SG11202005015XA - Glucuronylation as acidic post-translational modification on therapeutic monoclonal antibodies - Google Patents
Glucuronylation as acidic post-translational modification on therapeutic monoclonal antibodiesInfo
- Publication number
- SG11202005015XA SG11202005015XA SG11202005015XA SG11202005015XA SG11202005015XA SG 11202005015X A SG11202005015X A SG 11202005015XA SG 11202005015X A SG11202005015X A SG 11202005015XA SG 11202005015X A SG11202005015X A SG 11202005015XA SG 11202005015X A SG11202005015X A SG 11202005015XA
- Authority
- SG
- Singapore
- Prior art keywords
- glucuronylation
- monoclonal antibodies
- translational modification
- therapeutic monoclonal
- acidic post
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/2201—Streptopain (3.4.22.10)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/89—Inverse chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
- G01N2333/96405—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
- G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
- G01N2333/96413—Cysteine endopeptidases (3.4.22)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862624338P | 2018-01-31 | 2018-01-31 | |
| PCT/US2019/015549 WO2019152356A2 (en) | 2018-01-31 | 2019-01-29 | Glucuronylation as a new acidic post-translational modification on therapeutic monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202005015XA true SG11202005015XA (en) | 2020-06-29 |
Family
ID=65576657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202005015XA SG11202005015XA (en) | 2018-01-31 | 2019-01-29 | Glucuronylation as acidic post-translational modification on therapeutic monoclonal antibodies |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11366123B2 (ru) |
| EP (1) | EP3746472A2 (ru) |
| JP (2) | JP7301054B2 (ru) |
| KR (1) | KR20200115467A (ru) |
| CN (1) | CN112135839A (ru) |
| AR (1) | AR114569A1 (ru) |
| AU (1) | AU2019213647A1 (ru) |
| BR (1) | BR112020011797A2 (ru) |
| CA (1) | CA3084181A1 (ru) |
| EA (1) | EA202091577A1 (ru) |
| IL (1) | IL276075A (ru) |
| MX (1) | MX2020008115A (ru) |
| SG (1) | SG11202005015XA (ru) |
| TW (2) | TWI808123B (ru) |
| WO (1) | WO2019152356A2 (ru) |
| ZA (1) | ZA202003320B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| JP7301054B2 (ja) | 2018-01-31 | 2023-06-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療用モノクローナル抗体に対する酸性翻訳後修飾としてのグルクロニル化 |
| IL303510A (en) * | 2020-12-11 | 2023-08-01 | Genentech Inc | Methods for determining the relative distribution of glucuronidation, iduronidation, and galacturonidation of polypeptides |
| IL309833A (en) * | 2021-07-13 | 2024-02-01 | Regeneron Pharma | Characterization of proteins using anion exchange chromatography mass spectrometry (AEX-MS) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102308216B (zh) | 2009-02-09 | 2014-07-09 | 罗切格利卡特公司 | 免疫球蛋白糖基化模式分析 |
| AU2010305150A1 (en) | 2009-10-09 | 2012-04-05 | Symphogen A/S | Multiplex quantitation of individual recombinant proteins in a mixture by signature peptides and mass spectrometry |
| KR101902225B1 (ko) | 2011-07-08 | 2018-09-28 | 이엠디 밀리포어 코포레이션 | 일회용 생명공학적 공정용의 개선된 심층 필터 |
| CN104704499B (zh) | 2012-06-21 | 2018-12-11 | 菲利普莫里斯生产公司 | 与基于网络的生物标记签名相关的系统和方法 |
| RU2016107435A (ru) | 2013-09-13 | 2017-10-18 | Дженентек, Инк. | Композиции и способы обнаружения и количественного определения белка клеток-хозяев в клеточных линиях и рекомбинантные полипептидные продукты |
| EP3400248A4 (en) * | 2016-01-10 | 2019-09-04 | Sorrento Therapeutics, Inc. | IMPROVED SAFETY FOR THE TREATMENT OF CANCER WITH GLYCOSYLATED CHIMERIC ANTIBODY AGAINST EGFR |
