SG11201911647RA - Dual optical grating slide structured illumination imaging - Google Patents

Dual optical grating slide structured illumination imaging

Info

Publication number
SG11201911647RA
SG11201911647RA SG11201911647RA SG11201911647RA SG11201911647RA SG 11201911647R A SG11201911647R A SG 11201911647RA SG 11201911647R A SG11201911647R A SG 11201911647RA SG 11201911647R A SG11201911647R A SG 11201911647RA SG 11201911647R A SG11201911647R A SG 11201911647RA
Authority
SG
Singapore
Prior art keywords
optical grating
structured illumination
dual optical
illumination imaging
grating slide
Prior art date
Application number
SG11201911647RA
Inventor
Peter Newman
Danilo Condello
Shaoping Lu
Simon Prince
Merek Siu
Stanley Hong
Aaron Liu
Gary Skinner
Geraint Evans
Original Assignee
Illumina Inc
Illumina Cambridge Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc, Illumina Cambridge Ltd filed Critical Illumina Inc
Publication of SG11201911647RA publication Critical patent/SG11201911647RA/en

Links

Classifications

    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036Scanning details, e.g. scanning stages
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052Optical details of the image generation
    • G02B21/0076Optical details of the image generation arrangements using fluorescence or luminescence
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008Details of detection or image processing, including general computer control
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/06Means for illuminating specimens
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/06Means for illuminating specimens
    • G02B21/08Condensers
    • G02B21/082Condensers for incident illumination only
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/06Means for illuminating specimens
    • G02B21/08Condensers
    • G02B21/14Condensers affording illumination for phase-contrast observation
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/16Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/24Base structure
    • G02B21/26Stages; Adjusting means therefor
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/36Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365Control or image processing arrangements for digital or video microscopes
    • G02B21/367Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/10Beam splitting or combining systems
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/10Beam splitting or combining systems
    • G02B27/1086Beam splitting or combining systems operating by diffraction only
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/28Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for polarising
    • G02B27/283Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for polarising used for beam splitting or combining
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/42Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect
    • G02B27/4205Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect having a diffractive optical element [DOE] contributing to image formation, e.g. whereby modulation transfer function MTF or optical aberrations are relevant
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/42Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect
    • G02B27/4233Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect having a diffractive element [DOE] contributing to a non-imaging application
    • G02B27/425Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect having a diffractive element [DOE] contributing to a non-imaging application in illumination systems
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00Optical elements other than lenses
    • G02B5/18Diffraction gratings
    • G02B5/1814Diffraction gratings structurally combined with one or more further optical elements, e.g. lenses, mirrors, prisms or other diffraction gratings
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B7/00Mountings, adjusting means, or light-tight connections, for optical elements
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04NPICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/70Circuitry for compensating brightness variation in the scene
    • H04N23/72Combination of two or more compensation controls
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/02Objectives
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/58Optics for apodization or superresolution; Optical synthetic aperture systems

Landscapes

  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Diffracting Gratings Or Hologram Optical Elements (AREA)
SG11201911647RA 2018-01-16 2019-01-14 Dual optical grating slide structured illumination imaging SG11201911647RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862618057P 2018-01-16 2018-01-16
NL2020619A NL2020619B1 (en) 2018-01-16 2018-03-20 Dual optical grating slide structured illumination imaging
PCT/US2019/013496 WO2019143561A1 (en) 2018-01-16 2019-01-14 Dual optical grating slide structured illumination imaging

Publications (1)

Publication Number Publication Date
SG11201911647RA true SG11201911647RA (en) 2020-01-30

Family

ID=67296884

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201911647RA SG11201911647RA (en) 2018-01-16 2019-01-14 Dual optical grating slide structured illumination imaging

Country Status (15)

