SG11201903841PA - High speed deep tissue imaging system using multiplexed scanned temporal focusing - Google Patents
High speed deep tissue imaging system using multiplexed scanned temporal focusingInfo
- Publication number
- SG11201903841PA SG11201903841PA SG11201903841PA SG11201903841PA SG11201903841PA SG 11201903841P A SG11201903841P A SG 11201903841PA SG 11201903841P A SG11201903841P A SG 11201903841PA SG 11201903841P A SG11201903841P A SG 11201903841PA SG 11201903841P A SG11201903841P A SG 11201903841PA
- Authority
- SG
- Singapore
- Prior art keywords
- sub
- international
- target volume
- multiplexed
- laser pulse
- Prior art date
Links
- 238000003384 imaging method Methods 0.000 title abstract 3
- 230000002123 temporal effect Effects 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 abstract 3
- VXVIICNFYDEOJG-UHFFFAOYSA-N 2-(4-chloro-2-formylphenoxy)acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1C=O VXVIICNFYDEOJG-UHFFFAOYSA-N 0.000 abstract 1
- 230000005284 excitation Effects 0.000 abstract 1
- 101150068765 fcpA gene Proteins 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
- G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/10—Scanning
- G01N2201/105—Purely optical scan
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S3/00—Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
- H01S3/005—Optical devices external to the laser cavity, specially adapted for lasers, e.g. for homogenisation of the beam or for manipulating laser pulses, e.g. pulse shaping
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 0111111111111111M 111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/081711 Al 03 May 2018 (03.05.2018) W I P0 I P C T (51) International Patent Classification: (72) Inventor; and GO1N 21/63 (2006.01) HOlS 3/067(2006.01) (71) Applicant: VAZIRI, Alipasha [US/US]; 1161 York Av- GO1N 21/64 (2006.01) enue, #11E, New York, NY 10065 (US). (21) International Application Number: (74) Agent: ZUSCHLAG, Steven T.; Hoffmann & Baron, LLP, PCT/US2017/059044 6900 Jericho Turnpike, Syosset, New York 11791 (US). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 30 October 2017 (30.10.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (25) Filing Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (26) Publication Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (30) Priority Data: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 62/414,788 30 October 2016 (30.10.2016) US KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (71) Applicant: UNIVERSITY OF VIENNA [AT/AT]; Uni- OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, versitatsring 1, A-1010 Vienna (AT). SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: HIGH SPEED DEEP TISSUE IMAGING SYSTEM USING 139 FCPA DOE MULTIPLEXED SCANNED TEMPORAL FOCUSING 501, _. 520 , '---, 503 '- 509 530 515 1 z - - - 1. '- - - - 1 5141 4- 511 505 - T 1 , 516' _6. ky - 500 +10n..s. 507-,- 513 1 '' 518 ,-, (57) : A tissue imaging system Il laser pulse received from the laser module 1-1 IN optical delay module to a target volume 1-1 to excitation of the target volume by the X ) configured to receive the temporally multiplexed 0 ---. laser pulse into a plurality of sub-beams GC sub-beam are spatially separated with respect to a first image plane formed at a first depth within 1-1 c;;;;) to a second image plane formed at a second ei +2Ons ' L FIG. 5 includes a laser module for outputting a laser pulse, an optical delay module configured to split a into a plurality of time-delayed sub-pulses, a telescope for delivering the sub-pulses from the and a photodetector configured to collect photons generated within the target volume in response first and second sub-pulses. The system may further laser pulse from the optical delay module and including a first sub-beam and a second sub-beam, wherein the first sub-beam and the second depth within the target volume. include a spatial multiplexing module splitting the temporally multiplexed the target volume and with respect O [Continued on next page] WO 2018/081711 Al MIDEDIMOMBEFIDIONIMHOIniliMEMOIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662414788P | 2016-10-30 | 2016-10-30 | |
