SG11201908331SA - Sh2b adapter protein 3 for the prediction of bone marrow response and immune response - Google Patents

Sh2b adapter protein 3 for the prediction of bone marrow response and immune response

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Publication number
SG11201908331SA
SG11201908331SA SG11201908331SA SG11201908331SA SG 11201908331S A SG11201908331S A SG 11201908331SA SG 11201908331S A SG11201908331S A SG 11201908331SA SG 11201908331S A SG11201908331S A SG 11201908331SA
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Singapore
Prior art keywords
international
adapter protein
response
prediction
bone marrow
Prior art date
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Inventor
Gustav Steinhoff
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Univ Rostock Zentrale Univsverwaltung Referat 1 1 Recht
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Application filed by Univ Rostock Zentrale Univsverwaltung Referat 1 1 Recht filed Critical Univ Rostock Zentrale Univsverwaltung Referat 1 1 Recht
Publication of SG11201908331SA publication Critical patent/SG11201908331SA/en

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    • C—CHEMISTRY; METALLURGY
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/18—Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Data Mining & Analysis (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Analysis (AREA)
  • Theoretical Computer Science (AREA)
  • Pure & Applied Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Computational Mathematics (AREA)
  • Evolutionary Biology (AREA)
  • Probability & Statistics with Applications (AREA)
  • Databases & Information Systems (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Software Systems (AREA)
  • Algebra (AREA)
  • Operations Research (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

a) (b) De lta CT S H B3 oc e yQ 0 < ,6° e yQ + o o . (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) WIPOIPCT °Ens °nolo onoin mu Imo oimIE (10) International Publication Number WO 2018/189198 Al (51) International Patent Classification: C12Q 1/6813 (2018.01) C12Q 1/6883 (2018.01) (21) International Application Number: PCT/EP2018/059194 (22) International Filing Date: 10 April 2018 (10.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10 2017 107 661.1 10 April 2017 (10.04.2017) DE (71) Applicant: UNIVERSITAT ROSTOCK ZENTRALE UNIVERSITATSVERWALTUNG REFERAT 1.1 RECHT [DE/DE]; Universitatsplatz 1, 18051 Rostock (DE). (72) Inventor: STEINHOFF, Gustav; Zur Niederung 3, 18211 Rethwisch (DE). (74) Agent: NIEDLICH, Thorsten; BECKORD & NIEDLICH PATENTANWALTE PARTG MBB, Marktplatz 17, 83607 Holzkirchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) (54) Title: SH2B ADAPTER PROTEIN 3 FOR THE PREDICTION OF BONE MARROW RESPONSE AND IMMUNE RESPONSE SH2B3 gene expression analysis in peripheral blood of responder and non-responder 1-1 O O (57) : The present invention relates to SH2B adapter protein 3 (SH2B3) for use as a diagnostic marker. Further, the present invention relates to a method for the determination of SH2B3 gene expression.
SG11201908331S 2017-04-10 2018-04-10 Sh2b adapter protein 3 for the prediction of bone marrow response and immune response SG11201908331SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017107661.1A DE102017107661A1 (en) 2017-04-10 2017-04-10 SH2B adapter protein-3 for the prediction of a bone marrow response and immune response
PCT/EP2018/059194 WO2018189198A1 (en) 2017-04-10 2018-04-10 Sh2b adapter protein 3 for the prediction of bone marrow response and immune response

Publications (1)

Publication Number Publication Date
SG11201908331SA true SG11201908331SA (en) 2019-10-30

Family

ID=61913188

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201908331S SG11201908331SA (en) 2017-04-10 2018-04-10 Sh2b adapter protein 3 for the prediction of bone marrow response and immune response

Country Status (10)

Country Link
US (1) US20200115743A1 (en)
EP (1) EP3610038A1 (en)
JP (1) JP2020516301A (en)
KR (1) KR20200013636A (en)
CN (1) CN110506125A (en)
AU (1) AU2018251942A1 (en)
CA (1) CA3059647A1 (en)
DE (1) DE102017107661A1 (en)
SG (1) SG11201908331SA (en)
WO (1) WO2018189198A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102018125324A1 (en) * 2018-10-12 2020-04-16 Universität Rostock Procedure for predicting an answer to disease therapy

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030224383A1 (en) * 2002-04-23 2003-12-04 Mike West Atherosclerotic phenotype determinative genes and methods for using the same
JP4822205B2 (en) * 2005-09-30 2011-11-24 学校法人東海大学 Vascular endothelial progenitor cells in which the function of Lnk is destroyed or suppressed
WO2010067381A1 (en) * 2008-12-12 2010-06-17 Decode Genetics Ehf Genetic variants as markers for use in diagnosis, prognosis and treatment of eosinophilia, asthma, and myocardial infarction
US20100233733A1 (en) * 2009-02-10 2010-09-16 Nodality, Inc., A Delaware Corporation Multiple mechanisms for modulation of the pi3 kinase pathway
WO2011088125A1 (en) * 2010-01-14 2011-07-21 The Board Of Trustees Of The Leland Stanford Junior University Mutations in the lnk gene in patients with myeloproliferative neoplasms and other hematolymphoid malignancies
EP2739735A2 (en) * 2011-08-01 2014-06-11 Alnylam Pharmaceuticals, Inc. Method for improving the success rate of hematopoietic stem cell transplants
CN104141012B (en) * 2014-08-01 2016-06-08 武汉大学 SH2B adaptin 1(SH2B1) at the function and application for the treatment of in myocardial hypertrophy
CN104107429B (en) * 2014-08-01 2017-02-15 武汉大学 Function and application of SH2B adapter protein 3(SH2B3) for treating cardiac hypertrophy
WO2016085934A1 (en) * 2014-11-24 2016-06-02 Children's Medical Center Corporation Modulation of sh2b3 to improve red blood cell production from stem cells and/or progenitor cells
CN108138234A (en) * 2015-04-15 2018-06-08 普罗麦迪奥股份有限公司 The method for treating myeloproliferative disorders

Also Published As

Publication number Publication date
KR20200013636A (en) 2020-02-07
EP3610038A1 (en) 2020-02-19
JP2020516301A (en) 2020-06-11
CA3059647A1 (en) 2018-10-18
CN110506125A (en) 2019-11-26
DE102017107661A1 (en) 2018-10-11
US20200115743A1 (en) 2020-04-16
WO2018189198A1 (en) 2018-10-18
AU2018251942A1 (en) 2019-10-03

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