Country Link
US (1) US11226475B2 (en)
EP (2) EP3796066A1 (en)
JP (1) JP2020534553A (en)
KR (1) KR102308470B1 (en)
CN (2) CN110045508A (en)
AU (1) AU2019209791A1 (en)
BR (1) BR112019027615A2 (en)
CA (1) CA3066815A1 (en)
IL (1) IL271163A (en)
MX (1) MX2019014571A (en)
NL (1) NL2020619B1 (en)
RU (1) RU2740858C1 (en)
SG (1) SG11201911647RA (en)
TW (2) TW202043811A (en)
WO (1) WO2019143561A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110927948A (en) * 2019-12-05 2020-03-27 锘海生物科学仪器(上海)股份有限公司 Fluorescence microscope with solid-state optical system
US11053540B1 (en) * 2020-01-17 2021-07-06 Element Biosciences, Inc. High performance fluorescence imaging module for genomic testing assay
CN112730354B (en) * 2020-12-14 2022-11-01 南方科技大学 Structured light imaging method, imaging graph and application in biochemical detection
US11689213B2 (en) 2021-05-30 2023-06-27 Ceremorphic, Inc. Architecture for analog multiplier-accumulator with binary weighted charge transfer capacitors
CN116774417B (en) * 2023-08-25 2023-10-27 长春理工大学 Multi-point laser scanning microscope system based on cascade flexible grating