PCT/US2017/059044 WO2018081711A1 (en) | 2016-10-30 | 2017-10-30 | High speed deep tissue imaging system using multiplexed scanned temporal focusing |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201903841PA true SG11201903841PA (en) | 2019-05-30 |
Family
ID=62025515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201903841PA SG11201903841PA (en) | 2016-10-30 | 2017-10-30 | High speed deep tissue imaging system using multiplexed scanned temporal focusing |
Country Status (9)
Country | Link |
---|---|
US (1) | US20200182792A1 (en) |
EP (1) | EP3532827B1 (en) |
JP (1) | JP2019536059A (en) |
KR (1) | KR20190082252A (en) |
CN (1) | CN110168351A (en) |
CA (1) | CA3042229A1 (en) |
IL (1) | IL266284B2 (en) |
SG (1) | SG11201903841PA (en) |
WO (1) | WO2018081711A1 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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GB2566115B (en) | 2017-09-22 | 2020-04-01 | Univ Court Univ St Andrews | Imaging of a sample through a scattering medium |
WO2020014603A2 (en) | 2018-07-13 | 2020-01-16 | Trustees Of Boston University | Reverberation microscopy systems and methods |
WO2020058698A1 (en) * | 2018-09-20 | 2020-03-26 | University Court Of The University Of St Andrews | Imaging an object through a scattering medium |
EP3918303A4 (en) * | 2019-01-31 | 2023-03-22 | The Rockefeller University | Hybrid multi-photon microscopy |
CN109745010A (en) * | 2019-01-31 | 2019-05-14 | 北京超维景生物科技有限公司 | Positioning formula adsorbs microscope detection device and laser scanning microscope |
CN113508327A (en) | 2019-02-01 | 2021-10-15 | 统雷有限公司 | High dynamic range imaging |
RU190693U1 (en) * | 2019-03-13 | 2019-07-09 | Акционерное общество "Корпорация "Тактическое ракетное вооружение" | TEST STAND WITH CIRCULAR SCREEN DEFLECTOR |
US11408032B2 (en) | 2020-01-17 | 2022-08-09 | Element Biosciences, Inc. | Tube lens design for improved depth-of-field |
GB2593456B (en) * | 2020-03-18 | 2024-02-28 | Thermo Fisher Scient Ecublens Sarl | Double-pulse laser system |
EP4214562A1 (en) * | 2020-09-20 | 2023-07-26 | The Regents Of The University Of California | Transverse sheet illumination microscopy (transim) |
CN112816447B (en) * | 2020-12-30 | 2022-02-15 | 华南理工大学 | Multi-photon excitation imaging system and imaging method based on two-dimensional frequency space coding |
US11789333B2 (en) * | 2021-03-01 | 2023-10-17 | Lawrence Livermore National Security, Llc | System and method for temporal dispersion compensator |
TWI764627B (en) * | 2021-03-17 | 2022-05-11 | 上儀股份有限公司 | System for adjusting laser pulse width and laser pulse energy |
WO2022235909A1 (en) * | 2021-05-05 | 2022-11-10 | The Rockefeller University | Spatiotemporal multiplexing module |
CN113484281B (en) * | 2021-05-28 | 2023-03-14 | 太原理工大学 | Optical encryption device and method based on unique light scattering characteristics of biological tissues |
CN116148227B (en) * | 2023-04-23 | 2023-07-28 | 广东大湾区空天信息研究院 | Time-resolved spectrum rapid measurement system and method |
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DE69635521T2 (en) * | 1995-09-19 | 2006-08-17 | Cornell Research Foundation, Inc. | MULTI-PHOTON LASER MICROSCOPY |
US6631226B1 (en) * | 1997-01-27 | 2003-10-07 | Carl Zeiss Jena Gmbh | Laser scanning microscope |
US5796477A (en) * | 1997-02-27 | 1998-08-18 | Trustees Of Boston University | Entangled-photon microscopy, spectroscopy, and display |
