SG11201908183YA - Skin barrier composition - Google Patents
Skin barrier compositionInfo
- Publication number
- SG11201908183YA SG11201908183YA SG11201908183YA SG11201908183YA SG 11201908183Y A SG11201908183Y A SG 11201908183YA SG 11201908183Y A SG11201908183Y A SG 11201908183YA SG 11201908183Y A SG11201908183Y A SG 11201908183YA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- skin
- floor
- pct
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
0- 5.5- 5.0- x (l c ) 4.0- 2 3.5- 3.0- - No Cream - N- Test cream (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT omit VIII °nolo III olo 001 VIII Imo oimIE (10) International Publication Number WO 2018/206962 Al (51) International Patent Classification: A61K 47/10 (2017.01) A61K 31/191 (2006.01) A61K 9/06 (2006.01) A61K 31/7032 (2006.01) (21) International Application Number: PCT/GB2018/051262 (22) International Filing Date: 10 May 2018 (10.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1707489.9 10 May 2017 (10.05.2017) GB (71) Applicant: HYPHENS PHARMA PTE. LTD. [SG/SG]; 138 Joo Seng Road, 3rd Floor, 368361 (SG). (71) Applicant (for SC only): HASELTINE LAKE LLP [GB/GB]; Lincoln House, 5th Floor, 300 High Holborn, Greater London WC1V 7JH (GB). (72) Inventors: HAMMOND, Kevin; Alderside, 1 Porto Hey Road, Wirral Merseyside CH61 2XA (GB). DAVIS, Adri- an; 12 Limeway Terrace, Dorking Surrey RH4 1HZ (GB). (74) Agent: FINNIE, Isobel Lara; Haseltine Lake LLP, Lin- coln House, 5th Floor, 300 High Holborn, London Greater London WC1V 7JH (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (54) Title: SKIN BARRIER COMPOSITION W O 20 18/ 20696 2 Al 2.5 ............... O cp o cb o c p co o c. o 0 0 03 ts \ <0 Time post-application (minutes) Figure 2 (57) : The present invention provides a composition for topical administration of a polyhydroxy acid, such as lactobionate and especially zinc lactobionate, and low pH to an external body surface such as skin. The composition is designed to be highly effective in delivering low pH and zinc lactobionate across the layers of the skin to more effectively treat and prevent skin conditions involving a defective skin barrier such as eczema and severe dry skin. [Continued on next page] WO 2018/206962 Al MIDEDIMOMOIDEIRDERI001010110111110111011MEMOIS UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1707489.9A GB2562270B (en) | 2017-05-10 | 2017-05-10 | Skin barrier composition |
PCT/GB2018/051262 WO2018206962A1 (en) | 2017-05-10 | 2018-05-10 | Skin barrier composition |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201908183YA true SG11201908183YA (en) | 2019-10-30 |
Family
ID=59065602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201908183Y SG11201908183YA (en) | 2017-05-10 | 2018-05-10 | Skin barrier composition |
Country Status (11)
Country | Link |
---|---|
US (2) | US11173172B2 (en) |
EP (1) | EP3621653A1 (en) |
JP (1) | JP7228531B2 (en) |
KR (1) | KR102646319B1 (en) |
CN (1) | CN110621346B (en) |
AU (1) | AU2018267267B2 (en) |
GB (1) | GB2562270B (en) |
MY (1) | MY189248A (en) |
PH (1) | PH12019502062A1 (en) |
SG (1) | SG11201908183YA (en) |
WO (1) | WO2018206962A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10660838B2 (en) | 2017-06-23 | 2020-05-26 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
KR20210011964A (en) | 2018-07-03 | 2021-02-02 | 더 프록터 앤드 갬블 캄파니 | How to treat a skin condition |
WO2021247496A1 (en) | 2020-06-01 | 2021-12-09 | The Procter & Gamble Company | Method of improving penetration of a vitamin b3 compound into skin |
US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
GB2596286B (en) | 2020-06-20 | 2023-01-25 | Francis Davis Adrian | Adherence to topical therapy |
US20220192961A1 (en) * | 2020-12-17 | 2022-06-23 | L'oreal | Hydroglycolic cosmetic composition with a high active content |
GB2616294A (en) * | 2022-03-03 | 2023-09-06 | Hyphens Pharma Pte Ltd | Composition for use |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4954487A (en) * | 1979-01-08 | 1990-09-04 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
US5385938B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of using glycolic acid for treating wrinkles |
WO1994000127A1 (en) * | 1992-06-19 | 1994-01-06 | The Regents Of The University Of California | Lipids for epidermal moisturization and repair of barrier function |