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856986A (en) 1968-12-06 1974-12-24 American Express Invest Scanned holography systems using temporal modulation
US4213706A (en) 1977-08-19 1980-07-22 The University Of Arizona Foundation Background compensating interferometer
JP2000502444A (en) 1995-12-15 2000-02-29 フラウンホフェル―ゲゼルシャフト ツール フェルデルング デル アンゲヴァンテン フォルシュング エー ファウ Method and apparatus for determining spacing with high resolution in imaging of lens and aperture plate system
US5761085A (en) 1996-11-12 1998-06-02 The United States Of America As Represented By The Secretary Of The Navy Method for monitoring environmental parameters at network sites
US6188478B1 (en) 1998-10-21 2001-02-13 Philips Electronics North America Corporation Method and apparatus for film-thickness measurements
JP2002025106A (en) 2000-07-10 2002-01-25 Ricoh Co Ltd Device for assembling optical pickup
US7274446B2 (en) 2001-04-07 2007-09-25 Carl Zeiss Jena Gmbh Method and arrangement for the deep resolved optical recording of a sample
JP5048899B2 (en) 2001-09-28 2012-10-17 オリンパス株式会社 microscope
KR100489431B1 (en) 2002-06-28 2005-05-12 학교법인연세대학교 Phase-shifting profilometry system using scanning and measuring method thereof
JP2004037863A (en) 2002-07-03 2004-02-05 Nippon Sheet Glass Co Ltd Positioning method for diffraction grating and positioning device for diffraction grating
JP2005080181A (en) 2003-09-03 2005-03-24 Nikon Corp Image reading apparatus and image reading program
US7298494B2 (en) 2003-09-15 2007-11-20 Zygo Corporation Methods and systems for interferometric analysis of surfaces and related applications
US7532323B2 (en) 2003-10-28 2009-05-12 Cha-Min Tang Spatial light modulator apparatus and method
US20050221351A1 (en) 2004-04-06 2005-10-06 Affymetrix, Inc. Methods and devices for microarray image analysis
CN1292227C (en) 2005-07-12 2006-12-27 中国科学院上海光学精密机械研究所 Calibration method for spatial resolution of high-resolution digital interferometer
WO2007061632A2 (en) 2005-11-09 2007-05-31 Geometric Informatics, Inc. Method and apparatus for absolute-coordinate three-dimensional surface imaging
JP2007199397A (en) * 2006-01-26 2007-08-09 Nikon Corp Microscope apparatus
DE102006047912A1 (en) 2006-10-06 2008-04-10 Carl Zeiss Microimaging Gmbh Method and device for parallelized microscopic imaging
WO2008072597A1 (en) 2006-12-12 2008-06-19 Nikon Corporation Microscope device and image processing method
WO2009009081A2 (en) 2007-07-10 2009-01-15 Massachusetts Institute Of Technology Tomographic phase microscopy
US8222040B2 (en) 2007-08-28 2012-07-17 Lightspeed Genomics, Inc. Nucleic acid sequencing by selective excitation of microparticles
US8759077B2 (en) 2007-08-28 2014-06-24 Lightspeed Genomics, Inc. Apparatus for selective excitation of microparticles
US8509879B2 (en) 2007-11-06 2013-08-13 The Regents Of The University Of California Apparatus and method for widefield functional imaging (WiFI) using integrated structured illumination and laser speckle imaging
US20090219607A1 (en) 2008-01-17 2009-09-03 Baylor College Of Medicine Method and apparatus for enhanced resolution microscopy of living biological nanostructures
DE102008009216A1 (en) 2008-02-13 2009-08-20 Carl Zeiss Microimaging Gmbh Apparatus and method for spatially high resolution imaging of a structure of a sample
US20120249797A1 (en) 2010-02-28 2012-10-04 Osterhout Group, Inc. Head-worn adaptive display
US9465228B2 (en) 2010-03-19 2016-10-11 Optical Biosystems, Inc. Illumination apparatus optimized for synthetic aperture optics imaging using minimum selective excitation patterns
US8502867B2 (en) 2010-03-19 2013-08-06 Lightspeed Genomics, Inc. Synthetic aperture optics imaging method using minimum selective excitation patterns
JP5538072B2 (en) 2010-06-03 2014-07-02 株式会社日立ハイテクノロジーズ Defect inspection method and apparatus
WO2012049831A1 (en) 2010-10-14 2012-04-19 株式会社ニコン Structured illumination device, structured illumination microscope device, and surface shape measurement device
RU2572644C2 (en) * 2010-10-19 2016-01-20 Конинклейке Филипс Электроникс Н.В. Differential phase-contrast imaging
DE102010062341B4 (en) * 2010-12-02 2023-05-17 Carl Zeiss Microscopy Gmbh Device for increasing the depth discrimination of optical imaging systems
US10048480B2 (en) * 2011-01-07 2018-08-14 Zeta Instruments, Inc. 3D microscope including insertable components to provide multiple imaging and measurement capabilities
NL2006306C2 (en) 2011-02-28 2012-08-29 Inashco R & D B V Eddy current seperation apparatus, separation module, separation method and method for adjusting an eddy current separation apparatus.
WO2012122418A1 (en) 2011-03-08 2012-09-13 Lightspeed Genomics, Inc. Self-assembling high density ordered patterned biomolecule array and method for making and using the same
WO2012149459A1 (en) 2011-04-29 2012-11-01 Lightspeed Genomics, Inc. Modular pattern illumination and light beam multiplexing for selective excitation of microparticles
WO2012153495A1 (en) 2011-05-06 2012-11-15 株式会社ニコン Structured illumination microscope and structured illumination viewing method
KR101979470B1 (en) * 2011-06-06 2019-05-16 시리얼 테크놀로지즈 에스.에이. Method and device for the layered production of thin volume grid stacks, and beam combiner for a holographic display
WO2012170936A2 (en) 2011-06-09 2012-12-13 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
WO2013001805A1 (en) * 2011-06-29 2013-01-03 株式会社ニコン Structured illumination optical system and structured illumination microscope device
JP6140737B2 (en) * 2012-02-23 2017-05-31 ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ Multifocal structured irradiation microscopy system and method
WO2014013720A1 (en) * 2012-07-19 2014-01-23 株式会社ニコン Structured illumination microscope device
DE102012017922B4 (en) 2012-09-11 2024-03-14 Carl Zeiss Microscopy Gmbh Optical arrangement and light microscope
EP2898312B1 (en) 2012-09-24 2021-03-24 Global Life Sciences Solutions USA LLC Methods for resolving positions in fluorescence stochastic microscopy using three-dimensional structured illumination.
CN103091824B (en) * 2012-12-27 2015-04-15 中国科学院深圳先进技术研究院 Disc and manufacturing method thereof and structured light illumination mode generating device
DE102013004963A1 (en) 2013-03-22 2014-09-25 Carl Zeiss Microscopy Gmbh Microscope with structured illumination
EP2801854B1 (en) * 2013-05-10 2017-07-19 Ruprecht-Karls-Universität Heidelberg Method and apparatus for combination of localization microscopy and structured illumination microscopy
JP6409260B2 (en) 2013-09-06 2018-10-24 株式会社ニコン Structured illumination device and structured illumination microscope device
JP6413364B2 (en) 2014-06-06 2018-10-31 株式会社ニコン Illumination optical system and microscope apparatus
WO2016001910A1 (en) * 2014-06-29 2016-01-07 OPTICS 3D Ltd. Dual structured illumination modulated in phase and intensity
TWI684782B (en) * 2014-08-01 2020-02-11 德商拜耳材料科學股份有限公司 Layered setup comprising a photopolymer layer and a substrate layer
EP3037861A1 (en) 2014-12-23 2016-06-29 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Imaging method, and system, for obtaining an super-resolution image of an object
WO2016168996A1 (en) * 2015-04-22 2016-10-27 Shenzhen Genorivision Technology Co., Ltd. A biosensor
PT3411695T (en) * 2016-02-01 2022-03-03 Kla Tencor Corp Method and system for optical three-dimensional topography measurement
WO2017149526A2 (en) * 2016-03-04 2017-09-08 May Patents Ltd. A method and apparatus for cooperative usage of multiple distance meters
CN205981138U (en) * 2016-08-11 2017-02-22 广西师范大学 Phase shift formula optical projection three -dimensional measurement system
CN106770147B (en) * 2017-03-15 2019-07-19 北京大学 A kind of Structured Illumination super-resolution micro imaging method
WO2018170518A1 (en) 2017-03-17 2018-09-20 Apton Biosystems, Inc. Sequencing and high resolution imaging

