202005254RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11202005254RA 2017-12-05 2018-12-05 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors SG11202005254RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17382835 2017-12-05
EP18382562 2018-07-26
PCT/EP2018/083655 WO2019110663A1 (en) 2017-12-05 2018-12-05 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors

Publications (1)

Publication Number Publication Date
SG11202005254RA true SG11202005254RA (en) 2020-07-29

Family

ID=64556931

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202005254RA SG11202005254RA (en) 2017-12-05 2018-12-05 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors

Country Status (12)

Country Link
US (2) US20200339569A1 (he)
EP (1) EP3720851A1 (he)
JP (1) JP7369458B2 (he)
KR (1) KR20200097294A (he)
CN (1) CN111406054B (he)
AU (1) AU2018379321B2 (he)
BR (1) BR112020010534A2 (he)
CA (1) CA3083061A1 (he)
IL (1) IL274973B1 (he)
MX (1) MX2020005841A (he)
SG (1) SG11202005254RA (he)
WO (1) WO2019110663A1 (he)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
EP3980416A1 (en) * 2019-06-06 2022-04-13 Oryzon Genomics, S.A. 3-(2-(heteroaryl)-pyridin-4-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole derivatives as hdac6 inhibitors
KR102576148B1 (ko) * 2020-04-13 2023-09-07 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
KR20220030134A (ko) * 2020-09-02 2022-03-10 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 새로운 구조의 화합물 및 이를 포함하는 약제학적 조성물
CN117561059A (zh) 2021-04-23 2024-02-13 特纳亚治疗股份有限公司 用于治疗扩张型心肌病的hdac6抑制剂
IL308152A (he) 2021-05-04 2024-01-01 Tenaya Therapeutics Inc 2-פלואורואלקיל-4,3,1-אוקסאדיאזול-5-איל-תיאזול, מעכבי hdac6 לשימוש בטיפול במחלה מטבולית ו hfpef

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2006109817A1 (ja) 2005-04-06 2008-11-20 萬有製薬株式会社 1,4−置換ピペラジン誘導体
WO2013066839A2 (en) 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods
AU2012345557A1 (en) * 2011-11-28 2014-06-26 Novartis Ag Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
EP3342772A4 (en) 2015-08-25 2019-03-27 Takeda Pharmaceutical Company Limited HETEROCYCLIC COMPOUND
WO2017161033A1 (en) 2016-03-15 2017-09-21 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
WO2017222952A1 (en) 2016-06-23 2017-12-28 Merck Sharp & Dohme Corp. 3- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
PL3558984T3 (pl) 2016-12-20 2024-01-15 Fmc Corporation Oksadiazole grzybobójcze

Also Published As

Publication number Publication date
CN111406054B (zh) 2024-01-02
RU2020121391A (ru) 2022-01-10
RU2020121391A3 (he) 2022-01-20
CN111406054A (zh) 2020-07-10
AU2018379321B2 (en) 2024-05-16
US20200339569A1 (en) 2020-10-29
CA3083061A1 (en) 2019-06-13
AU2018379321A1 (en) 2020-06-11
KR20200097294A (ko) 2020-08-18
EP3720851A1 (en) 2020-10-14
IL274973B1 (he) 2024-03-01
JP7369458B2 (ja) 2023-10-26
US20230026909A1 (en) 2023-01-26
JP2021505684A (ja) 2021-02-18
IL274973A (he) 2020-07-30
WO2019110663A1 (en) 2019-06-13
MX2020005841A (es) 2020-09-07
BR112020010534A2 (pt) 2020-10-20

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