| JP7301054B2 (ja) | 2018-01-31 | 2023-06-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療用モノクローナル抗体に対する酸性翻訳後修飾としてのグルクロニル化 |
-
2019
- 2019-01-29 JP JP2020537726A patent/JP7301054B2/ja active Active
- 2019-01-29 EA EA202091577A patent/EA202091577A1/ru unknown
- 2019-01-29 KR KR1020207016649A patent/KR20200115467A/ko not_active Application Discontinuation
- 2019-01-29 AU AU2019213647A patent/AU2019213647A1/en active Pending
- 2019-01-29 CA CA3084181A patent/CA3084181A1/en active Pending
- 2019-01-29 MX MX2020008115A patent/MX2020008115A/es unknown
- 2019-01-29 CN CN201980018896.7A patent/CN112135839A/zh active Pending
- 2019-01-29 BR BR112020011797-8A patent/BR112020011797A2/pt unknown
- 2019-01-29 SG SG11202005015XA patent/SG11202005015XA/en unknown
- 2019-01-29 EP EP19707919.7A patent/EP3746472A2/en not_active Withdrawn
- 2019-01-29 US US16/260,482 patent/US11366123B2/en active Active
- 2019-01-29 WO PCT/US2019/015549 patent/WO2019152356A2/en unknown
- 2019-01-30 TW TW108103588A patent/TWI808123B/zh active
- 2019-01-30 TW TW112131836A patent/TW202348623A/zh unknown
- 2019-01-31 AR ARP190100229A patent/AR114569A1/es unknown
-
2020
- 2020-06-03 ZA ZA2020/03320A patent/ZA202003320B/en unknown
- 2020-07-15 IL IL276075A patent/IL276075A/en unknown
-
2022
- 2022-05-16 US US17/745,140 patent/US20220276260A1/en not_active Abandoned
-
2023
- 2023-06-20 JP JP2023100438A patent/JP2023134463A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN112135839A (zh) | 2020-12-25 |
| MX2020008115A (es) | 2020-09-25 |
| EP3746472A2 (en) | 2020-12-09 |
| WO2019152356A2 (en) | 2019-08-08 |
| JP2021512280A (ja) | 2021-05-13 |
| ZA202003320B (en) | 2023-10-25 |
| US20220276260A1 (en) | 2022-09-01 |
| JP2023134463A (ja) | 2023-09-27 |
| TW201940884A (zh) | 2019-10-16 |
| TWI808123B (zh) | 2023-07-11 |
| AR114569A1 (es) | 2020-09-23 |
| AU2019213647A1 (en) | 2020-07-23 |
| IL276075A (en) | 2020-08-31 |
| KR20200115467A (ko) | 2020-10-07 |
| WO2019152356A3 (en) | 2019-10-17 |
| US11366123B2 (en) | 2022-06-21 |
| US20190234964A1 (en) | 2019-08-01 |
| JP7301054B2 (ja) | 2023-06-30 |
| EA202091577A1 (ru) | 2020-10-26 |
| CA3084181A1 (en) | 2019-08-08 |
| BR112020011797A2 (pt) | 2020-11-17 |
| TW202348623A (zh) | 2023-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL279321A (en) | Anti-SIRPalpha antibody | |
| IL280780A (en) | Anti-TIGIT antibodies | |
| IL279352A (en) | IL-11RA antibodies | |
| IL280013A (en) | Anti-IL36R antibodies | |
| IL278010A (en) | Antibodies to galectin 10 | |
| IL289112A (en) | Antibodies against tigit | |
| SG11202005015XA (en) | Glucuronylation as acidic post-translational modification on therapeutic monoclonal antibodies | |
| IL277030A (en) | Antibodies | |
| GB202110263D0 (en) | Anti-btla antibodies | |
| IL291068A (en) | Anti-cd73 antibodies | |
| ZA202101177B (en) | Anti-btla antibody | |
| GB201811368D0 (en) | Antibody | |
| IL284584A (en) | Anti-tigit antibodies | |
| IL281594A (en) | Antibodies against KLRG1 | |
| GB201817172D0 (en) | Antibody | |
| GB201905150D0 (en) | Ant-ige antibodies | |
| GB201806084D0 (en) | Antibodies | |
| ZA202005419B (en) | C-terminal antibody variants | |
| GB201917480D0 (en) | Antibodies | |
| GB201911211D0 (en) | Monoclonal antibodies against ambra-1 | |
| GB201900732D0 (en) | Antibodies | |
| IL289160A (en) | Anti-angpt2 antibodies | |
| GB201820006D0 (en) | Humanised anti-IL17BR antibody | |
| SG11202105718TA (en) | Modified antibodies | |
| GB201919280D0 (en) | Antibodies |