Also Published As

Publication number Publication date
TWI697699B (en) 2020-07-01
US20200192071A1 (en) 2020-06-18
TW201932883A (en) 2019-08-16
WO2019143561A1 (en) 2019-07-25
NL2020619B1 (en) 2019-07-25
TW202043811A (en) 2020-12-01
CA3066815A1 (en) 2019-07-25
KR102308470B1 (en) 2021-10-05
CN110045508A (en) 2019-07-23
JP2020534553A (en) 2020-11-26
IL271163A (en) 2020-01-30
BR112019027615A2 (en) 2020-09-01
CN209656566U (en) 2019-11-19
EP3625606A4 (en) 2020-07-22
AU2019209791A1 (en) 2020-01-02
EP3796066A1 (en) 2021-03-24
EP3625606A1 (en) 2020-03-25
MX2019014571A (en) 2020-09-09
RU2740858C1 (en) 2021-01-21
KR20200024155A (en) 2020-03-06
US11226475B2 (en) 2022-01-18

Similar Documents

Publication Publication Date Title
IL271163A (en) Dual optical grating slide structured illumination imaging
GB2583167B (en) Optical components for imaging
SG11202103846PA (en) Optical lens
CA185679S (en) Light
EP3779556A4 (en) Optical illumination device
IL271318A (en) Illumination for fluorescence imaging using objective lens
CA187451S (en) Light
CA187450S (en) Light
CA188813S (en) Light
CA188630S (en) Light
CA187452S (en) Light
EP3847446A4 (en) Multimodality multiplexed illumination for optical inspection systems
PL3973275T3 (en) Auto-focussing libs system
EP3763995A4 (en) Illumination lens
EP3559640A4 (en) Optical imaging system using lateral illumination for digital assays
GB2591331B (en) Optical multiplexer
GB202106159D0 (en) Optical imaging
CA186903S (en) Light
CA186902S (en) Light
CA186904S (en) Light
CA186905S (en) Light
CA186901S (en) Light
GB2574577B (en) Optical element for distributing light
GB2583069B (en) Light cover
HK1247982A1 (en) Light distribution lens