SG11201912274UA - Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides - Google Patents
Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotidesInfo
- Publication number
- SG11201912274UA SG11201912274UA SG11201912274UA SG11201912274UA SG11201912274UA SG 11201912274U A SG11201912274U A SG 11201912274UA SG 11201912274U A SG11201912274U A SG 11201912274UA SG 11201912274U A SG11201912274U A SG 11201912274UA SG 11201912274U A SG11201912274U A SG 11201912274UA
- Authority
- SG
- Singapore
- Prior art keywords
- deprotection
- compositions
- methods
- chemical cleavage
- bound oligonucleotides
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 238000003776 cleavage reaction Methods 0.000 title 1
- 238000010511 deprotection reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000007017 scission Effects 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/107—Chemical cleaving agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862671816P | 2018-05-15 | 2018-05-15 | |
| US201962788045P | 2019-01-03 | 2019-01-03 | |
| PCT/US2019/032287 WO2019222264A1 (en) | 2018-05-15 | 2019-05-14 | Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201912274UA true SG11201912274UA (en) | 2020-01-30 |
Family
ID=66669137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201912274UA SG11201912274UA (en) | 2018-05-15 | 2019-05-14 | Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20190352327A1 (en) |
| EP (2) | EP4306532A3 (en) |
| JP (2) | JP7100069B2 (en) |
| KR (3) | KR102443569B1 (en) |
| CN (1) | CN111065645A (en) |
| AU (3) | AU2019271121B2 (en) |
| BR (1) | BR112019027944A2 (en) |
| CA (1) | CA3067434A1 (en) |
| DK (1) | DK3794012T3 (en) |
| FI (1) | FI3794012T3 (en) |
| IL (1) | IL271446A (en) |
| MX (2) | MX2019015174A (en) |
| PL (1) | PL3794012T3 (en) |
| PT (1) | PT3794012T (en) |
| RU (1) | RU2766688C2 (en) |
| SG (1) | SG11201912274UA (en) |
| WO (1) | WO2019222264A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112384295B (en) * | 2018-06-14 | 2023-10-31 | 康宁股份有限公司 | Patterned flow cell for biomolecular analysis |
| US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
| US11787831B2 (en) | 2020-06-22 | 2023-10-17 | Illumina Cambridge Limited | Nucleosides and nucleotides with 3′ acetal blocking group |
| EP4153606A2 (en) * | 2020-07-13 | 2023-03-29 | Singular Genomics Systems, Inc. | Methods of sequencing complementary polynucleotides |
| WO2022170212A1 (en) * | 2021-02-08 | 2022-08-11 | Singular Genomics Systems, Inc. | Methods and compositions for sequencing complementary polynucleotides |
| CN113248556B (en) * | 2021-05-18 | 2022-07-26 | 武汉科技大学 | Assembly of nucleic acid grafted azobenzene, preparation method and application |
| IL308173A (en) | 2021-05-20 | 2024-01-01 | Illumina Inc | Compositions and methods for sequencing by synthesis |
| EP4355476A1 (en) | 2021-06-15 | 2024-04-24 | Illumina, Inc. | Hydrogel-free surface functionalization for sequencing |
| US20230116852A1 (en) | 2021-07-23 | 2023-04-13 | Illumina, Inc. | Methods for preparing substrate surface for dna sequencing |
| WO2023069927A1 (en) | 2021-10-20 | 2023-04-27 | Illumina, Inc. | Methods for capturing library dna for sequencing |
| CN117813400A (en) * | 2021-11-02 | 2024-04-02 | 因美纳有限公司 | Primer sets and methods and kits for incorporating the same |
| CA3222829A1 (en) * | 2021-12-16 | 2023-06-22 | Gabriele CANZI | Methods for metal directed cleavage of surface-bound polynucleotides |
| WO2023122491A1 (en) | 2021-12-20 | 2023-06-29 | Illumina Cambridge Limited | Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides |
| CN117813399A (en) | 2021-12-20 | 2024-04-02 | 因美纳有限公司 | Periodate compositions and methods for chemically cleaving surface-bound polynucleotides |
| AU2022424380A1 (en) | 2021-12-29 | 2024-01-18 | Illumina, Inc. | Methods of nucleic acid sequencing using surface-bound primers |
| CN114457146A (en) * | 2022-01-28 | 2022-05-10 | 赛纳生物科技(北京)有限公司 | Method for sequencing on surface of solid-phase medium by double-end amplification |
| WO2023175021A1 (en) | 2022-03-15 | 2023-09-21 | Illumina, Inc. | Methods of preparing loop fork libraries |
| CA3222807A1 (en) | 2022-03-22 | 2023-09-28 | Alexandra SZEMJONOV | Substrate with orthogonally functional nanodomains |
| AU2023246691A1 (en) * | 2022-03-30 | 2024-01-18 | Illumina, Inc. | Methods for chemical cleavage of surface-bound polynucleotides |
| CN115820380B (en) * | 2023-01-04 | 2024-01-30 | 深圳赛陆医疗科技有限公司 | Microfluidic chip and preparation method and application thereof |
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| FR2567523B1 (en) * | 1984-07-12 | 1987-11-13 | Pasteur Institut | COVALENTLY BONDED POLYNUCLEOTIDES TO A SOLID SUPPORT, AND METHOD FOR THEIR PRODUCTION |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| WO1991006678A1 (en) | 1989-10-26 | 1991-05-16 | Sri International | Dna sequencing |