US6640014B1 (en) * | 1999-01-22 | 2003-10-28 | Jeffrey H. Price | Automatic on-the-fly focusing for continuous image acquisition in high-resolution microscopy |
US6839469B2 (en) * | 2000-01-21 | 2005-01-04 | Lam K. Nguyen | Multiparallel three dimensional optical microscopy system |
DE10038527A1 (en) * | 2000-08-08 | 2002-02-21 | Zeiss Carl Jena Gmbh | Arrangement to increase depth discrimination in optical imaging systems |
EP1362252A4 (en) * | 2001-01-12 | 2006-02-01 | Univ Texas | Method and apparatus for differential phase optical coherence tomography |
US7170675B2 (en) * | 2004-05-19 | 2007-01-30 | Celloptic, Inc. | Method and system for wide-field multi-photon microscopy having a confocal excitation plane |
US8189191B2 (en) * | 2005-07-26 | 2012-05-29 | Tufts University | Spectroscopic imaging microscopy |
US20100053743A1 (en) * | 2006-07-13 | 2010-03-04 | Massimo Galimberti | Apparatus for real-time three-dimensional laser scanning microscopy, with detection of single- and multi-photon fluorescence and of higher order harmonics |
EP2093601B1 (en) * | 2006-12-12 | 2013-03-13 | Nikon Corporation | Microscope device and image processing method |
GB0707433D0 (en) * | 2007-04-18 | 2007-05-23 | Stfc Science & Technology | Fluorescence measurement |
US8064059B2 (en) * | 2008-11-04 | 2011-11-22 | Alipasha Vaziri | Optical pulse duration measurement |
JP5639182B2 (en) * | 2009-11-02 | 2014-12-10 | オリンパス株式会社 | Beam splitter device, light source device, and scanning observation device |
US8953651B2 (en) * | 2010-02-24 | 2015-02-10 | Alcon Lensx, Inc. | High power femtosecond laser with repetition rate adjustable according to scanning speed |
WO2012135073A2 (en) * | 2011-03-25 | 2012-10-04 | Board Of Trustees Of Michigan State University | Adaptive laser system for ophthalmic use |
US9867525B2 (en) * | 2011-04-01 | 2018-01-16 | Nanyang Technological University | High sensitivity temporal focusing widefield multiphoton endoscope capable of deep imaging |
US20160238532A1 (en) * | 2013-06-21 | 2016-08-18 | Invenio Imaging Inc. | Multi-photon systems and methods |
DE102015107367A1 (en) * | 2015-05-11 | 2016-11-17 | Carl Zeiss Ag | Evaluation of Fluorescence Scanning Microscopy Signals Using a Confocal Laser Scanning Microscope |
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US10345565B2 (en) * | 2016-03-22 | 2019-07-09 | Robert David Frankel | Depth and speed enhanced orthogonal beam stimulated fluorescent and stimulated Raman emission for in-vivo imaging |
JP7089719B2 (en) * | 2017-02-07 | 2022-06-23 | ナノフォトン株式会社 | Spectroscopic microscope and spectroscopic observation method |
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2017
- 2017-10-30 CN CN201780081894.3A patent/CN110168351A/en active Pending
- 2017-10-30 CA CA3042229A patent/CA3042229A1/en active Pending
- 2017-10-30 IL IL266284A patent/IL266284B2/en unknown
- 2017-10-30 WO PCT/US2017/059044 patent/WO2018081711A1/en active Application Filing
- 2017-10-30 KR KR1020197015389A patent/KR20190082252A/en unknown
- 2017-10-30 US US16/346,339 patent/US20200182792A1/en active Pending
- 2017-10-30 EP EP17865830.8A patent/EP3532827B1/en active Active
- 2017-10-30 SG SG11201903841PA patent/SG11201903841PA/en unknown
- 2017-10-30 JP JP2019544795A patent/JP2019536059A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3042229A1 (en) | 2018-05-03 |
IL266284B1 (en) | 2023-09-01 |
IL266284A (en) | 2019-06-30 |
KR20190082252A (en) | 2019-07-09 |
US20200182792A1 (en) | 2020-06-11 |
JP2019536059A (en) | 2019-12-12 |
CN110168351A (en) | 2019-08-23 |
IL266284B2 (en) | 2024-01-01 |
WO2018081711A1 (en) | 2018-05-03 |
EP3532827B1 (en) | 2023-05-31 |
EP3532827A4 (en) | 2020-07-01 |
EP3532827A1 (en) | 2019-09-04 |
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