ATE197895T1 (en) * | 1994-03-29 | 2000-12-15 | Procter & Gamble | AGENTS FOR ARTIFICIAL BROWNING WITH IMPROVED COLOR DEVELOPMENT |
US5618850A (en) * | 1995-03-09 | 1997-04-08 | Focal, Inc. | Hydroxy-acid cosmetics |
DE19719856A1 (en) * | 1997-05-12 | 1998-11-19 | Henkel Kgaa | Skin care products |
US6335023B1 (en) * | 1999-06-30 | 2002-01-01 | Ruey J. Yu | Oligosaccharide aldonic acids and their topical use |
JP3713406B2 (en) | 1999-07-16 | 2005-11-09 | 株式会社資生堂 | Gel preparation for external use |
US20020035070A1 (en) * | 2000-07-26 | 2002-03-21 | The Procter & Gamble Company | Method of regulating hair growth using metal complexes of oxidized carbohydrates |
US20020119174A1 (en) * | 2000-07-26 | 2002-08-29 | Gardlik John Michael | Compositions useful for regulating hair growth containing metal complexes of oxidized carbohydrates |
MXPA03003132A (en) * | 2000-10-10 | 2003-07-14 | Procter & Gamble | Packaged scalp cosmetic compositions. |
JP5619337B2 (en) | 2003-10-10 | 2014-11-05 | フェリング ビー.ブイ. | Transdermal pharmaceutical formulation to minimize skin residue |
EP1838274A1 (en) | 2005-01-19 | 2007-10-03 | Cincinnati Childrens's Hospital Medical Center | Simulated vernix compositions for skin cleansing and other applications |
ES2353319T3 (en) | 2005-01-26 | 2011-03-01 | The Procter And Gamble Company | COMPOSITIONS FOR THE CARE OF THE LOW PH SKIN CONTAINING HYDROACETIC ACID. |
GB0617191D0 (en) | 2006-08-31 | 2006-10-11 | York Pharma Plc | Improvements in pharmaceutical compositions |
JP5578869B2 (en) | 2010-01-27 | 2014-08-27 | ユニチカ株式会社 | Stratum corneum turnover accelerator |
KR101773095B1 (en) | 2010-11-30 | 2017-08-31 | (주)아모레퍼시픽 | Non-separation type sunscreen composition with low viscosity |
JP2013060393A (en) | 2011-09-13 | 2013-04-04 | Nitto Denko Corp | Composition for enhancing transdermal absorption and patch preparation |
US9636376B2 (en) * | 2012-09-11 | 2017-05-02 | Innopharma, Inc. | Stable compositions of peptide epoxy ketones |
JP6151935B2 (en) | 2013-03-11 | 2017-06-21 | 日東電工株式会社 | Transdermal absorption enhancing composition and patch preparation |
US20150024074A1 (en) * | 2013-07-22 | 2015-01-22 | Johnson & Johnson Consumer Companies Inc. | Methods for treating skin barrier and reducing acne |
JP2014114291A (en) * | 2013-12-13 | 2014-06-26 | Showa Denko Kk | Cosmetic and skin external preparation |
KR20160026042A (en) | 2014-08-29 | 2016-03-09 | (주)아모레퍼시픽 | A composition for anti-stress or homeostasis containing lactobionic acid |
CN105434213A (en) * | 2015-08-04 | 2016-03-30 | 马南行 | Cosmetic composition capable of soothing skin and preparation method of cosmetic composition |
-
2017
- 2017-05-10 GB GB1707489.9A patent/GB2562270B/en active Active
-
2018
- 2018-05-10 CN CN201880031234.9A patent/CN110621346B/en active Active
- 2018-05-10 SG SG11201908183Y patent/SG11201908183YA/en unknown
- 2018-05-10 WO PCT/GB2018/051262 patent/WO2018206962A1/en active Search and Examination
- 2018-05-10 AU AU2018267267A patent/AU2018267267B2/en active Active
- 2018-05-10 US US16/611,529 patent/US11173172B2/en active Active
- 2018-05-10 MY MYPI2019005711A patent/MY189248A/en unknown
- 2018-05-10 EP EP18725608.6A patent/EP3621653A1/en active Pending
- 2018-05-10 KR KR1020197028922A patent/KR102646319B1/en active IP Right Grant
- 2018-05-10 JP JP2019562640A patent/JP7228531B2/en active Active
-
2019
- 2019-09-11 PH PH12019502062A patent/PH12019502062A1/en unknown
-
2021
- 2021-10-13 US US17/500,604 patent/US11890294B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN110621346A (en) | 2019-12-27 |
US20200222438A1 (en) | 2020-07-16 |
US20220031721A1 (en) | 2022-02-03 |
GB201707489D0 (en) | 2017-06-21 |
AU2018267267B2 (en) | 2023-09-07 |
EP3621653A1 (en) | 2020-03-18 |
JP2020519649A (en) | 2020-07-02 |
KR20190142324A (en) | 2019-12-26 |
GB2562270B (en) | 2020-07-01 |
US11173172B2 (en) | 2021-11-16 |
US11890294B2 (en) | 2024-02-06 |
CN110621346B (en) | 2024-04-12 |
AU2018267267A1 (en) | 2019-10-10 |
WO2018206962A1 (en) | 2018-11-15 |
MY189248A (en) | 2022-01-31 |
KR102646319B1 (en) | 2024-03-11 |
JP7228531B2 (en) | 2023-02-24 |
PH12019502062A1 (en) | 2020-07-06 |
GB2562270A (en) | 2018-11-14 |
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