| AU6846798A (en) | 1997-04-01 | 1998-10-22 | Glaxo Group Limited | Method of nucleic acid sequencing |
| ES2563643T3 (en) | 1997-04-01 | 2016-03-15 | Illumina Cambridge Limited | Nucleic acid sequencing method |
| AU9460898A (en) * | 1997-10-14 | 1999-05-03 | Sankyo Company Limited | Modified oligodeoxyribonucleotides having tggg sequence |
| AR021833A1 (en) | 1998-09-30 | 2002-08-07 | Applied Research Systems | METHODS OF AMPLIFICATION AND SEQUENCING OF NUCLEIC ACID |
| CN100462433C (en) | 2000-07-07 | 2009-02-18 | 维西根生物技术公司 | Real-time sequence determination |
| EP1790736A3 (en) | 2000-10-06 | 2007-08-15 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding DNA and RNA |
| US7211414B2 (en) | 2000-12-01 | 2007-05-01 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| SI3587433T1 (en) | 2002-08-23 | 2020-08-31 | Illumina Cambridge Limited | Modified nucleotides |
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| GB2446084B (en) * | 2005-10-31 | 2011-03-02 | Univ Columbia | Synthesis of four color 3-o-allyl modified photocleavable fluorescent nucleotides and related methods |
| EP4105644A3 (en) | 2006-03-31 | 2022-12-28 | Illumina, Inc. | Systems and devices for sequence by synthesis analysis |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
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| US9650406B2 (en) * | 2013-02-28 | 2017-05-16 | Centrillion Technology Holdings Corporation | Reversible terminator molecules and methods of their use |
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| KR102070483B1 (en) | 2013-07-01 | 2020-01-29 | 일루미나, 인코포레이티드 | Catalyst-free surface functionalization and polymer grafting |
| US11266673B2 (en) * | 2016-05-23 | 2022-03-08 | The Trustees Of Columbia University In The City Of New York | Nucleotide derivatives and methods of use thereof |
-
2019
- 2019-05-14 JP JP2019571259A patent/JP7100069B2/en active Active
- 2019-05-14 CA CA3067434A patent/CA3067434A1/en active Pending
- 2019-05-14 FI FIEP19727252.9T patent/FI3794012T3/en active
- 2019-05-14 KR KR1020197038929A patent/KR102443569B1/en active IP Right Grant
- 2019-05-14 PL PL19727252.9T patent/PL3794012T3/en unknown
- 2019-05-14 EP EP23203880.2A patent/EP4306532A3/en active Pending
- 2019-05-14 KR KR1020247005819A patent/KR20240027158A/en active Application Filing
- 2019-05-14 WO PCT/US2019/032287 patent/WO2019222264A1/en unknown
- 2019-05-14 KR KR1020227031363A patent/KR102640410B1/en active IP Right Grant
- 2019-05-14 AU AU2019271121A patent/AU2019271121B2/en active Active
- 2019-05-14 SG SG11201912274UA patent/SG11201912274UA/en unknown
- 2019-05-14 US US16/411,913 patent/US20190352327A1/en active Pending
- 2019-05-14 BR BR112019027944-0A patent/BR112019027944A2/en unknown
- 2019-05-14 EP EP19727252.9A patent/EP3794012B1/en active Active
- 2019-05-14 CN CN201980003387.7A patent/CN111065645A/en active Pending
- 2019-05-14 RU RU2019141655A patent/RU2766688C2/en active
- 2019-05-14 MX MX2019015174A patent/MX2019015174A/en unknown
- 2019-05-14 DK DK19727252.9T patent/DK3794012T3/en active
- 2019-05-14 PT PT197272529T patent/PT3794012T/en unknown
- 2019-12-13 MX MX2022014502A patent/MX2022014502A/en unknown
- 2019-12-15 IL IL271446A patent/IL271446A/en unknown
-
2021
- 2021-06-14 AU AU2021203934A patent/AU2021203934B2/en active Active
-
2022
- 2022-06-30 JP JP2022106365A patent/JP2022130644A/en active Pending
-
2023
- 2023-05-22 AU AU2023203187A patent/AU2023203187A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019271121B2 (en) | 2021-05-20 |
| WO2019222264A1 (en) | 2019-11-21 |
| AU2021203934B2 (en) | 2023-02-23 |
| PL3794012T3 (en) | 2024-03-25 |
| BR112019027944A2 (en) | 2020-12-01 |
| JP7100069B2 (en) | 2022-07-12 |
| RU2019141655A (en) | 2021-07-27 |
| MX2019015174A (en) | 2023-01-02 |
| CA3067434A1 (en) | 2019-11-21 |
| EP4306532A3 (en) | 2024-04-10 |
| KR20200026215A (en) | 2020-03-10 |
| JP2022130644A (en) | 2022-09-06 |
| RU2766688C2 (en) | 2022-03-15 |
| CN111065645A (en) | 2020-04-24 |
| KR102443569B1 (en) | 2022-09-15 |
| KR20220130246A (en) | 2022-09-26 |
| AU2019271121A1 (en) | 2020-01-16 |
| FI3794012T3 (en) | 2024-01-08 |
| KR102640410B1 (en) | 2024-02-23 |
| KR20240027158A (en) | 2024-02-29 |
| MX2022014502A (en) | 2023-01-11 |
| DK3794012T3 (en) | 2024-01-08 |
| PT3794012T (en) | 2024-01-17 |
| EP3794012A1 (en) | 2021-03-24 |
| AU2023203187A1 (en) | 2023-06-29 |
| AU2021203934A1 (en) | 2021-07-08 |
| IL271446A (en) | 2020-01-30 |
| EP4306532A2 (en) | 2024-01-17 |
| US20190352327A1 (en) | 2019-11-21 |
| JP2021500003A (en) | 2021-01-07 |
| RU2019141655A3 (en) | 2021-07-27 |
| EP3794012B1 (en) | 2023-10-18 |
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