SG11202005236QA - Hla class i-restricted t cell receptors against mutated ras - Google Patents

Hla class i-restricted t cell receptors against mutated ras

Info

Publication number
SG11202005236QA
SG11202005236QA SG11202005236QA SG11202005236QA SG11202005236QA SG 11202005236Q A SG11202005236Q A SG 11202005236QA SG 11202005236Q A SG11202005236Q A SG 11202005236QA SG 11202005236Q A SG11202005236Q A SG 11202005236QA SG 11202005236Q A SG11202005236Q A SG 11202005236QA
Authority
SG
Singapore
Prior art keywords
restricted
hla class
cell receptors
mutated ras
receptors against
Prior art date
Application number
SG11202005236QA
Other languages
English (en)
Inventor
Rami Yoseph
Yong-Chen Lu
Gal Cafri
Steven A Rosenberg
Original Assignee
The United States Of America As Represented By The Secretary
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The United States Of America As Represented By The Secretary filed Critical The United States Of America As Represented By The Secretary
Publication of SG11202005236QA publication Critical patent/SG11202005236QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464454—Enzymes
    • A61K39/464464—GTPases, e.g. Ras or Rho
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
SG11202005236QA 2017-12-04 2018-12-03 Hla class i-restricted t cell receptors against mutated ras SG11202005236QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762594244P 2017-12-04 2017-12-04
PCT/US2018/063581 WO2019112941A1 (en) 2017-12-04 2018-12-03 Hla class i-restricted t cell receptors against mutated ras

Publications (1)

Publication Number Publication Date
SG11202005236QA true SG11202005236QA (en) 2020-07-29

Family

ID=64949411

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202005236QA SG11202005236QA (en) 2017-12-04 2018-12-03 Hla class i-restricted t cell receptors against mutated ras

Country Status (15)

Country Link
US (2) US11466071B2 (es)
EP (1) EP3720478A1 (es)
JP (2) JP7385566B2 (es)
KR (1) KR20200115484A (es)
CN (1) CN111836638A (es)
AU (1) AU2018378200A1 (es)
BR (1) BR112020011111A2 (es)
CA (1) CA3084246A1 (es)
CR (1) CR20200287A (es)
EA (1) EA202091335A1 (es)
IL (1) IL275031A (es)
MA (2) MA51043A (es)
MX (1) MX2020005765A (es)
SG (1) SG11202005236QA (es)
WO (1) WO2019112941A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3635000A4 (en) * 2017-05-16 2021-04-14 The Johns Hopkins University MANABODIES AND METHODS OF USE
WO2020154617A1 (en) * 2019-01-25 2020-07-30 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting mutant ras
GB2613715B (en) 2019-02-20 2023-12-06 Fred Hutchinson Cancer Center Binding proteins specific for RAS neoantigens and uses thereof
EP3760217A1 (en) * 2019-07-01 2021-01-06 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Cd5 specific t cell receptor cell or gene therapy
CN112646024B (zh) * 2019-10-10 2023-03-24 香雪生命科学技术（广东）有限公司 一种识别kras突变的t细胞受体及其编码序列
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
EP4103597A1 (en) * 2020-02-12 2022-12-21 The United States of America, as represented by the Secretary, Department of Health and Human Services Hla class i-restricted t cell receptors against ras with g12d mutation
MX2022009825A (es) * 2020-02-14 2022-10-13 Us Health Receptores de células t restringidas por hla de la clase i contra ras con mutación g12v.
CA3169086A1 (en) * 2020-02-26 2021-09-02 Noam LEVIN Hla class ii-restricted t cell receptors against ras with g12v mutation
US20230365649A1 (en) * 2020-10-02 2023-11-16 The Usa, As Represented By The Secretary, Department Of Health And Human Services Hla class ii-restricted dq t cell receptors against ras with g13d mutation
KR102488353B1 (ko) * 2020-10-08 2023-01-12 부산대학교 산학협력단 돌연변이 kras를 표적하는 펩타이드 및 이의 용도
JP2024507929A (ja) 2021-02-25 2024-02-21 アラウノス セラピューティクス インコーポレイテッド 多シストロン性発現カセットを含む組換えベクター及びそれらの使用方法
BR112023024595A2 (pt) * 2021-05-25 2024-02-15 Memorial Sloan Kettering Cancer Center Receptores de células t direcionando mutações ras e usos dos mesmos
WO2023139257A1 (en) 2022-01-21 2023-07-27 T-Knife Gmbh Antigen recognizing construct that binds specific peptide with determinable affinity and t cell receptor having antigenic specificity for kras as well as corresponding nucleic acid sequence, vector, host cell, pharmaceutical composition and kit
WO2023150562A1 (en) 2022-02-01 2023-08-10 Alaunos Therapeutics, Inc. Methods for activation and expansion of t cells
WO2023241522A1 (zh) * 2022-06-14 2023-12-21 上海镔铁生物科技有限责任公司 靶向kras g12v突变多肽的t细胞受体及其用途
CN117430689A (zh) * 2022-11-04 2024-01-23 新景智源生物科技(苏州)有限公司 Kras_g12v突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1545204B1 (en) 2002-09-06 2016-08-10 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
ES2734889T3 (es) * 2010-09-21 2019-12-12 Us Health Receptores de células T anti-SSX-2 y materiales relacionados y métodos de uso
US20120244133A1 (en) 2011-03-22 2012-09-27 The United States of America, as represented by the Secretary, Department of Health and Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
EP3223850B1 (en) * 2014-11-26 2020-01-08 The United States of America, as represented by The Secretary, Department of Health and Human Services Anti-mutated kras t cell receptors
MX2018003062A (es) * 2015-09-15 2018-09-11 Us Health Receptores de celula t que reconocen kras mutante restringido en hla-cw8.
HUE053674T2 (hu) 2015-12-23 2021-07-28 Medigene Immunotherapies Gmbh Antigén-specifikus TCR receptorok új generációja
WO2017112944A1 (en) * 2015-12-23 2017-06-29 Fred Hutchinson Cancer Research Center High affinity t cell receptors and uses thereof
US20210052642A1 (en) * 2017-12-04 2021-02-25 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Methods of enriching cell populations for cancer-specific t cells using in vitro stimulation of memory t cells

Also Published As

Publication number Publication date
US20230026180A1 (en) 2023-01-26
KR20200115484A (ko) 2020-10-07
JP2023175703A (ja) 2023-12-12
US11466071B2 (en) 2022-10-11
MA51042A (fr) 2020-10-14
JP2021505136A (ja) 2021-02-18
WO2019112941A1 (en) 2019-06-13
CA3084246A1 (en) 2019-06-13
CR20200287A (es) 2020-11-11
MX2020005765A (es) 2020-09-25
EP3720478A1 (en) 2020-10-14
EA202091335A1 (ru) 2020-10-15
BR112020011111A2 (pt) 2020-11-17
US20210079058A1 (en) 2021-03-18
CN111836638A (zh) 2020-10-27
IL275031A (en) 2020-07-30
AU2018378200A1 (en) 2020-07-02
JP7385566B2 (ja) 2023-11-22
MA51043A (fr) 2020-10-14

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